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ARS Home » Pacific West Area » Pullman, Washington » Animal Disease Research » Research » Research Project #431742

Research Project: Development of Detection and Control Strategies for Bovine Babesiosis and Equine Piroplasmosis

Location: Animal Disease Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Identification of proteins expressed by Babesia bigemina kinetes - (Peer Reviewed Journal)

A recombinant bovine herpesvirus-4 vectored vaccine delivered via intranasal nebulization elicits viral neutralizing antibody titers in cattle - (Peer Reviewed Journal)
Williams, L.B., Fry, L.M., Herndon, D.R., Franceschi, V., Schneider, D.A., Donofrio, G., Knowles, D.P. 2019. A recombinant bovine herpesvirus-4 vectored vaccine delivered via intranasal nebulization elicits viral neutralizing antibody titers in cattle. PLoS One. https://doi.org/10.1371/journal.pone.0215605.

Detection and genotypic characterization of toxoplasma gondii DNA within the milk of Mongolian livestock - (Peer Reviewed Journal)
Iacobucci, E., Fritz, H., Papageorgiou, S., O'Conner, R., Taus, N.S., Ueti, M.W. 2019. Detection and genotypic characterization of toxoplasma gondii DNA within the milk of Mongolian livestock. Parasitology Research. https://doi.org/10.1007/s00436-019-06306-w.

Gene gun DNA immunization of cattle induces humoral and CD4 T-cell-mediated immune responses against the Theileria parva polymorphic immunodominant molecule - (Peer Reviewed Journal)
Fry, L.M., Bastos, R.G., Stone, B.C., Williams, L.B., Knowles, D.P., Murphy, S.C. 2019. Gene gun DNA immunization of cattle induces humoral and CD4 T-cell-mediated immune responses against the Theileria parva polymorphic immunodominant molecule . Vaccine. https://doi.org/10.1016/j.vaccine.2019.02.009.

Transgenic babesia bovis lacking 6-Cys sexual-stage genes as the foundation for non-transmissible live vaccines against bovine babesiosis - (Peer Reviewed Journal)
Alzan, H.F., Cooke, B.M., Suarez, C.E. 2019. Transgenic babesia bovis lacking 6-Cys sexual-stage genes as the foundation for non-transmissible live vaccines against bovine babesiosis. Ticks and Tick Borne Diseases. https://doi.org/10.1016/j.ttbdis.2019.01.006.

Silencing expression of the Rhipicephalus microplus vitellogenin receptor gene blocks Babesia bovis transmission and interferes with oocyte maturation - (Peer Reviewed Journal)
Hala, H.E., Johnson, W.C., Taus, N.S., Suarez, C.E., Scoles, G.A., Ueti, M.W. 2019. Silencing expression of the Rhipicephalus microplus vitellogenin receptor gene blocks Babesia bovis transmission and interferes with oocyte maturation . Parasites & Vectors. https://doi.org/10.1186/s13071-018-3270-1.

Unraveling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit? - (Peer Reviewed Journal)
Suarez, C.E., Alzan, A., Silva, M., Rathinasamy, V., Poole, W., Cooke, B. 2019. Unraveling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit?. International Journal for Parasitology. https://doi.org/10.1016/j.ijpara.2018.11.002.

Identification of a putative methyltransferase gene of Babesia bigemina as a novel molecular biomarker uniquely expressed in parasite tick stages. - (Peer Reviewed Journal)
Bohaliga, G.A., Johnson, W.C., Taus, N.S., Hussein, H.E., Ueti, M.W. 2018. Identification of a putative methyltransferase gene of Babesia bigemina as a novel molecular biomarker uniquely expressed in parasite tick stages. . International Journal for Parasitology. https://doi.org/10.1186/s13071-018-3052-9.

