Alfred M Handler
(Al)
Research Geneticist (Insects)
Publications
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A transposon-based genetic marker for species-specific identity in the Bactrocera dorsalis complex
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(Peer Reviewed Journal)
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Zimowska, G.J., Xavier, N., Qadri, M., Handler, A.M. 2024. A transposon-based genetic marker for species-specific identity in the Bactrocera dorsalis complex. Molecular Ecology. 14:1924. https://doi.org/10.1038/s41598-023-51068-2.
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The hAT-family hopper transposon exists as highly similar yet discontinuous elements in the Bactrocera tephritid fly genus
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(Peer Reviewed Journal)
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Handler, A.M., Furlong, R.B. 2024. The hAT-family hopper transposon exists as highly similar yet discontinuous elements in the Bactrocera tephritid fly genus. Insect Molecular Biology. 33(1):1-10. https://doi.org/10.1111/imb.12891.
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Sequence and expression analysis of the spermatogenesis-specific gene cognates, wampa and Prosa6T, in Drosophila suzukii
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(Peer Reviewed Journal)
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Xia, Q., Tariq, K., Hahn, D.A., Handler, A.M. 2023. Sequence and expression analysis of the spermatogenesis-specific gene cognates, wampa and Prosa6T, in Drosophila suzukii. Genetica. 151:215-223. https://doi.org/10.1007/s10709-023-00189-7.
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Tephritid fruit fly transgenesis and applications
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Mitochondrial superoxide dismutase overexpression and low oxygen conditioning hormesis improve the performance of irradiated sterile males
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(Peer Reviewed Journal)
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Dias, V.S., Caceres, C., Parker, A.G., Pereira, R., Demirbas-Uzel, G., Abd-Alla, A.M., Teets, N.M., Schetelig, M.F., Handler, A.M., Hahn, D.A. 2021. Mitochondrial superoxide dismutase overexpression and low oxygen conditioning hormesis improve the performance of irradiated sterile males. Scientific Reports. 11. Article 20182. https://doi.org/10.1038/s41598-021-99594-1.
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Toxicological risk assessment of some commonly used insecticides on cotesia flavipes, a larval parasitoid of the spotted stem borer chilo partellus
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(Peer Reviewed Journal)
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Raen-Akhtar, Z., Tariq, K., Handler, A.M., Ali, A., Zang,, L., Ullah, F., Ali, S., Ullah, M.I. 2021. Toxicological risk assessment of some commonly used insecticides on cotesia flavipes, a larval parasitoid of the spotted stem borer chilo partellus. Ecotoxicology. 30(3):448-458. https://doi.org/10.1007/s10646-021-02372-y.
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The hAT-family transposable element, hopper, from Bactrocera dorsalis is a vector for insect germline transformation
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(Peer Reviewed Journal)
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Handler, A.M., Schetelig, M. 2020. The hAT-family transposable element, hopper, from Bactrocera dorsalis is a functional vector for insect germline transformation. BioMed Central (BMC) Genetics. 21, Article 137. https://doi.org/10.1186/s12863-020-00942-3.
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Genetic breakdown of a transgenic Tet-off conditional lethality system for insect population control
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(Peer Reviewed Journal)
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Zhao, Y., Schetelig, M., Handler, A.M. 2020. Genetic breakdown of a transgenic Tet-off conditional lethality system for insect population control. Nature Communications. 11:3095. https://doi.org/10.1038/s41467-020-16807-3.
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Transcriptome analysis of the Oriental fruit fly Bactrocera dorsalis early embryos
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(Peer Reviewed Journal)
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Peng, W., Yu, S., Handler, A.M., Zhang, H. 2020. Transcriptome analysis of the Oriental fruit fly Bactrocera dorsalis early embryos. Insects. 11(5):323. https://doi.org/10.3390/insects11050323.
