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Research Project: Assessing the Impact of Diet on Inflammation in Healthy and Obese Adults in a Cross-Sectional Phenotyping Study and a Longitudinal Intervention Trial

Location: Immunity and Disease Prevention Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells Reprint Icon - (Peer Reviewed Journal)
Ehrlich, A.M., Pacheco, A.R., Henrick, B.M., Taft, D., Xe, G., Huda, N.M., Mishchuk, D., Goodson, M., Slupsky, C., Barile, D., Lebrilla, C.B., Stephensen, C.B., Mills, D.A., Raybould, H.E. 2020. Indole-3-lactic acid associated with Bifidobacterium-dominated microbiota significantly decreases inflammation in intestinal epithelial cells. Gut Microbes. (2020) 20:357. https://doi.org/10.1186/s12866-020-02023-y.

Endotoxin may not be the major cause of postprandial inflammation in adults who consume a single high-fat or moderately high-fat meal - (Peer Reviewed Journal)

The fecal resistome of dairy cattle is associated with diet during nursing Reprint Icon - (Peer Reviewed Journal)
Liu, J., Taft, D.H., Gomez, M.X., Johnson, D., Treiber, M.L., Lemay, D.G., Depeters, E., Mills, D.A. 2019. The fecal resistome of dairy cattle is associated with diet during nursing. Nature Communications. https://doi.org/10.1038/s41467-019-12111-x.

High-Dose, neonatal vitamin A supplementation transiently decreases thymic function in early infancy Reprint Icon - (Peer Reviewed Journal)
Ahmad, S., Raqib, R., Huda, N.M., Alam, M.J., Monirujjaman, M., Akhter, T., Wagatsuma, Y., Qadri, F., Tanumihardjo, S., Zerofsky, M.S., Stephensen, C.B. 2020. High-Dose, neonatal vitamin A supplementation transiently decreases thymic function in early infancy. Journal of Nutrition. Volume 150, Issue 1, January 2020, Pages 176–183. https://doi.org/10.1093/jn/nxz193.

Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal Reprint Icon - (Peer Reviewed Journal)
Lemay, D.G., Huang, S., Huang, L., Alkan, Z., Kirschke, C.P., Burnett, D.J., Wang, Y., Hwang, D.H. 2019. Temporal changes in postprandial blood transcriptomes reveal subject-specific pattern of expression of innate immunity genes after a high-fat meal. Journal of Nutritional Biochemistry. 72:108209. https://doi.org/10.1016/j.jnutbio.2019.06.007.

Fecal metatranscriptomics of macaques with idiopathic chronic diarrhea reveals altered mucin degradation and fucose utilization Reprint Icon - (Peer Reviewed Journal)
Westreich, S.T., Ardeshir, A., Alkan, Z., Kable, M.E., Korf, I., Lemay, D.G. 2019. Fecal metatranscriptomics of macaques with idiopathic chronic diarrhea reveals altered mucin degradation and fucose utilization. BMC Microbiome. 7:41. https://doi.org/10.1186/s40168-019-0664-z.

The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part I: Overview of Current Methods Reprint Icon - (Review Article)
Hughes, R.L., Marco, M., Hughes, J.P., Keim, N.L., Kable, M.E. 2019. The role of the gut microbiome in predicting response to diet and the development of precision nutrition models. Part I: Overview of Current Methods. Advances in Nutrition. https://doi.org/10.1093/advances/nmz022.

Neonatal vitamin A supplementation and vitamin A status are associated with gut microbiome composition in Bangladeshi infants in early infancy and at two years of age - (Peer Reviewed Journal)

Bifidobacterium abundance in early infancy and vaccine response at 2 years of age - (Peer Reviewed Journal)
Huda, N., Ahmad, S.M., Alam, M.J., Khanam, A., Kalanetra, K.M., Taft, D.H., Raqib, R., Underwood, M.A., Mills, D.A., Stephensen, C.B. 2019. Bifidobacterium abundance in early infancy and vaccine response at 2 years of age. Pediatrics. 143(2):e20181489.

Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms Reprint Icon - (Peer Reviewed Journal)
Sanctuary, M., Kain, J., Chen, S., Kalentra, K., Lemay, D.G., Rose, D., Yang, H., Tancredi, D.J., German, B.J., Slupsky, C., Ashwood, P., Mills, D., Smilowtz, J.T., Angkustsiri, K. 2019. Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms. PLoS One. 14(1):1-30. https://doi.org/10.1371/journal.pone.0210064.

The collaborative effect of scientific meetings: a study of the international milk genomics consortium Reprint Icon - (Peer Reviewed Journal)
Kwok, E., Porter, M., Korf, I., Pasin, G., German, B.J., Lemay, D.G. 2018. The collaborative effect of scientific meetings: a study of the international milk genomics consortium. PLoS One. 10.1371. https://doi.org/10.1371/journal.pone.0201637.

Infant cortisol stress-response is associated with thymic function and vaccine response Reprint Icon - (Peer Reviewed Journal)
Huda, M., Ahmad, S.D., Alam, J., Khanam, A., Alam, N., Raqib, R., Laugero, K.D., Stephensen, C.B. 2018. Infant cortisol stress-response is associated with thymic function and vaccine response. Stress: The International Journal on Biology of Stress. https://doi.org/10.1080/10253890.2018.1484445.

Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults Reprint Icon - (Peer Reviewed Journal)
Baldiviez, L.M., Keim, N.L., Laugero, K.D., Hwang, D.H., Huang, L., Woodhouse, L.R., Burnett, D.J., Zerofsky, M., Bonnel, E., Allen, L.H., Newman, J.W., Stephensen, C.B. 2017. Design and implementation of a cross-sectional nutritional phenotyping study in healthy US adults. Biomed Central (BMC) Nutrition. 3(79):1-13. https://doi.org/10.1186/s40795-017-0197-4.

SAMSA2: a standalone metatranscriptome analysis pipeline Reprint Icon - (Peer Reviewed Journal)
Westreich, S.T., Treiber, M.L., Mills, D.A., Lemay, D.G. 2018. SAMSA2: a standalone metatranscriptome analysis pipeline. BMC Bioinformatics. 19:175. https://doi.org/10.1186/s12859-018-2189-z.

Vitamin D3 supplementation increases spine bone mineral density in adolescents and young adults with HIV infection being treated with tenofovir disoproxil fumarate: a randomized, placebo controlled trial Reprint Icon - (Peer Reviewed Journal)
Havens, P.L., Stephensen, C.B., Van Loan, M.D., Schuster, G.U., Woodhouse, L.R., Flynn, P.M., Gordon, C.M., Pan, C.G., Rutledge, B., Harris, B., Price, G., Meyer, W.M., Hazra, R., Kapogiannis, B.G., Mulligan, K. 2018. Vitamin D3 supplementation increases spine bone mineral density in adolescents and young adults with HIV infection being treated with tenofovir disoproxil fumarate: a randomized, placebo controlled trial. Clinical Infectious Diseases. (2):220-228. 10.1093/cid/cix753.

The transcriptome of estrogen-independent mammary growth reveals that not all mammary glands are created equally - (Peer Reviewed Journal)
Berryhill, G.E., Lemay, D.G., Trott, J.F., Aimo, L., Lock, A.L., Hovey, R.C. 2017. The transcriptome of estrogen-independent mammary growth reveals that not all mammary glands are created equally. Endocrinology. doi: 10.1210/en.2017-00395.

21st century toolkit for optimizing population health through precision nutrition - (Trade Journal)
O'Sullivan, A., Henrick, B., Dixon, B., Barile, D., Zivkovic, A., Smilowitz, L., Lemay, D.G., Martin, W., German, B.J., Elizabeth, S. 2017. 21st century toolkit for optimizing population health through precision nutrition. Critical Reviews in Food Science and Nutrition. 57/45.

