Research Project: Sarcopenia, Nutrition, and Physical Activity

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults - (Peer Reviewed Journal)
Fielding, R.A., Reeves, A.R., Jasuja, R., Liu, C., Barrett, B.B., Lustgarten, M.S. 2019. Muscle strength is increased in mice that are colonized with microbiota from high-functioning older adults. Experimental Gerontology. 127. https://doi.org/10.1016/j.exger.2019.110722.

Sphingosine-1-phosphate analog FTY720 reverses obesity but not age-induced anabolic resistance to muscle contraction - (Peer Reviewed Journal)
Rivas, D., Rice, N., Ezzyat, Y., McDonald, D.J., Cooper, B.E., Fielding, R.A. 2019. Sphingosine-1-phosphate analog FTY720 reverses obesity but not age-induced anabolic resistance to muscle contraction. American Journal of Physiology - Cell Physiology. 317:C502-C512. https://doi.org/10.1152/ajpcell.00455.2018.

Circulating interleukin-6 is associated with skeletal muscle strength, quality, and functional adaptation with exercise training in mobility-limited older adults - (Peer Reviewed Journal)
Grosicki, G.J., Barrett, B.B., Englund, D.A., Liu, C., Travison, T.G., Cederholm, T., Koochek, A., Von Berens, A., Gustafsson, T., Benard, T., Reid, K.F., Fielding, R.A. 2019. Circulating interleukin-6 is associated with skeletal muscle strength, quality, and functional adaptation with exercise training in mobility-limited older adults. The Journal of Frailty and Aging. 9:57-63. https://doi.org/10.14283/jfa.2019.30.

Assessment of muscle function and physical performance in daily clinical practice: a position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Muscoloskeletal ... - (Review Article)
Beaudart, C., Rolland, Y., Cruz-Jentoft, A.J., Bauer, J.M., Sieber, C., Cooper, C., Al-Daghri, N., Araujo De Carvalho, I., Bautmans, I., Bernabei, R., Bruyere, O., Cesari, M., Cherubini, A., Dawson-Hughes, B., Kanis, J.A., Kaufman, J., Landi, F., Maggi, S., McCloskey, E., Petermans, J., Rodriguez Manas, L., Reginster, J., Roller-Wirnsberger, R., Schaap, L.A., Uebelhart, D., Rizzoli, R., Fielding, R.A. 2019. Assessment of muscle function and physical performance in daily clinical practice: a position paper endorsed by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Muscoloskeletal Diseases (ESCEO). Calcified Tissue International. 105(1):1-14. https://doi.org/10.1007/s00223-019-00545-w.

Establishing the link between lean mass and grip strength cut points with mobility disability and other health outcomes: proceedings of the Sarcopenia Definitions and Outcomes Consortium Conference - (Peer Reviewed Journal)
Cawthon, P., Travison, T.G., Manini, T.M., Patel, S., Pencina, K.M., Fielding, R.A., Magaziner, J.M., Newman, A.B., Brown, T., Kiel, D.P., Cummings, S.R., Shardell, M., Guralnik, J.M., Woodhouse, L.J., Pahor, M., Binder, E., D'Agostino, Sr., R.B., Quian-Li, X., Orwoll, E., Landi, F., Orwig, D., Schaap, L., Latham, N.K., Hirani, V., Kwok, T., Pereira, S.L., Rooks, D., Kashiwa, M., Torres-Gonzalez, M., Menetski, J.P., Correa-De-Araujo, R., Bhasin, S. 2019. Establishing the link between lean mass and grip strength cut points with mobility disability and other health outcomes: proceedings of the Sarcopenia Definitions and Outcomes Consortium Conference. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/glz081.

Lower-extremity torque capacity and physical function in mobility-limited older adults - (Peer Reviewed Journal)
Grosicki, G.J., Englund, D.A., Price, L.L., Iwai, M., Kashiwa, M., Reid, K.F., Fielding, R.A. 2019. Lower-extremity torque capacity and physical function in mobility-limited older adults. Journal of Nutrition Health and Aging. 23:703-709. https://doi.org/10.1007/s12603-019-1232-8.

A case for promoting movement medicine: preventing disability in the LIFE Randomized Controlled Trial - (Peer Reviewed Journal)
Fanning, J., Rejeski, W., Chen, S., Nicklas, B.J., Walkup, M.P., Axtell, R.S., Fielding, R.A., Glynn, N.W., King, A.C., Manini, T.M., McDermott, M.M., Newman, A.B., Pahor, M., Tudor-Locke, C., Miller, M.E. 2019. A case for promoting movement medicine: preventing disability in the LIFE Randomized Controlled Trial. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/glz050.

Impact of gut dysbiosis on neurohormonal pathways in chronic kidney disease - (Review Article)
Jazani, N.H., Savoj, J., Lustgarten, M., Lau, W., Vaziri, N.D. 2019. Impact of gut dysbiosis on neurohormonal pathways in chronic kidney disease. Diseases. 7(1):21. https://doi.org/10.3390/diseases7010021.

Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial - (Peer Reviewed Journal)
Pahor, M., Anton, S.D., Beavers, D.P., Cauley, J.A., Fielding, R.A., Kritchevsky, S.B., Leeuwenburgh, C., Lewis, K.H., Liu, C.K., Lovato, L., Lu, J., Manini, T.M., McDermott, M.M., Miller, M.E., Newman, A.B., Radziszewska, B., Stowe, C.L., Tracy, R.P., Walkup, M.P., Wu, S., Ambrosius, W.T. 2018. Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/gly277.

Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: VIVE2 randomized controlled trial - (Peer Reviewed Journal)
Von Berens, A., Fielding, R.A., Gustafsson, T., Kirn, D., Laussen, J., Nydahl, M., Reid, K.F., Travison, T.G., Zhu, H., Cederholm, T., Koochek, A. 2018. Effect of exercise and nutritional supplementation on health-related quality of life and mood in older adults: VIVE2 randomized controlled trial. BMC Geriatrics. 18:286. https://doi.org/10.1186/s12877-018-0976-z.