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Gene content evolution in the arthropods
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(Peer Reviewed Journal)
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Thomas, G.C., Dohmen, E., Hughes, D.T., Murali, S.C., Poelchau, M.F., Glastad, K., Anstead, C.A., Ayoub, N.A., Batterham, P., Bellair, M., Childers, C., Duan, J.J., Gundersen, D.E., Handler, A.M., Hunter, W.B., Scully, E.D., Hackett, K.J., et all. 2020. Gene content evolution in the arthropods. Genome Biology. 21:15. https://doi.org/10.1186/s13059-019-1925-7.
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miRNA-1-3p, is an early embryonic male sex-determining factor in the Oriental fruit fly, Bactrocera dorsalis
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(Peer Reviewed Journal)
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Peng, W., Yu, S., Handler, A.M., Tu, Z., Saccone, G., Xi, Z., Zhang, H. 2020. miRNA-1-3p, is an early embryonic male sex-determining factor in the Oriental fruit fly, Bactrocera dorsalis. Nature Communications. 11:932. https://doi.org/10.1038/s41467-020-14622-4.
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Overexpression of an antioxidant enzyme improves male mating performance after stress in a lek-mating fruit fly
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(Peer Reviewed Journal)
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Teets, N.M., Dias, V., Pierce, B., Schetelig, M.F., Handler, A.M., Hahn, D.A. 2019. Overexpression of an antioxidant enzyme improves male mating performance after stress in a lek-mating fruit fly. Proceedings of the Royal Society B. 286(1904):20190898. https://doi.org/10.1098/rspb.2019.0531.
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CRISPR/Cas9-mediated gene editing in an exogenous transgene and an endogenous sex determination gene in the Caribbean fruit fly, Anastrepha suspensa
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(Peer Reviewed Journal)
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Li, J., Handler, A.M. 2019. CRISPR/Cas9-mediated gene editing in an exogenous transgene and an endogenous sex determination gene in the Caribbean fruit fly, Anastrepha suspensa. Gene. 691:160-166. https://doi.org/10.1016/j.gene.2018.12.055.
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Arthropod genomics research in the United States Department of Agriculture-Agricultural Research Service: Applications of RNA interference and CRISPR gene editing technologies in pest control
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Gundersen, D.E., Adrianos, S.L., Allen, M.L., Becnel, J.J., Chen, Y., Choi, M.Y., Estep, A., Evans, J.D., Garczynski, S.F., Geib, S.M., Ghosh, S.B., Handler, A.M., Hasegawa, D.K., Heerman, M.C., Hull, J.J., Hunter, W.B., Kaur, N., Li, J., Li, W., Ling, K., Nayduch, D., Oppert, B.S., Perera, O.P., Perkin, L.C., Sanscrainte, N.D., Sim, S.B., Sparks, M., Temeyer, K.B., Vander Meer, R.K., Wintermantel, W.M., James, R.R., Hackett, K.J., Coates, B.S. 2017. Arthropod genomics research in the United States Department of Agriculture-Agricultural Research Service: Applications of RNA interference and CRISPR gene editing technologies in pest control. Trends in Entomology. 13:109-137.
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Recommendations for laboratory containment and management of gene drive systems in arthropods
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(Peer Reviewed Journal)
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Benedict, M.Q., Bier, E.A., Burt, A., Capurro, M.L., De Barro, P., Handler, A.M., Hayes, K.R., Marshall, J.M., Tabachnick, W.J., Adelman, Z.N. 2018. Recommendations for laboratory containment and management of gene drive systems in arthropods. Vector-Borne and Zoonotic Diseases. 18(1):2-13. https://doi.org/10.1089/vbz.2121.
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Temperature-dependent sex-reversal by a transformer-2 gene-edited mutation in the spotted wing drosophila, Drosophila suzukii
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(Peer Reviewed Journal)
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Li, J., Handler, A.M. 2017. Temperature-dependent sex-reversal by a transformer-2 gene-edited mutation in the spotted wing drosophila, Drosophila suzukii. Scientific Reports. 7:12363. https://doi.org/10.1038/s41598-017-12405-4.
