1a. Objectives (from AD-416)
The objective of this effort is to support the engagement of USDA collaborative research with ILRI and National research institutions engaged in research that addresses the development of new generation vaccines, diagnostic tests, management strategies and drugs for diseases of critical importance including Rift Valley fever (RVF), MCF, foot-and-mouth disease (FMD), and other diseases of strategic importance.
1b. Approach (from AD-416)
ILRI will participate in and help support activities that underpin the establishment and implementation of collaborative research and supporting activities, such as establishing sub agreements with relevant NARS, developing publications, co-organizing and supporting attendance at meetings and facilitating working groups that support research cooperation that would help to meet the objective. These activities will be identified in consultation with, and under the agreement of, the ADODR and ARS cooperators.
3. Progress Report
This report serves to document research conducted under a Specific Cooperative agreement between ARS and the International Livestock Research Institute (ILRI). The purpose of this cooperation is to underpin and seed cooperative research activities between ARS, ILRI and other animal health research institutions. This first year, ILRI supported the efforts of the Global Foot and Mouth Disease Research Alliance, GFRA (http://www.ars.usda.gov/gfra/) by helping to design and print outreach materials for the consortium. In addition, ILRI supported the participation of a Kenyan scientist from the Central Veterinary Laboratory to participate in the "Rift Valley Fever Workshop: An Integrated Approach to Controlling Rift Valley Fever in Africa and the Middle East," which took place in Cairo in January 2009 (http://www.ars.usda.gov/meetings/rvf2009/index.htm). ILRI also helped to co-organize a follow on workshop with ARS to help develop three of the RVF-related projects, two to be conducted in Kenya which were identified during the Cairo workshop, and one with OVI-South Africa, based on a proposal made by ARS NPL, Dr. Cyril Gay, who noted the need for a scientifically valid challenge model to run vaccine trials. ARS staff Eileen Herrera, OIRP, Dan Strickman, APP, Ken Linthicum, CMAVE (Gainesville) and Kristine Bennett and Bill Wilson, ABADRL (Laramie) traveled to Kenya the last week of August 2009 where they visited sites where collaborators are planning to collect potential Rift Valley fever (RVF) mosquito vectors and samples from sentinel cattle, sheep and goat herds (Marigat-Baringo) to monitor RVF transmission. In Marigat they also visited the US Army Medical Research Unit – Kenya (Walter Reed) laboratory and field site where vector control research is being conducted on mosquitoes and sand flies. They also visited the Walter Reed and CDC field site in Kisumu where significant effort is made to address Malaria, RVF and other diseases and to control vectors and biting arthropods (mosquitoes, sand flies and others). ARS and ILRI then met over two days with key national research institutional cooperators, KARI and KEMRI, and partners ILRI, Walter Reed, CDC, FAO, OVI and OBP (South Africa), ICIPE, and the University of Nairobi to develop detailed work plans for the BEP funded projects. The two main projects that will be supported are 1) development of a young animal challenge model to underpin a vaccine field trial that GALV MED plans to support in Kenya; and 2) the expansion of the proposed blood meal study into a longitudinal study to provide a more valid base of information and to take advantage of some of the resources that will be provided by a Google funded Metagenomics project run through ICIPE in cooperation with KEMRI, KARI, ILRI and the Kenyan Vet Services.