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United States Department of Agriculture

Agricultural Research Service

Research Project: Toxicology and Toxinology of Mycotoxins in Foods

Location: Toxicology & Mycotoxin Research

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)

Elevated Nuclear Sphingoid Base-1-Phosphates and Decreased Histone Deacetylase Activity after Fumonisin B1 Treatment in Mouse Embryonic Fibroblasts - (Peer reviewed journal)
Gardner, N., Riley, R.T., Showker, A.J., Voss, K.A., Sachs, A., Maddox, J., Gelineau-Van Waes, J. 2016. Elevated Nuclear Sphingoid Base-1-Phosphates and Decreased Histone Deacetylase Activity after Fumonisin B1 Treatment in Mouse Embryonic Fibroblasts. Journal of Toxicology and Applied Pharmacology. 298:56-65.

Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects - (Peer reviewed journal)
Gardner, N., Riley, R.T., Showker, A.J., Voss, K.A., Sachs, A., Maddox, J., Gelineau-Van Waes, J. 2015. Elevated Nuclear and Cytoplasmic FTY720-Phosphate in Mouse Embryonic Fibroblasts Suggests the Potential for Multiple Mechanisms in FTY720-Induced Neural Tube Defects. Toxicological Sciences. 150(1):161-168.

Evidence for ceramide synthase inhibition in humans exposed to fumonisins in maize-based foods and living in low or high exposure communities in Guatemala - (Abstract only)
Riley, R.T., Torres, O., Mutate, J., Grergory, S., Ashley-Koch, A., Showker, A.J., Mitchell, T.R., Maddox, J., Gelineau-Van Waes, J., Voss, K.A. 2016. Evidence for ceramide synthase inhibition in humans exposed to fumonisins in maize-based foods and living in low or high exposure communities in Guatemala. UJNR Toxic Microorganisms Panel Meeting. January 24-29,2016. Tokyo/Nagasaki, Japan.

Fumonisin exposure in women linked to inhibition of an enzyme that is a key event in farm and laboratory animal diseases. - (Abstract only)
Riley, R.T., Voss, K.A., Showker, A.J., Mitchell, T.R., Torres, O., Matute, J., Gregory, S., Ashley-Koch, A., Maddox, J., Gelineau-Van Waes, J. 2016. Fumonisin exposure in women linked to inhibition of an enzyme that is a key event in farm and laboratory animal diseases. American Chemical Society Abstracts. San Diego, California., March 13, 2016. AGFD 101.

Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala - (Peer reviewed journal)
Riley, R.T., Torres, O., Matute, J., Gregory, S., Ashley-Koch, A., Showker, A.J., Mitchell, T.R., Voss, K.A., Maddox, J., Gelineau-Van Waes, J. 2015. Evidence for fumonisin inhibition of ceramide synthase in humans consuming maize-based foods and living in high exposure communities in Guatemala. Molecular Nutrition and Food Research. 59(11):2209-2224.

Chronic aflatoxin exposure in children living in Bhaktapur, Nepal: Extension of the MAL-ED study - (Peer reviewed journal)
Mitchell, N.J., Riley, R.T., Egner, P.A., Groopman, J.D., Wu, F. 2016. Chronic aflatoxin exposure in children living in Bhaktapur, Nepal: Extension of the MAL-ED study. Journal of Exposure Science and Environmental Epidemiology. doi:10.1038/jes.2015.87.

Co-occurence of aflatoxins and fumonisins in maize: guatemala as a case study - (Abstract only)
Voss, K.A., Torres, O., Matute, J., Gelineau-Van Waes, J., Maddox, J., Gregory, S., Ashley-Kich, A., Showker, A.J., Riley, R.T. 2015. Co-occurence of aflatoxins and fumonisins in maize: guatemala as a case study. Gordon Research Conferences. June 14-19,2015. Easton, Massachusetts.

Co-exposure to fumonisins and aflatoxins in maize-based foods in central america: guatemala as a case study - (Abstract only)
Voss, K.A., Torres, O., Matute, J., Gelineau-Van Waes, J., Maddox, J.R., Gregory, S., Ashley-Koch, A.E., Showker, A.J., Riley, R.T. 2015. Co-exposure to fumonisins and aflatoxins in maize-based foods in central america: guatemala as a case study. Society of Toxicology. March 22-26,2015. San Diego,California.

