|National Animal Germplasm Program (NAGP)|
NAGP research objectives will strengthen the genetic diversity of the collection; improve cryopreservation procedures, provide potential users with comprehensive information about the collection through the GRIN database and enable greater efficiency in reconstituting populations. A multidisciplinary approach using quantitative and molecular genetics, reproductive biology, cryopreservation, awareness and evaluation of live animal populations, and information systems is needed to accomplish NAGP research objectives. Objectives are based on customer and stakeholder comments received at a 2004 Discover Conference, sponsored by the American Dairy Science Association and a 2006 Workshop about ARS National Program 101 (Animal Genetic Resources). [Animal Collections]
Objective 1: Further develop and expand a scientifically based germplasm and DNA/tissue collection.
Objective 2: Further develop the animal section of the GRIN network.
Objective 3: Develop methods for population regeneration: Computationally determine approaches for population regeneration and management.
Objective 4: Improve cryopreservation methods for tissues.
Need for Research
Nearly 45% of mammalian and avian breeds in North America are imperiled and another 13% have already been lost in the US according to a UN Food and Agriculture Organization (FAO) report in 2000. This attrition of genetic diversity can lead to American products being less competitive in global markets.
The progressive loss of genetic diversity in all livestock species results from industrial consolidation, combined use of highly effective genetic selection, reproductive technologies, and changing economic conditions. Intense selection for economically desirable traits, when practiced to extremes, results in genetic abnormalities or genetic combinations that lower viability and profitability. Ameliorating this situation requires availability of alternative genetic stocks. The 2001 outbreak of Foot and Mouth Disease in Europe demonstrated how easily genetic resources can be lost and subsequently lead to long and short term economic loss. Diverse genetic resources are needed to develop resistant lines to emerging diseases. A national animal germplasm repository will allow the US to respond quickly to threats to our production systems. Reserves of genetic material for reintroduction to industry provide protection to American producers and consumers.
Conservation of animal genetic resources also provides breeders with the resources to structure livestock populations in a way that meets the growing global demand for food and fiber. More efficient production systems and new livestock products relies on available genetic diversity among and across breeds.
A reserve of cryopreserved germplasm will be available for public and private breeders and other researchers to improve management and productivity of American livestock and to ensure sufficient genetic diversity is available to reconstitute lost populations. Repository collections provide a ready source of research material to enhance knowledge about disease resistance, reproductive biology, growth and other traits that will be used to enhance productivity and management tools. Collateral information gathered while collecting germplasm samples will be used to locate breeds and quantify breed resources and productivity within the US. This information will be accessible via the Internet to guide decisions. Hence, the diverse beneficiaries of NAGP's effort include livestock breeders, researchers reconstituting populations and performing various types of molecular studies, and all American, who need a healthy and secure food supply.