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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Healthy Processed Foods Research » Research » Research Project #425089

Research Project: Prevention of Obesity Related Metabolic Diseases by Bioactive Components of Wine Grape Byproducts in Animal Models

Location: Healthy Processed Foods Research

Project Number: 2030-41440-007-02-C
Project Type: Cooperative Research and Development Agreement

Start Date: Jun 1, 2012
End Date: May 31, 2017

Objective:
Determine if the byproducts of wine grape processing contain useful amounts of bioactive components that prevent diet related diseases or improve human health by feeding studies of seed flours, seed oils and skin flours. Determination of bioactivity will be based on evaluation of physiological and molecular biological responses.

Approach:
The Cooperator will select three grape varietal sources of seed flour and skin fraction based on their knowledge of flavor, amounts available, processing history and biochemical composition for the small animal feeding study. Based on a previous study the diets will contain 10% seed flour, skin fraction or seed oil. In addition 1 commercial vegetable oil and 2 grape seed oils will also be evaluated. Hamsters will be preferred for studies of cholesterol or fat metabolism because of their similarity to humans and our extensive experience with this animal model. Blood and liver lipids, and liver and adipose composition and gene expression will be analyzed to support physiological observations.