A Blood Spot Method for Detecting Fumonisin-Induced Changes in Putative Sphingolipid Biomarkers in LM/Bc Mice and Humans - (Peer reviewed journal)
Riley, R.T., Showker, A.J., Lee, C.M., Zipperer, C.E., Mitchell, T.R., Voss, K.A., Zitomer, N.C., Torres, O., Matute, J., Gregory, S.G., Ashley-Koch, A.E., Maddox, J.R., Gardner, N., Gelineau-Van Waes, J. 2015. A Blood Spot Method for Detecting Fumonisin-Induced Changes in Putative Sphingolipid Biomarkers in LM/Bc Mice and Humans. Journal of Food Additives & Contaminants. 32(6):934-949.

In vivo Metabolism of Hydrolyzed Fumonisin B1 and Fumonisin B1 - (Abstract only)
Harrer, H., Humpf, H., Voss, K.A. 2015. In vivo Metabolism of Hydrolyzed Fumonisin B1 and Fumonisin B1. Annual Meeting of the United States Japan Cooperative Program on the Development and Utilizatin of Natural Resources. January 25-30, 2015. New Orleans, Louisiana.

Aflatoxin control measures: A basis for improved health in developing countries - (Monograph)

The Statement that Some Ochratoxins are “..classified as human carcinogens” is Not Accurate - (Peer reviewed journal)
Riley, R.T., Miller, D.J. 2014. The Statement that Some Ochratoxins are “..classified as human carcinogens” is Not Accurate. Toxicological Sciences. 143(1):1-2.

In vivo formation of N-acyl-fumonisin B1 - (Peer reviewed journal)
Harrer, H., Humpf, H., Voss, K.A. 2015. In vivo formation of N-acyl-fumonisin B1. Mycotoxin Research. 31(1):33-40.

Nixtamalization Reduces Fumonisin Toxicity - (Research notes)
Voss, K.A., Riley, R.T., Gelineau-Van Waes, J.B. 2014. Nixtamalization Reduces Fumonisin Toxicity. University Annual Newsletter. 23(2):3.

Fumonisins, Tortillas and Neural Tube Defects: Untangling a Complex Issue - (Abstract only)
Voss, K.A., Riley, R.T., Gelineau-Van Waes, J.B. 2014. Fumonisins, Tortillas and Neural Tube Defects: Untangling a Complex Issue. Corn Utilization and Technology Conference. June 2-4, 2014. Lousiville, Kentucky.

Human health implications from co-exposure to aflatoxins and fumonisins in maize-based foods in Latin America: Guatemala as a case study - (Peer reviewed journal)
Torres, O., Matute, J., Gelineau-Van Waes, J., Maddox, J.R., Gregory, S.G., Ashley-Koch, A.E., Showker, A.J., Voss, K.A., Riley, R.T. 2015. Human health implications from co-exposure to aflatoxins and fumonisins in maize-based foods in Latin America: Guatemala as a case study. World Mycotoxin Journal. 8(2):143-159.

In vivo metabolism of fumonisin B1 to N-acylated ceramide-like compounds - (Abstract only)
Voss, K.A., Harrer, H., Riley, R.T., Humpf, H. 2014. In vivo metabolism of fumonisin B1 to N-acylated ceramide-like compounds. Society of Toxicology. March 23-27,2014. Phoenix, Arizona.

Maize seedling blight induced by Fusarium verticillioides: accumulation of fumonisin B1 in leaves without colonization of the leaves Reprint Icon - (Peer reviewed journal)
Baldwin, T.T., Zitomer, N.C., Mitchell, T.R., Zimeri, A., Bacon, C.W., Riley, R.T., Glenn, A.E. 2014. Maize seedling blight induced by Fusarium verticillioides: accumulation of fumonisin B1 in leaves without colonization of the leaves. Journal of Agricultural and Food Chemistry. 62:2118-2125. doi: 10.1021/jf5001106.

