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United States Department of Agriculture

Agricultural Research Service

Research Project: Intervention Strategies to Support the Global Control and Eradication of Foot-and-Mouth Disease Virus(FMDV)

Location: Foreign Animal Disease Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Transcriptomic analysis of persistent infection with foot-and-mouth disease virus in cattle suggests impairment of cell-mediated immunity in the nasopharynx - (Peer reviewed journal)

Infection dynamics of foot-and-mouth disease virus in cattle following intra-nasopharyngeal inoculation or contact exposure - (Peer reviewed journal)

Constitutively active IRF7/IRF3 fusion protein completely protects swine against Foot-and-Mouth Disease - (Peer reviewed journal)
Ramirez-Carvajal, L., Diaz-San Segundo, F., Ramirez-Medina, E., Rodriguez, L.L., De Los Santos, T.B. 2016. Constitutively active IRF7/IRF3 fusion protein completely protects swine against Foot-and-Mouth Disease. Journal of Virology. de los Santos, T. 2016. Journal of Virology. doi: 10.1128/JVI.00800-16.

Control of foot-and-mouth disease by using replication-defective human adenoviruses to deliver vaccines and biotherapeutics - (Book / chapter)

The pathogenesis of Foot-and-Mouth Disease in pigs - (Peer reviewed journal)
Stenfeldt, C., Diaz-San Segundo, F., De Los Santos, T.B., Rodriguez, L.L., Arzt, J. 2016. The pathogenesis of Foot-and-Mouth Disease in pigs. Frontiers in Veterinary Science. 3:41. doi: 10.3389/fvets.2016.00041.

A universal next generation sequencing protocol to generate non-infectious barcoded cDNA libraries from high containment RNA viruses - (Peer reviewed journal)
Moser, L.A., Ramirez-Carvajal, L., Puri, V., Pauszek, S.J., Matthews, K., Dilley, K., Mullan, C., Mcgraw, J., Yee, A., Dugan, V., Heise, M.T., Frieman, M.B., Rodriguez, L.L., Bernard, K.A., Wentworth, D.E., Stockwell, T.B., Shabman, R.S. 2016. A universal next generation sequencing protocol to generate non-infectious barcoded cDNA libraries from high containment RNA viruses. mSystems. Rodrigues, L. L.2016. RNA Viruses. A universal doi:10.1128/mSystems.00039-15.

Novel 6xHis tagged foot-and-mouth disease virus vaccine bound to nanolipoprotein adjuvant via metal ions provides antigenic distinction and effective protective immunity - (Peer reviewed journal)
Rai, D., Daiz-San Segundo, F., Schafer, E.A., Burrage, T., Rodriguez, L.L., De Los Santos, T.B., Hoeprich, P.D., Rieder, A.E. 2016. Novel 6xHis tagged Foot-and-Mouth Disease Virus vaccine bound to nanolipoprotein adjuvant via metal ions provides antigenic distinction and effective protective immunity. Virology. 495:136-147. doi: 10.1016/j.virol.2016.04.027.

The foot-and-mouth disease carrier state divergence in vaccinated and non-vaccinated cattle - (Peer reviewed journal)
Stenfeldt, C., Eschbaumer, M., Rekant, S.I., Pacheco, J.M., Smoliga, G.R., Hartwig, E.J., Rodriguez, L.L., Arzt, J. 2016. The foot-and-mouth disease carrier state divergence in vaccinated and non-vaccinated cattle. Journal of Virology. DOI:10.1128/JVL00388-16.

Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina - (Peer reviewed journal)
Brito, B., Konig, G., Cabanne, S., Perez-Beascoechea, C., Rodriguez, L.L., Perez, A. 2016. Phylogeographic analysis of the 2000-2002 foot-and-mouth disease epidemic in Argentina. Infection, Genetics and Evolution. 41:93-99.

Effect of foot-and-mouth disease virus on the frequency, phenotype and function of circulating dendritic cells in cattle - (Peer reviewed journal)

Sero-prevalence of foot-and-mouth disease (FMD) in large ruminants at peri urban dairy farms near Islamabad, Pakistan - (Peer reviewed journal)
Farooq, U., Ullah, A., Irshad, H., Naeem, K., Bin Zahur, A., Ahmad, Z., Rodriguez, L.L. 2016. Sero-prevalence of foot-and-mouth disease (FMD) in large ruminants at peri urban dairy farms near Islamabad, Pakistan. Asian Biomedicine. 10(2):123-127. doi: 10.5372/1905-7415.1002.472.