Community-based activity and sedentary patterns are associated with cognitive performance in mobility-limited older adults - (Peer Reviewed Journal)
Wanigatunga, A.A., Manini, T.M., Cook, D.R., Katula, J., Fielding, R.A., Kramer, A.F., Verghese, J., Rapp, S.R., Sink, K.M., King, A.C., Buford, T.W., Anton, S., Nadkarni, N., Jennings, J.M., Reid, K.F., Espeland, M.A., Gill, T.M., Pahor, M., Nocera, J.R. 2018. Community-based activity and sedentary patterns are associated with cognitive performance in mobility-limited older adults. Frontiers in Aging Neuroscience. 10:341. https://doi.org/10.3389/fnagi.2018.00341.

Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial - (Peer Reviewed Journal)
Liu, Z., Hsu, F., Trombetti, A., King, A.C., Liu, C.K., Manini, T.M., Fielding, R.A., Pahor, M., Newman, A.B., Kritchevsky, S., Gill, T.M. 2018. Effect of 24-month physical activity on cognitive frailty and the role of inflammation: the LIFE randomized clinical trial. BioMed Central (BMC) Medicine. https://doi.org/10.1186/s12916-018-1174-8.

Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed - (Peer Reviewed Journal)
Manini, T.M., Buford, T.W., Kairalla, J.A., McDermott, M.M., Vazfragoso, C.A., Fielding, R.A., Hsu, F., Johannsen, N., Kritchevsky, S., Harris, T.B., Newman, A.B., Cummings, S.R., King, A.C., Pahor, M., Santanasto, A.J., Tranah, G.C. 2018. Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed. GeroScience. https://doi.org/10.1007/s11357-018-0043-x.

Effect of hospitalizations on physical activity patterns in mobility-limited older adults - (Peer Reviewed Journal)
Wanigatunga, A.A., Gill, T.M., Marsh, A.P., Shu, F., Yaghjyan, L., Woods, A.J., Glynn, N.W., King, A.C., Newton, R.L., Fielding, R.A., Pahor, M., Manini, T.M. 2018. Effect of hospitalizations on physical activity patterns in mobility-limited older adults. Journal of the American Geriatrics Society. https://doi.org/10.1111/jgs.15631.

Promoting safe walking among older people: the effects of a physical and cognitive training intervention vs. physical training alone on mobility and falls among older community-dwelling men and women (the PASSWORD study): des - (Peer Reviewed Journal)
Sipila, S., Tirkkonen, A., Hanninen, T., Laukkanen, P., Alen, M., Fielding, R.A., Kivipelto, M., Kokko, K., Kulmala, J., Rantanen, T., Sihvonen, S.E., Sillanpaa, E., Stigsdotter-Neely, A., Tormakangas, T. 2018. Promoting safe walking among older people: the effects of a physical and cognitive training intervention vs. physical training alone on mobility and falls among older community-dwelling men and women (the PASSWORD study): design and methods of a randomized controlled study. BMC Geriatrics. 18:215. https://doi.org/10.1186/s12877-018-0906-0.

Progressive resistance training improves torque capacity and strength in mobility-limited older adults - (Peer Reviewed Journal)
Englund, D., Price, L.L., Grosicki, G., Iwai, M., Kashiwa, M., Liu, C., Reid, K.F., Fielding, R.A. 2018. Progressive resistance training improves torque capacity and strength in mobility-limited older adults. The Journals of Gerontology: Medical Sciences. https://doi.org/10.1093/gerona/gly199.

JNK regulates muscle remodeling via myostatin/SMAD inhibition - (Peer Reviewed Journal)
Lessard, S.J., MacDonald, T.L., Pathak, P., Han, M., Coffey, V.G., Edge, J., Rivas, D.A., Hirshman, M.F., Davis, R.J., Goodyear, L.J. 2018. JNK regulates muscle remodeling via myostatin/SMAD inhibition. Nature Communications. 9:3030. https://doi.org/10.1038/s41467-018-05439-3.

Risk of knee osteoarthritis with obesity, sarcopenic obesity and sarcopenia - (Peer Reviewed Journal)
Mirsa, D., Fielding, R.A., Felson, D.T., Niu, J., Brown, C., Nevitt, M., Lewis, C.E., Torner, J., Neogi, T. 2018. Risk of knee osteoarthritis with obesity, sarcopenic obesity and sarcopenia. Arthritis and Rheumatology. https://doi.org/10.1002/art.40692.

Mitochondrial DNA sequence variants associated with blood pressure among 2 cohorts of older adults - (Peer Reviewed Journal)
Buford, T.W., Manini, T.M., Kairalla, J.A., McDermott, M.M., Vaz Fragoso, C.A., Chen, H., Fielding, R.A., King, A.C., Newman, A.B., Tranah, G.J. 2018. Mitochondrial DNA sequence variants associated with blood pressure among 2 cohorts of older adults. Journal of the American Heart Association. 7(18):e010009. https://doi.org/10.1161/JAHA.118.010009.

The Enabling Reduction of low-grade inflammation in seniors (ENRGISE) pilot study: screening methods and recruitment results - (Peer Reviewed Journal)
Cauley, J.A., Manini, T.M., Lovato, L., Talton, J., Anton, S.D., Domanchuk, K., Kennedy, K., Stowe, C.L., Walkup, M., Fielding, R.A., Kritchevesky, S., McDermott, M.M., Newman, A.B., Ambrosius, W.T., Pahor, M. 2018. The Enabling Reduction of low-grade inflammation in seniors (ENRGISE) pilot study: screening methods and recruitment results. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/gly204.

