Location: Food Components and Health Laboratory
Project Number: 8040-51530-011-07-T
Project Type: Trust Fund Cooperative Agreement
Start Date: Jul 1, 2015
End Date: Dec 31, 2019
To determine the effect of cashew nut consumption on established and emerging markers of cardiovascular disease, and to determine the metabolizable energy value of cashew nuts when fed to humans.
The planned study is designed as a controlled-feeding (all food provided and measured to the nearest 1 g during the entirety of each treatment period), randomized crossover trial. The volunteer recruitment, feeding, sample collection, and sample analysis will take place at the Beltsville Human Nutrition Research Center. Two treatments will be fed, one with 0 g/day of cashew nuts (control), and one with 42 g/day of whole cashew nuts. The diets will include a variety of typical Western foods, and will be fed as part of a weight maintaining diet. The 8-week study will be conducted with two periods each lasting 4 weeks. The length of the feeding periods (4 weeks) is selected to optimize the time needed for a response and stabilization of circulating lipoproteins to a dietary intervention. Blood samples will be collected at the beginning of the study and at the end of each feeding period. At each sampling time point, two samples will be collected, separated by at least 24 hours for a total of 6 samples. Also, during the end of each treatment period, volunteers will collect all feces and urine voided. These samples will be processed and analyzed for energy and macronutrient composition.