Role of Jumonji c-domain containing protein 6 (JMJD6) in infectivity of foot-and-mouth disease virus - (Peer reviewed journal)
Lawrence, P.J., Rai, D.K., Conderino, J.S., Uddowla, S., Rieder, A.E. 2016. Role of Jumonji c-domain containing protein 6 (JMJD6) in infectivity of foot-and-mouth disease virus. Virology. 492:38-52. doi: 10.1016/j-virol.2016.02.005.

Pathogenesis and micro-anatomic characterization of a cell-adapted mutant foot-and-mouth disease virus in cattle: impact of the Jumonji C-domain containing protein 6 (JMJD6) and route of innoculation - (Peer reviewed journal)
Lawrence, P.J., Pacheco Tobin, J., Stenfeldt, C., Arzt, J., Rai, D., Rieder, A.E. 2016. Pathogenesis and micro-anatomic characterization of a cell-adapted mutant foot-and-mouth disease virus in cattle: impact of the Jumonji C-domain containing protein 6 (JMJD6) and route of innoculation. Journal of Virology. 492:108-117. doi: 10.1016/j.virol.2016.02.004.

Evaluation of infectivity, virulence and transmission of FDMV field strains of serotypes O and A isolated in 2010 from outbreaks in the Republic of Korea - (Peer reviewed journal)
Pacheco Tobin, J., Lee, K., Bishop, E.A., Hartwig, E.J., Pauszek, S.J., Smoliga, G.R., Kim, S., Park, J., Ko, Y., Lee, H., Dongseob, T., Cho, I., Kim, B., Rodriguez, L.L., Arzt, J. 2016. Evaluation of infectivity, virulence and transmission of FDMV field strains of serotypes O and A isolated in 2010 from outbreaks in the Republic of Korea. PLoS One. 11(1): e0146445. doi: 10.1371/journal.pone.0146445.

Bioinformatic and molecular analysis of evolutionary relation between bovine rhinitis A viruses and Foot-and-Mouth Disease Virus - (Peer reviewed journal)
Rai, D., Lawrence, P.J., Pauszek, S.J., Piccone, M.E., Knowles, N., Rieder, A.E. 2016. Bioinformatic and molecular analysis of evolutionary relation between bovine rhinitis A viruses and Foot-and-Mouth Disease Virus. Bioinformatics and Biology Insights. 2:43-58 doi: 10.4137/BBI.S37223.

Analysis of the interactions between host factor Sam68 and viral elements during foot-and-mouth disease virus infection - (Peer reviewed journal)
Rai, D., Lawrence, P.J., Schafer, E.A., Kloc, A., Rieder, A.E. 2015. Analysis of the interactions between host factor Sam68 and viral elements during foot-and-mouth disease virus infection. Virology Journal. doi: 10.1186/s12985-015-0452-8.

Pathogenesis of primary foot-and-mouth disease virus infection in the nasopharynx of vaccinated and non-vaccinated cattle - (Peer reviewed journal)
Stenfeldt, C., Eschbaumer, M., Rekant, S.I., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2015. Pathogenesis of primary foot-and-mouth disease virus infection in the nasopharynx of vaccinated and non-vaccinated cattle. PLoS One. 10(11): e0143666. doi: 10.1371/journal.pone.0143666.

Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle - (Peer reviewed journal)
Montiel, N., Medina, G.N., Sturza, D., Diaz-San Segundo, F., Ramirez-Medina, E., Grubman, M.J., De Los Santos, T.B. 2016. Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle. Clinical and Vaccine Immunology. 23:125-136. doi: 10.1128/CVI.00426-15.

Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response - (Peer reviewed journal)
Diaz-San Segundo, F., Koster, M.J., Ramirez-Medina, E., Medina, G.N., Velazquez-Salinas, L., Grubman, M.J., De Los Santos, T.B. 2015. Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response. Journal of Virology. 90:1298-1310. doi:10.1128/JVI.02167-15.

