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United States Department of Agriculture

Agricultural Research Service

Related Topics

Research Project: INTERVENTION STRATEGIES TO CONTROL VIRAL DISEASES OF SWINE

Location: Virus and Prion Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Leading edge analysis of transcriptomic changes during pseudorabies virus infection - (Peer Reviewed Journal)
Fleming, D.S., Miller, L.C. 2016. Leading edge analysis of transcriptomic changes during pseudorabies virus infection. Genomics Data. 10:104-106.

Comparative pathogenesis and characterization of contemporary 1-7-4 PRRSV isolates in weanling age piglets - (Abstract Only)

Comparative pathogenesis and characterization of contemporary 1-7-4 PRRSV isolates in weanling age piglets - (Abstract Only)

Enhancement of innate immunity with granulocyte colony-stimulating factor did not mitigate disease in pigs infected with a highly pathogenic Chinese PRRSV strain - (Peer Reviewed Journal)
Schlink, S.N., Lager, K.M., Brockmeier, S.L., Loving, C.L., Miller, L.C., Vorwald, A.C., Yang, H., Kehrli, Jr., M.E., Faaberg, K.S. 2016. Enhancement of innate immunity with granulocyte colony-stimulating factor did not mitigate disease in pigs infected with a highly pathogenic Chinese PRRSV strain. Veterinary Immunology and Immunopathology. 179:70-76.

The genetic diversity of contemporary swine influenza A viruses in the United States - (Popular Publication)
Walia, R.R., Anderson, T.K., Vincent, A.L. 2016. The genetic diversity of contemporary swine influenza A viruses in the United States. Available: https://www.pig333.com/swine-influenza/.

The molecular determinants of antibody recognition and antigenic drift in the H3 hemagglutinin of swine influenza A virus - (Peer Reviewed Journal)
Abente, E.J., Santos, J., Lewis, N.S., Gauger, P.C., Stratton, J., Skepner, E., Anderson, T.K., Rajao, D.S., Perez, D.R., Vincent, A.L. 2016. The molecular determinants of antibody recognition and antigenic drift in the H3 hemagglutinin of swine influenza A virus. Journal of Virology. 90(18):8266-8280.

Neuraminidase inhibiting antibody responses in pigs differ between influenza A virus N2 lineages and by vaccine type - (Peer Reviewed Journal)
Sandbulte, M.R., Gauger, P.C., Kitikoon, P., Chen, H., Perez, D.P., Roth, J.A., Vincent, A.L. 2016. Neuraminidase inhibiting antibody responses in pigs differ between influenza A virus N2 lineages and by vaccine type. Vaccine. 34(33):3773-3779.

Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): historical and current concepts - (Review Article)
Langel, S.N., Paim, F.C., Lager, K.M., Vlasova, A.N., Saif, L.J. 2016. Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): historical and current concepts. Virus Research. doi: 10.1016/j.virusres.2016.05.016.

The avian-origin H3N2 canine influenza virus has limited replication in swine - (Peer Reviewed Journal)
Abente, E.J., Anderson, T.K., Rajao, D.S., Swenson, S., Gauger, P.C., Vincent, A.L. 2016. The avian-origin H3N2 canine influenza virus that recently emerged in the United States has limited replication in swine. Influenza and Other Respiratory Viruses. 10(5):429-432.

Vaccine-associated enhanced respiratory disease is influenced by hemagglutinin and neuraminidase in whole inactivated influenza virus vaccines - (Peer Reviewed Journal)
Rajão, D.S., Chen, H., Perez, D.R., Sandbulte, M.R., Gauger, P.C., Loving, C.L., Shanks, G., Vincent, A.L. 2016. Vaccine-associated enhanced respiratory disease is influenced by hemagglutinin and neuraminidase in whole inactivated influenza virus vaccines. Journal of General Virology. 97(7):1489-1499.

Age at vaccination and timing of infection do not alter vaccine-associated enhanced respiratory disease in influenza A virus infected pigs - (Peer Reviewed Journal)
Souza, C.K., Rajão, D.S., Loving, C.L., Gauger, P.C., Pérez, D.R., Vincent, A.L. 2016. Age at vaccination and timing of infection do not alter vaccine-associated enhanced respiratory disease in influenza A virus infected pigs. Clinical and Vaccine Immunology. 23:470–482.

Quantifying the global antigenic diversity of swine influenza A viruses - (Peer Reviewed Journal)
Lewis, N.S., Russell, C.A., Langat, P., Anderson, T.K., Berger, K., Bielejec, F., Burke, D.F., Dudas, G., Fonville, J.M., Fouchier, R.A., Kellam, P., Koel, B.F., Lemey, P., Nguyen, T., Nuansrichy, B., Peiris, J.M., Saito, T., Simon, G., Skepner, E., Takemae, N., ESNIP3 consortium, Webby, R.J., van Reeth, K., Brookes, S.M., Larsen, L., Watson, S.J., Brown, I.H., Vincent, A.L. 2016. The global antigenic diversity of swine influenza A viruses. eLife. 5:e12217.

