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United States Department of Agriculture

Agricultural Research Service

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Location: Jean Mayer Human Nutrition Research Center On Aging

2011 Annual Report

1a. Objectives (from AD-416)
LAB: Epidemiology 1. Using an epidemiologic approach, investigate the role of whole grains, selected nutrients, other bioactive food components, and healthy dietary patterns in preventing age-related development of metabolic risk factors for type 2 diabetes mellitus, cardiovascular disease, cancer and musculoskeletal disorders, and age-related eye disease. 1A. Determine if higher whole-grain intake is associated with less visceral adiposity and a lower waist circumference. 1B. Determine if diet differs between “metabolically healthy but obese" (MHO) individuals and “metabolically abnormal obese” (MAO) individuals. 1C. Determine if higher intakes of various classes of flavonoids are associated with a healthier profile of intermediate markers of CVD risk. 1D. Determine if a plant-based diet will improve the diet quality and consequently affect disease risk through its effects on underlying inflammation, lipid metabolism, insulin sensitivity and endothelial function. 1E. Determine if higher whole grain intake is associated with a lower risk congestive heart failure (CHF) 2. Determine the validity of biomarkers for whole grain intake, their use in assessing relationships between whole grains intake and disease risk, and the relationship between these biomarkers and insulin resistance phenotypes. 3. Using an epidemiologic approach, examine determinants of adherence to the recommended dietary patterns in the Dietary Guidelines for Americans (DGA) and the relation between adherence to these patterns and prevention of age-related weight gain, abdominal obesity, and related metabolic disorders such as inflammation, endothelial dysfunction and insulin resistance. 4. Using an epidemiologic approach, investigate safe upper limits for the dietary intake of folic acid. 5. Using an epidemiologic approach, determine relationships between B-vitamin status, homocysteine levels, genetic mutations and the prevention of age-related cognitive decline in humans. 6. Using an epidemiologic approach, investigate the role of nutritional factors in limiting the coromorbidities such as CVD and premature mortality in individuals with chronic kidney disease (CKD). LAB: Dietary Assessment 1. Use an epidemiologic approach to determine if micronutrient intake and dietary patterns are associated with bone status and fracture risk in older adults. 2. Use an epidemiologic approach to determine if micronutrient intake and dietary patterns are associated with depression and cognitive function in older adults. 3. Use an epidemiologic approach to identify behavioral factors that are associated with obesity in diverse population groups. 4. Use an epidemiologic approach to determine how genetic polymorphisms modify dietary effects on risk of diabetes in older adults. 5. Use an epidemiologic approach to determine associations between stress, diabetes and physical disability in older Puerto Rican adults, and the role of dietary patterns in moderating these associations.

1b. Approach (from AD-416)
LAB: Epidemiology Many age-related conditions, such as cardiovascular disease, diabetes, dementia, cancer, musculoskeletal disorders and age-related eye disease, appear to have strong nutritional components. Improved nutrition through public health recommendations and interventions could have a tremendous impact on the economic and societal costs associated with these disabilities, but development of recommendations and interventions requires a greater understanding of the presumptive role that nutrition plays in delaying the onset of disease and disability. Epidemiologic methods applied to community-based investigations of aging populations provide a valuable tool to help meet this need. We will use these methods to address project objectives. LAB: Dietary Assessment We will achieve project objectives by continuing to work with existing cohorts of aging adults in the US population, including our own Boston Puerto Rican Health Study and Nutrition and Memory in the Elderly Study, and through active collaboration with the Framingham Studies, the Baltimore Longitudinal Study on Aging and the VA Normative Aging Study. In each of these, we either collect and analyze or interpret dietary intake and/or biochemical measures and relate them to health outcomes. In addition, we will collaborate across the ARS Human Nutrition Research Centers to conduct a new multi-center assessment of barriers and facilitators of adherence to dietary guidelines to prevent obesity. Together this body of work will contribute to a better understanding of the importance of specific foods, nutrients and dietary patterns in health maintenance with aging and in prevention of obesity and related chronic conditions.

3. Progress Report
This progress report includes the work of two subordinate projects at the HNRCA funded through a Specific Cooperative Agreement with TUFTS UNIVERSITY. For further information and progress reports, see 1950-51530-009-01S (Epidemiology, Nutrition and Problems of Aging) and 1950-51530-009-02S (Dietary Assessment and Epidemiology).