Fumonisins as a potential risk factor for neural tube defects: a review - (Abstract only)
Voss, K.A., Riley, R.T., Gelineau-Van Waes, J., Torres, O. 2014. Fumonisins as a potential risk factor for neural tube defects: a review. United States-Japan Cooperative Program in Natural Resources (UJNR). January 26-31,2014. Tokyo/Shizuoka, Japan.

Evidence for Fumonisin inhibition of ceramide synthase in humans: validation in follow-up studies in Guatemala - (Abstract only)
Riley, R.T., Showker, A.J., Voss, K.A., Gelineau-Van Waes, J., Maddox, J.R., Ashley-Koch, A.E., Gregory, S.G., Matuate, J., Torres, O. 2014. Evidence for Fumonisin inhibition of ceramide synthase in humans: validation in follow-up studies in Guatemala. Toxicologist. 138(1):86.

Fumonisin B1 induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet - (Peer reviewed journal)
Voss, K.A., Riley, R.T., Gelineau-Van Waes, J. 2014. Fumonisin B1 induced neural tube defects were not increased in LM/Bc mice fed folate-deficient diet. Molecular Nutrition and Food Research. 58(6):1190-1198.

Urinary fumonisin B1 and estimated fumonisin intake in women from high and low exposure communities in Guatemala Reprint Icon - (Peer reviewed journal)
Torres, O., Matute, J., Gelineau-Van Waes, J., Maddox, J.R., Gregory, S.G., Ashley-Koch, A.E., Showker, A.J., Zitomer, N.C., Voss, K.A., Riley, R.T. 2014. Urinary fumonisin B1 and estimated fumonisin intake in women from high and low exposure communities in Guatemala. Molecular Nutrition and Food Research. 58(5):973-983. doi: 10.1002/mnfr.201300481.

Increased nuclear sphingoid base-1-phosphates and HDAC inhibition after fumonisin and FTY720-treatment: the link between epigenomic modifications and neural tube defects? - (Abstract only)
Gardner, N.M., Sachs, A.J., Riley, R.T., Maddox, J.R., Gelineau-Van Waes, J. 2013. Increased nuclear sphingoid base-1-phosphates and HDAC inhibition after fumonisin and FTY720-treatment: the link between epigenomic modifications and neural tube defects?. 8th International Conference on Neural Tube Defects. October 7, 2013. Austin, Texas.

Naturally occurring chemical carcinogens - (Monograph)
Riley, R.T. 2014. Naturally occurring chemical carcinogens.In: World Cancer Report, pp.169 B. Stewart and C.P. Wild, eds, Interantional Agency for Research on Cancer, Lyon, France

Fumonisin toxicity and mechanism of action: overview and current perspectives Reprint Icon - (Peer reviewed journal)
Voss, K.A., Riley, R.T. 2013. Fumonisin toxicity and mechanism of action: overview and current perspectives. Food Safety. 1(1):49-69. doi: 10.14252/foodsafetyfscj.2013006.

Fumonisin biomarkers in maize eaters and implications for human disease Reprint Icon - (Peer reviewed journal)
van der Westhuizen, L., Shephard, G.S., Gelderblom,, W.A., Torres, O., Riley, R.T. 2013. Fumonisin biomarkers in maize eaters and implications for human disease. World Mycotoxin Journal. DOI: 10.3920/WMJ2013.1589.

Gene-environment interactions in susceptibility to fumonisin-induced neural tube defects - (Abstract only)
Gelineau-Van Waes, J., Gardner, N.M., Maddox, J.R., Krupp, D., Gregory, S.G., Ashley-Koch, A.E., Riley, R.T. 2013. Gene-environment interactions in susceptibility to fumonisin-induced neural tube defects. 8th International Conference on Nearal Tube Defects. October 7-10, 2013 Austin, Texas.

Risk control and food safety - (Proceedings)
Yamamoto, S., Voss, K.A. 2013. Risk control and food safety. Food Additives & Contaminants: Part A. 30(8):1349-1350. DOI: 10.1080/19440049.2013.812440.

Mycotoxins - (Book / chapter)
Haschek, W.M., Voss, K.A. 2013. Mycotoxins. Book Chapter. pgs. 1187-1258.