Vesicular disease in 9-week-old pigs experimentally infected with Senecavirus A - (Peer Reviewed Journal)
Montiel, N., Buckley, A., Guo, B., Kulshreshtha, V., Van Geelen, A., Hoang, H., Rademacher, C., Yoon, K., Lager, K.M. 2015. Vesicular disease in 9-week-old pigs experimentally infected with Senecavirus A. Emerging Infectious Diseases. 22(7):1246-1248.

Susceptibility of swine to H5 and H7 low pathogenic avian influenza viruses Reprint Icon - (Peer Reviewed Journal)
Balzli, C., Lager, K., Vincent, A., Gauger, P., Brockmeier, S., Miller, L., Richt, J.A., Ma, W., Suarez, D., Swayne, D.E. 2016. Susceptibility of swine to H5 and H7 low pathogenic avian influenza viruses. Influenza and Other Respiratory Viruses. 10(4):346-352.

Reassortment between swine H3N2 and 2009 pandemic H1N1 generated diverse genetic constellations in influenza A viruses currently circulating in pigs in the United States - (Abstract Only)

PEDV exposure protects pigs against homologous re-exposure 44 days later - (Abstract Only)

Demonstration of Senecavirus A protective immunity in a pig model - (Abstract Only)

Vesicular disease in 9-week-old pigs experimentally infected with Senecavirus A - (Proceedings)

Current trends from the USDA influenza a virus in swine surveillance system - (Abstract Only)

Genetic evolution of recently emerged novel human-like swine H3 influenza A viruses (IAV) in United States swine - (Abstract Only)

Pathogenesis and transmission of highly pathogenic avian influenza H5Nx in swine - (Abstract Only)

Vaccine efficacy of live-attenuated virus, whole inactivated virus and alphavirus vectored subunit vaccines against antigenically distinct H3N2 swine influenza A viruses - (Abstract Only)

Heterologous challenge in the presence of maternally-derived antibodies results in vaccine-associated enhanced respiratory disease in weaned piglets - (Peer Reviewed Journal)
Rajao, D.S., Sandbulte, M.R., Gauger, P.C., Kitikoon, P., Platt, R., Roth, J.A., Perez, D.R., Loving, C.L., Vincent, A.L. 2016. Heterologous challenge in the presence of maternally-derived antibodies results in vaccine-associated enhanced respiratory disease in weaned piglets. Virology. 491:79-88.

Pathogenesis and transmission studies: non-swine influenza A viruses in the swine host - (Proceedings)

Effects of pseudorabies virus infection on the tracheobronchial lymph node transcriptome - (Peer Reviewed Journal)
Miller, L.C., Bayles, D.O., Zanella, E.L., Lager, K.M., 2016. Effects of pseudorabies virus infection on the tracheobronchial lymph node transcriptome. Bioinformatics and Biology Insights. 9(Suppl 2):25-36.

Novel reassortant human-like H3N2 and H3N1 influenza A viruses detected in pigs are virulent and antigenically distinct from swine viruses endemic to the United States - (Peer Reviewed Journal)
Rajao, D.S., Gauger, P.C., Anderson, T.K., Lewis, N.S., Abente, E.J., Killian, M.L., Perez, D.R., Sutton, T.C., Zhang, J., Vincent, A.L. 2015. Novel reassortant human-like H3N2 and H3N1 influenza A viruses detected in pigs are virulent and antigenically distinct from swine viruses endemic to the United States. Journal of Virology. 89(22):11213-11222.

Live porcine reproductive and respiratory syndrome virus vaccines: current status and future direction - (Peer Reviewed Journal)
Renukaradhya, G.J., Meng, X., Calvert, J.G., Roof, M., Lager, K.M. 2015. Live porcine reproductive and respiratory syndrome virus vaccines: current status and future direction. Vaccine. 33(33):4069-4080.

Evaluation of two real-time polymerase chain reaction assays for porcine epidemic diarrhea virus (PEDV) to assess PEDV transmission in growing pigs - (Peer Reviewed Journal)
Miller, L.C., Crawford, K.K., Lager, K.M., Kellner, S.G., Brockmeier, S. 2016. Evaluation of two real-time polymerase chain reaction assays for porcine epidemic diarrhea virus (PEDV) to assess PEDV transmission in growing pigs. Journal of Veterinary Diagnostic Investigation. 28(1):20-29.

Ring test evaluation of the detection of influenza A virus in swine oral fluids by real-time, reverse transcription polymerase chain reaction (rRT-PCR) and virus isolation - (Peer Reviewed Journal)
Goodell, C.K., Zhang, J., Strait, E., Harmon, K., Patnayak, D., Otterson, T., Culhane, M., Christopher-Hennings, J., Clement, T., Leslie-Steen, P., Hesse, R., Anderson, J., Skarbek, K., Vincent, A., Kitikoon, P., Swenson, S., Jenkins-Moore, M., McGill, J., Rauh, R., Nelson, W., O'Connell, C., Shah, R., Wang, C., Main, R., Zimmerman, J.J. 2016. Ring test evaluation of the detection of influenza A virus in swine oral fluids by real-time reverse-transcription polymerase chain reaction and virus isolation. Canadian Journal of Veterinary Research. 80(1):12-20.

Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail - (Peer Reviewed Journal)
Obadan, A.O., Kimble, B.J., Rajao, D., Lager, K.M., Santos, J.J., Vincent, A.L., Perez, D.R. 2015. Replication and transmission of mammalian-adapted H9 subtype influenza virus in pigs and quail. Journal of General Virology. 96:2511-2521.

Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: current status and future direction - (Review Article)
Renukaradhya, G.J., Meng, X.J., Calvert, J.G., Roof, M., Lager, K.M. 2015. Inactivated and subunit vaccines against porcine reproductive and respiratory syndrome: Current status and future direction. Vaccine. 33(27):3065-3072.

Continual re-introduction of human pandemic H1N1 influenza A viruses into US swine, 2009-2014 - (Peer Reviewed Journal)
Nelson, M.I., Stratton, J., Killian, M.L, Janas-Martindale, A., Vincent, A.L. 2015. Continual reintroduction of human pandemic H1N1 influenza A viruses into swine in the United States, 2009-2014. Journal of Virology. 89(12):6218-6226.

A TaqMan-based real-time PCR assay for porcine parvovirus 4 detection and quantification in reproductive tissues of sows - (Peer Reviewed Journal)
Gava, D., Souza, C.K., Schaefer, R., Vincent, A.L., Cantão, M.E., Coldebella, A., Ciacci-Zanella, J.R. 2015. A TaqMan-based real-time PCR for detection and quantification of porcine parvovirus 4. Journal of Virological Methods. 219:14–17.

Immunological dysfunction role in transition dairy cow health disorders: biotherapeutics for disease prevention - (Proceedings)
Kehrli Jr, M.E. 2015. Immunological dysfunction role in transition dairy cow health disorders: biotherapeutics for disease prevention. In: International Veterinary Congress, April 22-24, 2015, Moscow, Russia. p. 22-44.

Global migration of influenza A viruses in swine - (Peer Reviewed Journal)
Nelson, M.I., Viboud, C., Vincent, A.L., Culhane, M.R., Detmer, S.E., Wentworth, D.E., Rambaut, A., Suchard, M.A., Holmes, E.C., Lemey, P. 2015. Global migration of influenza A viruses in swine. Nature Communications. 6:6696.

Characterization of co-circulating swine influenza A viruses in North America and the identification of a novel H1 genetic clade with antigenic significance - (Peer Reviewed Journal)
Anderson, T.K., Campbell, B.A., Nelson, M.I., Lewis, N.S., Janas-Martindale, A., Killian, M., Vincent, A.L. 2015. Characterization of co-circulating swine influenza A viruses in North America and the identification of a novel H1 genetic clade with antigenic significance. Virus Research. 201:24–31.

PRRSV structure, replication and recombination: origin of phenotype and genotype diversity - (Peer Reviewed Journal)
Kappes, M.A., Faaberg, K.S. 2015. PRRSV structure, replication and recombination: Origin of phenotype and genotype diversity. Virology. 479-480C:475-486.

Specific functions of the Rep and Rep' proteins of porcine circovirus during copy-release and rolling-circle DNA replication - (Peer Reviewed Journal)
Cheung, A.K. 2015. Specific functions of the Rep and Rep' proteins of porcine circovirus during copy-release and rolling-circle DNA replication. Virology. 481:43-50.

Reverse zoonosis of influenza to swine: new perspectives on the human–animal interface - (Review Article)
Nelson, M.I., Vincent, A.L. 2015. Reverse zoonosis of influenza to swine: new perspectives on the human–animal interface. Trends in Microbiology. 23(3):142-153.

Swine as a model for influenza A virus infection - (Book / Chapter)
Rajao, D.S., Vincent, A.L. 2015. Swine as a model for influenza A virus infection and immunity. ILAR Journal. 56(1):44-52.

Performance assessment of a real-time polymerase chain reaction assay for porcine epidemic diarrhea virus to assess PEDV transmission in growing pigs - (Abstract Only)

Efficacy of type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs - (Peer Reviewed Journal)
Lager, K.M., Schlink, S.N., Brockmeier, S.L., Miller, L.C., Henningson, J.N., Kappes, M.A., Kehrli, M.E., Loving, C.L., Guo, B., Swenson, S.L., Yang, H., Faaberg, K.S. 2014. Efficacy of type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs. Vaccine. 32(48):6457–6462.

Identification of several clades of novel single-stranded circular DNA viruses with conserved stem-loop structures in pig feces - (Peer Reviewed Journal)
Cheung, A.K., Ng, TF., Lager, K.M., Alt, D.P., Delwart, E., Pogranichniy, R.M. 2015. Identification of several clades of novel single-stranded circular DNA viruses with conserved stem-loop structures in pig feces. Archives of Virology. 160(1):353-358.