4. Accomplishments

Review Publications
Bhupathiraju, S., Lichtenstein, A.H., Dawson-Hughes, B., Tucker, K.L. 2011. Adherence index based on the AHA 2006 diet and lifestyle recommendations is associated with select cardiovascular disease risk factors in older Puerto Ricans. American Journal of Clinical Nutrition. 141(3):460-469.

Gao, X., Lai, C., Scott, T., Shen, J., Cai, T., Ordovas, J.M., Tucker, K. 2010. Urinary 8-hydroxy-2-deoxyguanosine and cognitive function in Puerto Rican adults. American Journal of Epidemiology. 172(3):271-278.

Noel, S.E., Newby, P.K., Ordovas, J.M., Tucker, K. 2010. Empirically derived dietary fatty acid patterns and metabolic syndrome risk factors: the Boston Puerto Rican Health Study. Journal of Nutrition. 140(10):1846-1854.

Johnson, E.J., Maras, J.E., Rasmussen, H.M., Tucker, K.L. 2010. Intake of lutein and zeaxanthin differ with age, sex, and ethnicity. Journal Of The American Dietetic Association. 110(9):1357-1362.

Liu, E., Mckeown, N.M., Pittas, A.G., Meigs, J.B., Economos, C., Booth, S.L., Jacques, P.F. 2010. Predicted 25-hydroxyvitamin D score and incident type 2 diabetes in the Framingham Offspring Study. American Journal of Clinical Nutrition. 91(6):1627-1633.

Bhupathiraju, S.N., Tucker, K.L. 2011. Greater variety in fruit and vegetable intake is associated with lower inflammation in Puerto Rican adults. American Journal of Clinical Nutrition. 93(1):37-46.

Buell, J., Dawson-Hughes, B., Scott, T., Weiner, D., Dallal, G., Qiao, W., Bergethon, P., Rosenberg, I., Folstein, M., Patz, S. 2010. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology. 74(1):18-26.

Lee, J.E., Jacques, P.F., Dougherty, L., Selhub, J., Giovannucci, E., Zeisel, S.H., Cho, E. 2010. Are dietary choline and betaine intakes determinants of total homocysteine concentration? American Journal of Clinical Nutrition. 91(5):1303-1310.

Liu, E., Meigs, J.B., Pittas, A.G., Economos, C.D., Mckeown, N.M., Booth, S.L., Jacques, P.F. 2010. Predicted 25-hydroxyvitamin D Score and incident type 2 diabetes in the Framingham Offspring Study. American Journal of Clinical Nutrition. 91(6):1627-1633.

Mckeown, N., Troy, L.M., Jacques, P.F., Hoffman, U., O'Donnell, C.J., Fox, C. 2011. Whole- and refined-grain intakes are differentially associated with abdominal visceral and subcutaneous adiposity in healthy adults: The Framingham Heart Study. Journal of Nutrition. 141:1011S-1022S.

Corella, D., Arregui, M., Coltell, O., Portoles, O., Guillem-Saiz, P., Carrasco, P., Sorli, J.V., Ortega-Azorin, C., Gonzalez, J.I., Ordovas, J.M. 2011. Association of the LCT-13910C>T polymorphism with obesity and its modulation by dairy products in a Mediterranean population. Obesity. 19(8):1707-1714.

Scofield, D.E., Mcclung, H.L., Mcclung, J.P., Kraemer, W., Rarick, K., Pierce, J.R., Cloutier, G., Fielding, R.A., Matheny, R.W., Young, A. 2011. A novel, non-invasive transdermal fluid sampling methodology: IGF-I measurement following exercise. American Journal of Physiology Regulatory Integrative and Comparative Physiology. 300(6):R1326-1332.

Bhupathiraju, S., Lichtenstein, A., Dawson-Hughes, B., Tuckey, K. 2011. Adherence index based on the American Heart Association 2006 diet and lifestyle recommendations: associations with cardiovascular disease risk factors in the Boston Puerto Rican health study. Journal of Nutrition. 141:460-469. PMID 21270369.

Marti, A., Ordovas, J. 2011. Epigenetics lights up the obesity field. Obesity Facts: The European Journal of Obesity. 4(3):187-190.

Last Modified: 10/20/2017
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