Research Project: Cancer Prevention via Diet

Location: Jean Mayer Human Nutrition Research Center On Aging

Publications (Clicking on the reprint icon will take you to the publication reprint.)

Nutritional principles and assessment of the gastroenterology patient - (Book / Chapter)
Mason, J.B. 2020. Nutritional principles and assessment of the gastroenterology patient. In: Feldman, M., Lawrence, Friedman, S., Brandt, L.J. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 11th edition. Philadelphia, PA: Elsevier. Volume 1. p.52-73.

Vitamins, trace minerals, and other micronutrients - (Book / Chapter)
Mason, J.B., Booth, S.L. 2019. Vitamins, trace minerals, and other micronutrients. In: Goldman, L., Schafer, A.I., editors. Goldman-Cecil Medicine. 26th edition. Maryland Heights, MO: Elsevier. p.73-79.

Lycopene inhibits smoke-induced chronic obstructive pulmonary disease and lung carcinogenesis by modulating reverse cholesterol transport in ferrets - (Peer Reviewed Journal)
Mustra Rakic, J., Liu, C., Veeramachaneni, S., Wu, D., Paul, L., Chen, C., Ausman, L.M., Wang, X. 2019. Lycopene inhibits smoke-induced chronic obstructive pulmonary disease and lung carcinogenesis by modulating reverse cholesterol transport in ferrets. Cancer Prevention Research. https://doi.org/10.1158/1940-6207.CAPR-19-0063.

Dietary beta-cryptoxanthin inhibits high-refined carbohydrate diet-induced fatty liver via differential protective mechanisms depending on carotenoid cleavage enzymes in male mice - (Peer Reviewed Journal)
Lim, J., Liu, C., Hu, K., Smith, D.E., Wu, D., Lamon-Fava, S., Ausman, L., Wang, X. 2019. Dietary beta-cryptoxanthin inhibits high-refined carbohydrate diet-induced fatty liver via differential protective mechanisms depending on carotenoid cleavage enzymes in male mice. Journal of Nutrition. https://doi.org/10.1093/jn/nxz106.

Beta-Cryptoxanthin prevents non-alcoholic fatty liver disease through different mechanisms depending on the presence or absence of carotenoid cleavage enzymes - (Abstract Only)
Lim, J., Liu, C., Hu, K., Smith, D.E., Wu, D., Lamon-Fava, S., Ausman, L.M., Wang, X. 2019. Beta-Cryptoxanthin prevents non-alcoholic fatty liver disease through different mechanisms depending on the presence or absence of carotenoid cleavage enzymes [abstract]. Current Developments in Nutrition. 3(Suppl_1). Abstract No. FS06-03-192. https://doi.org/10.1093/cdn/nzz029.FS06-03-192.

Modulation of reverse cholesterol transport by lycopene is associated with its protective role against cigarette smoke induced COPD and lung carcinogenesis in ferrets - (Abstract Only)
Mustra Rakic, J., Liu, C., Veeramachaneni, S., Wu, D., Paul, L., Chen, C., Ausman, L.M., Wang, X. 2019. Modulation of reverse cholesterol transport by lycopene is associated with its protective role against cigarette smoke induced COPD and lung carcinogenesis in ferrets. [abstract]. Current Developments in Nutrition. 3(Suppl_1). Abstract No. OR05-02-19. https://doi.org/10.1093/cdn/nzz029.OR05-02-19.

Ablation of sirtuin 1 deacetylase activity induces pulmonary emphysema by inducing cellular senescence and disrupting circadian clock in mice - (Abstract Only)
Wang, X., Hu, K., Liu, C., McBurney, M.W. 2019. Ablation of sirtuin 1 deacetylase activity induces pulmonary emphysema by inducing cellular senescence and disrupting circadian clock in mice [abstract]. Current Developments in Nutrition. 3(Suppl_1). Abstract No. P01-022-19. https://doi.org/10.1093/cdn/nzz028.P01-022-19.

Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers and promotes intestinal barrier integrity in azoxymethane-treated mice - (Abstract Only)
Koh, G., Kane, A.V., Wu, X., Mason, J.B., Crott, J.W. 2019. Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers and promotes intestinal barrier integrity in azoxymethane-treated mice [abstract]. Current Developments in Nutrition. 3(Suppl_1). Abstract No. OR04-02-19. https://doi.org/10.1093/cdn/nzz030.OR04-02-19.

