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United States Department of Agriculture

Agricultural Research Service

Research Project: Discovery and Development of Natural Product-based Insect Management Compounds for Medical, Veterinary and Urban Concern

Location: Biological Control of Pests Research

2013 Annual Report

1a. Objectives (from AD-416):
The goal of this project is to discover, develop, and foster commercialization of new, natural insect management products for control of insects of medicinal, veterinary, and urban concern.

1b. Approach (from AD-416):
(1) Collect biological material from terrestrial, aquatic, and marine sources for which there are reasons to suspect the presence of arthropod-active compounds. (2) Conduct bioassay-directed isolation of insect-active compounds against mosquitoes, fire ants, termites, and other insects of medicinal, urban, or veterinary concern. (3) Scale up the production of compounds of interest in order to conduct development research. (4) Conduct development research, such as insect target range and toxicological studies.

3. Progress Report:
The University of Mississippi’s National Center for Natural Products Research (NCNPR) is working with ARS scientists (Natural Product Utilization Research Unit, (NPURU) with the objectives of discovering, developing, and commercialization of new, safer and more effective insect management products from natural sources. Following progress has been made in these areas 1) Mosquito screening bioassays: NCNPR's and ARS scientists have screened more than 180 extracts/pure compounds in mosquito larval bioassays for this reporting period (1,450 over the course of the entire program). Further screening of the active products was completed at lower dosages. Dose response bioassays were completed for more than 150 compounds/extracts against 1-day old mosquito larvae and more than 50 compounds/extracts were tested against 4-day old mosquito larvae. 2) More than 325 extracts/ natural products were evaluated to determine the biting deterrence effects of these compounds using Klun & Debboun (K & D) modules over the past year (1,225 samples over the course of the entire program). Out of these products, replicated bioassays were completed for more than 100 extracts/compounds for publications. 3) Lastly, NCNPR's and ARS' scientists have developed topical bioassay system for adult mosquitoes and fire ant repellency and are in the process of developing a bioassay system to test the repellency of natural products against mosquitoes. With continued funding it is anticipated that significant progress can be made to identify a leading natural product based candidate for the development of an insect management product.

4. Accomplishments

Last Modified: 05/21/2017
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