Location: Food Components and Health Laboratory2012 Annual Report
1a. Objectives (from AD-416):
To determine the effect of different cereal grains on risk factors for cardiovascular disease.
1b. Approach (from AD-416):
ARS will conduct a randomized clinical trial to investigate the effect of cereal grains on biomarkers of glucoregulatory control and cardiovascular disease. Grains will be incorporated into foods to maintain a double blind intervention.
3. Progress Report:
This is a project to evaluate the impact of whole grain barley and oats on cardiovascular disease risk factors and metabolic changes. In 2012, extensive sample analysis was conducted on samples collected from two studies conducted in 2011. The first study was a randomized, double-blind, parallel arm intervention to investigate the health effects of chronic ingestion of whole grain barley and oats. The study included three treatments: 1) low fiber control, 2) whole grain barley, and 3) whole grain oats. The intervention included food products that were incorporated into a controlled 7-day menu rotation that were served to volunteers for 6 weeks. Products included breakfast cereal, granola, trail mix, and fruit-cereal bars to achieve 4 to 8 servings of whole grain intake per day. Subjects (n=69, approximately equal number of men and women) were stratified by gender and initial body mass index (BMI), and randomly assigned to a treatment. At the end of the intervention, blood and urine samples were collected, and during the past year, these samples have been analyzed for treatment differences in long-term biomarkers of glucoregulatory control and cardiovascular disease. The second study was a randomized, double-blind, crossover intervention to investigate the health effects of acute ingestion of whole grain barley and oats. The study included three treatments: 1) a high fat, low fiber control meal, 2) a high fat meal including whole grain barley, and 3) a high fat meal containing whole grain oats. Subjects (n=18, approximately equal number of men and women) were randomly assigned to a treatment sequence. At the end of the intervention period, subjects underwent a meal tolerance test or an assessment of blood vessel reactivity. During the past year, blood samples were analyzed for glucose and fat appearance after the meal. Data interpretation is underway.