Neural Tube Defect Induction by Fumonisin B1 in LM/Bc Mice Fed Folate Deficient or Folate Replete Diets - (Abstract only)
Voss, K.A., Riley, R.T., Gelineau-Van, W.J. 2013. Neural Tube Defect Induction by Fumonisin B1 in LM/Bc Mice Fed Folate Deficient or Folate Replete Diets [abstract]. United States-Japan Cooperative Program in Natural Resources (UJNR). p. 34.

Effects of long term exposure to the mycotoxin fumonisin B1 in p53 heterozygous and p53 homozygous transgenic mice Reprint Icon - (Peer reviewed journal)
Bondy, G.S., Mehta, R., Caldwell, D., Coady, L., Armstrong, C., Savard, M., Miller, J., Chomyshyn, E., Bronson, R., Zitomer, N.C., Riley, R.T. 2012. Effects of long term exposure to the mycotoxin fumonisin B1 in p53 heterozygous and p53 homozygous transgenic mice. Food and Chemical Toxicology. 50(10):3604-3613. DOI: 10.1016/j.fct.2012.07.024.

Development of biomarkers to assess fumonisin exposure and birth defects - (Book / chapter)
Riley, R.T., Voss, K.A., Showker, A.J., Torres, O., Matute, J., Maddox, J.R., Rainey, M., Gardner, N.M., Sachs, A., Gregory, S.G., Ashley-Koch, A.E., Krupp, D., Gelineau-Van Waes, J. 2012. Development of biomarkers to assess fumonisin exposure and birth defects. In: Binder, E.M., editor. Proceedings of the World Nutrition Forum, October 10-13, 2012, Marina Bay, Singapore. p. 249-256.

Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720 Reprint Icon - (Peer reviewed journal)
Gelineau-Van Waes, J., Rainey, M.A., Maddox, J.R., Voss, K.A., Sachs, A.J., Gardner, N.M., Wilberding, J.D., Riley, R.T. 2012. Increased sphingoid base-1-phosphates and failure of neural tube closure after exposure to fumonisin or FTY720. Birth Defects Research Part A: Clinical and Molecular Teratology. 94(10):790-803.

Effects of different extrusion conditions on the chemical and toxicological fate of fumonisin B1 in maize: a review - (Review article)
Jackson, L.S., Voss, K.A., Ryu, D. 2012. Effects of different extrusion conditions on the chemical and toxicological fate of fumonisin B1 in maize: a review. World Mycotoxin Journal. 5(3):251-260.

Alkaline cooking (nixtamalisation) and the reduction in the in vivo toxicity of fumonisin-contaminated corn in a rat feeding Bioassay Reprint Icon - (Peer reviewed journal)
Voss, K.A., Riley, R.T., Moore, N.D., Burns, T.D. 2013. Alkaline cooking (nixtamalisation) and the reduction in the in vivo toxicity of fumonisin-contaminated corn in a rat feeding Bioassay. Food Additives & Contaminants: Part A. 30(8):1415-1421. DOI: 10.1080/19440049.2012.712064.

The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets Reprint Icon - (Peer reviewed journal)
Riley, R.T., Torres, O., Showker, A.J., Zitomer, N.C., Matute, J., Voss, K.A., Gelineau-van Waes, J., Maddox, J.R., Gregory, S.G., Ashley-Koch, A.E. 2012. The kinetics of urinary fumonisin B1 excretion in humans consuming maize-based diets. Molecular Nutrition and Food Research. 56:1445-1455.

Improving public health through mycotoxin control - (Book / chapter)
Pitt, J.I., Wild, C.P., Gelderblom, W., Miller, J., Riley, R.T., Wu, F., Bann, R.A. 2012. Improving public health through mycotoxin control. Lyon, France: International Agency for Research on Cancer. Publication No. 158. 162 p.

The use of bioassay to determine the effects of cooking on the toxicity of fumonisins - (Abstract only)
Voss, K.A., Riley, R.T., Gelineau-Van Waes, J.B., Ryu, D., Jackson, L.S., Bianchini, A., Bullerman, L.B., Hanna, M.A. 2012. The use of bioassay to determine the effects of cooking on the toxicity of fumonisins [abstract]. In: Proceedings of the 11th International Symposium on Toxic Microorganisms "Risk Control and Food Safety." US Japan Joint Panel on Toxic Microorgnisms, March 5-6, 2012, Seiryo, Kaikan. p. 162.