A modern approach for epitope prediction: identification of foot-and-mouth disease virus peptides binding bovine leukocyte antigen (BoLA) class I molecules - (Peer reviewed journal)
Pandya, M., Rasmusen, M., Hansen, A., Nielsen, M., Buus, S., Golde, W.T., Barlow, J. 2015. A modern approach for epitope prediction: identification of foot-and-mouth disease virus peptides binding bovine leukocyte antigen (BoLA) class I molecules. Immunogenetics. 67:691-703. doi: 10.1007/s00251-015-0877-7.

An integrative analysis of foot-and-mouth disease virus carriers in Vietnam achieved through targeted surveillance and molecular epidemiology Reprint Icon - (Peer reviewed journal)
De Carvalho Ferreira, H.C., Pauszek, S.J., Ludi, A., Huston, C.L., Pacheco Tobin, J., Dung, D., Thuy, N., Vu, L., Tho, N., Long, N., Rodriguez, L.L., Arzt, J. 2015. An integrative analysis of foot-and-mouth disease virus carriers in Vietnam achieved through targeted surveillance and molecular epidemiology. Transboundary and Emerging Diseases. doi: 10.1111/tbed.12403.

Subpopulations of bovine T lymphocytes collected during foot-and-mouth disease virus infection are affected by freezing, but are subsequently stable in frozen samples - (Peer reviewed journal)

Inhibition of EHMT2 induces a robust antiviral response against Foot-and-Mouth Disease and Vesicular Stomatitis Virus infections in bovine cells - (Peer reviewed journal)
Singh, N., Ramirez-Carvajal, L., De Los Santos, T.B., Golding, M.C., Long, C.R. 2015. Inhibition of EHMT2 induces a robust antiviral response against Foot-and-Mouth Disease and Vesicular Stomatitis Virus infections in bovine cells. Journal of Interferon and Cytokine Research. doi:10.1089/jir.2015.0006.

Early detection of foot-and-mouth disease virus from infected cattle using a dry filter air sampling system Reprint Icon - (Peer reviewed journal)
Pacheco Tobin, J., Brito, B., Hartwig, E.J., Smoliga, G.R., Perez, A., Arzt, J., Rodriguez, L.L. 2015. Early detection of foot-and-mouth disease virus from infected cattle using a dry filter air sampling system. Transboundary and Emerging Diseases. doi: 10.1111/tbed.12404.

Systemic foot-and-mouth disease vaccination in cattle promotes specific antibody secreting cells at the respiratory tract and triggers local anamnestic-compatible responses upon aerosol infection Reprint Icon - (Peer reviewed journal)
Pega, J., Di Giacomo, S., Bucafusco, D., Schammas, J.M., Barrionuevo, F., Capozzo, A., Rodriguez, L.L., Borca, M.V., Perez-Filgueira, M. 2015. Systemic foot-and-mouth disease vaccination in cattle promotes specific antibody secreting cells at the respiratory tract and triggers local anamnestic-compatible responses upon aerosol infection. Journal of Virology. 89(18):9581-9590. doi: 10.1128/JVI.01082-15.

Review of the global distribution of foot-and-mouth disease virus from 2007 to 2014 Reprint Icon - (Review article)
Brito, B.P., Rodriguez, L.L., Hammond, J., Pinto, J., Perez, A.M. 2015. Review of the global distribution of foot-and-mouth disease virus from 2007 to 2014. Transboundary and Emerging Diseases. DOI: 10.1111/tbed.12373.

Antiviral immunity and virus vaccines - (Book / chapter)

Veterinary applications of infrared thermography - (Review article)

Clinical and virological dynamics of a serotype O 2010 South East Asia lineage foot-and-mouth disease virus in sheep using natural and simulated natural inoculation and exposure systems Reprint Icon - (Peer reviewed journal)
Stenfeldt, C., Pacheco Tobin, J., Singanallur, N.B., De Carvalho Ferreira, H.C., Howey, E.B., Vosloo, W., Rodriguez, L.L., Arzt, J. 2015. Clinical and virological dynamics of a serotype O 2010 South East Asia lineage foot-and-mouth disease virus in sheep using natural and simulated natural inoculation and exposure systems. Veterinary Microbiology. DOI:10.1016/j.vetmic.2015.04.004.

