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United States Department of Agriculture

Agricultural Research Service

Kate Joh Claycombe
Nutritionist


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Maternal low protein diet leads to placental angiogenic compensation via dysregulated M1/M2 macrophages and TNFa expression in Sprague-Dawley rats -
Nutrition, genetic programming and immunometabolism -
Evaluation of markers of beige adipocytes in white adipose tissue of the mouse Reprint Icon -
Garcia Garcia, R.A., Roemmich, J.N., Claycombe, K.J. 2016. Evaluation of markers of beige adipocytes in white adipose tissue of the mouse. Nutrition and Metabolism. 13:24-36.
Decreased beige adipocyte number and mitochondrial respiration coincide with reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets -
Claycombe, K.J., Dekrey, E.E., Garcia Garcia, R.A., Johnson, W., Uthus, E., Roemmich, J.N. 2016. Decreased beige adipocyte number and mitochondrial respiration coincide with reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets [abstract]. Federation of American Societies for Experimental Biology Conference, April 1-6, 2016, San Diego, California. 30:912.11.
Maternal low protein diet leads to placental angiogenic compensation via dysregulated M1/M2 macrophages and TNFa expression in Sprague-Dawley rats -
Dekrey, E.E., Roemmich, J.N., Claycombe, K.J. 2016. Maternal low protein diet leads to placental angiogenic compensation via dysregulated M1/M2 macrophages and TNFa expression in Sprague-Dawley rats [abstract]. Federation of American Societies for Experimental Biology Conference, April 1-6, 2016, San Diego, California. 30:1169.8.
Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (G9a) and reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat Reprint Icon -
Claycombe, K.J., Dekrey, E.E., Garcia Garcia, R.A., Johnson, W.T., Uthus, E., Roemmich, J.N. 2016. Decreased beige adipocyte number and mitochondrial respiration coincide with increased histone methyl transferase (G9a) and reduced FGF21 gene expression in Sprague Dawley rats fed prenatal low protein and postnatal high fat diets. Journal of Nutritional Biochemistry. 31:133-121.
The epigenetics of obesity: Role of diet and exercise on adipose, skeletal muscle, and placental tissue metabolism -
Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation Reprint Icon -
Zeng, H., Claycombe, K.J., Reindl, K.M. 2015. Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation. Journal of Nutritional Biochemistry. 26:1022-1028.
Maternal low protein diet-induced low birth weight in male, neonate Sprague-Dawley rats is mediated by altered brown adipose tissue thermogenesis -
Claycombe, K.J., Dekrey, E.E., Roemmich, J.N., Rhen, T., Ghribi, O. 2015. Maternal low protein diet-induced low birth weight in male, neonate Sprague-Dawley rats is mediated by altered brown adipose tissue thermogenesis [abstract]. Keystone Symposia. April 17-22, 2015. Snowbirth, Utah. p. 50.
Maternal low protein diet causes body weight loss in male, neonate Sprague-Dawley rats involving UCP-1 mediated thermogenesis Reprint Icon -
Claycombe, K.J., Dekrey, E.E., Roemmich, J.N., Ghribi, O., Rhen, T. 2015. Maternal low protein diet causes body weight loss in male, neonate Sprague-Dawley rats involving UCP-1 mediated thermogenesis. Journal of Nutritional Biochemistry. 26(7):729-735.
Maternal low protein diet reduces birth weight and increases brown adipose tissue UCP-1 and FNDC5 gene expression in male neonatal Sprague-Dawley rats -
Claycombe, K.J., Dekrey, E.E., Roemmich, J.N., Rhen, T., Ghribi, O. 2015. Maternal low protein diet reduces birth weight and increases brown adipose tissue UCP-1 and FNDC5 gene expression in male neonatal Sprague-Dawley rats [abstract]. Journal of Federation of American Societies for Experimental Biology. 29:749.1.
Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation -
Zeng, H., Claycombe, K.J., Reindl, K.M. 2015. Butyrate and deoxycholic acid play common and distinct roles in HCT116 human colon cell proliferation [abstract]. Journal of Federation of American Societies for Experimental Biology. 29:752.4.