Translating the lifestyle interventions and independence for elders clinical trial to older adults in a real-world community-based setting - (Peer Reviewed Journal)
Reid, K.F., Laussen, J., Bhatia, K., Englund, D., Kirn, D.R., Price, L., Manini, T., Liu, C., Kowaleski, C., Fielding, R.A. 2018. Translating the lifestyle interventions and independence for elders clinical trial to older adults in a real-world community-based setting. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/gly152.

Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: a systematic review and meta-analysis - (Review Article)
Custodero, C., Mankowski, R.T., Lee, S.A., Chen, Z., Wu, S., Manini, T.M., Hincapie Echeverri, J., Sabba, C., Beavers, D.P., Cauley, J.A., Espeland, M.A., Fielding, R.A., Kritchevsky, S.B., Liu, C.K., Mcdermott, M.M., Miller, M.E., Tracy, R.P., Newman, A.B., Ambrosius, W.T., Pahor, M., Anton, S.D. 2018. Evidence-based nutritional and pharmacological interventions targeting chronic low-grade inflammation in middle-age and older adults: a systematic review and meta-analysis. Ageing Research Reviews. 46:42-59. https://doi.org/10.1016/j.arr.2018.05.004.

Nutritional intervention in sarcopenia: report from the International Conference on Frailty and Sarcopenia Research Task Force - (Review Article)
Landi, F., Sieber, C., Fielding, R.A., Rolland, Y., Guralnik, J. 2018. Nutritional intervention in sarcopenia: report from the International Conference on Frailty and Sarcopenia Research Task Force. The Journal of Frailty and Aging. 7(4):247-252. https://doi.org/10.14283/jfa.2017.26.

Self-reported physical function as a predictor of hospitalization in the Lifestyle Interventions and Independence for Elders Study - (Peer Reviewed Journal)
Callahan, K.E., Lovato, L., Miller, M.E., Marsh, A.P., Fielding, R.A., Gill, T.M., Groessl, E.J., Guralnik, J., King, A.C., Kritchevsky, S.B., McDermott, M.M., Manini, T.M., Newman, A.B., Rejeski, W. 2018. Self-reported physical function as a predictor of hospitalization in the Lifestyle Interventions and Independence for Elders Study. Journal of the American Geriatrics Society. 66(10):1927-1933. https://doi.org/10.1111/jgs.15468.

Pilot study examining the influence of potassium bicarbonate supplementation on nitrogen balance and whole-body ammonia and urea turnover following short-term energy restriction in older men - (Peer Reviewed Journal)
Margolis, L.M., Ceglia, L., Rivas, D.A., Dawson-Hughes, B., Fielding, R.A. 2018. Pilot study examining the influence of potassium bicarbonate supplementation on nitrogen balance and whole-body ammonia and urea turnover following short-term energy restriction in older men. Nutrients. 10(5):624. https://doi.org/10.3390/nu10050624.

Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial - (Peer Reviewed Journal)
Wang, C., Schmid, C.H., Fielding, R.A., Harvey, W.F., Reid, K.F., Price, L., Driban, J.B., Kalish, R., Rones, R., McAlindon, T. 2018. Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial. The BMJ. 360:k851. https://doi.org/10.1136/bmj.k851.

Gait speed and mobility disability: revisiting meaningful levels in diverse clinical populations - (Peer Reviewed Journal)
Miller, M.E., Magaziner, J., Marsh, A.P., Fielding, R.A., Gill, T.M., King, A.C., Kritchevsky, S., Manini, T., McDermott, M.M., Neiberg, R., Orwig, D., Santanasto, A.J., Pahor, M., Guralnik, J., Rejeski, W. 2018. Gait speed and mobility disability: revisiting meaningful levels in diverse clinical populations. Journal of the American Geriatrics Society. 66(5):954-961. https://doi.org/10.1111/jgs.15331.

Maintenance of physical function 1 year after exercise intervention in at-risk older adults: follow-up from the LIFE study - (Peer Reviewed Journal)
Henderson, R.M., Miller, M.E., Fielding, R.A., Gill, T.M., Glynn, N.W., Guralnik, J.M., King, A., Newman, A.B., Manini, T.M., Marsh, A.P., Pahor, M., McDermott, M.M., Rejeski, J., Tudor-Locke, C., Kritchevsky, S. 2018. Maintenance of physical function 1 year after exercise intervention in at-risk older adults: follow-up from the LIFE study. Journal of Gerontology Medical Science. 73(5):688-694. https://doi.org/10.1093/gerona/glx231.

Effect of physical activity on frailty: secondary analysis of a randomized controlled trial - (Peer Reviewed Journal)
Trombetti, A., Hars, M., Hsu, F., Reid, K.F., Church, T.S., Gill, T.M., King, A.C., Liu, C.K., Manini, T.M., McDermott, M.M., Newman, A.B., Rejeski, J.W., Guralnik, J.M., Pahor, M., Fielding, R.A. 2018. Effect of physical activity on frailty: secondary analysis of a randomized controlled trial. Annals Of Internal Medicine. 168(5):309-316. https://doi.org/10.7326/M16-2011.

Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle axis - (Review Article)
Grosicki, G.J., Fielding, R.A., Lustgarten, M.S. 2018. Gut microbiota contribute to age-related changes in skeletal muscle size, composition, and function: biological basis for a gut-muscle axis. Calcified Tissue International. 102(4):433-442. https://doi.org/10.1007/s00223-017-0345-5.