Persistent foot-and-mouth disease virus infection in the nasopharynx of cattle: tissue-specific distribution and local cytokine expression - (Peer reviewed journal)
Pacheco Tobin, J., Smoliga, G.R., O'Donnell, V., Brito-Rodriguez, B., Stenfeldt, C., Rodriguez, L.L., Arzt, J. 2015. Persistent foot-and-mouth disease virus infection in the nasopharynx of cattle: tissue-specific distribution and local cytokine expression. Virology. DOI:10.1371/journal.pone.0125698.

A colorimetric bioassay for high-througput and cost-effectively assessing anti-foot-and-mouth disease virus activity - (Peer reviewed journal)
Ramanathan, P., Puckette, M., Hartwig, E.J., Bishop, E.A., Rodriguez, L.L., Grubman, M.J., Zhu, J.J. 2015. A colorimetric bioassay for high-througput and cost-effectively assessing anti-foot-and-mouth disease virus activity. Veterinary Immunology and Immunopathology. 164(1-2):74-78. DOI: 0.1016/j.vetimm.2015.01.005.

Review of the global distribution of foot-and-mouth disease virus from 2007 to 2014 - (Peer reviewed journal)
Brito, B.P., Rodriguez, L.L., Hammond, J., Pinto, J., Perez, A.M. 2015. Review of the global distribution of foot-and-mouth disease virus from 2007 to 2014. Transboundary and Emerging Diseases. DOI: 10.1111.tbed.12373.

Cell culture adaptation mutations in foot-and-mouth disease virus serotype A capsid proteins: implications for receptor interactions - (Peer reviewed journal)
Mohapatra, J.K., Pandey, L.K., Rai, D.K., Das, B., Rodriguez, L.L., Rout, M., Subramaniam, S., Sanyal, A., Rieder, A.E., Pattnaik, B. 2015. Cell culture adaptation mutations in foot-and-mouth disease virus serotype A capsid proteins: implications for receptor interactions. Journal of General Virology. 96:553-564.

Phenotypic, ultra-structural and functional characterization of bovine peripheral blood dendritic cell subsets - (Peer reviewed journal)
Sei, J.J., Ochoa, A.S., Bishop, E.A., Barlow, J.W., Golde, W.T. 2014. Phenotypic, ultra-structural and functional characterization of bovine peripheral blood dendritic cell subsets. PLoS One. 9(10):e109273. DOI: 10.1371/journal.pone.0109273.

Characterization of binding specificities of Bovine Leucocyte class I molecules: Impacts for rational epitope discovery - (Peer reviewed journal)
Hansen, A.M., Rasmussen, M., Svitek, N., Harndahl, M., Golde, W.T., Barlow, J., Nene, V., Buus, S., Nielsen, M. 2014. Characterization of binding specificities of Bovine Leucocyte class I molecules: Impacts for rational epitope discovery. Immunogenetics. 66(12):705-718. DOI: 10.1007/s00251-014-0802-5.

Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine - (Peer reviewed journal)
Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Weiss, M., Perez-Martin, E., Salazar, A.M., Grubman, M.J., De Los Santos, T.B. 2014. Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine. Virology. 468-470C:283-292.

Virus-host interactions in persistently FMDV-infected cells derived from bovine pharynx - (Peer reviewed journal)
O'Donnell, V., Pacheco Tobin, J., Larocco, M.A., Gladue, D.P., Pauszek, S.J., Smoliga, G.R., Krug, P.W., Baxt, B., Borca, M.V., Rodriguez, L.L. 2014. Virus-host interactions in persistently FMDV-infected cells derived from bovine pharynx. Virology. 468-470C:185-196.

Early events in the pathogenesis of foot-and-mouth disease in pigs; identification of oropharyngeal tonsils as sites of primary and sustained viral replication - (Peer reviewed journal)
Stenfeldt, C., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2014. Early events in the pathogenesis of foot-and-mouth disease in pigs; identification of oropharyngeal tonsils as sites of primary and sustained viral replication. PLoS One. DOI:10.1371/journal.pone.0106859.

