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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Parasitic Diseases Laboratory » Research » Research Project #428625

Research Project: Effector Diversification and Toxoplasma Virulence

Location: Animal Parasitic Diseases Laboratory

Project Number: 8042-32420-007-11-R
Project Type: Reimbursable Cooperative Agreement

Start Date: Dec 1, 2014
End Date: Nov 30, 2018

Objective:
To determine the molecular basis of pathogenicity of Toxoplasma gondii and Hammondia hammondi.

Approach:
Oocysts of two 2 parasites, Toxoplasma gondii and Hammondia hammondi, will be obtained from feces of experimentally infected cats, and will be used for DNA harvest as well as to initiate in vitro cultures with sporozoites. The virulence of the parasites will be tested in outbred mice to dissect out the genes responsible for the virulence of Toxoplasma or lack of it. These experiments will be performed at the University of Pittsburgh as the Cooperator is expert in the biology of these 2 parasites.