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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Research Project #427212

Research Project: Obesity and Energy Regulation throughout the Adult Lifecycle

Location: Jean Mayer Human Nutrition Research Center On Aging

Project Number: 8050-51000-097-01-S
Project Type: Non-Assistance Cooperative Agreement

Start Date: Apr 17, 2014
End Date: Apr 16, 2019

Objective:
LAB NAME: ENERGY METABOLISM 1: Determine the effects of specific dietary composition factors, including macronutrient type, fiber and food form on hunger, satiety and energy regulation. 1A: In a randomized controlled trial we will provide all food at weight maintenance levels of energy intake for 6 weeks in 80 healthy adults, and determine the effects of a whole grain (WG) versus refined grain (RG) food regimen on hunger, satiety, fecal energy excretion, resting metabolic rate, and the relation of hunger and satiety to circulating glucose levels. 2: Demonstrate effective methods for sustainable weight control and prevention of obesity in adult population groups spanning a range of ages and demographics. 2A: In pregnant obese and overweight women, examine the effectiveness of an intervention that prioritizes hunger suppression for prevention of excess weight gain prior to delivery, with the focus on prevention of long-term weight gain.2B: Form an International Obesity Consortium and conduct a cross-sectional study in three or more countries with high rates of obesity to identify dietary and lifestyle predictors of excess weight. These data will be used to develop and test country-specific interventions for sustainable weight control. 2C: In overweight and obese U.S. adults aged 21-65 years, conduct a randomized trial comparing different dietary composition recommendations for sustainable weight loss over 2 years. The purpose of having a relatively wide age-range is to ensure that the results are broadly applicable. The primary outcome will be weight change from baseline to 2 years. Secondary outcome will include cardiometabolic risk factors and quality of life. 3: Develop new methodology for improving the accuracy and precision of assessment of energy and nutrient intakes and energy requirements in adults. 3A: Develop a voice-recognition software prototype for self-monitoring of energy and nutrient intakes. 3B: Conduct analyses of the energy content of randomly selected meals from non-chain restaurants not reporting meal energy content in 3 locations in the U.S.

Approach:
LAB NAME: ENERGY METABOLISM The mission of the Obesity and Energetics Laboratory is to understand the effects of lifestyle factors on energy metabolism and weight regulation. Our research examines dietary and behavioral variables that influence both energy intake and metabolism throughout the adult lifecycle, and our focus is to develop and test effective lifestyle interventions for implementing sustainable, healthy weight control at all ages. Studies in our laboratory include in-depth biological examinations of the impact of different dietary factors on biochemical and neurological factors involved in energy regulation and body composition, chemical studies of food composition, and randomized controlled trials testing practical interventions that can be scaled for population-wide benefits.