Infection with foot-and-mouth disease virus (FMDV) induces a natural killer (NK) cell response in cattle that is lacking following vaccination - (Peer reviewed journal)
Patch, J.P., Dar, P., Waters, R., Toka, F., Barerra, J., Schutta, C., Kondabattula, G., Golde, W.T. 2014. Infection with foot-and-mouth disease virus (FMDV) induces a natural killer (NK) cell response in cattle that is lacking following vaccination. Comparative Immunology Microbiology and Infectious Diseases. 37(4):249-257.

Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication - (Peer reviewed journal)
Ramirez-Carvajal, L., Long, C.R., Zhu, J.J., Diaz San Segundo, F.C., Rodriguez, L.L., De Los Santos, T.B. 2014. Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication. Journal of Virology. 88(19):11140-11153.

Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A - (Peer reviewed journal)
Stenfeldt, C., Pacheco Tobin, J., Borca, M.V., Rodriguez, L.L., Arzt, J. 2014. Morphologic and phenotypic characteristics of myocarditis in two pigs infected by foot-and mouth disease virus strains of serotypes O or A. Acta Veterinaria Scandinavica. 56(1):42.

Type III interferon protects swine against foot-and-mouth disease - (Peer reviewed journal)
Perez-Martin, E., Diaz San Segundo, F.C., Weiss, M., Sturza, D., Dias, C.C., Ramirez, E., Grubman, M.J., De Los Santos, T.B. 2014. Type III interferon protects swine against foot-and-mouth disease. Journal of Interferon and Cytokine Research. 345(10):810-812 DOI:10.1089/jir.2013.0112.

Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state - (Peer reviewed journal)
Stenfeldt, C., Pacheco Tobin, J., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., Rodriguez, L.L., Arzt, J. 2014. Detection of Foot-and-Mouth Disease Virus RNA and capsid protein in lymphoid tissues of convalescent pigs does not indicate existence of a carrier state. Transboundary and Emerging Diseases. DOI: 10.1111/tbed.12235.

Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods Reprint Icon - (Peer reviewed journal)
Stenfeldt, C., Pacheco Tobin, J., Rodriguez, L.L., Arzt, J. 2014. Infection dynamics of foot-and-mouth disease virus in pigs using two novel simulated natural inoculation methods. Research in Veterinary Science. 96:396-405.

Serotype diversity of Foot-and-Mouth-Disease virus in livestock without history of vaccination in the far north region of Cameroon - (Peer reviewed journal)
Ludi, A., Ahmed, Z., Pomeroy, L.W., Pauszek, S.J., Smoliga, G.R., Moritz, M., Dickmu, S., Abdoulkadiri, S., Arzt, J., Garabed, R., Rodriguez, L.L. 2014. Serotype diversity of Foot-and-Mouth-Disease virus in livestock without history of vaccination in the far north region of Cameroon. Transboundary and Emerging Diseases. DOI: 10.1111/TBED.12227.

Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection Reprint Icon - (Peer reviewed journal)
Arzt, J., Pacheco Tobin, J., Tucker, M.T., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., De Los Santos, T.B., Rodriguez, L.L. 2014. Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection. Virology. 452-453:12-22.

Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: role of jumonji C-domain containing protein 6 in RHA demethylation - (Peer reviewed journal)
Lawrence, P., Conderino, J., Rieder, A.E. 2014. Redistribution of demethylated RNA helicase A during foot-and-mouth disease virus infection: role of jumonji C-domain containing protein 6 in RHA demethylation. Virology. 452-453:1-11.

Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle - (Peer reviewed journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Pacheco Tobin, J., Holinka-Patterson, L.G., Arzt, J., Pauszek, S.J., Fernandez-Sainz, I., Fletcher, P., Brocchi, E., Lu, Z., Rodriguez, L.L., Borca, M.V. 2014. Interaction of foot-and-mouth disease virus non-structural protein 3A with host protein DCTN3 is important for viral virulence in cattle. Journal of Virology. 88(5):2737-2747.

