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United States Department of Agriculture

Agricultural Research Service

Related Topics

Research Project: TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES

Location: Virus and Prion Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

A comparison of classical and H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism in wild type and EK211 cattle following intracranial inoculation - (Peer reviewed journal)
Moore, S.J., West Greenlee, M.H., Smith, J.D., Vrentas, C.E., Nicholson, E.M., Greenlee, J.J. 2016. A comparison of classical and H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism in wild type and EK211 cattle following intracranial inoculation. Frontiers in Veterinary Science. 3:78.

Pathological features of chronic wasting disease in reindeer and demonstration of horizontal transmission - (Peer reviewed journal)

Genetic variation of the prion protein gene (PRNP) in alpaca (Vicugna pacos) - (Peer reviewed journal)
Vermette, M.S., Schleining, J.A., Greenlee, J.J., Smith, J.D. 2016. Genetic variation of the prion protein gene (PRNP) in alpaca (Vicugna pacos). Gene Reports. 4:213–217.

Temporal resolution of misfolded prion protein transport, accumulation, glial activation, and neuronal death in the retinas of mice inoculated with scrapie - (Peer reviewed journal)
West Greenlee, M.H., Lind, M., Kokemuller, R., Mammadova, N., Kondru, N., Manne, S., Smith, J., Kanthasamy, A., Greenlee, J. 2016. Temporal resolution of misfolded prion protein transport, accumulation, glial activation, and neuronal death in the retinas of mice inoculated with scrapie. American Journal of Pathology. 186(9):2302–2309.

Disparate modes of evolution shaped modern prion (PRNP) and prion-related doppel (PRND) variation in domestic cattle - (Peer reviewed journal)
Brunelle, B.W., Hannen, A.M., Nicholson, E.M., Seabury, C.M. 2016. Disparate modes of evolution shaped modern prion (PRNP) and prion-related doppel (PRND) variation in domestic cattle. PLoS One. 11(5):e0155924. doi: 10.1371/journal.pone.0155924.

Limited amplification of chronic wasting disease prions in the peripheral tissues of intracerebrally inoculated cattle - (Peer reviewed journal)
Haley, N.J., Siepker, C., Greenlee, J.J., Richt, J.A. 2016. Limited amplification of chronic wasting disease prions in the peripheral tissues of intracerebrally inoculated cattle. Journal of General Virology. 97:1720-1724.

Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrPSc accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype - (Peer reviewed journal)
Greenlee, J.J., Smith, J.D., Hamir, A.N. 2016. Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrPSc accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype. Research in Veterinary Science. 105:188–191.

Comparison of two US sheep scrapie isolates supports identification as separate strains - (Peer reviewed journal)
Moore, S.J., Smith, J.D., Greenlee, M.H., Nicholson, E.M., Richt, J.A., Greenlee, J.J. 2016. Comparison of two US sheep scrapie isolates supports identification as separate strains. Veterinary Pathology. doi: 10.1177/0300985816629712.

Antemortem detection of chronic wasting disease prions in nasal brush collections and rectal biopsies from white-tailed deer by real time quaking-induced conversion - (Peer reviewed journal)
Haley, N.J., Siepker, C., Walter, W.D., Thomsen, B.V., Greenlee, J.J., Lehmkuhl, A.D., Richt, J.A. 2016. Antemortem detection of chronic wasting disease prions in nasal brush collections and rectal biopsy specimens from white-tailed deer by real time quaking-induced conversion. Journal of Clinical Microbiology. 54(4):1108-1116.

Scrapie transmits to white-tailed deer by the oral route and has a molecular profile similar to chronic wasting disease - (Abstract only)

Transmission of chronic wasting disease to sentinel reindeer (Rangifer tarandus tarandus) - (Abstract only)

Transmission of scrapie prions to primate after an extended silent incubation period - (Peer reviewed journal)
Comoy, E.E., Mikol, J., Luccantoni-Freire, S., Correia, E., Lescoutra-Etchegaray, N., Durand, V., Dehen, C., Andreoletti, O., Casalone, C., Richt, J.A., Greenlee, J.J., Baron, T., Benestad, S., Brown, P., Deslys, J. 2015. Transmission of scrapie prions to primate after an extended silent incubation period. Scientific Reports. 5:11573.

H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism: clinical and pathologic features in wild-type and E211K cattle following intracranial inoculation - (Abstract only)
Moore, S.J., West Greenlee, M.H., Smith, J., Nicholson, E., Vrentas, C., Greenlee, J. 2015. H-type bovine spongiform encephalopathy associated with E211K prion protein polymorphism: clinical and pathologic features in wild-type and E211K cattle following intracranial inoculation. Prion 2015. p. S5.

