Project Number: 6040-32000-063-07-R
Project Type: Reimbursable Cooperative Agreement
Start Date: Oct 1, 2011
End Date: Sep 30, 2015
To improve control of avian influenza virus (AIV) by better understanding vaccine failure, immunity and transmission in avian species: a) evaluate AIV transmission and spread in ducks and peri-domestic species of birds; b) determine the conditions that lead to vaccine failure in chickens and ducks; c) and to elucidate the immune response of ducks to AIV.
Using a team approach we will address each sub-objective individually. AIV transmission will be evaluated by comparing routes of inoculation and by using several different species of bird to see they are susceptible to selected strains of AIV including the Asian highly pathogenic H5N1 lineage. Transmission to contact birds and measure of virus shed will also be tested. The approach to vaccine failure will be to vaccinate chickens with different immune statuses and after exposure to other common vaccines and pathogens to see the effect on vaccine efficacy. A further component will be to include challenge viruses which are not related to the vaccine strain. The immune response of ducks to AIV will be assessed by measuring the cell mediated immune response and other immunological and genetic factors in ducks which are exposed to the virus.