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Cre/lox-recombinase-mediated cassette exchange for reversible site-specific genomic targeting of the disease vector, Aedes aegypti
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(Peer Reviewed Journal)
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Hacker, I., Harrell Ii, R., Eichnerd, G., Pilitt, K., O Brochta, D., Handler, A.M., Schetelig, M.F. 2017. Cre/lox-recombinase-mediated cassette exchange for reversible site-specific genomic targeting of the disease vector, Aedes aegypti. Scientific Reports. 7:43883. https://doi.org/10.1038/srep43883.
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The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedmann), reveals insights into the biology and adaptive evolution of a highly invasive pest species
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(Peer Reviewed Journal)
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Papanicolaou, A., Schetelig, M.F., Arensburger, P., Atkinson, P.W., Benoit, J.B., Bourtzis, K., Castanera, P., Cavanaugh, J.P., Chao, H., Childers, C., Curril, I., Dinh, H., Doddaapaneli, H.V., Dolan, A., Dugan, S., Friedrich, M., Gasperi, G., Geib, S.M., Georgakilas, G., Gibbs, R.A., Giers, S.D., Gomulski, L.M., Gonzalez-Guzman, M., Guillem-Amat, A., Han, Y., Hatzigeorgiou, A.G., Hernandez-Crespo, P., Hughes, D.S., Jones, J.W., Karagkouni, D., Koskinioti, P., Lee, S.L., Malacrida, A.R., Manni, M., Mathiopoulos, K., Murali, S.C., Murphy, T.D., Muzny, D.M., Oberhofer, G., Ortego, F., Paraskevopoulou, M.D., Poelchau, M.F., Qu, J., Reczko, M., Robertson, H.M., Rosendale, A.J., Rosselot, A.E., Saccone, G., Salvemini, M., Savini, G., Schreiner, P., Scolari, F., Siciliano, P., Sim, S.B., Tsiamis, G., Urena, E., Vlachos, I.S., Werren, J.H., Wimmer, E.A., Worley, K.C., Zacharopoulou, A., Richards, S., Handler, A.M. 2016. The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedmann), reveals insights into the biology and adaptive evolution of a highly invasive pest species. Genome Biology. 17:192. https://doi.org/10.1186/s13059-016-1049-2.
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Tetracycline-suppressible female lethality and sterility in the Mexican fruit fly, Anastrepha ludens
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(Peer Reviewed Journal)
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Schetelig, M.F., Targovska, A., Meza, J.S., Bourtzis, K., Handler, A.M. 2016. Tetracycline-suppressible female lethality and sterility in the Mexican fruit fly, Anastrepha ludens. Insect Molecular Biology. 25(4):500-508. https://doi.org/10.1111/imb.12238.
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Germline transformation of the olive fruit fly, Bactrocera oleae (Rossi)(Diptera:Tephritidae) with a piggyBac transposon vector
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(Peer Reviewed Journal)
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Genc, H., Schetelig, M.F., Xavier, N., Handler, A.M. 2015. Germline transformation of the olive fruit fly, Bactrocera oleae (Rossi)(Diptera:Tephritidae) with a piggyBac transposon vector. Turkish Journal of Biology. 40:845-855. https://doi.org/10.3906/biy-1510-55.
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Arthropod genomics research in the United States Department of Agriculture-Agricultural Research Service: Current impacts and future prospects
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(Peer Reviewed Journal)
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Coates, B.S., Poelchau, M.F., Childers, C., Evans, J.D., Handler, A.M., Guerrero, F., Skoda, S.R., Hopper, K.R., Wintermantel, W.M., Ling, K., Hunter, W.B., Oppert, B.S., Perez De Leon, A.A., Hackett, K.J., Shoemaker, D.D. 2015. Arthropod genomics research in the United States Department of Agriculture-Agricultural Research Service: Current impacts and future prospects. Trends in Entomology. 11(1):1-27.