The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2 - (Peer Reviewed Journal)
Sinkora, M., Butler, J.E., Lager, K.M., Potockova, H., Sinkorova, J. 2014. The comparative profile of lymphoid cells and the T and B cell spectratype of germ-free piglets infected with viruses SIV, PRRSV or PCV2. Veterinary Research. 45:91.

Identification of eight clades of novel single-stranded circular DNA viruses in pig feces - (Abstract Only)

Introductions and evolution of human-origin seasonal influenza A viruses in multinational swine populations - (Peer Reviewed Journal)
Nelson, M.I., Wentworth, D.E., Culhane, M.R., Vincent, A.L., Viboud, C., LaPointe, M.P., Lin, X., Holmes, E.C., Detmer, S.E. 2014. Introductions and evolution of human-origin seasonal influenza A viruses in multinational swine populations. Journal of Virology. 88(17):10110-10119.

Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic - (Review Article)
Butler, J.E., Lager, K.M., Golde, W., Faaberg, K.S., Sinkora, M., Loving, C., Zhang, Y.I. 2014. Porcine reproductive and respiratory syndrome (PRRS): an immune dysregulatory pandemic. Immunologic Research. 59(1-3):81-108.

Immune response to influenza A virus hemagglutinin protein is sufficient to induce vaccine-associated enhanced respiratory disease - (Abstract Only)
Rajão, D.S., Loving, C.L., Gauger, P.C., Kitikoon, P., Vincent, A.L. 2014. Immune response to influenza A virus hemagglutinin protein is sufficient to induce vaccine-associated enhanced respiratory disease. American Society for Virology 33rd Annual Meeting. p. 199.

Identification of a novel circular DNA virus in pig feces - (Peer Reviewed Journal)
Cheung, A.K., Ng, T.F., Lager, K.M., Alt, D.P., Delwart, E.L., Pogranichniy, R.M. 2014. Identification of a novel single-stranded circular DNA virus in pig feces. Genome Announcements. 2(2):e00347-14.

A unique circovirus-like genome detected in pig feces - (Peer Reviewed Journal)
Cheung, A.K., Ng, T.F., Lager, K.M., Alt, D.P., Delwart, E.L., Pogranichniy, R.M. 2014. Unique circovirus-like genome detected in pig feces. Genome Announcements. 2(2):e00251-14.

In vivo models for pathotyping and vaccine efficacy for swine influenza - (Book / Chapter)
Lager, K.M., Vincent, A.L. 2014. In vivo models for pathotyping and vaccine efficacy for swine influenza. In: Spackman, E., editor. Methods in Molecular Biology, Animal Influenza Virus. 2nd edition. New York, NY: Springer. p. 355-361.

Serum virus neutralization assay for detection and quantitation of serum neutralizing antibodies to influenza A virus in swine - (Book / Chapter)
Gauger, P.C., Vincent, A.L. 2014. Serum virus neutralization assay for detection and quantitation of serum neutralizing antibodies to influenza A virus in swine. In: Spackman, E., editor. Methods in Molecular Biology, Animal Influenza Virus. 2nd edition. New York, NY: Springer. p. 313-324.

Enzyme-linked immunosorbent assay for detection of serum or mucosal isotype specific IgG and IgA whole virus antibody to influenza A virus in swine - (Book / Chapter)
Gauger, P.C., Loving, C.L., Vincent, A.L. 2014. Enzyme-linked immunosorbent assay for detection of serum or mucosal isotype specific IgG and IgA whole virus antibody to influenza A virus in swine. In: Spackman, E., editor. Methods in Molecular Biology: Animal Influenza Virus. 2nd edition. Springer New York, Humana Press. 1161:303-312.

A brief introduction to influenza A virus in swine - (Book / Chapter)
Vincent, A.L., Lager, K.M., Anderson, T.K. 2014. A brief introduction to influenza A virus in swine. In: Spackman, E., editor. Methods in Molecular Biology, Animal Influenza Virus. 2nd edition. New York, NY: Springer. p. 243-258.

Microneutralization assay for swine influenza virus in swine serum - (Book / Chapter)
Kitikoon, P., Vincent, A.L. 2014. Microneutralization assay for swine influenza virus in swine serum. In: Spackman, E., editor. Methods in Molecular Biology, Animal Influenza Virus. 2nd edition. New York, NY: Springer. p. 325-335.

Hemagglutinin inhibition assay with swine sera - (Book / Chapter)
Kitikoon, P., Gauger, P.C., Vincent, A.L. 2014. Hemagglutinin inhibition assay with swine sera. In: Spackman, E., editor. Methods in Molecular Biology, Animal Influenza Virus. 2nd edition. New York, NY: Springer. p. 295-301.

Antibody secreting cell assay for influenza A virus in swine - (Book / Chapter)
Kitikoon, P., Loving, C.L., Vincent, A.L. 2014. Antibody secreting cell assay for influenza A virus in swine. In: Spackman, E., editor. Methods in Molecular Biology, Animal Influenza Virus. 2nd edition. New York, NY: Springer. p. 347-353.

Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses - (Peer Reviewed Journal)
Miller, L.C., Jiang, Z., Sang, Y., Harhay, G.P., Lager, K.M. 2014. Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses. Veterinary Immunology and Immunopathology. 159(3-4):180-191.

The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference - (Peer Reviewed Journal)
Deaton, M.K., Spear, A., Faaberg, K.S., Pegan, S.D. 2014. The vOTU domain of highly-pathogenic porcine reproductive and respiratory syndrome virus displays a differential substrate preference. Virology. 454-455:247-253.

Influenza A virus pathogenesis and vaccination in swine - (Book / Chapter)
Rajao, D.S., Anderson, T.K., Gauger, P.C., Vincent, A.L. 2014. Pathogenesis and vaccination of influenza A virus in swine. In: Compans, R.W., Oldstone, M.B.A., editors. Influenza Pathogenesis and Control, Current Topics in Microbiology and Immunology. Switzerland: Springer International Publishing. p. 307-326.

Status report on Porcine Epidemic Diarrhea Virus in the United States - (Review Article)
Kehrli, Jr., M.E., Stasko, J.A., Lager, K.M. 2014. Status report on porcine epidemic diarrhea virus in the United States. Animal Frontiers. 4(1):44-45.

Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak in US swine - (Peer Reviewed Journal)
Chen, Q., Li, G., Stasko, J., Thomas, J.T., Stensland, W.R., Pillatzki, A.E., Gauger, P.C., Schwartz, K.J., Madson, D., Yoon, K.J., Stevenson, G.W., Burrough, E.R., Harmon, K.M., Main, R.G., Zhang, J. 2014. Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak among swine in the United States. Journal of Clinical Microbiology. 52(1):234-243.

Swine influenza virus vaccine research and technology: What does the future hold and what are our next steps? - (Proceedings)
Kehrli Jr, M.E., Vincent, A.L., Loving, C.L., Lager, K.M. 2013. Swine influenza virus vaccine research and technology: What does the future hold and what are our next steps? Swine Disease Conference Proceedings, November 14-15, 2013, Ames, Iowa. p. 16-20.

Highly divergent strains of porcine reproductive and respiratory syndrome virus incorporate multiple isoforms of nonstructural protein 2 into virions - (Peer Reviewed Journal)
Kappes, M.A., Miller, C.L., Faaberg, K.S. 2013. Highly divergent strains of porcine reproductive and respiratory syndrome virus incorporate multiple isoforms of nonstructural protein 2 into virions. Journal of Virology. 87(24):13456-13465.

Evolutionary characterization of pig interferon-inducible transmembrane gene family and member expression dynamics in tracheobronchial lymph nodes of pigs infected with swine respiratory disease viruses - (Abstract Only)

Heterologous challenge of weaned piglets in the presence of maternal derived antibodies results in vaccine-associated enhanced respiratory disease - (Abstract Only)
Rajao, D., Vincent, A.L., Loving, C.L., Sandbulte, M., Kitikoon, P. 2013. Heterologous challenge of weaned piglets in the presence of maternal derived antibodies results in vaccine-associated enhanced respiratory disease [abstract]. 2013 Conference of Research Workers in Animal Diseases, December 8-10, 2013, Chicago, IL. Paper No. 090.

Maternal derived antibodies induce vaccine-associated enhanced respiratory disease in weaned pigs challenged with heterologous virus - (Abstract Only)
Rajao, D., Vincent, A.L., Loving, C.L., Sandbulte, M., Kitikoon, P. 2014. Maternal derived antibodies induce vaccine-associated enhanced respiratory disease in weaned pigs challenged with heterologous virus. Proceedings of the 45th American Association of Swine Veterinarians Annual Meeting, p.41-47.

Maternal derived antibodies induce vaccine-associated enhanced respiratory disease in weaned pigs challenged with heterologous virus - (Proceedings)
Rajao, D., Vincent, A.L., Loving, C.L., Gauger, P.C., Sandbulte, M., Kitikoon, P. 2014. Maternal derived antibodies induce vaccine-associated enhanced respiratory disease in weaned pigs challenged with heterologous virus. Proceedings of 45th American Association of Swine Veterinarians Annual Meeting. p. 51-54.

Chinese and Vietnamese strains of HP-PRRSV cause different pathogenic outcomes in United States high health swine Reprint Icon - (Peer Reviewed Journal)
Guo, B., Lager, K.M., Schlink, S.N., Kehrli, Jr., M.E., Brockmeier, S.L., Miller, L.C., Swensen, S.L., Faaberg, K.S. 2013. Chinese and Vietnamese strains of HP-PRRSV cause different pathogenic outcomes in United States high health swine. Virology. 446(1-2):238-250.

The growing diversity of H3N2 influenza A virus in swine and the impact on control in swine and at the human animal interface - (Proceedings)
Vincent, A.L., Kitikoon, P., Anderson, T.K., Loving, C.L. 2013. The growing diversity of H3N2 influenza A virus in swine and the impact on control in swine and at the human animal interface. Proceedings of the 2013 Allen D Leman Swine Conference. p. 161-63.