Transmission of the agent of sheep scrapie to deer results in PrPSc with two distinct molecular profiles - (Abstract only)
Greenlee, J., Moore, S.J., Smith, J.., West Greenlee, M.H., Kunkle, R. 2015. Scrapie transmits to white-tailed deer by the oral route and has a molecular profile similar to chronic wasting disease and distinct from the scrapie inoculum. Prion 2015. p. S62.

Development and characterization of an ex-vivo brain slice culture model of chronic wasting disease - (Abstract only)
Kondru, N., Greenlee, J., Greenlee, H., Manne, S., Kong, Q., Halbur, P., Kanthasamy, A., Kanthasamy, A. 2015. Development and characterization of an ex-vivo brain slice culture model of chronic wasting disease. Prion 2015. p. S68.

Relationship of PrPSc molecular properties with incubation time in a natural prion disease host: a characterization of three isolates of U.S. sheep scrapie - (Abstract only)
Vrentas, C., Smith, J., Greenlee, J., Nicholson, E. 2015. Relationship of PrPSc molecular properties with incubation time in a natural prion disease host: a characterization of 3 isolates of US sheep scrapie. Prion 2015. p. S92.

Clinical stage of infection is critical in the antemortem diagnosis of chronic wasting disease in deer and elk - (Abstract only)

Prion peripheralization is a host-driven trait of prion infection, independent of strain - (Abstract only)

The transmissible spongiform encephalopathies of livestock - (Review article)
Greenlee, J.J., West Greenlee, M.,H. 2015. The transmissible spongiform encephalopathies of livestock. ILAR Journal. 56(1):7-25.

Raman spectroscopy reveals spectroscopic changes in histologically normal retinas in a mouse model of alpha-synucleinopathy - (Abstract only)

Detection of the disease associated form of the prion protein in biological samples - (Review article)
Nicholson, E.M. 2015. Detection of the disease-associated form of the prion protein in biological samples. Bioanalysis. 7(2):253-261.

Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculated with the agent of scrapie - (Peer reviewed journal)
Greenlee, J.J., Kunkle, R.A., Richt, J.A., Nicholson, E.M., Hamir, A.N. 2014. Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculated with the agent of scrapie. PLoS One. 9(9):e108029.

Bovine Spongiform Encephalopathy: Atypical Pros and Cons - (Proceedings)
Kehrli Jr, M.E., Greenlee, J.J., Nicholson, E.M. 2014. Bovine Spongiform Encephalopathy: Atypical Pros and Cons. Proceedings of the California Animal Nutrition Conference, May 13-16, 2014, Fresno, California. p. 70-81.

The prion diseases of animals - (Book / chapter)
Greenlee J.J. 2014. The prion diseases of animals. In: McManus, L.M., Mitchell, R.N., editors. Pathobiology of Human Disease. San Diego: Elsevier. p. 1124-1133.

Time-course study of retinal pathology in C57BL/6 mice infected with RML scrapie - (Abstract only)
Lind, M., Smith, J.D., Briggie, L., West Greenlee, M., Greenlee, J.J. 2013. Time-course study of retinal pathology in C57BL/6 mice infected with RML scrapie. American College of Veterinary Pathologists Meeting. Available: http://www.acvp.org/index.php/en/2014-11-07-21-58-13/2013-annual-meeting.

Stability properties of PrPSc from cattle with experimental transmissible spongiform encephalopathies - (Peer reviewed journal)
Vrentas, C.E., Greenlee, J.J., Baron, T., Caramelli, M., Czub, S., Nicholson, E.M. 2013. Stability properties of PrPSc from cattle with experimental transmissible spongiform encephalopathies: use of a rapid whole homogenate, protease-free assay. BMC Veterinary Research. 9:167.

Evaluation of the zoonotic potential of transmissible mink encephalopathy - (Peer reviewed journal)
Comoy, E.E., Mikol, J., Ruchoux, M., Durand, V., Luccantoni-Freire, S., Dehen, C., Correia, E., Casalone, C., Richt, J.A., Greenlee, J.J., Torres, J.M., Brown, P., Deslys, J. 2013. Evaluation of the zoonotic potential of transmissible mink encephalopathy. Pathogens. 2:(3)520-532.

Characterization of the first case of naturally occurring chronic wasting disease in a captive red deer (Cervus elaphus) in North America - (Abstract only)
Lehmkuhl, A.L., Thomsen, B.V., Greenlee, J.J., Balachandran, A., O'Rourke, K., Hall, S. 2013. Characterization of the first case of naturally occurring chronic wasting disease in a captive red deer (Cervus elaphus) in North America. Prion 2013. AD-12-Prion (2013).7:22.

Atypical BSE: role of the E211K prion polymorphism - (Abstract only)
Greenlee, J.J. 2013. Atypical BSE: role of the E211K prion polymorphism. 2013 American Veterinary Medical Association (AVMA) Annual Convention, July 19-23, 2013, Chicago, Illinois. Paper No. 13920. p. 45.

