Research Project: Dietary Regulation of Immunity and Inflammation

Location: Diet, Genomics and Immunology Laboratory

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Pomegranate peel extract reduced the pathogenicity of Citrobacter rodentium-infections in mice - (Peer Reviewed Journal)
Smith, A.D., George, N.S., Cheung, L., Bhagavathy, G.V., Luthria, D.L., John, K.M., Bhagwat, A.A. 2020. Pomegranate peel extract reduced the pathogenicity of Citrobacter rodentium-infections in mice. Nutrition Research. 73:27-37. https://doi.org/doi:10.1016/j.nutres.2019.11.001.

Neuropeptide CGRP limits group 2 innate lymphoid cell responses and constrainst type 2 inflammation - (Peer Reviewed Journal)
Nagashima, H., Mahlakoiv, T., Shih, H., Davis, F.P., Meylan, F., Huang, Y., Harrison, O., Yao, C., Mikami, Y., Urban Jr, J.F., Caron, K., Belkaid, Y., Kanno, Y., Artis, D.C., O'Shea, J.J. 2019. Neuropeptide CGRP limits group 2 innate lymphoid cell responses and constrains type 2 inflammation. Immunity. 51(4):682-695e6. https://doi.org/10.1016/j.immuni.2019.06.009.

Pomegranate peel extract alters the microbiome in mice and dysbiosis caused by Citrobacter rodentium infection - (Peer Reviewed Journal)
George, N.S., Cheung, L., Luthria, D.L., Santin, M., Dawson, H.D., Bhagwat, A.A., Smith, A.D. 2019. Pomegranate peel extract alters the microbiome in mice and dysbiosis caused by Citrobacter rodentium infection. Journal of Food Science and Nutrition. https://doi.org/10.1002/fsn3.1106.

The regulatory actions of retinoic acid on M2 polarization of porcine macrophages - (Peer Reviewed Journal)
Chen, C.T., Perry, T.L., Chitko-Mckown, C.G., Smith, A.D., Cheung, L., Beshah, E., Urban Jr, J.F., Dawson, H.D. 2019. The regulatory actions of retinoic acid on M2 polarization of porcine macrophages. Developmental and Comparative Immunology. 98(9):20-23. https://doi.org/10.1016/j.dci.2019.03.020.

Heligmosomoides polygyrus bakeri infection decreases Smad7 expression in intestinal CD4+ T cells which allows TGF-beta to induce IL10-producing regulatory T cells that block colitis - (Peer Reviewed Journal)
Hang, L., Kumar, S., Blum, A.M., Urban Jr, J.F., Fantini, M.X., Weinstock, J.V. 2019. Heligmosomoides polygyrus bakeri infection decreases Smad7 expression in intestinal CD4+ T cells which allows TGF-beta to induce IL10-producing regulatory T cells that block colitis. Journal of Immunology. (8)2473-2481. https://doi.org/10.4049/jimmunol.1801392.

Aryl hydrocarbon receptor signaling cell intrinsically inhibits intestinal group 2 innate lymphoid cell function - (Peer Reviewed Journal)
Li, S., Bostick, J.W., Ye, J., Qiu, J., Zhang, B., Urban Jr, J.F., Avram, D., Zhou, L. 2018. Aryl hydrocarbon receptor signaling cell intrinsically inhibits intestinal group 2 innate lymphoid cell function. Immunity. 49(5):915-928,e5. https://doi.org/10.1016/j.immuni.2018.09.015.

Recirculating immunocompetent cells in colitic mice intensify their lung response to bacterial endotoxin - (Peer Reviewed Journal)
Metwali, A., Thorne, P.S., Ince, M.N., Metwali, N., Winckler, S., Guan, X., Beyatli, S., Truscott, J., Urban Jr, J.F., Elliott, D.E. 2018. Recirculating immunocompetent cells in colitic mice intensify their lung response to bacterial endotoxin. Digestive Disease and Science. 63(11)2930-2939. https://doi.org/10.1007/s10620-018-5196-z.

Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine - (Peer Reviewed Journal)
Lei, W., Ren, W., Ohmoto, M., Urban Jr, J.F., Matsumoto, I., Margolskee, R.F., Jiang, P. 2018. Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proceedings of the National Academy of Sciences. (21):5552-5557. https://doi.org/10.1073/pnas.1720758115.

Impact of micronutrients on the immune response of animals - (Review Article)
Smith, A.D., Panickar, K.S., Urban Jr, J.F., Dawson, H.D. 2018. Impact of micronutrients on the immune response of animals. Annual Review of Animal Biosciences. 6:227-254. https://doi.org/10.1146/annurev-animal-022516-022914.

The porcine translational research database: A manually curated, genomics and proteomics-based research resource - (Peer Reviewed Journal)
Dawson, H.D., Chen, C.T., Gaynor, B., Shao, J.Y., Urban Jr, J.F. 2017. The porcine translational research database: A manually curated, genomics and proteomics-based research resource. Biomed Central (BMC) Genomics. doi: 10.1186/s12864-017-4009-7.

ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production - (Peer Reviewed Journal)
Damie, S.R., Martin, R.K., Cockburn, C.L., Lownik, J.C., Carlyon, J.A., Smith, A.D., Conrad, D.H. 2017. ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production. Allergy. 148(4):542-551. https://doi.org//101111/a11.13261.

Il-4 up-regulates cyclooxygenase-1 expression in macrophages - (Peer Reviewed Journal)
Shay, A.E., Tukaramrao, D.B., Guan, B., Narayan, V., Urban Jr, J.F., Prabhu, S.K. 2017. Il-4 up-regulates cyclooxygenase-1 expression in macrophages. Journal of Biological Chemistry. 292(35):14544-14555. https://doi.org/10.1074/jbc.M117.785014.

Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice - (Peer Reviewed Journal)
Ma, E.L., Smith, A.D., Desai, N., Cheung, L., Hanscom, M., Stoica, B.A., Loane, D.J., Shea-Donohue, T., Faden, A.I. 2017. Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice. Brain Behavior and Immunity. pii: S0889-1591(17)30207-6. doi: 10.1016/j.bbi.2017.06.018.

Down-regulation of E protein activity augments an ILC2 differentiation program in the thymus - (Peer Reviewed Journal)
Wang, H., Zhao, Y., Qian, M.L., Adrianto, I., Montgomery, C.G., Urban Jr, J.F., Fung, K., Sun, X. 2017. Downregulation of E protein activity augments an ILC2 differentiation program in the thymus. Journal of Immunology. 198(8):3149-3156. doi: 10.4049/jimmunol.1602009.

Parasites, nutrition, immune responses, and biology of metabolic tissues - (Review Article)
Shea-Donohue, T., Qin, B., Smith, A.D. 2017. Parasites, nutrition, immune responses, and biology of metabolic tissues. Parasite Immunology. 39(5). doi: 10.1111/pim.12422

An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome - (Peer Reviewed Journal)
Dawson, H.D., Smith, A.D., Chen, C.T., Urban Jr, J.F. 2016. An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome. Veterinary Microbiology. pii:S0378-1135(16)30137-7. doi: 10.1016/j.vetmic.2016.05.013.

Neuroimmune modulation of gut function - (Review Article)
Shea-Donohue, Urban Jr, J.F. 2016. Neuroimmune Modulation of Gut Function. Neuroimmune Modulation of Gut Function - Gastrointestinal Pharmacology. 165(5):1120-1133. doi: 10.1016/j.cell.2016.04.029.

Acidic Chitinase Limits Allergic Inflammation and Promotes Intestinal Nematode Expulsion - (Peer Reviewed Journal)
Vannella, K.M., Ramalingam, T.R., De Queiroz, P.R., Sciurba, J., Barron, L., Borthwick, L., Smith, A.D., Mentink-Kane, M., White, S., Thompson, R.W., Cheever, A.W., Bock, K., Moore, I., Fitz, L.J., Urban Jr, J.F., Wynn, T.A. 2016. Acidic Chitinase Limits Allergic Inflammation and Promotes Intestinal Nematode Expulsion. Nature Immunology. 17(5):538-44 doi: 101038/ni.3417.

Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of nippostrongylus brasiliensis through induction of Th2 cytokines - (Peer Reviewed Journal)
Mclean, L.P., Smith, A.D., Cheung, L., Urban Jr, J.F., Sun, R., Grinchuk, V., Dasai, Zhao, A., Raufman, J.P., Shea-Donohue, T. 2016. Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of nippostrongylus brasiliensis through induction of Th2 cytokines. American Journal of Physiology - Gastrointestinal and Liver Physiology. 311(1):G130-141. doi: 10.1152/ajpgi.00461.2014.

Migratory CD103+ dendritic cells suppress Helminth-driven Type 2 immunity through constitutive expression of IL-12 - (Peer Reviewed Journal)
Everts, B., Tussiwand, R., Dreesen, L., Fairfax, K.C., Huang, S.C., Smith, A.M., Oneil, C.M., Lam, W.Y., Edelson, B.T., Urban Jr, J.F., Murphy, K.M., Pearce, E.J. 2016. Migratory CD103+ dendritic cells suppress Helminth-driven Type 2 immunity through constitutive expression of IL-12. Journal of Experimental Medicine. 213(1):35-51. doi: 10.1084/jem.20150235..

Immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis - (Peer Reviewed Journal)
Fricke, F.W., Song, Y., Wang, A., Smith, A.D., Grinchuk, V., Mongodin, E., Pei, C., Ma, B., Lu, N., Urban Jr, J.F., Shea-Donohue, T. 2015. Immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis. BMC Microbiome. doi: 10.1186/S40168-015-0103-8.

Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium - (Peer Reviewed Journal)
Mclean, L.P., Smith, A.D., Cheung, L., Sun, R., Grinchuk, V., Vanuytsel, T., Desai, N., Urban Jr, J.F., Zhao, A., Raufman, J.P., Shea-Donohue, T. 2015. Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium. Inflammatory Bowel Diseases. DOI: 10.1097/MIB.0000000000000408.

Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice - (Peer Reviewed Journal)
Wang, A., Smith, A.D., Li, Y., Urban Jr, J.F., Thirumalai, R.R., Wynn, T., Lu, N., Shea-Donohue, T., Yang, Z., Zhao, A. 2014. Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice. Cell & Bioscience. DOI: 10.1186/2045-3701-4-72.

No evidence of harms of probiotic Lactobacillus rhamnosus GG ATCC 53103 in healthy elderly-a Phase I Open Label Study to assess safety, tolerability and cytokine responses - (Peer Reviewed Journal)
Hibberd, P.L., Kleimola, L., Florina, A.M., Botelho, C., Haverkamp, M., Andreyeva, I., Poutsiaka, D., Fraser, C., Solano Aguilar, G., Syndman, D.R. 2014. No evidence of harms of probiotic Lactobacillus rhamnosus GG ATCC 53103 in healthy elderly-a Phase I Open Label Study to assess safety, tolerability and cytokine responses. PLoS One. 1:9(12):e113456. DOI: 10.1371/journal.pone.0113456.

The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response - (Peer Reviewed Journal)
He, J., Meyer-Hermann, M., Xiangying, D., Zuan, L.Y., Jones, L.A., Ramakrishna, L., De Vries, V.C., Dolpady, J., Aina, H., Joseph, S., Narayanan, S., Subramaniam, S., Putia, M., Wong, G., Xiong, H., Poidinger, M., Urban Jr, J.F., Lafaille, J.J., Curotto De Lafaille, M.A. 2013. The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response. Journal of Experimental Medicine. 210(12):2755-71. doi: 10.1084/jem.20131539.

Effect of Lactobacillus brevis ATCC 8287 as a feeding supplement on the performance and immune function of piglets - (Peer Reviewed Journal)
Lanteinen, T., Lindnholm, A., Rinttila, T., Junnikkala, S., Ravi, K., Pietila, T.E., Levonen, K., Von Ossowski, I., Solano Aguilar, G., Jakava-Viljanen, M. 2014. Effect of Lactobacillus brevis ATCC 8287 as a feeding supplement on the performance and immune function of piglets. Veterinary Immunology and Immunopathology. 158(1-2):12-25. DOI: 10.1016/J.VETIMM.2013.09.002.