Endocrine modulators of mouse subcutaneous adipose tissue beige adipocyte markers -
Garcia Garcia, R.A., Claycombe, K.J., Roemmich, J.N. 2015. Endocrine modulators of mouse subcutaneous adipose tissue beige adipocyte markers [abstract]. Journal of Federation of American Societies for Experimental Biology. 29:595.5.
Maternal low protein diet leads to dysregulation of placental iNKT cells and M1/M2 macrophage ratio, body weight loss in male, neonate Sprague-Dawley rats and increased UCP-1 mediated thermogenesis -
Dekrey, E.E., Roemmich, J.N., Claycombe, K.J. 2015. Maternal low protein diet leads to dysregulation of placental iNKT cells and M1/M2 macrophage ratio, body weight loss in male, neonate Sprague-Dawley rats and increased UCP-1 mediated thermogenesis [abstract]. Journal of Federation of American Societies for Experimental Biology. 29:LB257.
Impact of nutrition on immune function and the inflammatory response Reprint Icon -
Stephensen, C.B., Dawson, H.D., Claycombe, K.J. 2015. Impact of nutrition on immune function and the inflammatory response. Journal of Nutrition. 145(5):1039S-1108S. DOI: 10.3945/jn.114.194571.
Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low protein diet Reprint Icon -
Claycombe, K.J., Roemmich, J.N., Johnson, L., Dekrey, E.E., Johnson, W.T. 2015. Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low protein diet. Journal of Nutritional Biochemistry. 26(2):184-189.
Maternal low protein diet causes body weight loss in male, neonate Sprague-Dawley rats involving UCP-1 mediated thermogenesis -
Claycombe, K.J., Dekrey, E.E., Roemmich, J.N., Ghribi, O., Rhen, T. 2014. Maternal low protein diet causes body weight loss in male, neonate Sprague-Dawley rats involving UCP-1 mediated thermogenesis. Abstract presentation at: The Obesity Society Annual Meeting at ObesityWeekSM 2014; November 2-7, 2014; Boston, MA. www.obesityweek.com.
Epigenetics of inflammation, maternal infection and nutrition Reprint Icon -
Claycombe, K.J., Brissette, C., Ghibri, O. 2015. Epigenetics of inflammation, maternal infection and nutrition. Journal of Nutrition. 145(5):1109S-15S.
Maternal low protein diet induces muscle mitochondrial respiration impairment, catch-up growth and PGC-1a expression -
Claycombe, K.J., Roemmich, J.N., Johnson, W.T. 2014. Maternal low protein diet induces muscle mitochondrial respiration impairment, catch-up growth and PGC-1a expression. Federation of American Societies for Experimental Biology Conference. 28:271.6.
Dietary effects on adipocyte metabolism and epigenetics -
Claycombe, K.J., Zeng, H., Combs, G.F. 2015. Dietary effects on adipocyte metabolism and epigenetics. In: Ho, E. Domann, F. Nutrition and Epigenetics. Boca Raton, FL. CRC Press. p. 323-335.
Eicosapentaenoic acid regulation of muscle lipid metabolism in vivo and in vitro -
Aljawadi, A., Lemieux, M., Kalupahana, N.S., Claycombe, K.J., Moustaid-Moussa, N. 2014. Eicosapentaenoic acid (EPA) regulation of muscle lipid metabolism in vivo and in vitro. Federation of American Societies for Experimental Biology Conference. 28:1037.2.
Eicosapentaenoic acid reduces high-fat diet-induced insulin resistance by altering adipose tissue glycolytic and inflammatory function -
Lemieux, M.J., Kalupahana, N.S., Aljawadi, A., Pahlavani, M., Claycombe, K.J., Moustaid-Moussa, N. 2014. Eicosapentaenoic acid reduces high-fat diet-induced insulin resistance by altering adipose tissue glycolytic and inflammatory function. Federation of American Societies for Experimental Biology Conference. 28:383.8.