Pitfalls in the measurement of muscle mass: a need for a reference standard - (Review Article)
Buckinx, F., Landi, F., Matteo, C., Fielding, R.A., Visser, M., Engelke, K., Maggi, S., Dennison, E., Al-Daghri, N.M., Allepaerts, S., Bauer, J., Bautmans, I., Brandi, M.L., Bruyere, O., Cederholm, T., Cerreta, F., Cherubini, A., Cooper, C., Cruz-Jentoft, A., Mccloskey, E., Dawson-Hughes, B., Kaufman, J., Laslop, A., Petermans, J., Reginster, J., Rizzoli, R., Robinson, S., Rolland, Y., Rueda, R., Vellas, B., Kanis, J. 2018. Pitfalls in the measurement of muscle mass: a need for a reference standard. Journal of Cachexia, Sarcopenia and Muscle. 9(2):269-278. https://doi.org/10.1002/jcsm.12268.

Metabolites related to renal function, immune activation, and carbamylation are associated with muscle composition in older adults - (Peer Reviewed Journal)
Lustgarten, M.S., Fielding, R.A. 2017. Metabolites related to renal function, immune activation, and carbamylation are associated with muscle composition in older adults. Experimental Gerontology. 100:1-10. https://doi.org/10.1016/j.exger.2017.10.003.

Implications of ICD-10 for sarcopenia clinical practice and clinical trials: report by the International Conference on Frailty and Sarcopenia Research Task Force - (Review Article)
Vellas, B., Fielding, R.A., Bens, C., Bernabei, R., Cawthon, P.M., Cederholm, T., Cruz-Jentoft, A.J., Del Signore, S., Donahue, S., Morley, J., Pahor, M., Reginster, J., Rodriguez Manas, L., Rolland, Y., Roubenoff, R., Sinclair, A., Cesari, M. 2017. Implications of ICD-10 for sarcopenia clinical practice and clinical trials: report by the International Conference on Frailty and Sarcopenia Research Task Force. The Journal of Frailty and Aging. 7(1):2-9. https://doi.org/10.14283/jfa.2017.30.

"Feeling more self-confident, cheerful, and safe". Experiences from a health-promoting intervention in community dwelling older-adults- a qualitative study - (Peer Reviewed Journal)
Von Berens, A., Koocheck, A., Nydahl, M., Fielding, R.A., Gustafsson, T., Kirn, D.R., Cederholm, T., Sodergren, M.H. 2018. "Feeling more self-confident, cheerful, and safe". Experiences from a health-promoting intervention in community dwelling older-adults- a qualitative study. Journal of Nutrition Health and Aging. 22(4):541-548. https://doi.org/10.1007/s12603-017-0981-5.

Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: results from the LIFE study randomized trial - (Peer Reviewed Journal)
Fielding, R.A., Guralnik, J.M., King, A.C., Pahor, M., McDermott, M.M., Tudor-Locke, C., Manini, T.M., Glynn, N.W., Marsh, A.P., Axtell, R.S., Hsu, F., Rejeski, W. 2017. Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: results from the LIFE study randomized trial. PLoS One. 12(8):e0182155. https://doi.org/10.1371/journal.pone.0182155.

Nutritional supplementation with physical activity improves muscle composition in mobility-limited older adults, The VIVE2 Study: a randomized, double-blind, placebo-controlled trial - (Peer Reviewed Journal)
Englund, D.A., Kirn, D., Koochek, A., Zhu, H., Travison, T.G., Reid, K.F., Von Berens, A., Melin, M., Cederholm, T., Gustafsson, T., Fielding, R.A. 2017. Nutritional supplementation with physical activity improves muscle composition in mobility-limited older adults, The VIVE2 Study: a randomized, double-blind, placebo-controlled trial. Journal of Gerontology Biological Science. 73(1):95-101. https://doi.org/10.1093/gerona/glx141.

Upregulation of circulating myomiR following short-term energy restriction is inversely associated with whole body protein synthesis - (Peer Reviewed Journal)
Margolis, L., Rivas, D.A., Pasiakos, S., McClung, J.P., Ceglia, L., Fielding, R.A. 2017. Upregulation of circulating myomiR following short-term energy restriction is inversely associated with whole body protein synthesis. American Journal of Physiology - Regulatory Integrative & Comparative Physiology. 313(3):R298-R304. https://doi.org/10.1152/ajpregu.00054.2017.

Effect of structured physical activity and nutritional supplementation on physical function in mobility-limited older adults: results from the VIVE2 randomized trial - (Peer Reviewed Journal)
Fielding, R.A., Travison, T.G., Kirn, D.R., Koochek, A., Reid, K.F., Von Berens, A., Zhu, H., Folta, S.C., Sachek, J.M., Nelson, M.E., Liu, C., Aberg, A.C., Nydahl, M., Lilja, M., Gustafsson, T., Cederholm, T. 2017. Effect of structured physical activity and nutritional supplementation on physical function in mobility-limited older adults: results from the VIVE2 randomized trial. Journal of Nutrition Health and Aging. 21(9):936-942. https://doi.org/10.1007/s12603-017-0936-x.

Social participation modifies the effect of a structured physical activity program on major mobility disability among older adults: results from the LIFE study - (Peer Reviewed Journal)
Corbett, D.B., Rejeski, J.W., Tudor-Locke, C., Glynn, N.W., Kritchevsky, S.B., McDermott, M., Church, T., Fielding, R.A., Gill, T.M., King, A.C., Miller, M.E., Chen, H., Pahor, M., Manini, T. 2017. Social participation modifies the effect of a structured physical activity program on major mobility disability among older adults: results from the LIFE study. Journals of Gerontology. https://doi.org/10.1093/geronb/gbx051.

Effect of physical activity versus health education on physical function, grip strength and mobility - (Peer Reviewed Journal)
Santanasto, A.J., Glynn, N.W., Lovato, L.C., Blair, S.N., Fielding, R.A., Gill, T.M., Guralnik, J.M., Hsu, F., King, A.C., Strotmeyer, E.S., Manini, T.M., March, A.P., McDermott, M.M., Goodpaster, B.H., Pahor, M., Newman, A.B. 2017. Effect of physical activity versus health education on physical function, grip strength and mobility. Journal of American Geriatric Society. 65(7):1427-1433. https://doi.org/10.1111/jgs.14804.