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The role of the transformer gene in sex determination and
reproduction in the tephritid fruit fly, Bactrocera dorsalis (Hendel)
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(Peer Reviewed Journal)
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Peng, W., Wenping, Z., Handler, A.M., Zhang, H. 2015. The role of the transformer gene in sex determination and reproduction in the tephritid fruit fly, Bactrocera dorsalis (Hendel). Genetica. 143(6):717-727.
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Enhancing the stability and ecological safety of mass-reared transgenic strains for field release by redundant conditional lethality systems
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(Peer Reviewed Journal)
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Handler, A.M. 2015. Enhancing the stability and ecological safety of mass-reared transgenic strains for field release by redundant conditional lethality systems. Insect Science. doi: 10.1111/1744-7919.12245.
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Pro-apoptotic gene regulation and its activation by gamma-irradiation in the Caribbean fruit fly, Anastrepha suspensa
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(Peer Reviewed Journal)
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Nirmala, X., Schetelig, M.F., Zimowska, G.J., Handler, A.M., Zhou, L. 2015. Pro-apoptotic gene regulation and its activation by gamma-irradiation in the Caribbean fruit fly, Anastrepha suspensa. Apoptosis. 20(1):1-9.
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Male-specific Y-linked transgene markers to enhance biologically-based control of the Mexican fruit fly, Anastrepha ludens (Diptera: Tephritidae)
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(Peer Reviewed Journal)
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Meza, J., Schetelig, M.F., Zepeda-Cisneros, C., Handler, A.M. 2014. Male-specific Y-linked transgene markers to enhance biologically-based control of the Mexican fruit fly, Anastrepha ludens (Diptera: Tephritidae). BMC Medical Genetics. 15(Suppl. 2):1-7.
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Fitness cost implications of phiC31-mediated site-specific integrations in target-site strains of the Mexican fruit fly, Anastrepha ludens (Diptera: Tephritidae)
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(Peer Reviewed Journal)
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Meza, J.S., Diaz-Fleischer, F., Sanchez-Velasquez, L.R., Zepeda-Cisneros, C., Handler, A.M., Schetelig, M.F. 2014. Fitness cost implications of phiC31-mediated site-specific integrations in target-site strains of the Mexican fruit fly, Anastrepha ludens (Diptera: Tephritidae). PLoS One. 10(9):e109690. DOI: 10.1371/journal.pone.0109690.
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Not all GMOs are crop plants: non-plant GMO applications in agriculture
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(Peer Reviewed Journal)
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Hokanson, K.E., Handler, A.M., Schetelig, M.F., St.Leger, R.J., Dawson, W.O. 2013. Not all GMOs are crop plants: non-plant GMO applications in agriculture. Transgenic Research. Online: (DOI) 10.1007/s11248-013-9769-5.
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Tephritid fruit fly transgenesis and applications
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Germline transformation of the spotted wing drosophilid, Drosophila suzukii, with a piggyBac transposon vector
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(Peer Reviewed Journal)
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Schetelig, M., Handler, A.M. 2013. Germline transformation of the spotted wing drosophilid, Drosophila suzukii, with a piggyBac transposon vector. Genetica. 141(4-6):189-193.
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Y-Linked markers for improved population control of the tephritid fruit fly pest, Anastrepha suspensa
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(Peer Reviewed Journal)
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Schetelig, M.F., Handler, A.M. 2013. Y-Linked markers for improved population control of the tephritid fruit fly pest, Anastrepha suspensa. Advances in Biochemical Engineering/Biotechnology. Available: http://dx.doi.org/10.1007/10 _2013_209.
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A functional comparison of the 3XP3 promoter by recombinase-mediated cassette exchange in Drosophila and tephritid fly, Anastrepha suspensa
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(Peer Reviewed Journal)
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Schetelig, M.A., Handler, A.M. 2013. A functional comparison of the 3XP3 promoter by recombinase-mediated cassette exchange in Drosophila and tephritid fly, Anastrepha suspensa. G3:Genes, Genomes, and Genomics. 3:687-693.
