Location: Foreign Animal Disease Research
Project Number: 1940-32000-056-08-N
Project Type: Non-Funded Cooperative Agreement
Start Date: Nov 1, 2010
End Date: Oct 31, 2013
The main objective is to understand the molecular basis of the pathogenesis and immune response during the infection with African Swine Fever virus (ASFV). It is expected to gain knowledge to allow the development of experimental immunogens.
1) Evaluate the effect of specific ASFV genes as immunogens in the induction of protection against the challenge with virulent virus. 2) Evaluate the interaction of ASFV genes previously involved in virus virulence with host swine proteins. 3) Evaluate the effect of chemical compounds, which have demonstrated effect in the virus growth in vitro, in the pathogenesis of the disease in swine.