The effect of chronic kidney disease on a physical activity intervention: impact on physical function, adherence, and safety - (Peer Reviewed Journal)
Liu, C.K., Milton, J., Hsu, F., Beavers, K.M., Yank, V., Church, T., Shegog, J., Kashaf, S., Nayfield, S., Newman, A.B., Stafford, R.S., Nicklas, B.J., Weiner, D.E., Fielding, R.A. 2017. The effect of chronic kidney disease on a physical activity intervention: impact on physical function, adherence, and safety. Journal of Clinical Nephrology and Renal Care. 3:021. https://doi.org/10.23937/2572-3286.1510021.

Efficacy of a novel formulation of L-Carnitine, creatine, and leucine on lean body mass and functional muscle strength in healthy older adults: a randomized, double-blind placebo-controlled study - (Peer Reviewed Journal)
Evans, M., Guthrie, N., Pezzullo, J., Sanli, T., Fielding, R.A., Bellamine, A. 2017. Efficacy of a novel formulation of L-Carnitine, creatine, and leucine on lean body mass and functional muscle strength in healthy older adults: a randomized, double-blind placebo-controlled study. Nutrition and Metabolism. 14:7. https://doi.org/10.1186/s12986-016-0158-y.

Preserving older adults' routine outdoor activities in contrasting neighborhood environments through a physical activity intervention - (Peer Reviewed Journal)
King, A., Salvo, D., Banda, J.A., Ahn, D.K., Chapman, J.E., Gill, T., Fielding, R.A., Demons, J., Tudor-Locke, C., Rosso, A., Pahor, M., Frank, L.D. 2016. Preserving older adults' routine outdoor activities in contrasting neighborhood environments through a physical activity intervention. Preventive Medicine. 96:87-93. https://doi.org/10.1016/j.ypmed.2016.12.049.

Efficacy of an exercise and nutritional supplement program on physical performance and nutritional status in older adults with mobility limitations residing at senior living facilities - (Peer Reviewed Journal)
Cocoran, M., Nelson, M.E., Sacheck, J., Reid, K.F., Kirn, D., Fielding, R.A., Chui, K.K., Folta, S.C. 2017. Efficacy of an exercise and nutritional supplement program on physical performance and nutritional status in older adults with mobility limitations residing at senior living facilities. Journal of Aging and Physical Activity. 25(3):453-463. https://doi.org/10.1123/japa.2016-0173.

Circulating microRNA are predictive of aging and acute adaptive response to resistance exercise in men - (Peer Reviewed Journal)
Margolis, L., Lessard, S., Ezzyat, Y., Fielding, R.A., Rivas, D.A. 2016. Circulating microRNA are predictive of aging and acute adaptive response to resistance exercise in men. Journal of Gerontology Biological Science. https://doi.org/10.1093/gerona/glw243.

Prolonged calorie restriction downregulates skeletal muscle mTORC1 signaling independent of dietary protein intake and associated microRNA expression - (Peer Reviewed Journal)
Margolis, L., Rivas, D.A., Berrone, M., Ezzyat, Y., Young, A.J., McClung, J.P., Fielding, R.A., Pasiakos, S.M. 2016. Prolonged calorie restriction downregulates skeletal muscle mTORC1 signaling independent of dietary protein intake and associated microRNA expression. Frontiers in Physiology. https://doi.org/10.3389/fphys.2016.00445.

Calorie restricted high protein diets downregulate lipogenesis and lower intrahepatic triglyceride concentrations in male rats - (Peer Reviewed Journal)
Margolis, L., Rivas, D.A., Ezzyat, Y., Gaffney-Stomberg, E., Young, A.J., McClung, J.P., Fielding, R.A., Stefan, P.A. 2016. Calorie restricted high protein diets downregulate lipogenesis and lower intrahepatic triglyceride concentrations in male rats. Nutrients. 8(9):E571. https://doi.org/10.3390/nu8090571.

Physical performance and serum 25(OH)vitamin D status in community dwelling old mobility limited adults: a cross-sectional study - (Peer Reviewed Journal)
Von Berens, A., Cederholm, T., Fielding, R.A., Gustafsson, T., Kirn, D., Laussen, J., Nydahl, M., Travison, T.G., Reid, K.F., Koochek, A. 2018. Physical performance and serum 25(OH)vitamin D status in community dwelling old mobility limited adults: a cross-sectional study. Journal of Nutrition Health and Aging. 22(1):1-7. https://doi.org/10.1007/s12603-016-0849-0.

Examining new preoperative assessment tools - (Other)
Kapoor, A., Schaffer, N., Mcdonough, C.M., White, D.K., Wang, N., Rosenkranz, P., Glantz, A., Mcaneny, D., Doherty, G.M., Cabral, H.J., Gurwitz, J.H., Fielding, R.A., Jette, A.M., Silliman, R.A. 2016. Examining new preoperative assessment tools. Journal of the American Geriatrics Society. 64(10):e102-e104.

Effect of structured physical activity on overall burden and transitions between states of major mobility disability in older persons: secondary analysis of a randomized trial - (Peer Reviewed Journal)
Gill, T.M., Guralnik, J.M., Pahor, M., Church, T.S., Fielding, R.A., King, A.C., Marsh, A.P., Newman, A.B., Pellegrini, C.A., Chen, S., Allore, H.G., Miller, M. 2016. Effect of structured physical activity on overall burden and transitions between states of major mobility disability in older persons: secondary analysis of a randomized trial. Annals Of Internal Medicine. 165(12):833-840.