Eicosapentaenoic acid regulates brown adipose tissue gene expression and metabolism in high fat fed mice -
Pahlavani, M., Kalupahana, N.S., Lemieux, M., Aljawadi, A., Scoggin, S., Claycombe, K.J., Moustaid-Moussal, N. 2014. Eicosapentaenoic acid regulates brown adipose tissue gene expression and metabolism in high fat fed mice. Federation of American Societies for Experimental Biology Conference. 28:1037.5.
Epigenetics in adipose tissue, obesity, weight loss and diabetes Reprint Icon -
Martinez, J.A., Milagro, F.I., Claycombe, K.J., Schalinske, K.L. 2014. Epigenetics in adipose tissue, obesity, weight loss and diabetes. Advances in Nutrition. 5:71-81.
Maternal low protein diets decrease skeletal muscle growth, PGC-1alpha mRNA expression and mitochondrial oxidative respiration and increase obesity and insulin resistance in obesity prone Sprague-Dawley rats -
Claycombe, K.J., Roemmich, J.N., Uthus, E.O., Johnson, W.T. 2013. Maternal low protein diets decrease skeletal muscle growth, PGC-1alpha mRNA expression and mitochondrial oxidative respiration and increase obesity and insulin resistance in obesity prone Sprague-Dawley rats. Annual Scientific Meeting NAASO, The Obesity Society. www.obesityweek.com; 2013(S72).
Effects of voluntary running and soy supplementation on diet-induced metabolic disturbances and inflammation in mice Reprint Icon -
Yan, L., Graef, G.L., Claycombe, K.J., Johnson, L.K. 2013. Effects of voluntary running and soy supplementation on diet-induced metabolic disturbances and inflammation in mice. Journal of Agricultural and Food Chemistry. 61:9373-9379.
Nutritional Epigenomics: A Portal to Disease Prevention -
Choi, S., Claycombe, K.J., Martinez, J.A., Friso, S., Schalinske, K.L. 2013. Nutritional Epigenomics: A Portal to Disease Prevention. Advances in Nutrition. 4:530-532.
Prenatal low protein and postnatal high fat diets induce rapid adipose tissue growth by inducing Igf2 expression in Sprague Dawley rat offspring Reprint Icon -
Claycombe, K.J., Uthus, E.O., Roemmich, J.N., Johnson, L.K., Johnson, W.T. 2013. Prenatal low protein and postnatal high fat diets induce rapid adipose tissue growth by inducing Igf2 expression in Sprague Dawley rat offspring. Journal of Nutrition. 143:1533-1539.
Leptin differentially regulates STAT3 activation in the ob/ob mice adipose mesenchymal stem cells Reprint Icon -
Zhou, Z., Neupane, M., Zhou, H., Wu, D., Chang, C., Moustaid-Moussa, N., Claycombe, K.J. 2012. Leptin differentially regulates STAT3 activation in the ob/ob mice adipose mesenchymal stem cells. Nutrition and Metabolism. 9:109.
Consumption of carotenoid-rich diet improves plasma inflammatory markers -
Whigham Grendell, L.D., Jahns, L.A., Claycombe, K.J., Johnson, L. 2013. Consumption of carotenoid-rich diet improves plasma inflammatory markers. Federation of American Societies for Experimental Biology Conference. 27:846.2.
Metabolomic and genomic profiling of n-3 polyunsaturated fatty acid effects on muscle metabolism in mice fed a high fat diet -
Aljawadi, A., Lemieux, M., Kalupahana, N.S., Siriwardhana, N., Claycombe, K.J., Moustaid-Moussa, N. 2013. Metabolomic and genomic profiling of n-3 polyunsaturated fatty acid effects on muscle metabolism in mice fed a high fat diet. Federation of American Societies for Experimental Biology Conference. 27:lb319.
Eicosapentaenoic acid prevents high fat diet-induced metabolic disorders: Genomic and metabolomic analyses of underlying mechanism -
Lemieux, M., Kalupahana, N., Xin, W., Thanamool, C., Voorhees, V., Siriwardhana, N., Claycombe, K.J., Moustaid-Moussa, N. 2013. Eicosapentaenoic acid prevents high fat diet-induced metabolic disorders: Genomic and metabolomic analyses of underlying mechanism. Federation of American Societies for Experimental Biology Conference. 27:865.7.