The magic spot: identification of the binding site for ppGpp on E. coli RNA polymerase - (Peer reviewed journal)
Ross, W., Vrentas, C.E., Sanchez-Vazquez, P., Gaal, T., Gourse, R.L. 2013. The magic spot: a ppGpp binding site on E. coli RNA polymerase responsible for regulation of transcription initiation. Molecular Cell. 50(3):420-429.

A low molecular-weight ferroxidase is increased in the CSF of sCJD cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD - (Peer reviewed journal)
Haldar, S., Beveridge, A.J., Wong, J., Singh, A.J., Galimberti, D., Borroni, D., Zhu, X., Blevins, J., Greenlee, J., Perry, G., Mukhopadhyay, C.K., Schmotzer, C., Singh, N. 2014. A low-molecular-weight ferroxidase is increased in the CSF of sCJD Cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD. Antioxidants & Redox Signaling. 19(14):1662-1675.

Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases Reprint Icon - (Peer reviewed journal)
Di Bari, M.A., Nonno, R., Castilla, J., D'Agostino, C., Pirisinu, L., Riccardi, G., Conte, M., Richt, J., Kunkle, R., Langeveld, J., Vaccari, G., Agrimi, U. 2013. Chronic wasting disease in bank voles: characterisation of the shortest incubation time model for prion diseases. PLoS Pathogens. 9(3):e1003219.

Direct interactions between the coiled-coil tip of DksA and the trigger loop of RNA polymerase mediate transcriptional regulation - (Peer reviewed journal)
Lennon, C.W., Ross, W., Martin-Tumasz, S., Toulokhonov, I., Vrentas, C.E., Rutherford, S.T., Lee, J.H., Butcher, S.E., Gourse, R.L. 2012. Direct interactions between the coiled-coil tip of DksA and the trigger loop of RNA polymerase mediate transcriptional regulation. Genes and Development. 26(23):2634-2646.

Relationships between PrPSc stability and incubation time for United States scrapie strains in a natural host system - (Peer reviewed journal)
Vrentas, C.E., Greenlee, J.J., Tatum, T.L., Nicholson, E.M. 2012. Relationships between PrPSc stability and incubation time for United States scrapie isolates in a natural host system. PLoS ONE. 7(8):e43060.

Comparative aspects of bovine spongiform encephalopathy isolates found in the U.S. - (Abstract only)
Greenlee, J.J., Smith, J.D., Vrentas, C.E., West Greenlee, M.H., Nicholson, E.M. 2012. Comparative aspects of bovine spongiform encephalopathy isolates found in the U.S. American College of Veterinary Pathologists 63rd Annual Meeting. Paper No. E-16.

Susceptibility of cattle to the agent of chronic wasting disease from elk after intracranial inoculation - (Peer reviewed journal)
Greenlee, J.J., Nicholson, E.M., Smith, J.D., Kunkle, R.A., Hamir, A.N. 2012. Susceptibility of cattle to the agent of chronic wasting disease from elk after intracranial inoculation. Journal of Veterinary Diagnostic Investigation. 24(6):1087-1093.

Use of an ELISA-based stability assay to examine host genotype, PrP**Sc stability, and incubation time relationships in U.S. livestock prion strains - (Abstract only)
Vrentas, C.E., Nicholson, E.M., Greenlee, J.J. 2012. Use of an ELISA stability assay to examine host genotype, PrPSc stability, and incubation time relationships in U.S. livestock prion strains. 26th Annual Symposium of The Protein Society. p. 211.

Stability of PrP**Sc from cattle inoculated with different BSE strains - (Abstract only)
Nicholson, E.M., Vrentas, C.E., Greenlee, J.J. 2012. Stability of PrPSc from cattle inoculated with different BSE strains. 26th Annual Symposium of The Protein Society. p. 210.

Chronic wasting disease and atypical forms of BSE and scrapie are not transmissible to mice expressing wild-type levels of human PrP - (Peer reviewed journal)
Wilson, R., Plinston, C., Hunter, N., Casalone, C., Corona, C., Tagliavini, F., Suardi, S., Ruggerone, M., Moda, F., Graziano, S., Sbriccoli, M., Cardone, F., Pocchiari, M., Ingrosso, L., Baron, T., Richt, J., Andreoletti, O., Simmons, M., Lockey, R., Manson, J.C., Barron, R.M. 2012. Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein. Journal of General Virology. 93(Pt 7):1624-1629.

A comparative analysis of rapid methods for purification and refolding of recombinant bovine prion protein - (Peer reviewed journal)
Vrentas, C.E., Onstot, S., Nicholson, E.M. 2012. A comparative analysis of rapid methods for purification and refolding of recombinant bovine prion protein. Protein Expression and Purification. 82(2):380-388.

Last Modified: 2/23/2016
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