Location: Animal Disease Research
Project Number: 2090-32000-039-05-T
Project Type: Trust Fund Cooperative Agreement
Start Date: Oct 1, 2013
End Date: Jun 30, 2017
The first objective is to improve a key parameter in the production of the ITM vaccine, the second objective is to target antibody response to the sporozoite stage, the third objective is to target T-cell responses to the schizont stage and the fourth stage is to target immune responses to both parasite life-cycle stages. These objectives will provide a denser map of candidate vaccine antigens and critical knowledge on protective immune responses. The most important project result will be proof-of-concept for a subunit vaccine (immunity in 70~80% of animals of defined MHC genotype given a homologous parasite challenge), which will set the stage for developing a broad-spectrum vaccine for ECF.
This proposal aligns with the BMGF investment focus on Research and Development in Agricultural Development with potential breakthroughs arising from science as a key mechanism to reduce hunger and poverty of millions of poor farm families in sub-Saharan Africa and promotes and protects global food security. The outputs of the project will contribute to livestock health and improvement by developing new vaccines for the control of ECF in cattle, a prioritized livestock species and disease by BMGF. Improved vaccines for ECF will contribute to Foundation investments being made to improve dairy value chains and veterinary services in the region through the efforts of East Africa Dairy Development, Dairy Genetics East Africa, GALVmed, and Sidai.