Associations of low vitamin D and elevated parathyroid hormone concentrations with bone mineral density in perinatally HIV-infected children - (Trade Journal)
Jacobson, D.L., Stephensen, C.B., Miller, T.L., Patel, K., Chen, J.S., Van Dyke, R.B., Mirza, A., Schuster, G., Hazra, R., Ellis, A., Brummel, S.S., Geffner, M., Silio, M., Spector, S.A., Dimeglio, L. 2017. Associations of low vitamin D and elevated parathyroid hormone concentrations with bone mineral density in perinatally HIV-infected children. Journal of Acquired Immune Deficiency Syndromes. doi: 10.1097/QAI.0000000000001467.

Using metatranscriptomics to determine effects of dietary supplementation with bovine milk oligosaccharides in healthy adults - (Abstract Only)
Westreich, S.T., Barile, D., Salcedo, J., Mills, D.A., Smilowitz, J.T., Korf, I., Lemay, D.G. 2017. Using metatranscriptomics to determine effects of dietary supplementation with bovine milk oligosaccharides in healthy adults. Experimental Biology. 31/940.

Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity - (Peer Reviewed Journal)
Ono-Moore, K.D., Zhao, L., Huang, S., Kim, J., Rutkowsky, J.M., Snodgrass, R.G., Schneider, D.A., Quon, M.J., Graham, J.L., Havel, P.J., Hwang, D.H. 2017. Transgenic mice with ectopic expression of constitutively active TLR4 in adipose tissues do not show impaired insulin sensitivity. European Journal of Immunology. doi: 10.1002/iid3.162.

Host determinants of expression of the helicobacter pylori BabA adhesin - (Peer Reviewed Journal)
Kable, M.E., Hansen, L.M., Styer, C.M., Gideonsson, P., Deck, S.L., Shevtsova, A., Rakhimova, O., Eaton, K.A., Martin, M.E., Boren, T., Solnick, J.V. 2017. Host determinants of expression of the helicobacter pylori BabA adhesin. Scientific Reports. 7:46499.

Metabolic effects of inflammation on vitamin A and carotenoids in humans and animal models - (Peer Reviewed Journal)
Rubin, L.P., Ross, C.A., Stephensen, C.B., Bohn, T., Tanumihardjo, S.A. 2017. Metabolic effects of inflammation on vitamin A and carotenoids in humans and animal models. Advances in Nutrition. 8:197-212. doi: 10.39945:an.116.014167.

Resveratrol-3-O-glucuronide and resveratrol-4’-O-glucuronide reduce DNA strand breakage but not apoptosis in Jurkat T cells treated with camptothecin - (Peer Reviewed Journal)
Zunino, S.J., Storms, D.H. 2017. Resveratrol-3-O-glucuronide and resveratrol-4’-O-glucuronide reduce DNA strand breakage but not apoptosis in Jurkat T cells treated with camptothecin. Oncology Letters. 14:2517-2522.

Increased cytokine production by monocytes from human subjects who consumed grape powder was not mediated by differences in dietary intake patterns - (Peer Reviewed Journal)
Zunino, S.J., Keim, N.L., Kelley, D.S., Bonnel, E.L., Souza, E.C., Peerson, J.M. 2017. Increased cytokine production by monocytes from human subjects who consumed grape powder was not mediated by differences in dietary intake patterns. Nutrition Research. 40:32-39.