Vaccine-associated enhanced respiratory disease does not interfere with the adaptive immune response following challenge with pandemic A/H1N1 2009 - (Peer Reviewed Journal)
Gauger, P.C., Loving, C.L., Lager, K.M., Janke, B.H., Kehrli, Jr., M.E., Roth, J.A., Vincent, A.L. 2013. Vaccine-associated enhanced respiratory disease does not interfere with the adaptive immune response following challenge with pandemic A/H1N1 2009. Viral Immunology. 26(5):314-321.

Swine influenza - need for global surveillance and improved vaccines - (Abstract Only)

Human infections with influenza A(H3N2) variant virus in the United States, 2011-2012 - (Peer Reviewed Journal)
Epperson, S., Jhung, M., Richards, S., Quinlisk, P., Ball, L., Moll, M., Boulton, R., Haddy, L., Biggerstaff, M., Brammer, L., Trock, S., Burns, E., Gomez, T., Wong, K.K., Katz, J., Lindstrom, S., Klimov, A., Bresee, J.S., Jernigan, D.B., Cox, N., Finelli, L., Influenza A(H3N2)v Virus Investigation Team (Vincent, A.L.). 2013. Human infections with influenza A(H3N2) variant virus in the United States, 2011-2012. Clinical Infectious Diseases. 57(S1):S4-S11.

A divergent picornavirus from a turkey with gastro-intestinal disease Reprint Icon - (Peer Reviewed Journal)
Ng, T.F.F., Cheung, A.K., Wong, W., Lager, K.M., Kondov, N.O., Cha, Y., Murphy, D.A., Pogranichniy, R.M., Delwart, E. 2013. Divergent picornavirus from a turkey with gastro-intestinal disease. Genome Announcements. 1(3):e00134-13.

A divergent clade of circular single-stranded DNA viruses from pig feces - (Peer Reviewed Journal)
Cheung, A.K., Ng, T.F., Lager, K.M., Bayles, D.O., Alt, D.P., Delwart, E.L., Pogranichniy, R.M., Kehrli, Jr., M.E. 2013. A divergent clade of circular single-stranded DNA viruses from pig feces. Archives of Virology. 158(10):2157-2162.

Divergent immune responses and disease outcomes in piglets immunized with inactivated and attenuated H3N2 swine influenza vaccines in the presence of maternally-derived antibodies - (Abstract Only)

Increased diversity of H3N2 influenza virus in pigs in the United States and implications for pigs and humans - (Abstract Only)

Genotype patterns of contemporary reassorted H3N2 virus in U.S. swine Reprint Icon - (Peer Reviewed Journal)
Kitikoon, P., Nelson, M.I., Killian, M.L., Anderson, T.K., Koster, L., Culhane, M.R., Vincent, A.L. 2013. Genotype patterns of contemporary reassorted H3N2 virus in US swine. Journal of General Virology. 94(Pt 6):1236-1241.

Pathogenicity and transmission of the novel A (H3N2v) influenza virus isolated from humans in experimentally inoculated pigs - (Abstract Only)

Two Asian highly pathogenic strains of Type 2 PRRSV in United States swine - (Abstract Only)
Faaberg, K., Lager, K., Brockmeier, S., Guo, B., Swenson, S., Yang, H., Kehrli, M., Nicholson, T., Miller, L., Henningson, J., Schlink, S., Kappes, M. 2013. Two Asian highly pathogenic strains of Type 2 PRRSV in United States swine. Positive Strand RNA Viruses, Keystone Symposia on Molecular and Cellular Biology. Paper No. 1063.

The use of epitope tags in modified porcine respiratory and reproductive syndrome virus vaccines to differentiate infected from vaccinated animals - (Abstract Only)
Spear, A.R., Lager, K.M., Faaberg, K.S. 2013. The use of epitope tags in modified porcine respiratory and reproductive syndrome virus vaccines to differentiate infected from vaccinated animals. Positive Strand RNA Viruses, Keystone Symposia on Molecular and Cellular Biology. Paper No. 2079, p. 94.

Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus Reprint Icon - (Peer Reviewed Journal)
Jiang, Z., Zhou, X., Michal, J.J., Wu, X.-L., Zhang, L., Zhang, M., Ding, B., Liu, B., Manoranjan, V.S., Neill, J.D., Harhay, G.P., Kehrli, Jr., M.E., Miller, L.C. 2013. Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus. PLoS One. 8(3):e59229.

MontanideTM Gel01 ST adjuvant enhances PRRS modified live vaccine efficacy by regulating porcine humoral and cellular immune responses Reprint Icon - (Peer Reviewed Journal)
Li, X., Galliher-Beckley, A., Nietfeld, J.C., Faaberg, K.S., Shi, J. 2013. MontanideTM Gel01 ST adjuvant enhances PRRS modified live vaccine efficacy by regulating porcine humoral and cellular immune responses. World Journal of Vaccines. 3(1):1-9.