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An EST database of the Caribbean fruit fly, Anastrephas suspensa (Diptera:Tephritidae)
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(Peer Reviewed Journal)
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Xavier, N., Fahong, Y., Schetelig, M.A., Handler, A.M. 2013. An EST database of the Caribbean fruit fly, Anastrephas suspensa (Diptera:Tephritidae). Gene. 517:212-217.
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A transgenic embryonic sexing system for Anastrepha suspensa (Diptera:Tephritidae)
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(Peer Reviewed Journal)
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Schetelig, M.A., Handler, A.M. 2012. A transgenic embryonic sexing system for Anastrepha suspensa (Diptera:Tephritidae). Journal of Insect Biochemistry and Molecular Biology. 42:790-795.
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FLP recombinase-mediated site-specific recombination in silkworm, Bombyx mori
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(Peer Reviewed Journal)
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Long, D., Zhao, A., Chen, X., Zhang, Y., Lu, W., Guo, Q., Handler, A.M. 2012. FLP recombinase-mediated site-specific recombination in silkworm, Bombyx mori. PLoS One. 7(6):e40150. doi: 10.1371/journal.pone.00401.
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Strategy for enhanced transgenic strain development for embryonic conditionnal lethality in Anastrepha suspensa
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(Peer Reviewed Journal)
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Schetelig, M.A., Handler, A.M. 2012. Strategy for enhanced transgenic strain development for embryonic conditionnal lethality in Anastrepha suspensa. Proceedings of the National Academy of Sciences. 109(24):9348-9353.
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The use and manipulation of insect reproductive molecules for controlling insect populations
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(Abstract Only)
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Male only progeny in Anastrepha suspensa by RNAi-induced sex reversion of chromosomal females
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(Peer Reviewed Journal)
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Schetelig, M.A., Milano, A., Saccone, G., Handler, A.M. 2012. Male only progeny in Anastrepha suspensa by RNAi-induced sex reversion of chromosomal females. Journal of Insect Biochemistry and Molecular Biology. 42:51-57.
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Transposable elements for insect transformation
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Handler, A.M., O'Brochta, D.A. 2012. Transposable elements for insect transformation. In: Gilbert, L.I.,editor. Insect Biochemistry and Molecular Biology. London, United Kingdom: Academic Press. p. 90-133.
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Pro-apoptotic cell death genes, hid and reaper, from the tephritid pest species, Anastrepha suspensa
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(Peer Reviewed Journal)
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Schetelig, M.A., Xavier, N., Handler, A.M. 2011. Pro-apoptotic cell death genes, hid and reaper, from the tephritid pest species, Anastrepha suspensa. International Congress On Apoptosis. 16(8):759-768.
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Conditional lethality strains for the biological control of Anastrepha species
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(Abstract Only)
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A DsRed fluorescent protein marker under polyubiquitin promoter regulation allows visual and amplified gene detection of transgenic Caribbean fruit flies in liquid traps
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(Peer Reviewed Journal)
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Nirmala, X., Olson, S., Holler, T., Cho, K., Handler, A.M. 2011. A DsRed fluorescent protein marker under polyubiquitin promoter regulation allows visual and amplified gene detection of transgenic Caribbean fruit flies in liquid traps. Biocontrol. 56(3):333-340.
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Recombination technologies for enhanced transgene stability in bioengineered insects
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(Peer Reviewed Journal)
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Schetelig, M.A., Gotschel, F., Viktorinova, I., Handler, A.M., Wimmer, E. 2011. Recombination technologies for enhanced transgene stability in bioengineered insects. Genetica. 139:71-78.
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Germ-line transformation of the Queensland fruit fly, Bactrocera tryoni, using a piggyBac vector in the presence of endogenous piggyBac elements
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(Peer Reviewed Journal)
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Raphael, K.A., Streamer, K., Morrow, J.L., Handler, A.M., Frommer, M., Shearman, D.C. 2011. Germ-line transformation of the Queensland fruit fly, Bactrocera tryoni, using a piggyBac vector in the presence of endogenous piggyBac elements. Genetica. 139:91-97.