Adipose dysfunction, interaction of reactive oxygen species, and inflammation -
Picklo, M.J., Claycombe, K.J., Meydani, M. 2012. Adipose dysfunction, interaction of reactive oxygen species, and inflammation. Advances in Nutrition. 3:734-735.
Synergistic inhibition of interleukin-6 production in adipose stem cells by tart cherry anthocyanins and atorvastatin Reprint Icon -
Zhou, Z., Nair, M.G., Claycombe, K.J. 2012. Synergistic inhibition of interleukin-6 production in adipose stem cells by tart cherry anthocyanins and atorvastatin. Phytomedicine. 19(2012)878-881.
N-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines in part via NF-kB dependent mechanisms Reprint Icon -
Siriwardhana, N., Kalupahana, N., Fletcher, S., Claycombe, K.J., Quignard-Boulange, A., Xin, W., Zhao, L., Moustaid-Moussa, N. 2012. N-3 and n-6 polyunsaturated fatty acids differentially regulate adipose angiotensinogen and other inflammatory adipokines in part via NF-kB dependent mechanisms. Journal of Nutritional Biochemistry. 23:1661-1667.
Maternal low protein diet and postnatal high fat diet increases adipose imprinted gene expression -
Claycombe, K.J., Uthus, E.O., Johnson, W.G. 2012. Maternal low protein diet and postnatal high fat diet increases adipose imprinted gene expression. Federation of American Societies for Experimental Biology Conference. 26:128.2.
Effects of pre- and postnatal diets on body compositions of diet-induced obesity prone Sprague-Dawley rats -
Uthus, E.O., Claycombe, K.J., Johnson, W.T. 2012. Effects of pre- and postnatal diets on body compositions of diet-induced obesity prone Sprague-Dawley rats. Federation of American Societies for Experimental Biology Conference. 26:648.4.
Low dietary protein intake during pregnancy differentially affects mitochondrial copy number in stromal vascular cells from subcutaneous versus visceral adipose tissue in the offspring -
Johnson, W.T., Uthus, E.O., Claycombe, K.J. 2012. Low dietary protein intake during pregnancy differentially affects mitochondrial copy number in stromal vascular cells from subcutaneous versus visceral adipose tissue in the offspring. Federation of American Societies for Experimental Biology Conference. 26:128.3.
Immunity as a link between obesity and insulin resistance Reprint Icon -
Kalupahana, N.S., Moustaid-Moussa, N., Claycombe, K.J. 2012. Immunity as a link between obesity and insulin resistance. Molecular Aspects of Medicine . 33:26-34.
(n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: Mechanistic insights Reprint Icon -
Kaluphahana, N.S., Claycombe, K.J., Moustaid-Moussa, N. 2011. (n-3) Fatty acids alleviate adipose tissue inflammation and insulin resistance: Mechanistic insights. Advances in Nutrition. 2:304-316.
Stearidonic and eicosapentaenoic acids inhibit interleukin-6 expression in ob/ob mouse adipose stem cells via toll-like receptor-2-mediated pathways Reprint Icon -
Hsueh, H.W., Zhou, Z., Whelan, J., Allen, K.G., Moustaid-Moussa, N., Kim, H., Claycombe, K.J. 2011. Stearidonic and eicosapentaenoic acids inhibit interleukin-6 expression in ob/ob mouse adipose stem cells via toll-like receptor-2-mediated pathways. Journal of Nutrition. 141:1260-1266.
The hepatic Igf2/H19 locus is not altered in 1-day old pups born to obese-prone Sprague-Dawley rats fed a low protein diet containing adequate folic acid -
Uthus, E.O., Claycombe, K.J., Johnson, W.T. 2011. The hepatic Igf2/H19 locus is not altered in 1-day old pups born to obese-prone Sprague-Dawley rats fed a low protein diet containing adequate folic acid. Federation of American Societies for Experimental Biology Conference. 25:990.16.
Last Modified: 8/26/2016
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