Up-regulated expression of spherical body protein 2 truncated copy 11 is associated with reduced in vitro endothelial cell cytoadhesion by babesia bovis - (Peer Reviewed Journal)
Gallego-Lopez, G., Lau, A., O'Connor, R., Ueti, M.W., Cooke, B., Laughery, J., Graca, T., Madsen-Bouterse, S., Oldiges, D., Suarez, C.E. 2018. Up-regulated expression of spherical body protein 2 truncated copy 11 is associated with reduced in vitro endothelial cell cytoadhesion by babesia bovis. International Journal for Parasitology. https://doi.org/10.1016/j.ijpara.2018.05.015.

Exercise-induced pulmonary hemorrhage in barrel racing horses in the Pacific Northwest region of the United States - (Peer Reviewed Journal)
Gold, J.R., Knowles, D.P., Coffey, T., Bayly, W.M. 2018. Exercise-induced pulmonary hemorrhage in barrel racing horses in the Pacific Northwest region of the United States. Journal of Veterinary Internal Medicine. https://doi.org/10.1111/jvim.15066.

Immunomolecular characterization of MIC-1, a novel antigen in babesia bigemina, which contains conserved and immunodominant B-cell epitopes that induce neutralizing antibodies - (Peer Reviewed Journal)
Hernández-Silva, D., Valdez-Espinoza, U., Mercado Uriostegui, M., Aguilar-Tipacamú, G., Ramos-Aragón, J., Hernández-Ortiz, R., Ueti, M.W., Mosqueda, J. 2018. Immunomolecular characterization of MIC-1, a novel antigen in babesia bigemina, which contains conserved and immunodominant B-cell epitopes that induce neutralizing antibodies. Journal of Veterinary Science. https://doi.org/10.3390/vetsci5020032.

Discovery of a novel species Theileria haneyi n. sp. infective to equids highlights exceptional genomic diversity within the genus Theileria: implications for apicomplexan parasite surveillance - (Peer Reviewed Journal)
Knowles Jr, D.P., Kappmeyer, L.S., Haney, D., Herndon, D.R., Fry, L.M., Munro, J.B., Sears, K., Ueti, M.W., Wise, L.N., Silva, M., Schneider, D.A., Grause, J., White, S.N., Trentina, K., Bishop, R., Odongo, D.O., Pelzel-Mccluske, A.M., Scoles, G.A., Mealey, R.H., Silva, J.C. 2018. Discovery of a novel species Theileria haneyi n. sp. infective to equids highlights exceptional genomic diversity within the genus Theileria: implications for apicomplexan parasite surveillance. International Journal for Parasitology. https://doi.org/10.1016j.ijpara.2018.03.010.

Spherical body protein 2 truncated copy 11 as a specific babesia bovis attenuation marker - (Peer Reviewed Journal)
Gallego-Lopez, G., Lau, A., Johnson, W.C., Ueti, M.W., Suarez, C.E. 2018. Spherical body protein 2 truncated copy 11 as a specific babesia bovis attenuation marker. Parasites & Vectors. 11:169. https://doi.org/10.1186/s13071-018-2782-z.

Stable transformation of Babesia bigemina and Babesia bovis using a single transfection plasmid - (Peer Reviewed Journal)
Silva, M.G., Knowles, D.P., Mazuz, M.L., Cooke, B.M., Suarez, C.E. 2018. Stable transformation of Babesia bigemina and Babesia bovis using a single transfection plasmid. Scientific Reports. 8:6096. doi:10.1038/s41598-018-23010-4.

Comparisons of the topographic characteristics and electrical charge distributions among Babesia-infected erythrocytes and extraerythrocytic merozoites using AFM - (Peer Reviewed Journal)
Scudiero, L., Mercado, W.J., Rudolph, A., Wang, J., Laughery, J.M., Suarez, C.E. 2018. Comparisons of the topographic characteristics and electrical charge distributions among Babesia-infected erythrocytes and extraerythrocytic merozoites using AFM. Journal of Microscopy. doi:10.1111/jmi.12697.

Molecular detection and characterization of theileria spp infecting cattle in Sennar State, Sudan - (Peer Reviewed Journal)
Mohamad, S.B., Alagib, A., Abdelkareim, T.B., Haasan, M.M., Johnson, W.C., Hussein, H.E., Taus, N.S., Ueti, M.W. 2018. Molecular detection and characterization of theileria spp infecting cattle in Sennar State, Sudan. Parasitology Research. https://doi.org/10.1007/s00436.