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Development of transgenic strains for the biological control of the Mexican fruit fly, Anastrepha ludens
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(Peer Reviewed Journal)
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Meza, J., Xavier, N., Zimowska, G.J., Zepeda, C., Handler, A.M. 2011. Development of transgenic strains for the biological control of the Mexican fruit fly, Anastrepha ludens. Genetica. 139:53-62.
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Embryonic transcriptome analysis of the Caribbean fruit fly, Anastrepha suspensa
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(Abstract Only)
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Embryonic transcriptome analysis of the Caribbean fruit fly, Anastrepha suspensa
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(Abstract Only)
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New genetic tools for improving SIT in Ceratitis capitata: embryonic lethality and sperm marking
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Schetelig, M.F., Scolari, F., Handler, A.M., Gasperi, G., Wimmer, E.A. 2009. New genetic tools for improving SIT in Ceratitis capitata: embryonic lethality and sperm marking. Fruit Flies of Economic Importance International Symposium. 299-305.
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Quality Testing of Three Species of Tephritid Fruit Flies After Embryo Cryopreservation
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(Peer Reviewed Journal)
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Leopold, R.A., Rajamohan, A., Shelly, T.E., Handler, A.M. 2010. Quality Testing of Three Species of Tephritid Fruit Flies After Embryo Cryopreservation. Annals of the Entomological Society of America. 103(2):264-272.
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Quality testing of three species of Tephritid fruit flies after embryo cryopreservation
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(Peer Reviewed Journal)
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Leopold, R.A., Rajamohan, A., Shelly, T.E., Handler, A.M. 2010. Quality testing of three species of Tephritid fruit flies after embryo cryopreservation. Annals of the Entomological Society of America. 103(2):264-272.
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Site-specific recombination for the modification of transgenic strains of the Mediterranean fruit fly Ceratitis capitata
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(Peer Reviewed Journal)
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Schetelig, M.F., Scolari, F., Handler, A.M., Kittelmann, S., Gasperi, G., Wimmer, E.A. 2009. Site-specific recombination for the modification of transgenic strains of the Mediterranean fruit fly Ceratitis capitata. Proceedings of the National Academy of Sciences. 106(43):18171-18176.
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The ß 2-tubulin gene from three tephritid fruit fly species and use of its promoter for sperm marking
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(Peer Reviewed Journal)
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Zimowaska, G.J., Nirmala, X., Handler, A.M. 2009. The ß 2-tubulin gene from three tephritid fruit fly species and use of its promoter for sperm marking. Insect Biochemistry and Molecular Biology. 30:508-515.
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Characterization of the proteasome ß2 subunit gene and its mutant allele in the tephritid fruit fly pest, Anastrepha suspensa
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(Peer Reviewed Journal)
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Nirmala, X., Zimowska, G., Handler, A.M. 2009. Characterization of the proteasome ß2 subunit gene and its mutant allele in the tephritid fruit fly pest, Anastrepha suspensa. Insect Molecular Biology. 18(3):333-340.
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Development and utilization of transgenic New World screwworm, Cochliomyia hominivorax
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(Peer Reviewed Journal)
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Handler, A.M., Allen, M.L., Skoda, S.R. 2009. Development and utilization of transgenic New World screwworm, Cochliomyia hominivorax. Medical and Veterinary Entomology. 23(s1):98-105.
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Highly similar piggyBac elements in Bactrocera that share a common lineage with elements in noctuid moths
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(Peer Reviewed Journal)
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Handler, A.M., Zimowska, G., Armstrong, K.F. 2008. Highly similar piggyBac elements in Bactrocera that share a common lineage with elements in noctuid moths. Insect Molecular Biology. 17(4):387-393
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Perspectives on the state of insect transgenics
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O'Brochta, D.A., Handler, A.M. 2008. Perspectives on the state of insect transgenics. In: Aksoy, S., editor. Transgenesis and the Management of Vector-Borne Disease. Vol. 627. New York, NY: Landes Bioscience. p. 1-18.