Predictors of change in physical function in older adults in response to long-term, structured physical activity: the LIFE study - (Peer Reviewed Journal)
Layne, A.S., Hsu, F., Blair, S.N., Chen, S., Dungan, J., Fielding, R.A., Glynn, N.W., Hajduk, A.M., King, A.C., Manini, T., Marsh, A.P., Pahor, M., Pellegrini, C.A., Buford, T.W. 2016. Predictors of change in physical function in older adults in response to long-term, structured physical activity: the LIFE study. Physical Medicine and Rehabilitation Archives. 98(1):11-24. https://doi.org/10.1016/j.apmr.2016.07.019.

Actigraphy features for predicting mobility disability in older adults - (Peer Reviewed Journal)
Kheirkhahan, M., Tudor-Locke, C., Axtell, R., Buman, M., Fielding, R.A., Glynn, N.W., Guralnik, J.M., King, A.C., White, D.K., Miller, M.E., Siddique, J., Brubaker, P.H., Rejeski, W., Ranshous, S., Pahor, M., Ranka, S., Manini, T. 2016. Actigraphy features for predicting mobility disability in older adults. Physiological Measurement. 37(10):1813-1833.

Cognitive performance does not limit physical activity participation in the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P) - (Peer Reviewed Journal)
Reid, K.F., Walkup, M.P., Katula, J.A., Sink, K.M., Anton, S., Axtell, R., Kerwin, D.R., King, A.C., Kramer, A.F., Miller, M.E., Myers, V., Rosano, C., Studenski, S.A., Lopez, O.L., Verghese, J., Fielding, R.A., Williamson, J. 2016. Cognitive performance does not limit physical activity participation in the Lifestyle Interventions and Independence for Elders Pilot Study (LIFE-P). The Journal of Prevention of Alzheimer's Disease. 4(1):44-50. https://doi.org/10.14283/jpad.2016.107.

Cardiovascular events in a physical activity intervention compared with a successful aging intervention: The LIFE Study randomized trial - (Peer Reviewed Journal)
Newman, A.B., Dodson, J.A., Church, T.S., Buford, T.W., Fielding, R.A., Kritchevsky, S.B., Beavers, D.P., Pahor, M., Stafford, R.S., Szady, A.D., Ambrosius, W.T., McDermott, M. 2016. Cardiovascular events in a physical activity intervention compared with a successful aging intervention: The LIFE Study randomized trial. The Journal of the American Medical Association: Cardiology. 1(5):568-574.

Comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: a randomized trial - (Peer Reviewed Journal)
Wang, C., Schmid, C.H., Iversen, M.D., Harvey, W.F., Fielding, R.A., Driban, J.B., Price, L., Wong, J.B., Reid, K.F., Rones, R., Mcalindon, T. 2016. Comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: a randomized trial. Annals Of Internal Medicine. doi: 10.7326/M15-2143.

Effect of statin use on mobility disability and its prevention in at-risk older adults: the LIFE study - (Peer Reviewed Journal)
Henderson, R.M., Lovato, L., Miller, M.E., Fielding, R.A., Church, T.S., Newman, A.B., Buford, T.W., Pahor, M., McDermott, M.M., Stafford, R.S., Lee, D.S., Kritchevsky, S.B. 2016. Effect of statin use on mobility disability and its prevention in at-risk older adults: the LIFE study. Journal of Gerontology Medical Science. https://doi.org/10.1093/gerona/glw057.

Dynapenia and metabolic health in obese and nonobese adults aged 70 years and older: The LIFE Study - (Peer Reviewed Journal)
Aubertin-Leheudre, M., Anton, S.D., Beavers, D.P., Manini, T.M., Fielding, R.A., Newman, A., Church, T., Kritchevsky, S.B., Conroy, D., McDermott, M.M., Botoseneanu, A., Hauser, M.E., Pahor, M. 2017. Dynapenia and metabolic health in obese and nonobese adults aged 70 years and older: The LIFE Study. Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine. 18(4):312-319.

Metabolites associated with circulating interleukin-6 in older adults - (Peer Reviewed Journal)
Lustgarten, M., Fielding, R.A. 2016. Metabolites associated with circulating interleukin-6 in older adults. Journal of Gerontology. doi: 10.1093/gerona/glw039.

Disseminating a clinically effective physical activity program to preserve mobility in a community setting for older adults - (Peer Reviewed Journal)
Laussen, J.C., Kowaleski, C., Martin, K., Hickey, C., Fielding, R.A., Reid, K.F. 2016. Disseminating a clinically effective physical activity program to preserve mobility in a community setting for older adults. The Journal of Frailty and Aging. 5(2):82-87. https://doi.org/10.14283/jfa.2016.94.

Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study) - (Peer Reviewed Journal)
Gill, T.M., Pahor, M., Guralnik, J.M., McDermott, M.M., King, A.C., Buford, T.W., Strotmeyer, E.S., Nelson, M.E., Sink, K.M., Demons, J.L., Kashaf, S.S., Walkup, M.P., Miller, M.E., Reid, K.F., Fielding, R.A. 2016. Effect of structured physical activity on prevention of serious fall injuries in adults aged 70-89: randomized clinical trial (LIFE Study). British Medical Journal. doi: 10.1136/bmj.i245.

Hospitalizations during a physical activity intervention in older adults at risk of mobility disability: analyses from the lifestyle interventions and independence for elders randomized clinical trial - (Peer Reviewed Journal)
Marsh, A.P., Applegate, W.B., Guralnik, J.M., Rejeski, J.W., Church, T.S., Fielding, R.A., Gill, T.M., King, A.C., Kritchevsky, S.B., Manini, T.M., McDermott, M.M., Newman, A.B., Stowe, C.L., Walkup, M.P., Pahor, M., Miller, M.E. 2016. Hospitalizations during a physical activity intervention in older adults at risk of mobility disability: analyses from the lifestyle interventions and independence for elders randomized clinical trial. Journal of the American Geriatrics Society. (64)5:933-943. https://doi.org/10.1111/jgs.14114.