First detection of diffuse and cerebral theileria equi infection in neonatal filly - (Peer Reviewed Journal)
Levi, M.M., Tirosh-Levy, S., Dahan, R., Berlin, D., Steinman, A., Edery, N., Savistsky, I., Lebovich, B., Knowles Jr, D.P., Suarez, C.E. 2017. First detection of diffuse and cerebral theileria equi infection in neonatal filly. Journal of Equine Veterinary Science. 60:23-28.

The babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction - (Peer Reviewed Journal)
Hussein, H.E., Bastos, R.G., Schneider, D.A., Johnson, W.C., Adham, F.K., Davis, W.C., Laughery, J.M., Herndon, D.R., Alzan, H.F., Ueti, M.W., Suarez, C.E. 2017. The babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction. PLOS Neglected Tropical Diseases. 11(10):e0005965. https://doi.org/10.1371/journal.pntd.0005965.

Advances in the application of genetic manipulation methods to apicomplexan parasites - (Peer Reviewed Journal)
Suarez, C.E., Bishop, R.P., Alzan, H., Poole, W., Cook, B. 2017. Advances in the application of genetic manipulation methods to apicomplexan parasites. International Journal for Parasitology. https://doi.org/10.1016/j.ijpara.2017.08.002.

Assessment and optimization of theileria parva sporozoite full-length p67 antigen expression in mammalian cells - (Peer Reviewed Journal)
Tebaldi, G., Williams, L.B., Verna, A.E., Macchi, F., Franceshi, V., Fry, L.M., Knowles Jr, D.P., Donofrio, G. 2017. Assessment and optimization of theileria parva sporozoite full-length p67 antigen expression in mammalian cells. PLOS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0005803.

Geno- and phenotypic characteristics of a transfected babesia bovis 6-Cys-E knockout clonal line - (Peer Reviewed Journal)
Alzan, A., Silva, M., Davis, W., Herndon, D.R., Schneider, D.A., Suarez, C.E. 2017. Geno- and phenotypic characteristics of a transfected babesia bovis 6-Cys-E knockout clonal line. Parasites & Vectors. 10(1):214.

Characterization of leukocyte subsets in buffalo (Bubalus bubalis) with cross-reactive monoclonal antibodies specific for bovine MHC class I and class II molecules and leukocyte differentiation molecules - (Peer Reviewed Journal)
Davis, W.C., Grandoni, F., Mahmoud, E.M., Abdellrazeq, G.S., Fry, L.M., Mack, V., Marchitelli, C., Barile, V.L. 2017. Characterization of leukocyte subsets in buffalo (Bubalus bubalis) with cross-reactive monoclonal antibodies specific for bovine MHC class I and class II molecules and leukocyte differentiation molecules. Developmental and Comparative Immunology. 74:101-109.

Inhibition of the in vitro growth of babesia bigemina, babesia caballi and theileria equi parasites by trifluralin analogues - (Peer Reviewed Journal)
Silva, M.G., Knowles, D.P., Domingos, A., Esteves, A.M., Antunes, S., Suarez, C.E. 2017. Inhibition of the in vitro growth of babesia bigemina, babesia caballi and theileria equi parasites by trifluralin analogues. Ticks and Tick Borne Diseases. 8(4):593-597.

Characterization and use of new monoclonal antibodies to CD11c,CD14, and CD163 to analyze the phenotypic complexity of ruminantmonocyte subsets - (Peer Reviewed Journal)
Elnaggar, M.M., Abdellrazeq, G.S., Mack, V., Fry, L.M., Davis, W.C., Park, T. 2016. Characterization and use of new monoclonal antibodies to CD11c,CD14, and CD163 to analyze the phenotypic complexity of ruminantmonocyte subsets. Veterinary Immunology and Immunopathology. 178:57-63.