Functions of Rep and Rep' during porcine circovirus rolling-circle replication - (Abstract Only)
Cheung, A.K. 2013. Functions of Rep and Rep' during porcine circovirus rolling-circle replication [abstract]. DNA Replication and Recombination - training for proteins involved in eukaryotic DNA replication, Keystone Symposium, March 3-8, 2013, Banff, Canada. Paper No. Abs. x5 1017. p. 80.

Outbreak of influenza A (H3N2) in people and pigs at county fairs - (Abstract Only)
Swenson, S.L., Killian, M., Pogranichniy, R.N., Strasser, J., Lindstrom, S., Kitikoon, P., House, J., Lenz, S., Koster, L., Marsh, B., Vincent, A.L. 2013. Outbreak of influenza A (H3N2) in people and pigs at county fairs. Proceedings of the 44th American Association of Swine Veterinarians Annual Meeting. p. 417.

Comparative transcriptome response in swine tracheobronchial lymph nodes to viral infection - (Abstract Only)
Miller, L.C., Harhay, G.P., Kehrli, Jr., M.E., Lager, K.M. 2013. Comparative transcriptome response in swine tracheobronchial lymph nodes to viral infection [abstract]. International Plant & Animal Genome XXI, January 12-16, 2013, San Diego, California. Paper No. W756.

Antibody repertoire development in fetal and neonatal piglets. XV. Porcine circovirus type 2 infection differentially affects serum IgG levels and antibodies to ORF2 in piglets free from other environmental factors - (Peer Reviewed Journal)
Sun, X., Wertz, N., Lager, K.M., Butler, J.E. 2012. Antibody repertoire development in fetal and neonatal piglets. XV. Porcine circovirus type 2 infection differentially affects serum IgG levels and antibodies to ORF2 in piglets free from other environmental factors. Vaccine. 31(1):141-148.

Pathogenesis of HP-PRRSV in gnotobiotic pigs - (Abstract Only)
Lager, K.M., Faaberg, K.S., Brockmeier, S.L., Miller, L.C., Kappes, M.A., Spear, A., Kehrli, Jr., M.E. 2012. Pathogenesis of HP-PRRSV in gnotobiotic pigs. 2012 International PRRS Symposium. p. 92.

Swine tracheobronchial lymph node mRNA responses in swine infected with a highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Abstract Only)
Miller, L.C., Fleming, D., Arbogast, A., Bayles, D.O., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Yang, H., Faaberg, K.S., Kehrli, Jr., M.E. 2012. Swine tracheobronchial lymph node mRNA responses in swine infected with a highly pathogenic strain of porcine reproductive and respiratory syndrome virus. 2012 International PRRS Symposium. p. 96.

Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream C-gamma genes - (Peer Reviewed Journal)
Butler, J.E., Sun, X., Wertz, N., Vincent, A.L., Zanella, E.L., Lager, K.M. 2013. Antibody repertoire development in fetal and neonatal piglets. XVI. Influenza stimulates adaptive immunity, class switch and diversification of the IgG repertoire encoded by downstream C-gamma genes. Immunology. 138(2):134-144.

Frequency of genomic reassortment of influenza A virus in North American swine, 1998-2011 - (Peer Reviewed Journal)
Nelson, M.I., Detmer, S.E., Wentworth, D.E., Tan, Y., Schwartzbard, A., Halpin, R.A., Stockwell, T.B., Lin, X., Vincent, A.L., Gramer, M.R., Holmes, E.C. 2012. Genomic reassortment of influenza A virus in North American swine, 1998-2011. Journal of General Virology. 93(Pt 12):2584-2589.

Infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Guo, B., Lager, K.M., Henningson, J.N., Miller, L.C., Schlink, S.N., Kappes, M.A., Kehrli, Jr., M.E., Brockmeier, S.L., Nicholson, T.L., Yang, H., Faaberg, K.S. 2013. Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. Virology. 435(2):372-384.

Diversity of viruses detected by deep sequencing in pigs from a common background - (Peer Reviewed Journal)
Lager, K.M., Ng, T.F., Bayles, D.O., Alt, D.P., Delwart, E.L., Cheung, A.K. 2012. Diversity of viruses detected by deep sequencing in pigs from a common background. Journal of Veterinary Diagnostic Investigation. 24(6):1177-1179.

Analysis of the swine tracheobronchial lymphnode transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Peer Reviewed Journal)
Miller, L.C., Fleming, D., Arbogast, A., Bayles, D.O., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Yang, H.-C., Faaberg, K.S., Kehrli, Jr., M.E. 2012. Analysis of the swine tracheobronchial lymph node transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. BioMed Central (BMC) Veterinary Research. 8(1):208. Available: http://www.biomedcentral.com/1746-6148/8/208.

Analysis of the swine tracheobronchial lymphnode transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus - (Abstract Only)

Replicative intermediates of porcine circovirus in animal tissue cultured cells or in bacteria undergoing copy-release replication - (Peer Reviewed Journal)
Cheung, A.K. 2012. Replicative intermediates of porcine circovirus in animal tissue cultured cells or in bacteria undergoing copy-release replication. Virology. 434(1):38-42.