Decline in bone mass with tenofovir disoproxil fumarate/emtricitabine is associated with hormonal changes in the absence of renal impairment when used by HIV uninfected adolescent boys and young men for HIV pre-exposure - (Peer Reviewed Journal)
Havens, P.L., Stephensen, C.B., Van Loan, M.D., Schuster, G., Woodhouse, L.R., Flynn, P.M., Gordon, C.M., Pan, C.G., Rutledge, B., Liu, N., Wilson, C.M., Hazra, R., Hosek, S.G., Anderson, P.L., Seifert, S.M., Kapogiannis, B.G., Mulligan, K. 2016. Decline in bone mass with tenofovir disoproxil fumarate/emtricitabine is associated with hormonal changes in the absence of renal impairment when used by HIV uninfected adolescent boys and young men for HIV pre-exposure. Clinical Infectious Diseases. 64/317-325.

What causes high fat diet-induced postprandial inflammation: endotoxin or free fatty acids? - (Abstract Only)

Daily cholecalciferol supplementation during pregnancy alters markers of regulatory immunity, inflammation, and clinical outcomes in a randomized controlled trial - (Peer Reviewed Journal)

Biomarkers of Nutrition for Development – Vitamin A Review - (Peer Reviewed Journal)
Tanuminhardjo, S.A., Russell, R.M., Stephensen, C.B., Gannon, B.M., Craft, N.E., Haskell, M.J., Lietz, G., Schulze, K., Raiten, D.J. 2016. Biomarkers of Nutrition for Development – Vitamin A Review. Journal of Nutrition. 146/p.18165-18485.

The metatranscriptome of the rhesus macaque: investigating potential causes of idiopathic chronic diarrhea - (Abstract Only)
Westreich, S.T., Ardeshir, A., Kable, M.E., Korf, I., Lemay, D.G. 2016. The metatranscriptome of the rhesus macaque: investigating potential causes of idiopathic chronic diarrhea. Experimental Biology. 31/650.

‘‘Omics’’ of Selenium Biology: A Prospective Study of Plasma Proteome Network Before and After Selenized-Yeast Supplementation in Healthy Men - (Peer Reviewed Journal)
Sinha, I., Karagoz, K., Fogle, R.L., Hollenbeak, C.S., Zea, A.H., Arga, K.Y., Stanley, A.E., Hawkes, W.C., Sinha, R. 2016. ‘‘Omics’’ of Selenium Biology: A Prospective Study of Plasma Proteome Network Before and After Selenized-Yeast Supplementation in Healthy Men. Omics - A Journal Of Integrative Biology. Vol 20(4), 2016;DOI: 10.1089/omi.2015.0187.

Comparisons of the effect of naturally acquired maternal pertussis antibodies and antenatal vaccination induced maternal tetanus antibodies on infant's antibody secreting lymphocyte responses and circulating plasma antibody - (Peer Reviewed Journal)
Ahmad, S.M., Alam, J., Afsar, N.A., Huda, N., Kabir, Y., Qadri, F., Raqib, R., Stephensen, C.B. 2016. Comparisons of the effect of naturally acquired maternal pertussis antibodies and antenatal vaccination induced maternal tetanus antibodies on infant's antibody secreting lymphocyte responses and circulating plasma antibody. Taylor and Francis Group. 12/886-893.

Vitamin A and Epigenetic Modifications - (Trade Journal)
Stephensen, C.B. 2015. Vitamin A and Epigenetic Modifications. Sight and Life Newsletter. Vol.29(2) Pg 21-23.

Toll-like receptor 4-induced endoplasmic reticulum stress contributes to endothelial dysfunction - (Peer Reviewed Journal)
Kim, J., Jang, H., Hwang, D.H. 2015. Toll-like receptor 4-induced endoplasmic reticulum stress contributes to endothelial dysfunction. American Journal of Physiology. doi: 10.1152/ajpendo.00369.2015.

Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress - (Peer Reviewed Journal)
Snodgrass, R.G., Huang, S., Namgaladze, D., Jandali, O., Shao, T., Sama, S., Brune, B., Hwang, D.H. 2016. Docosahexaenoic acid and palmitic acid reciprocally modulate monocyte activation in part through endoplasmic reticulum stress. Journal of Lipid Research. doi: 10.1016/j.jnutbio.2016.01.010.