The combination of curcumin and salsalate is superior to either agent alone in suppressing pro-cancerous molecular pathways and colorectal tumorigenesis in obese mice - (Peer Reviewed Journal)
Wu, X., Koh, G., Huang, Y., Crott, J.W., Bronson, R.T., Mason, J.B. 2019. The combination of curcumin and salsalate is superior to either agent alone in suppressing pro-cancerous molecular pathways and colorectal tumorigenesis in obese mice. Molecular Nutrition and Food Research. https://doi.org/10.1002/mnfr.201801097.

Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development - (Review Article)
Stice, C.P., Xia, H., Wang, X. 2018. Tomato lycopene prevention of alcoholic fatty liver disease and hepatocellular carcinoma development. Chronic Diseases and Translational Medicine. https://doi.org/10.1016/j.cdtm.2018.11.001.

Interleukin-1 signaling mediates obesity-promoted elevations in inflammatory cytokines, Wnt activation, and epithelial proliferation in the mouse colon - (Peer Reviewed Journal)
Pfalzer, A.C., Crott, J.W., Koh, G., Smith, D.E., Garcia, P.E., Mason, J.B. 2018. Interleukin-1 signaling mediates obesity-promoted elevations in inflammatory cytokines, Wnt activation, and epithelial proliferation in the mouse colon. Journal of Interferon and Cytokine Research. 38(10):445-451. https://doi.org/10.1089/jir.2017.0134.

Incremental elevations of TNF-alpha and IL-6 in the human colon and procancerous changes in the mucosal transcriptome accompany adiposity - (Peer Reviewed Journal)
Pfalzer, A.C., Leung, K., Crott, J.W., Kim, S.J., Tai, A.K., Parnell, L.D., Kamanu, F.K., Liu, Z., Rogers, G., Shea, K., Garcia, P.E., Mason, J.B. 2018. Incremental elevations of TNF-alpha and IL-6 in the human colon and procancerous changes in the mucosal transcriptome accompany adiposity. Cancer Epidemiology Biomarkers and Prevention. https://doi.org/10.1158/1055-9965.EPI-18-0121.

Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway - (Peer Reviewed Journal)
Lim, J., Liu, C., Hu, K., Smith, D.E., Wang, X. 2018. Ablation of carotenoid cleavage enzymes (BCO1 and BCO2) induced hepatic steatosis by altering the farnesoid X receptor/miR-34a/sirtuin 1 pathway. Archives of Biochemistry and Biophysics. 654:1-9. https://doi.org/10.1016/j.abb.2018.07.007.

Fostering strategies to expand the consumption of edible insects: the value of a tripartite coalition between academia, industry, and government - (Review Article)
Mason, J.B., Black, R., Booth, S.L., Brentano, A., Broadbent, B., Connolly, P., Finley, J.W., Goldin, J., Griffin, T., Hagen, K., Lesnik, J., Lewis, G., Pan, Z., Morales Ramos, J.A., Ranalli, M., Rojas, M.G., Shockley, M., Stull, V., Swietlik, D.M. 2018. Fostering strategies to expand the consumption of edible insects: the value of a tripartite coalition between academia, industry, and government. Current Developments in Nutrition. https://doi.org/10.1038/s41598-017-10675-6.

Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice - (Peer Reviewed Journal)
Koh, G., Kane, A., Lee, K., Xu, Q., Wu, X., Roper, J., Mason, J.B., Crott, J.W. 2018. Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice. International Journal of Cancer. https://doi.org/10.1002/ijc.31559.

The combination of curcumin and salsalate suppresses high fat diet-induced pro-carcinogenic signaling and colorectal tumorigenesis in azoxymethane-treated mice - (Abstract Only)
Wu, X., Koh, G., Crott, J.W., Mason, J.B. 2018. The combination of curcumin and salsalate suppresses high fat diet-induced pro-carcinogenic signaling and colorectal tumorigenesis in azoxymethane-treated mice [abstract]. American Society of Nutrition 2018 Meeting. Abstract No. P08-125.

Short-term administration of Parabacteroides distasonis attenuates obesity-induced colonic inflammation in high-fat diet-fed mice - (Abstract Only)
Koh, G., Kane, A.V., Wu, X., Roper, J., Mason, J.B., Crott, J.W. 2018. Short-term administration of Parabacteroides distasonis attenuates obesity-induced colonic inflammation in high-fat diet-fed mice [abstract]. American Soceity of Nutrition 2018 Meeting. Abstract No. P23-054.

Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor gamma - (Peer Reviewed Journal)
Cheng, J., Miao, B., Hu, K., Fu, X., Wang, X. 2018. Apo-10'-lycopenoic acid inhibits cancer cell migration and angiogenesis and induces peroxisome proliferator-activated receptor gamma. Journal of Nutritional Biochemistry. 56:26-34. https://doi.org/10.1016/j.jnutbio.2018.01.003.

Tomato powder inhibits hepatic steatosis and inflammation potentially through restoring SIRT1 activity and adiponectin function independent of carotenoid cleavage enzymes in mice - (Peer Reviewed Journal)
Li, C., Liu, C., Fu, M., Hu, K., Aizawa, K., Takahashi, S., Hiroyuki, S., Cheng, J., Von Lintig, J., Wang, X. 2018. Tomato powder inhibits hepatic steatosis and inflammation potentially through restoring SIRT1 activity and adiponectin function independent of carotenoid cleavage enzymes in mice. Molecular Nutrition and Food Research. 62(8):e1700738. https://doi.org/10.1002/mnfr.201700738.

Curcumin and salsalate suppresses colonic inflammation and procarcinogenic signaling in high-fat-fed, azoxymethane-treated mice - (Peer Reviewed Journal)
Wu, X., Pfalzer, A.C., Koh, G., Tang, S., Crott, J.W., Thomas, M.J., Meydani, M., Mason, J.B. 2017. Curcumin and salsalate suppresses colonic inflammation and procarcinogenic signaling in high-fat-fed, azoxymethane-treated mice. Journal of Agricultural and Food Chemistry. 65(33):7200-7209. https://doi.org/10.1021/acs.jafc.7b02648.

Vitamin A - (Book / Chapter)
Wang, X.D. Caudill, M.A. 2018. Vitamin A. IN: Stipanuk, M.H., Caudill, M.A., editors. Biochemical, Physiological, and Molecular Aspects of Human Nutrition. 4th edition. Philadelphia, PA: Saunders. p. 721-741.

Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization - (Abstract Only)
Cheng, J., Liu, C., Hu, K., Greenberg, A., Wu, D., Ausman, L.M., Mcburney, M.W., Wang, X. 2017. Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization. Federation of American Societies for Experimental Biology Conference. 31(1):458.1.

Beta-cryptoxanthin protection against cigarette smoke-induced inflammatory responses in the lung is due to the action of its own molecule - (Abstract Only)
Chiaverelli, R.A., Liu, C., Hu, K., Wang, X. 2017. Beta-cryptoxanthin protection against cigarette smoke-induced inflammatory responses in the lung is due to the action of its own molecule. Federation of American Societies for Experimental Biology Conference. 31(1):170.2.

Oral administration of curcumin and salsalate attenuates high fat diet-induced up-regulation of pro-inflammatory colonic cytokines via suppression of Akt/NFkappaB in azoxymethane-treated mice - (Abstract Only)
Wu, X., Pfalzer, A.C., Koh, G., Crott, J.W., Tang, S., Thomas, M.J., Meydani, M., Mason, J.B. 2017. Oral administration of curcumin and salsalate attenuates high fat diet-induced up-regulation of pro-inflammatory colonic cytokines via suppression of Akt/NFkappaB in azoxymethane-treated mice [abstract]. Federation of American Societies for Experimental Biology Conference. 31(1):46.6.

Parabacteroides distasonis attenuates colonic inflammation and prevents tumor formation in azoxymethane-treated high-fat diet-fed mice - (Abstract Only)
Koh, G., Kane, A.V., Lee, K., Xu, Q., Wu, X., Mason, J.B., Crott, J.W. 2017. Parabacteroides distasonis attenuates colonic inflammation and prevents tumor formation in azoxymethane-treated high-fat diet-fed mice [abstract]. Federation of American Societies for Experimental Biology Conference. 31(1):435.2.

The influence of tumor necrosis factor-a on the tumorigenic Wnt-signaling pathway in human mammary tissue from obese women - (Peer Reviewed Journal)
Roubert, A., Gregory, K., Li, Y., Pfalzer, A.C., Li, J., Schneider, S.S., Wood, R.J., Liu, Z. 2017. The influence of tumor necrosis factor-a on the tumorigenic Wnt-signaling pathway in human mammary tissue from obese women. Oncotarget. 8(22):36127-36136. https://doi.org/10.18632/oncotarget.16632.

Folate status and colorectal cancer risk: a 2016 update - (Review Article)
Mason, J.B., Tang, S. 2016. Folate status and colorectal cancer risk: a 2016 update. Molecular Aspects of Medicine. doi: 10.1016/j.mam.2016.11.010.

