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United States Department of Agriculture

Agricultural Research Service

Title: Method to Control Insect Reproduction for Insect Control
See also: US Patent Office Full Record

Patent Number: 6664371
Docket Number: 23900
Serial Number: 9680201
Date Patented: 12/16/2003

Technology Description:

The invention relates to novel pseudopeptide analogs of the insect allatostatin neuropeptide family, which possessbiological activity mimicking that of the naturally occurring neuropeptides. By addition of a hydrophobic moiety to anactive portion of the allatostatin peptides, analogs are produced which exhibit an overall amphiphilic nature and which arecapable of penetrating the insect cuticle while still retaining biological activity. By substituting sterically hindered aminoacids or aromatic acids for any or all of the second, third, or fifth amino acid residues of the allatostatic C-terminalpentapeptide, analogs have been produced which are resistant to degradation by insect peptidases while still retainingbiological activity. The analogs may be used for insect control by disrupting critical reproductive and/or developmentalprocesses normally regulated by allatostatins in insects.


Please refer to patent application S.N. 10/385,317 (Docket #0062.03), "Mimetic Insect Allatostatin Analogs for Insect Control," which was filed on March 10, 2003, and is a divisional of USPN 6,664,371 (Docket #0239.00), which issued on December 17, 2003, and is a divisional of USPN 6,207,643 (Docket #0047.99), which issued on March 27, 2001. 

Foreign rights are not available.


Ronald J. Nachman
Areawide Pest Management Research
2881 F&B Road
College Station, TX 77845
(979) 260-9315 / Fax: (979) 260-9386

Peter E. A. Teal
Chemistry Research
1600-1700 S.W. 23rd Drive
Gainesville, FL 32604
(352) 374-5788 / Fax: (352) 374-5707

Christopher S. Garside
University of Toronto
Toronto, Canada
(416) 978-3517 / Fax: (416) 978-3522
Stephen S. Tobe
University of Toronto
Toronto, Canada
(416) 978-3517 / Fax: (416) 978-3522

Last Modified: 10/1/2015
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