Frequent global transmission of H1N1pdm09 influenza viruses from humans to swine, 2009-2011 - (Peer Reviewed Journal)
Nelson, M.I., Gramer, M.R., Vincent, A.L., Holmes, E.C. 2012. Global transmission of influenza viruses from humans to swine. Journal of General Virology. 93(10):2195-2203.

Flu virus continues to evolve in swine - (Trade Journal)
Gauger, P.C., Zhang, J., Vincent, A.L. 2012. Flu virus continues to evolve in swine. National Hog Farmer. Available: http://nationalhogfarmer.com/health/flu-virus-continues-evolve-swine.

Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 - (Abstract Only)
Cheung, A.K., Kehrli, Jr., M.E., Lager, K.M., Gauger, P.C., Rohrer, G.A., Michael, D.D., Miller, L.C., Vincent, A.L., Braucher, D.R. 2012. Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 [abstract]. IXth International Congress of Veterinary Virology. p. 189-190.

Antibody repertoire development in fetal and neonatal piglets. XXII. Lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine - (Peer Reviewed Journal)
Sun, X., Wertz, N., Lager, K., Sinkora, M., Stepanova, K., Tobin, Butler, J.E. 2012. Antibody repertoire development in fetal and neonatal piglets. XXII. Lambda rearrangement precedes kappa rearrangement during B-cell lymphogenesis in swine. Immunology. 137(2):149-159.

Evolution of H3N2v viruses in North American swine and humans, 2009-2011 - (Peer Reviewed Journal)
Nelson, M.I., Vincent, A.L., Kitikoon, P., Holmes, E.C., Gramer, M.R. 2012. The evolution of novel reassortant A/H3N2 influenza viruses in North American swine and humans, 2009-2011. Journal of Virology. 86(16):8872-8878.

Chimeric viruses containing the N-terminal ectodomains of GP5 and M proteins of porcine reproductive and respiratory syndrome do not change the cellular tropism of equine arteritis virus - (Peer Reviewed Journal)
Lu, Z., Zhang, J., Huang, C.M., Go, Y.Y., Faaberg, K.S., Rowland, R.R., Timoney, P.J., Balasuriya, U.B. 2012. Chimeric viruses containing the N-terminal ectodomains of GP5 and M proteins of porcine reproductive and respiratory syndrome virus do not change the cellular tropism of equine arteritis virus. Virology. 432(1):99-109.

Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate - (Peer Reviewed Journal)
Nan, Y., Wang, R., Shen, M., Faaberg, K.S., Samal, S.K., Zhang, Y.J. 2012. Induction of type I interferons by a novel porcine reproductive and respiratory syndrome virus isolate. Virology. 432(2):261-270.

Simultaneous infection of pigs and people with triple reassortant swine influenza virus H1N1 at a U.S. county fair Reprint Icon - (Peer Reviewed Journal)
Killian, M.L., Swenson, S.L., Vincent, A.L., Landgraf, J.G., Shu, B., Lindstrom, S., Xu, X., Klimov, A., Zhang, Y., Bowman, A.S. 2013. Simultaneous infection of pigs and people with triple-reassortant swine influenza virus H1N1 at a U.S. county fair. Zoonoses and Public Health. 60(3):196-201.

National surveillance for swine influenza virus in the United States, 2009-present - (Proceedings)
Schiltz, J., Korslund, J.A., Pyburn, D., Swenson, S., Tomlinson, S., Kasari, E.M., Vincent, A.L. 2012. National surveillance for swine influenza virus in the United States, 2009-present. Proceedings of the 22nd International Pig Veterinary Society Congress. p. 415.

Antibody repertoire development in fetal and neonatal piglets. XXIII: fetal piglets infected with a vaccine strain of PRRS virus display the same immune dysregulation seen in isolator piglets - (Peer Reviewed Journal)
Sun, X.Z., Wertz, N., Lager, K.M., Tobin, G., Butler, J.E. 2012. Antibody repertoire development in fetal and neonatal piglets. XXIII: fetal piglets infected with a vaccine strain of PRRS virus display the same immune dysregulation seen in isolator piglets. Vaccine. 30(24):3646-3652.

Virion packaging of multiple cleavage isoforms of porcine reproductive and respiratory syndrome virus nonstructural protein 2 - (Abstract Only)
Kappes, M.A., Faaberg, K.S. 2012. Virion packaging of multiple cleavage isoforms of porcine reproductive and respiratory syndrome virus nonstructural protein 2 [abstract]. American Society for Virology 31st Annual Meeting. p. 161-162.

Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models - (Peer Reviewed Journal)
Ma, W., Lager, K.M., Li, X., Janke, B.H., Mosier, D.A., Painter, L.E., Ulery, E.S., Ma, J., Lekcharoensuk, P., Webby, R.J., Richt, J.A. 2011. Pathogenicity of swine influenza viruses possessing an avian or swine-origin PB2 polymerase gene evaluated in mouse and pig models. Virology. 410(1):1-6.

Last Modified: 2/23/2016
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