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Active Integration: New Strategies for Transgenesis
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(Peer Reviewed Journal)
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Shinohara, E.T., Kaminski, J.M., Segal, D.J., Pelczar, P., Kolhe, R., Ryan, T., Coates, C.J., Fraser, M.J., Handler, A.M., Yanagimachi, R., Moisyadi, S. 2007. Active integration: New strategies for transgenesis. Transgenic Research. 16:333-339.
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Can the technical issues related to risk assessment of transgenic arthropods be solved?
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Atkinson, P.W., Handler, A.M. 2006. Can the technical issues related to risk assessment of transgenic arthropods be solved? International Atomic Energy Agency-TEC-DOC 1483:57-68.
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Development of an embryonic lethality system for transgenic sit in the fruit pest, ceratitis capitata
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Schetelig, M.F., Horn, C., Handler, A.M., Wimmer, E.A. 2007. Development of an embryonic lethality system for transgenic sit in the fruit pest, ceratitis capitata. IAEA-FAO Area Wide Insect Management Symposium Proceedings. 85-93.
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Use of missense proteasome subunits for conditional lethality in the tephritid fruit flies Anastrepha suspensa and Ceratitis capitata
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(Proceedings)
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Xavier, N., Handler, A.M. 2006. Use of missense proteasome subunits for conditional lethality in the tephritid fruit flies Anastrepha suspensa and Ceratitis capitata. Fruit Flies of Economic Importance International Symposium, September 10-11, 2006, Salvador, Brazil.
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PiggyBac:A flexible and highly active transposon as compared to Sleeping Beauty, Tol2, and Mos1 in mammalian cells
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(Peer Reviewed Journal)
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Wu, S.C., Meir, Y.J., Coates, C.J., Handler, A.M., Pelczar, P., Moisyadi, S., Kaminski, J.M. 2006. PiggyBac: A flexible and highly active transposon as compared to Sleeping Beauty, Tol2, and Mos1 in mammalian cells. Proceedings of the National Academy of Sciences. 103:15008-15013.
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NEW TRANSFORMATION VECTORS FOR IMPROVED SIT AND ECOLOGICAL SAFETY IN TEPHRITID SPECIES
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(Abstract Only)
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INSECT TRANSGENESIS: MECHANISMS, APPLICATIONS AND ECOLOGICAL SAFETY
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Handler, A.M., Atkinson, P.W. 2006. Insect transgenesis: mechanisms, applications and ecological safety. In: Harding, S.E., editor. Biotechnology and Genetic Engineering Reviews. Vol. 23. Lavoisier/Intercept. p. 129-156.
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AREAS OF CONCERN FOR THE EVALUATION OF TRANSGENIC ARTHROPODS
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Handler, A.M., Atkinson, P.W. 2006. AREAS OF CONCERN FOR THE EVALUATION OF TRANSGENIC ARTHROPODS. International Atomic Energy Agency. IAEA Tech. Doc 1483.pps. 46-56.
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Use Of Missense Proteasome Subunits For Conditional Lethality In the Tephritid Fruit Flies Anastrepha Suspensa And Ceratitis Capitata
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(Proceedings)
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Xavier, N., Handler, A.M. 2006. Use Of Missense Proteasome Subunits For Conditional Lethality In the Tephritid Fruit Flies Anastrepha Suspensa And Ceratitis Capitata. 5th International Symposium on Molecular Insect Science, May 21, 2006, Tucson, Arizona.
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NEW PIGGYBAC VECTORS FOR FUNCTIONAL GENOMICS AND TRANSGENIC INSECT RELEASE
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(Abstract Only)
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HIGHLY CONSERVED PIGGYBAC ELEMENTS IN NOCTUID SPECIES OF LEPIDOPTERA
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(Peer Reviewed Journal)
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Zimowska, G.J., Handler, A.M. 2006. HIGHLY CONSERVED PIGGYBAC ELEMENTS IN NOCTUID SPECIES OF LEPIDOPTERA. Insect Biochemistry and Molecular Biology. 3:421-428.
