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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Diet, Genomics and Immunology Laboratory » Research » Research Project #426502

Research Project: Health Promoting Roles of Food Bio-Active Phenolic Compounds on Obesity-Altered Metabolic Functions and Physiology

Location: Diet, Genomics and Immunology Laboratory

2015 Annual Report


4. Accomplishments
1. Isolation and synthesis of Javamide-I and -II found in coffee. The javamides are phenolic amides found in coffee. However, there is currently no information related to their effect on human health and purified compounds are not available. A novel purification method and a chemical synthesis method were successfully developed by ARS researchers in the Beltsville Human Nutrition Research Center, Beltsville, Maryland, that allow for obtaining large quantities of Javamide-I and –II. Availability of the compounds and methods for their purification and synthesis provide valuable tools that will facilitate investigation of the biological effects on human health.

2. Javamide-I and -II and Monocyte Chemotardiv Protein 1 (MCP-1). Inflammation-associated tubulointerstitial injury is a common pathogenetic feature of chronic kidney disease (CKD). Increased expression of MCP-1 may play a crucial role in tubulointerstitial inflammation by recruiting and activating macrophages. ARS researchers in the Beltsville Human Nutrition Research Center, Beltsville, Maryland, observed, at relatively low concentrations, the amides inhibited MCP-1 mRNA expression and suppress the production of MCP-1 protein. This was the first report that coffee chemicals, javamide-I and -II, are potent suppressors of MCP-1, a major player in tubulointerstitial inflammation. Importantly, these results provide molecular evidence that coffee consumption may help alleviate tubulointerstitial inflammation in CKD.

3. Javamide-II and sirtuin2. ARS researchers in the Beltsville Human Nutrition Research Center, Beltsville, Maryland, identified Javamide II as a novel sirtuin2 inhibitor. This observation provided critical information on novel mechanisms by which coffee or coffee-derived compounds may exert their health promoting effects on human diseases.


Review Publications
Park, J.B. 2015. Becatamide found in Houttuynia cordata suppresses P-selectin expression via inhibiting COX enzyme, not increasing cAMP in platelets. Phytotherapy Research. DOI: 10.1002/ptr.5391

Park, J.B. 2014. Synthesis and characterization of norbelladine, a precursor of Amaryllidaceae alkaloid, as a potent anti-inflammatory/anti-COX compound. Bioorganic and Medicinal Chemistry Letters. 1:24(23):5381-5384.

Park, J.B. 2014. Potential effects of chlorogenic acids on platelet activiation. In: Preedy, V.R., editor. Coffee in Health and Disease. Academic Press. Amersterdam, Boston, New York. Book Chapter. p709-715.