Animal health: foot-and-mouth disease - (Book / chapter)
Diaz San Segundo, F.C., Medina, G.N., Grubman, M.J., De Los Santos, T.B. 2014. Animal health: Foot-and-Mouth Disease. In: Van Alfen, N.K., editor. Encyclopedia of Agriculture and Food Systems. 2nd edition. United States of America: Elsevier/Academic Press. p. 327-345.

Enhanced IRES activity by the 3’UTR element determines the virulence of FMDV isolates Reprint Icon - (Peer reviewed journal)
Garcia-Nunez, S., Gismondi, M.I., Konig, G., Berinstein, A., Taboga, O., Rieder, A.E., Martinez-Salas, E., Carrillo, E. 2014. Enhanced IRES activity by the 3’UTR element determines the virulence of FMDV isolates. Virology. 448:303-313.

Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase Reprint Icon - (Peer reviewed journal)
Uddowla, S., Pacheco Tobin, J., Larson, C., Bishop, E.A., Rodriguez, L.L., Rai, D., Arzt, J., Rieder, A.E. 2013. Characterization of a chimeric foot-and-mouth disease virus bearing bovine rhinitis B virus leader proteinase. Virology. 447(1-2):172-180.

A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle Reprint Icon - (Peer reviewed journal)
Pacheco Tobin, J., Gladue, D.P., Holinka-Patterson, L.G., Arzt, J., Bishop, E.A., Smoliga, G.R., Pauszek, S.J., Bracht, A.J., O'Donnell, V., Fernandez-Sainz, I., Fletcher, P., Piccone, M.E., Rodriguez, L.L., Borca, M.V. 2013. A partial deletion in non-structural protein 3A can attenuate foot-and-mouth disease virus in cattle. Virology. 446(1-2):260-267.

Heterogeneity in the antibody response to foot-and-mouth disease primo-vaccinated calves - (Peer reviewed journal)
Di Giacomo, S., Brito, B.P., Perez, A.M., Bucafusco, D., Pega, J., Rodriguez, L.L., Borca, M.V., Perez-Filgueira, M. 2013. Heterogeneity in the antibody response to foot-and-mouth disease primo-vaccinated calves. Transboundary and Emerging Diseases. DOI:10.1111/tbed.12130.

Understanding the mechanism of interferon-induced protection against foot-and-mouth disease Reprint Icon - (Book / chapter)
Diaz San Segundo, F.C., Montiel, N., De Los Santos, T.B., Grubman, M.J. 2014. Understanding the mechanism of interferon-induced protection against foot-and-mouth disease. In: IConcept Press, Ltd. Virology II Advanced Issues. 1st edition. United States of America: IConcept Press Ltd. p. 51-72.

Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: A unique landscape of innate immunity Reprint Icon - (Review article)
Toka, F.N., Golde, W.T. 2013. Cell mediated innate responses of cattle and swine are diverse during foot-and-mouth disease virus (FMDV) infection: A unique landscape of innate immunity. Immunology Letters. 152(2):135-143 DOI:10.1016/j.imlet.2013.05.007.

Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression Reprint Icon - (Peer reviewed journal)
Zhu, J.J., Arzt, J., Puckette, M.C., Smoliga, G.R., Pacheco Tobin, J., Rodriguez, L.L. 2013. Mechanisms of foot-and-mouth disease virus tropism inferred from differential tissue gene expression. PLoS One. 8(5):e64119. DOI:10.1371/journal.pone.0064119.

Foot-and-mouth disease virus modulates cellular vimentin for virus survival Reprint Icon - (Peer reviewed journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Holinka-Patterson, L.G., Pacheco Tobin, J., Fernandez Sainz, I.J., Lu, Z., Brocchi, E., Piccone, M.E., Fletcher, P., Ambroggio, X., Rodriguez, L.L., Borca, M.V. 2013. Foot-and-mouth disease virus modulates cellular vimentin for virus survival. Journal of Virology. 87(12):6794-6803.

Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of Foot-and-Mouth Disease Virus in host cells. Reprint Icon - (Peer reviewed journal)
Rai, D.K., Schafer, E.A., Singh, K., Mcintosh, M., Sarafianos, S., Rieder, A.E. 2013. Repeated exposure to 5D9, an inhibitor of 3D polymerase, effectively limits the replication of Foot-and-Mouth Disease Virus in host cells. Antiviral Research. 98(3):380-385 DOI:10.1016/j.antiviral.2013.03.022.

