Project Number: 8042-32000-008-13-I
Project Type: Interagency Reimbursable Agreement
Start Date: Oct 1, 2015
End Date: Sep 30, 2017
Novel insecticide chemistries and formulations to control important disease vector species, especially mosquitoes and other blood sucking insects. 1. Large scale synthesis, toxicological evaluation, and field evaluation of optimized pyriproxyfen-based insect growth regulators (IGRs). 2. Identify and evaluate novel adjuvants and synergistics of public health pesticides. 3. Development and evaluation of novel chemistries as vector control tools.
Existing industrial method for commercial production of pyriproxyfen will be modified in my laboratory to suit gram scale synthesis of analogues IIBBL has developed. Evaluate new chemistries including chiral piperidines as toxicants and repellents: Non-pyrethroid chemicals comprised in three classes as contact irritant\toxicants against blood feeding mosquitoes will be explored in order to find those with highest efficacy and/or novel modes of action. Among these three classes, oxazinones are the most economically viable candidates. Analysis of mode of action and toxicological profile would be the first sub objective for oxazinones. Another class of compound IIBBL identified was bis-furan (abundant in annona squamosa). However, the sever eye-irritancy of many known plant-based bis-furans is major concern. IIBBL will evaluate some of the novel pyrethroid-type chemicals which do not exhibit modes of action resembling those of pyrethroid insecticides.