Location: Infectious Bacterial Diseases Research
Project Number: 3625-32000-084-00-D
Project Type: Appropriated
Start Date: Nov 9, 2006
End Date: Nov 8, 2011
1)Develop effective strategies to prevent B. abortus or B. suis infections in free-ranging wildlife (bison, cervidae, feral swine) by characterizing immune responses, and determining safety and efficacy of available brucellosis vaccines. (2) Enhance immunologic responses of domestic livestock or free-ranging wildlife to brucellosis vaccines by use of adjuvants, vaccine engineering, or alternative delivery methods. (3) Develop and evaluate molecular markers to assist in diagnosis and epidemiology of brucellosis. (4) Characterize the genomic determinants of virulence and pathogenicity in wild-type Brucella species and vaccine strains.
The project will use standardized methods to evaluate protection of brucellosis vaccines in domestic livestock or wildlife reservoirs of brucellosis. In an effort to develop improved brucellosis vaccines, immunologic methods will be used to identify antigens involved in protection, and immunomodulators which enhance vaccine efficacy. Molecular procedures will be used to develop assays which allow epidemiologic traceback of brucella strains, and characterize genes involved in virulence and pathogenicity. BSL-3 Recertified February 3, 2011 (IBC-#0258) BSL-2, BSL-3N; Recertified March 21, 2011 (IBC-#0257A) BSL-2/BSL-1N/BSL-3N; Recertified June 5, 2011. (IBC#0282) BSL2, BSL3, BSL3-N Recertified October 21, 2010. (IBC#0313) BSL2; Recertified August 17, 2010. (IBC#0324) BSL2, BSL3; Recertified August 17, 2010. (IBC#0325) BSL2, BSL3; Recertified August 17, 2010. (IBC#0326) BSL2, BSL3; Recertified January 13, 2011. (IBC#0330) BSL3; Certified January 19, 2011. (IBC#001RA) BSL3; Certified January 19, 2011. (IBC#002RA)