Analysis of SAT type foot-and-mouth disease virus capsid proteins and the identification of putative amino acid residues in virus stability Reprint Icon - (Peer reviewed journal)
Maree, F.F., Blignaut, B., De Beer, T.A., Rieder, A.E. 2013. Analysis of SAT type foot-and-mouth disease virus capsid proteins and the identification of putative amino acid residues in virus stability. PLoS One. 8(5):e61612 DOI:10.1371/journal.pone.0061612.

Structure-based discovery of foot-and-mouth disease inhibitors that target the 3Dpol RNA-dependent RNA polymerase - (Peer reviewed journal)

An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine Reprint Icon - (Peer reviewed journal)
Alejo, D.M., Moraes, M.P., Liao, X., Dias, C.C., Tulman, E.R., Diaz San Segundo, F.C., Rood, D., Grubman, M.J., Silbart, L.K. 2013. An adenovirus vectored mucosal adjuvant augments protection of mice immunized intranasally with an adenovirus-vectored foot-and-mouth disease virus subunit vaccine. Vaccine. 313(18):2302-2309.

Venezuelan Equine Encephalitis Virus replicon particles can induce rapid protection against Foot-and-Mouth Disease Virus Reprint Icon - (Peer reviewed journal)
Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Weiss, M., Perez-Martin, E., Owens, G., Custer, M., Kamrud, K., De Los Santos, T.B., Grubman, M.J. 2013. Venezuelan Equine Encephalitis Virus replicon particles can induce rapid protection against Foot-and-Mouth Disease Virus. Journal of Virology. 87(10):5447-5460. DOI: 10.1128/JVI.03462-12.

Early adaptive immune responses in the respiratory tract of foot and mouth disease-infected cattle Reprint Icon - (Peer reviewed journal)
Pega, J., Bucafusco, D., Di Giacomo, S., Malacari, D., Capozzo, A., Arzt, J., Perez-Beascoechea, C., Maradei, E., Rodriguez, L.L., Borca, M.V., Perez-Filgueira, M. 2012. Early adaptive immune responses in the respiratory tract of foot and mouth disease-infected cattle. Journal of Virology. 87(5):2489-2495.

Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis Reprint Icon - (Peer reviewed journal)
Lawrence, P., Uddowla, S., Pacheco Tobin, J., Kotecha, A., Fry, E., Rieder, A.E. 2012. Foot-and-mouth disease virus (FMDV) with a stable FLAG epitope in the VP1 G-H loop as a new tool for studying FMDV pathogenesis. Virology. 136(1):150-161.

Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism Reprint Icon - (Peer reviewed journal)
Loughran, G., Libbey, J.E., Uddowla, S., Scallan, M.F., Ryan, M.D., Fujinami, R.S., Rieder, A.E., Atkins, J.F. 2013. Theiler’s murine encephalomyelitis virus contrasts with encephalomyocarditis and foot-and-mouth disease viruses in its functional utilization of the StopGo non-standard translation mechanism. Journal of General Virology. 94(2):348-353.

Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate agent for rAd5-FMDV vaccines in cattle Reprint Icon - (Peer reviewed journal)
Montiel, N.A., Smoliga, G.R., Arzt, J. 2012. Time-dependent biodistribution and transgene expression of a recombinant human adenovirus serotype 5-luciferase vector as a surrogate agent for rAd5-FMDV vaccines in cattle. Veterinary Immunology and Immunopathology. 151(1-2):37-48. DOI: 110.1016/j.vetimm.2012.10.003.

Novel approaches to foot-and-mouth disease vaccine development - (Proceedings)
Ludi, A., Rodriguez, L.L. 2012. Novel approaches to foot-and-mouth disease vaccine development[abstract]. Vaccines and Diagnostics for Transboundary Animal Diseases. 135:107-116.

Foot and mouth disease virus non structural protein 2C interacts with Beclin1 modulating virus replication Reprint Icon - (Peer reviewed journal)
Gladue, D.P., O'Donnell, V., Baker-Branstetter, R., Pacheco Tobin, J., Holinka-Patterson, L.G., Fernandez Sainz, I.J., Lu, Z., Brocchi, E., Baxt, B., Piconne, M.E., Rodriguez, L.L., Borca, M.V. 2012. Foot and mouth disease virus non structural protein 2C interacts with Beclin1 modulating virus replication. Journal of Virology. 86(22):12080-12090. doi:10.1128/JVI.01610-12.

