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United States Department of Agriculture

Agricultural Research Service

Research Project: Development of a Prebiotic Intervention to Reduce Carriage of Zoonotic Pathogens of Swine During On-farm Rearing and Entering the Abattoir

Location: Food and Feed Safety Research

Project Number: 3091-32000-030-66-T
Project Type: Trust Fund Cooperative Agreement

Start Date: May 1, 2014
End Date: Oct 30, 2015

1) Determine the inhibitory concentration of thymol-beta-D-glucopyranoside (called beta-D-thymol) needed to achieve efficacious reductions of Campylobacter coli, Salmonella spp., and E. coli in laboratory and animal feeding studies. 2) Evaluate the potential of beta-D-thymol to co-select for antibiotic-resistant Campylobacter coli, Salmonella spp., and generic E. coli or to make resistant strains of these bacteria more sensitive to antibiotics when grown in mixed populations of porcine gut bacteria.

A series of laboratory and live animal studies will be conducted to test the effects of a novel antimicrobial compound, thymol-beta-D-glucopyranoside, on the survivability and antimicrobial susceptibility of zoonotic pathogens.

Last Modified: 10/19/2017
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