Evidence for fumonisin inhibition of ceramide synthase in humans - (Abstract only)
Riley, R.T., Showker, A.J., Voss, K.A., Gelineau-van Waes, J., Maddox, J.R., Gregory, S.G., Ashley-Koch, A.E., Torres, O. 2012. Evidence for fumonisin inhibition of ceramide synthase in humans [abstract]. The Toxicologist (supplement to Toxicological Sciences). 126(1):237.

Ceramide, sphingoid bases, and sphingoid base metabolites as lipid mediators in signaling pathways leading to cell death and disease - (Abstract only)
Riley, R.T. 2012. Ceramide, sphingoid bases, and sphingoid base metabolites as lipid mediators in signaling pathways leading to cell death and disease [abstract]. The Toxicologist (supplement to Toxicological Sciences). 126(1):178.

Consumption of folate deficient diet did not increase neural tube defects in LM/Bc mice exposed to fumonisin B1 - (Abstract only)
Voss, K.A., Riley, R.T., Gelineau-Van Waes, J.B. 2012. Consumption of folate deficient diet did not increase neural tube defects in LM/Bc mice exposed to fumonisin B1. Toxicological Sciences. 126(1):238.

Fumonisins - (Monograph)
Bulder, A.S., Arcella, D., Bolger, M., Carrington, C., Kpodo, K., Resnik, S.,Riley, R.T., Wolterink, G., Wu, F. 2012. Fumonisins. In: Safety evaluation of certain food additives and contaminants. Geneva. World Health Organization. WHO Food Additives Series. 65:325-794.

Current perspectives on Fusarium mycotoxins: fumonisin and deoxynivalenol - (Abstract only)
Voss, K.A., Riley, R.T., Gelineau-Van Waes, J.B., Pestka, J.J. 2011. Current perspectives on Fusarium mycotoxins: fumonisin and deoxynivalenol [abstract]. 7th Canadian Workshop on Fusarium Head Blight Proceedings. p. 24

Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydro-sphingosine 1-phosphate in human neural progenitor cells Reprint Icon - (Peer reviewed journal)
Callihan, P., Zitomer, N., Stoeling, M., Kennedy, P., Lynch, K.R., Riley, R.T., Hooks, S.B. 2012. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydro-sphingosine 1-phosphate in human neural progenitor cells. Neuropharmacology. 62:988-996.

Evaluation of certain food additives and contaminants - (Other)
Members of Joint Expert Committee on Food Additives (JECFA), Riley, R.T. 2011. Evaluation of certain food additives and contaminants. In: Seventy-fourth meeting of the Joint Food and Agriculture Organization (FAO)/World Health Organization (WHO) Expert Committee on Food Additives, June 14-23, 2011, Rome, Italy. WHO Technical Report Series. 966:1-136.

Analytical methods for evaluating the effect of thermal processing on fumonisins in corn-based food - (Abstract only)
Jackson, L.S., Jablonski, J.E., Voss, K.A., Ryu, D. 2011. Analytical methods for evaluating the effect of thermal processing on fumonisins in corn-based food [abstract]. Cornucopia, Division of Agricultural and Food Chemistry, American Chemical Society. Abstract AGFD18:27.

The conserved global regulator veA is necessary for symptom production and mycotoxin synthesis in maize seedlings by Fusarium verticillioides Reprint Icon - (Peer reviewed journal)
Myung, K., Zitomer, N.C., Duvall, M., Glenn, A.E., Riley, R.T., Calvo, A.M. 2011. The conserved global regulator veA is necessary for symptom production and mycotoxin synthesis in maize seedlings by Fusarium verticillioides. Plant Pathology. (2012) 61:152-160. DOI: 10.1111/j.1365-3059.2011.02504.x.

Reduction of fumonisin B1 in corn grits by twin-screw extrusion Reprint Icon - (Peer reviewed journal)
Jackson, L.W., Jablonski, J.E., Bullerman, L.B., Bianchini, A., Hanna, M.A., Voss, K.A., Hollub, A.D., Ryu, D. 2011. Reduction of fumonisin B1 in corn grits by twin-screw extrusion. Journal of Food Science. 76(6):150-155.

Last Modified: 2/23/2016
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