Why devote an entire issue to the topic of how nutrients in one-carbon metabolism play roles in modern medicine? - (Other)
Mason, J.B. 2016. Why devote an entire issue to the topic of how nutrients in one-carbon metabolism play roles in modern medicine?. Molecular Aspects of Medicine. doi: 10.1016/j.mam.2016.11.006.

Beta-cryptoxanthin reduced lung tumor multiplicity and inhibited lung cancer cell motility by downregulating nicotinic acetylcholine receptor alpha7 signaling - (Peer Reviewed Journal)
Iskandar, A.R., Miao, B., Li, X., Hu, C., Liu, C., Wang, X. 2016. Beta-cryptoxanthin reduced lung tumor multiplicity and inhibited lung cancer cell motility by downregulating nicotinic acetylcholine receptor alpha7 signaling. Cancer Prevention Research. doi: 10.1158/1940-6207.CAPR-16-0161.

Diet- and genetically-induced obesity produces alterations in the microbiome, inflammation and Wnt pathway in the intestine of Apc+/1638N mice: comparisons and contrasts - (Peer Reviewed Journal)
Liu, W., Crott, J.W., Lyu, L., Pfalzer, A.C., Li, J., Choi, S., Yang, Y., Mason, J.B., Liu, Z. 2016. Diet- and genetically-induced obesity produces alterations in the microbiome, inflammation and Wnt pathway in the intestine of Apc+/1638N mice: comparisons and contrasts. Journal of Cancer. 7(13):1780-1790.

Interactions between the colonic transcriptome, metabolome and microbiome in mouse models of obesity-induced intestinal cancer - (Peer Reviewed Journal)
Pfalzer, A., Kamanu, F.K., Parnell, L.D., Tai, A., Liu, Z., Mason, J.B., Crott, J.W. 2016. Interactions between the colonic transcriptome, metabolome and microbiome in mouse models of obesity-induced intestinal cancer. Physiological Genomics. 48(8):545-553.

Association between body condition score and cancer prognosis in dogs with lymphoma and osteosarcoma - (Peer Reviewed Journal)
Romano, F.R., Heinze, C.R., Barber, L.G., Mason, J.B., Freeman, L.M. 2016. Association between body condition score and cancer prognosis in dogs with lymphoma and osteosarcoma. Journal of Veterinary Internal Medicine. 30(4):1179-1186. https://doi.org/10.1111/jvim.13965.

Genetic variation in one-carbon metabolism in relation to genome-wide DNA methylation in breast tissue from healthy women - (Peer Reviewed Journal)
Song, M., Brasky, T.M., Catalin, M., Weng, D.Y., Taslim, C., Llanos, A.A., Dumitrescu, R.G., Liu, Z., Mason, J.B., Spear, S.L., Kallakury, B.V., Freudenheim, J.L., Shields, P.G. 2016. Genetic variation in one-carbon metabolism in relation to genome-wide DNA methylation in breast tissue from healthy women. Carcinogenesis. 37(5):471-480. https://doi.org/10.1093/carcin/bgw030.

Paternal B vitamin intake is a determinant of growth, hepatic lipid metabolism and intestinal tumor volume in female Apc1638N mouse offspring - (Peer Reviewed Journal)
Sabet, J.A., Park, L.K., Iyer, L.K., Tai, A.K., Koh, G., Pfalzer, A., Parnell, L.D., Mason, J.B., Liu, Z., Byun, A.J., Crott, J.W. 2016. Paternal B vitamin intake is a determinant of growth, hepatic lipid metabolism and intestinal tumor volume in female Apc1638N mouse offspring. PLoS One. 11(3):e0151579. https://doi.org/10.1371/journal.pone.0151579.

Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues - (Peer Reviewed Journal)
Llano, A.A., Marian, C., Brasky, T.M., Dumitrescu, R.G., Liu, Z., Mason, J.B., Makambi, K.H., Spears, S.L., Kallakury, B.V., Freudenheim, J.L., Shields, P.G. 2015. Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues. Epigenetics. 10(8):727-735.

Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations - (Peer Reviewed Journal)
Bird, J.K., Ronnenberg, A.G., Choi, S., Du, F., Mason, J.B., Liu, Z. 2014. Obesity is associated with increased red blood cell folate despite lower dietary intakes and serum concentrations. Journal of Nutrition. 145(1):79-86. https://doi.org/10.3945/jn.114.199117.