Pharmacological intervention in frailty and sarcopenia: report by the International Conference on Frailty and Sarcopenia Research Task Force - (Review Article)
Cesari, M., Fielding, R.A., Benichou, O., Bernabei, R., Bhasin, S., Guralnik, J.M., Jette, A., Landi, F., Pahor, M., Rodriguez-Manas, L., Rolland, Y., Roubenoff, R., Sinclair, A.J., Studenski, S., Travison, T., Vellas, B. 2015. Pharmacological intervention in frailty and sarcopenia: report by the International Conference on Frailty and Sarcopenia Research Task Force. The Journal of Frailty and Aging. 4(3):114-120. https://doi.org/10.14283/jfa.2015.64.

Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: the LIFE randomized trial - (Peer Reviewed Journal)
Sink, K.M., Espeland, M.A., Castro, C.M., Church, T., Cohen, R., Dodson, J.A., Guralnik, J., Hendrie, H.C., Jennings, J., Katula, J., Lopez, O.L., McDermott, M.M., Pahor, M., Reid, K.F., Rushing, J., Verghese, J., Rapp, S., Williamson, J.D. 2015. Effect of a 24-month physical activity intervention vs health education on cognitive outcomes in sedentary older adults: the LIFE randomized trial. Journal of the American Medical Association. 314(8):781-790.

Oxandrolone augmentation of resistance training in older women: a randomized trial - (Peer Reviewed Journal)
Mavros, Y., O'Neill, E., Connerty, M., Bean, J.F., Broe, K., Kiel, D.P., Maclean, D., Taylor, A., Fielding, R., Fiatarone-Singh, M.A. 2015. Oxandrolone augmentation of resistance training in older women: a randomized trial. Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0000000000000690.

Associations between ankle-brachial index and cognitive function: results from the Lifestyle Interventions and Independence for Elders trial - (Peer Reviewed Journal)
Espeland, M.A., Newman, A.B., Sink, K., Gill, T.M., King, A.C., Miller, M.E., Guralnik, J., Katula, J., Church, T., Manini, T., Reid, K.F., McDermott, M.M. 2015. Associations between ankle-brachial index and cognitive function: results from the Lifestyle Interventions and Independence for Elders trial. Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine. 16(8):682-689. https://doi.org/10.1016/j.jamda.2015.03.010.

Accelerometer assessment of physical activity and its association with physical function in older adults residing at assisted care facilities - (Peer Reviewed Journal)
Corcoran, M.P., Chui, K.K., White, D.K., Reid, K.F., Kirn, D., Nelson, M., Sacheck, J., Folta, S., Fielding, R.A. 2015. Accelerometer assessment of physical activity and its association with physical function in older adults residing at assisted care facilities. Journal of Nutrition Health and Aging. 20(7):752-758.

The vitality, independence, and vigor in the elderly 2 study (VIVE2): design and methods - (Peer Reviewed Journal)
Kirn, D., Koochek, A., Reid, K.F., Von Berens, A., Travison, T.G., Folta, S., Sacheck, J., Nelson, M., Liu, C., Phillips, E., Aberg, A.C., Nydahl, M., Gustafsson, T., Cederholm, T., Fielding, R.A. 2015. The vitality, independence, and vigor in the elderly 2 study (VIVE2): design and methods. Contemporary Clinical Trials. 43:164-171. https://doi.org/10.1016/j.cct.2015.06.001.

Collaborative evaluation of the healthy habits program: an effective community intervention to improve mobility and cognition of Chinese older adults living in the U.S - (Peer Reviewed Journal)
Hau, C., Reid, K.F., Wong, K.F., Chin, R.J., Botto, T.J., Eliasziw, M., Bermudez, O.I., Fielding, R.A. 2015. Collaborative evaluation of the healthy habits program: an effective community intervention to improve mobility and cognition of Chinese older adults living in the U.S. Journal of Nutrition Health and Aging. 20(4):391-397. https://doi.org/10.1007/s12603-015-0623-8.

A novel comparative effectiveness study of Tai Chi versus aerobic exercise for fibromyalgia study protocol for a randomized controlled trial - (Peer Reviewed Journal)
Wang, C., McAlindon, T., Fielding, R.A., Harvey, W.F., Driban, J., Price, L., Kalish, R., Schmid, A., Scott, T., Schmid, C.H. 2015. A novel comparative effectiveness study of Tai Chi versus aerobic exercise for fibromyalgia: study protocol for a randomized controlled trial. Trials. 16:34. https://doi.org/10.1186/s13063-015-0548-x.

Recruitment of mobility limited older adults into a facility-led exercise-nutrition study: the effect of social involvement - (Peer Reviewed Journal)
Corcoran, M.P., Nelson, M.E., Sacheck, J.M., Reid, K.F., Kirn, D., Fielding, R.A., Folta, S.C. 2015. Recruitment of mobility limited older adults into a facility-led exercise-nutrition study: the effect of social involvement. Gerontologist. 56(4):669-676. https://doi.org/10.1093/geront/gnv018.

The MAT-sf: identifying risk for major mobility disability - (Peer Reviewed Journal)
Rejeski, W.J., Rushing, J., Guralnik, J.M., Ip, E.H., King, A.C., Manini, T.M., Marsh, A.P., McDermott, M.M., Fielding, R.A., Newman, A.B., Tudor-Locke, C., Gill, T.M. 2015. The MAT-sf: identifying risk for major mobility disability. Journal of Gerontology Medical Science. 70(5):641-646. https://doi.org/10.1093/gerona/glv003.