Homology modelling and analysis of structure predictions of the bovine rhinitis B virus RNA-dependent RNA polymerase (RdRp) Reprint Icon - (Peer reviewed journal)
Rai, D., Rieder, A.E. 2012. Homology modelling and analysis of structure predictions of the bovine rhinitis B virus RNA-dependent RNA polymerase (RdRp). International Journal of Molecular Sciences. 2012(3):8998-9013.

Identification of peptides fromm foot-and-mouth disease virus structural proteins bound by class I swine leucocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401 Reprint Icon - (Peer reviewed journal)
Pedersen, L.E., Harndahl, M., Nielsen, M., Patch, J.R., Jungersen, G., Buus, S., Golde, W.T. 2012. Identification of peptides fromm foot-and-mouth disease virus structural proteins bound by class I swine leucocyte antigen (SLA) alleles, SLA-1*0401 and SLA-2*0401. Animal Genetics. 44(3):251-258. DOI: 10.1111/j.1365-2052.2012.02400.x

Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease - (Peer reviewed journal)
Grubman, M.J., Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Perez-Martin, E., De Los Santos, T.B. 2012. Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease. Future Virology. 7(8):767-778.

Novel antiviral therapeutics to control foot-and-mouth disease Reprint Icon - (Peer reviewed journal)
Dias, C.C., Moraes, M.P., Weiss, M., Diaz San Segundo, F.C., Perez-Martin, E., Salazar, A.M., De Los Santos, T.B., Grubman, M.J. 2012. Novel antiviral therapeutics to control foot-and-mouth disease. Journal of Interferon and Cytokine Research. 32(10):462-473.

Foot-and-mouth disease virus serotype O phylodynamics: genetic variability associated with epidemiological factors in Pakistan Reprint Icon - (Peer reviewed journal)
Brito, B.P., Perez, A.M., Jamal, S.M., Belsham, G.J., Pauszek, S.J., Ahmed, Z., Rodriguez, L.L. 2012. Foot-and-mouth disease virus serotype O phylodynamics: genetic variability associated with epidemiological factors in Pakistan. Transboundary and Emerging Diseases. 60(6):516-524.

The early pathogenesis of foot-and-mouth disease - (Proceedings)
Arzt, J., Rodriguez, L.L. 2013. The early pathogenesis of foot-and-mouth disease. In: Tipics in Foot and Mouth Disease. Scientific Developments and Technical Challenges in the Progressive Control of Foot-and-Mouth Disease in South Asia, February 13-15, 2012, New Delhi, India. p. 24-36.

Host and viral factors responsible for FMD pathogenesis - (Proceedings)
Lawrence, P., Rieder, A.E. 2013. Host and viral factors responsible for FMD pathogenesis. In: Topics in Foot and Mouth Disease. Scientific Developments and Technical Challenges in the Progresive Control of Foot-and-Mouth Diseasein South Asia, February 13-15, 2012, New Delhi, India. p. 8-23.

Foot-and-mouth disease: global status and Indian perspective Reprint Icon - (Peer reviewed journal)
Biswal, J.K., Sanyal, A., Rodriguez, L.L., Subramaniam, S., Arzt, J., Sharma, G.K., Hammond, J.M., Parida, S., Mohapatra, J.K., Mathapati, B.S., Dash, B.B., Ranjan, R., Rout, M., Venketaramanan, R., Misri, J., Krishna, L., Prasad, G., Pathak, K.M., Pattnaik, B. 2012. Foot-and-mouth disease: global status and Indian perspective. Indian Journal of Animal Sciences. 82(2):109-131.

Designing bovine T-cell vaccines via reverse immunology - (Review article)
Nene, V., Svitek, N., Golde, W.T., Barlow, J., Buus, S., Nielsen, M. 2012. Designing bovine T-cell vaccines via reverse immunology. Ticks and Tick Borne Diseases. 3(2012):188-192.

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