Research Project: Dietary Strategies for Cancer Prevention

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice - (Peer Reviewed Journal)
Crossland, N.A., Beck, S., Tan, W.Y., Lo, M., Mason, J., Zhang, C., Crott, J. 2023. Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice. Gut Microbes. https://doi.org/10.1080/19490976.2023.2288187.

Protein binding assays for an accurate differentiation of vitamin B12 from its inactive analogue. A study on edible cricket powder - (Peer Reviewed Journal)
Fedosov, S.N., Nexo, E., Heegaard, C.W., Goldin, J., Mason, J.B. 2023. Protein binding assays for an accurate differentiation of vitamin B12 from its inactive analogue. A study on edible cricket powder. Food Chemistry. https://doi.org/10.1016/j.fochx.2023.100824.

Implication of SIRT1 on development of nonalcoholic fatty liver disease and impact of carotenoid intervention - (Review Article)
Neeson, C., Wang, X. 2023. Implication of SIRT1 on development of nonalcoholic fatty liver disease and impact of carotenoid intervention. JSM Gastroenterology and Hepatology. 10(1):1114.

Beta-Cryptoxanthin attenuates cigarette smoke-induced lung lesions in the absence of carotenoid cleavage enzymes in mice - (Peer Reviewed Journal)
Chiaverelli, R.A., Hu, K., Liu, C., Lim, J., Daniels, M.S., Xia, H., Mein, J., Lintig, J.V., Wang, X. 2023. Beta-Cryptoxanthin attenuates cigarette smoke-induced lung lesions in the absence of carotenoid cleavage enzymes in mice. Molecules. https://doi.org/10.3390/molecules28031383.

A new series in The American Journal of Clinical Nutrition: new developments from federal colleagues - (Other)
Mason, J., Duggan, C. 2022. A new series in The American Journal of Clinical Nutrition: new developments from federal colleagues. The American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqac227.

Lycopene improves bone quality and regulates AGEs/RAGE/NF-kB signaling pathway in high-fat diet-induced obese mice - (Peer Reviewed Journal)
Xia, B., Zhu, R., Zhang, H., Chen, B., Liu, Y., Dai, X., Ye, Z., Zhao, D., Mo, F., Gao, S., Wang, X., Bromme, D., Wang, L., Wang, X., Zhang, D. 2022. Lycopene improves bone quality and regulates AGEs/RAGE/NF-kB signaling pathway in high-fat diet-induced obese mice. Oxidative Medicine and Cellular Longevity. https://doi.org/10.1155/2022/3697067.

Combined supplementation with vitamin b-6 and curcumin is superior to either agent alone in suppressing obesity-promoted colorectal tumorigenesis in mice - (Peer Reviewed Journal)
Wu, X., Ueland, P.M., Roper, J., Koh, G., Liang, X., Crott, J.W., Yilmaz, O.H., Bronson, R.T., Mason, J.B. 2021. Combined supplementation with vitamin b-6 and curcumin is superior to either agent alone in suppressing obesity-promoted colorectal tumorigenesis in mice. Journal of Nutrition. https://doi.org/10.1093/jn/nxab320.

What's eating North America's edible insect industry? An examination of psychological, cultural and regulatory barriers - (Other)
Li, C., Cash, S.B., Lesnik, J., Griffin, T., Mason, J.B., Blackstone, N. 2021. What's eating North America's edible insect industry? An examination of psychological, cultural and regulatory barriers. Renewable Agriculture and Food Systems. https://doi.org/10.1017/S1742170521000314.

Folate and colon cancer: dietary habits from the distant past coming home to roost - (Other)
Mason, J.B. 2021. Folate and colon cancer: dietary habits from the distant past coming home to roost. American Journal of Clinical Nutrition. 114(1):1-2. https://doi.org/10.1093/ajcn/nqab117.

Dietary lycopene attenuates cigarette smoke-promoted nonalcoholic steatohepatitis by preventing suppression of antioxidant enzymes in ferrets - (Peer Reviewed Journal)
Mustra Rakic, J., Liu, C., Veeramachaneni, S., Wu, D., Paul, L., Ausman, L., Wang, X. 2021. Dietary lycopene attenuates cigarette smoke-promoted nonalcoholic steatohepatitis by preventing suppression of antioxidant enzymes in ferrets. Journal of Nutritional Biochemistry. 91(2021):108596. https://doi.org/10.1016/j.jnutbio.2021.108596.

Brain a-tocopherol concentration is inversely associated with neurofibrillary tangle counts in brain regions affected in earlier BRAAK stages: a cross-sectional finding in the oldest OLD - (Peer Reviewed Journal)
Tanprasertsuk, J., Scott, T., Johnson, M., Poon, L., Nelson, P., Davey, A., Woodard, J., Vishwanathan, R., Barbey, A.K., Barger, K., Wang, X., Johnson, E.J. 2021. Brain a-tocopherol concentration is inversely associated with neurofibrillary tangle counts in brain regions affected in earlier BRAAK stages: a cross-sectional finding in the oldest OLD. Journal of Aging Research & Lifestyle. 10:8-16. https://doi.org/10.14283/jarlife.2021.2.

Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop - (Review Article)
Maruvada, P., Stover, P.J., Mason, J.B., Bailey, R.L., Davis, C.D., Field, M., Finnell, R.H., Garza, C., Green, R., Gueant, J., Jacques, P.F., Klurfeld, D.M., Lamers, Y., MacFarlane, A.J., Miller, J.W., Molloy, A.M., O'Connor, D.L., Pfeiffer, C.M., Potischman, N.A., Rodricks, J.V., Rosenberg, I.H., Ross, S.A., Shane, B., Selhub, J., Stabler, S.P., Trasler, J., Yamini, S., Zappala, G. 2020. Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop. American Journal of Clinical Nutrition. 112(5):1390-1403. https://doi.org/10.1093/ajcn/nqaa259.

Xanthophyll beta-cryptoxanthin treatment inhibits hepatic steatosis without altering vitamin A status in beta-carotene 9'10'-oxygenase knockout mice - (Peer Reviewed Journal)
Liu, C., Rafacho, B.M., Wang, X. 2020. Xanthophyll beta-cryptoxanthin treatment inhibits hepatic steatosis without altering vitamin A status in beta-carotene 9'10'-oxygenase knockout mice. Hepatobiliary Surgery and Nutrition. https://doi.org/10.21037/hbsn-20-404.

Role of lycopene in smoke-promoted chronic obstructive pulmonary disease and lung carcinogenesis - (Review Article)
Mustra Rakic, J., Wang, X. 2020. Role of lycopene in smoke-promoted chronic obstructive pulmonary disease and lung carcinogenesis. Archives of Biochemistry and Biophysics. https://doi.org/10.1016/j.abb.2020.108439.

Lycopene in protection against obesity and diabetes: A mechanistic review - (Review Article)
Zhu, R., Chen, B., Bai, Y., Miao, T., Rui, L., Zhang, H., Xia, B., Li, Y., Gao, S., Wang, X., Zhang, D. 2020. Lycopene in protection against obesity and diabetes: A mechanistic review. Pharmacological Research. 159:104966. https://doi.org/10.1016/j.phrs.2020.104966.

Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers and promotes intestinal barrier integrity in azoxymethane-treated A/J mice - (Peer Reviewed Journal)
Koh, G., Kane, A.V., Wu, X., Crott, J.W. 2020. Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers and promotes intestinal barrier integrity in azoxymethane-treated A/J mice. Carcinogenesis. https://doi.org/10.1093/carcin/bgaa018.

A prospective, multicenter registry for patients with short bowel syndrome (SBS Registry): Methodology, baseline characteristics, and incidence of colorectal cancer in the context of teduglutide treatment - (Abstract Only)
Jeppesen, P., Allard, J.P., Gondolesi, G., Joly, F., Kemenyash, N., Mason, J.B., Pape, U., Pironi, L., Plewa, A., Zhang, P., Schwartz, L.K. 2020. A prospective, multicenter registry for patients with short bowel syndrome (SBS Registry): Methodology, baseline characteristics, and incidence of colorectal cancer in the context of teduglutide treatment [abstract]. Journal of Parenteral and Enteral Nutrition. 44(2): 209-211. https://doi.org/10.1002/jpen.1813.

Mechanistic understanding of beta-cryptoxanthin and lycopene in cancer prevention in animal models - (Review Article)
Lim, J., Wang, X. 2020. Mechanistic understanding of beta-cryptoxanthin and lycopene in cancer prevention in animal models. BBA Molecular and Cell Biology of Lipids. https://doi.org/10.1016/j.bbalip.2020.158652.

Xanthophyll beta-cryptoxanthin inhibits highly refined carbohydrate diet-promoted hepatocellular carcinoma progression in mice - (Peer Reviewed Journal)
Lim, J., Liu, C., Hu, K., Smith, D.E., Wu, D., Lamon-Fava, S., Ausman, L.M., Wang, X. 2019. Xanthophyll beta-cryptoxanthin inhibits highly refined carbohydrate diet-promoted hepatocellular carcinoma progression in mice. Molecular Nutrition and Food Research. 64(3):e1900949. https://doi.org/10.1002/mnfr.201900949.

Concentrations of circulating phylloquinone, but not cerebral menaquinone-4, are positively correlated with a wide range of cognitive measures: exploratory findings in centenarians - (Peer Reviewed Journal)
Tanprasertsuk, J., Ferland, G., Johnson, M., Poon, L., Scott, T.M., Barbey, A.K., Barger, K.K., Wang, X., Johnson, E. 2019. Concentrations of circulating phylloquinone, but not cerebral menaquinone-4, are positively correlated with a wide range of cognitive measures: exploratory findings in centenarians. Journal of Nutrition. 150(1): 82-90. https://doi.org/10.1093/jn/nxz200.