Vitamin D receptor protein is associated with interleukin-6 in human skeletal muscle - (Peer Reviewed Journal)
Pojednic, R., Ceglia, L., Lichtenstein, A.H., Dawson-Hughes, B., Fielding, R.A. 2014. Vitamin D receptor protein is associated with interleukin-6 in human skeletal muscle. Endocrine. 49(2):512-520. https://doi.org/10.1007/s12020-014-0505-6.

Light intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions and Independence for Elders (LIFE) study - (Peer Reviewed Journal)
Bann, D., Hire, D., Manini, T., Cooper, R., Botoseneanu, A., McDermott, M.M., Pahor, M., Glynn, N.W., Fielding, R.A., King, A.C., Church, T., Ambrosius, W.T., Gill, T. 2015. Light intensity physical activity and sedentary behavior in relation to body mass index and grip strength in older adults: cross-sectional findings from the Lifestyle Interventions and Independence for Elders (LIFE) study. PLoS One. 10(2):e0116058. https://doi.org/10.1371/journal.pone.0116058.

Effects of 1,25-dihydroxyvitamin D3 and vitamin D3 on the expression of the vitamin D receptor in human skeletal muscle cells - (Peer Reviewed Journal)
Pojednic, R., Ceglia, L., Olsson, K., Gustafsson, T., Lichtenstein, A.H., Dawson-Hughes, B., Fielding, R.A. 2014. Effects of 1,25-dihydroxyvitamin D3 and vitamin D3 on the expression of the vitamin D receptor in human skeletal muscle cells. Calcified Tissue International. 96(3):256-263.

Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults - (Peer Reviewed Journal)
Fitzgerald, J.D., Johnson, L., Ambrosius, W.T., Anton, S.D., Dodson, J.A., Marsh, A.P., McDermott, M.M., Nocera, J.R., Tudor-Locke, C., White, D.K., Yank, V., Pahor, M., Manini, T., Buford, T. 2015. Association of objectively measured physical activity with cardiovascular risk in mobility-limited older adults. Journal of the American Heart Association. 4:e001288. https://doi.org/10.1161/JAHA.114.001288.

Emerging impact of skeletal muscle in health and disease - (Other)
Fielding, R.A., Ralston, S.H., Rizzoli, R. 2015. Emerging impact of skeletal muscle in health and disease. Calcified Tissue International. 96(3):181-182. https://doi.org/10.1007/s00223-015-9.

Does physical activity change after progressive resistance exercise in functionally limited older adults? - (Other)
Laussen, J.C., Chale, A., Hau, C., Fielding, R.A., White, D.K. 2015. Does physical activity change after progressive resistance exercise in functionally limited older adults? Journal of the American Geriatrics Society. 63(2):392-393. https://doi.org/10.1111/jgs.13270.

Prevalence of and interventions for sarcopenia in ageing adults - a systematic review report of the international sarcopenia initiative (EWGSOP and IWGS) - (Review Article)
Cruz-Jentoft, A.J., Landi, F., Schneider, S.M., Zuniga, C., Arai, H., Boirie, Y., Chen, L., Fielding, R.A., Martin, F.C., Michel, J., Sieber, C., Stout, J.R., Studenski, S.A., Vellas, B., Woo, J., Zamboni, M., Cederholm, T. 2014. Prevalence of and interventions for sarcopenia in ageing adults - a systematic review report of the international sarcopenia initiative (EWGSOP and IWGS). Age and Ageing. 43:748-759. https://doi.org/10.1093/ageing/afu115.

Assessing the comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: design and rationale for a randomized trial - (Peer Reviewed Journal)
Wang, C., Iversen, M.D., McAlindon, T., Harvey, W.F., Wong, J.B., Fielding, R.A., Driban, J.B., Price, L., Rones, R., Gamache, T.C., Schmid, C. 2014. Assessing the comparative effectiveness of Tai Chi versus physical therapy for knee osteoarthritis: design and rationale for a randomized trial. BMC Complementary and Alternative Medicine. 14:333. https://doi.org/10.1186/1472-6882-14-333.

Physical activity and resting pulse rate in older adults: findings from a randomized controlled trial - (Peer Reviewed Journal)
O Hartaigh, B., Pahor, M., Buford, T.W., Dodson, J.A., Forman, D.E., Gill, T. 2014. Physical activity and resting pulse rate in older adults: findings from a randomized controlled trial. American Heart Journal. 168(4):597-604. https://doi.org/10.1016/j.ahj.2014.07.024.

Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations - (Peer Reviewed Journal)
Vaz Fragoso, C.A., Hsu, F., Brinkley, T., Church, T., Liu, C., Manini, T., Newman, A.B., Stafford, R.S., McDermott, M.M., Gill, T.M. 2014. Combined reduced forced expiratory volume in 1 second (FEV1) and peripheral artery disease in sedentary elders with functional limitations. Journal of the American Medical Directors Association - Post-Acute and Long Term Care Medicine. 15(9):665-670. https://doi.org/10.1016/j.jamda.2014.05.008.

A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study - (Peer Reviewed Journal)
Cesari, M., Vellas, B., Hsu, F., Newman, A.B., Doss, H., King, A.C., Manini, T.M., Church, T., Gill, T.M., Miller, M., Pahor, M.S. 2015. A physical activity intervention to treat the frailty syndrome in older persons-results from the LIFE-P study. Journals of Gerontology. 70(2):216-222.

Management of osteoporosis of the oldest old - (Review Article)
Rizzoli, R., Branco, J., Brandi, M., Boonen, S., Bruyere, O., Cacoub, P., Cooper, C., Diez-Perez, A., Duder, J., Fielding, R.A., Harvey, N.C., Hiligsmann, M., Kanis, J.A., Petermans, J., Ringe, J.D., Tsourderos, Y., Weinman, J., Reginster, J. 2014. Management of osteoporosis of the oldest old. Osteoporosis International. 25(11):2507-2529.