Location: Mosquito and Fly Research
Project Number: 6036-32000-050-15-S
Project Type: Non-Assistance Cooperative Agreement
Start Date: Aug 4, 2014
End Date: Aug 30, 2018
The objective of this cooperative project is to synthesize novel compounds which will lead to the discovery of new insecticides for use against mosquitoes and other biting flies.
Recent literature reports (2013-2014) indicate a promising class of compounds (isoxazolines) which have not shown resistance development in mosquitoes. One of the chemicals from this class (flurlaner) has been reported to be more potent than fipronil and dieldrin when tested against cat fleas, cattle ticks, brown dog ticks, and Aedes aegypti mosquitoes. This agreement is initiated as a means to explore further the potent ability of this class of chemical. Approach 1: Use structure-activity relationships to design and synthesize novel isoxazoline structures. The starting point for this study is a compound named “flurlaner.” Approach 2: Develop synthesis pathways and perform the synthesis of a number of these (8-12) type of compounds. Research on this pathway is publishable in Organic Chemistry journals. Approach 3: Evaluate the insecticidal activity of the synthesized compounds against susceptible and resistant mosquito strains. The results of this research are publishable in toxicological or entomological journals. This phase will be conducted by collaboration with the Mosquito and Fly Research Unit. Approach 4: Develop additional structures based on the results determined from tests in Approach 3 and evaluate the insecticidal activity of the second generation structures to determine if the structure-activity hypothesis was supported.