Project Number: 3060-32420-001-02-S
Project Type: Specific Cooperative Agreement
Start Date: Sep 1, 2013
End Date: Sep 30, 2016
To determine the plasma kinetics and tissue and milk residues of flunixin after IV (label) and IM administration of flunixin to healthy and endotoxin-challenged cull dairy cows.
A residue depletion study will be conducted in twenty normal and endotoxin-treated dairy cattle dosed intramuscularly (off-label) or intravenously (label use) with flunixin meglumine. Animals will be dosed with flunixin for three consecutive days with blood, milk, saliva, and urine samples being serially removed for flunixin analysis. Ninety-six hours after the last flunixin administration, cows will be euthanized and edible and non-edible tissues will be collected for the determination of flunixin tissue concentrations.