1a. Objectives (from AD-416):
To facilitate the characterization of contemporary FMDV strains collected from the Middle Eastern region by ARRIAH in ARRIAH laboratories. All successfully characterized FMDV strains will be shipped to DHS and ARS, PIADC for use in the ARS research and DHS FMD countermeasure programs. This amendment expands the original milestones and deliverables to include scientific consulting services for the Russian research project.
1b. Approach (from AD-416):
The All-Russian Research Institute of Animal Health (ARRIAH) in Vladimir, Russia is the lead veterinary research facility in Russia and the designated location for FMD monitoring, research, and vaccine development. Additionally, it is an OIE Collaborating Center for FMD. ARRIAH has a collection of approximately 550 field isolates of FMD strains, many of which are from critical regions of interest, such as the Middle East. Research on these isolates is critical for world health, and could yield not only several new sub serotypes, but also new primary serotypes, beyond the known seven. The results of such research would be extremely important for the world community’s ability to quickly identify, track, and mitigate FMD outbreaks, as well as for the development of new FMD vaccines for national veterinary stockpiles and commercial sale. DHS funding will complement State Department funding of the ARS – Russia proposal entitled “Analysis of the evolution of Foot-and-Mouth Disease Virus (FMDV) genome recovered from persistently infected cattle,” ARS #573. Elizabeth Rieder, ARS – PIADC, is the ARS collaborator on this project. Specifically, DHS funds will support Task 3 “FMDV field surveillance (characterization of newly emerged FMDV field isolates). AARIAH will characterize contemporary FMDV strains collected from the Middle Eastern region. The characterization will be conducted by ARRIAH in ARRIAH laboratories and results summarized in a sumbitted report to ARS and DHS. All successfully characterized FMDV strains will be shipped to ARS and DHS, PIADC for use in ARS research and DHS FMD countermeasure programs. DHS will reimburse ARRIAH for these services, including scientific and scientific support salaries, miscellaneous supplies and equipment, animal purchases and per diems.
3. Progress Report:
ARS signed a specific cooperative agreement with the Federal Center for Animal Health, Vladimir, Russia (ARRIAH), in September 2011. Through discussions with DHS, ARS rebudgeted the remaining funds in the agreement to include the participation of the ARS Foreign Animal Disease Research Unit, Plum Island Animal Disease Center, as a scientific collaborator and additional studies to be conducted at ARRIAH for an additional year. In July 2012, ARS officially extended the cooperative agreement with additional funds to September 2013 to support the additional studies. ARS received the first technical report from ARRIAH and submitted to DHS for their review and feedback.