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Improving the ecological safety of transgenic insects for field release: New vectors for stability and genomic targeting
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()
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Handler, A.M., Zimowska, G.J., Horn, C. 2007. Improving the ecological safety of transgenic insects for field release: New vectors for stability and genomic targeting. Area-Wide Control of Insect Pests: From Research to Field Implementation. 73-83.
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SITE-SPECIFIC GENOMIC TARGETING IN DROSOPHILA
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(Peer Reviewed Journal)
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Horn, C., Handler, A.M. 2005. Site-specific genomic targeting in Drosophila. Proceedings of the National Academy of Sciences. 102:12483-12488.
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GENETIC TRANSFORMATION
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()
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Handler, A.M. 2004. Genetic transformation. In: Capinera, J.L., editor. Encyclopedia of Entomology, Vol. 3. Dordrecht, Netherlands: Kluwer Academic Publishers. pps. 1211-1214.
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Terminal region proximal internal domain sequences of the piggyBac transposon are necessary for efficient transformation of target genomes
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(Peer Reviewed Journal)
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Li, X., Harrell, R.A., Handler, A.M., Beam, T., Hennessy, K., Fraser, Jr., M.J. 2005. Terminal region proximal internal domain sequences of the piggyBac transposon are necessary for efficient transformation of target genomes. Insect Molecular Biology. 14:17-30.
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POST-INTEGRATION STABILIZATION OF A TRANSPOSON VECTOR BY TERMINAL SEQUENCE DELETION IN DROSOPHILA MELANOGASTER
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(Peer Reviewed Journal)
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Handler, A.M., Zimowska, G.J., Horn, C. 2004. Post-integration stabilization of a transposon vector by terminal sequence deletion. Nature Biotechnology. 22:1150-1154.
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TRANSPOSABLE ELEMENTS FOR INSECT TRANSFORMATION
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()
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Handler, A.M., O'Brochta, D.A. 2005. Transposable elements for insect transformation. In: Gilbert, L.I., Iatrou, K., Gill, S.S., editors. Comprenehsive Molecular Insect Science, Volume 4. Oxford, UK: Elsevier. p. 437-474.
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PIGGYBAC TRANSFORMATION OF THE NEW WORLD SCREWWORM, COCHLIOMYIA HOMINIVORAX, PRODUCES MULTIPLE DISTINCT MUTANT STRAINS
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(Peer Reviewed Journal)
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ALLEN, M.L., HANDLER, A.M., BERKEBILE, D.R., SKODA, S.R. PIGGYBAC TRANSFORMATION OF THE NEW WORLD SCREWWORM, COCHLIOMYIA HOMINIVORAX, PRODUCES MULTIPLE DISTINCT MUTANT STRAINS. MEDICAL AND VETERINARY ENTOMOLOGY, 18(1), p. 1-9. 2004.
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Understanding and improving transgene stability and expression in insects for SIT and conditional lethal release programs
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(Peer Reviewed Journal)
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Handler, A.M. 2004. Understanding and improving transgene stability and expression in insects for SIT and conditional lethal release programs. Journal of Insect Biochemistry and Molecular Biology. 34:121-130.
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USE OF TRANSGENIC STRAINS OF INSECTS IN THE SCREWWORM PROGRAM
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()
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ALLEN, M.L., HANDLER, A.M., BERKEBILE, D.R., SKODA, S.R., SCHOLL, P.J. USE OF TRANSGENIC STRAINS OF INSECTS IN THE SCREWWORM PROGRAM. Fourth transgenesis and genomics of INVERTEBRATE Organisms. Pacific Grove, California, May 11-15, 2003.
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Advances in the molecular genetic analysis of insects and their application to pest management
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()
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Handler, A.M., Beeman, R.W. 2003. Advances in the molecular genetic analysis of insects and their application to pest management. Pest Management Science. 59:728-735.
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Prospects for using genetic transformation for improved SIT and new biocontrol methods
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(Peer Reviewed Journal)
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Handler, A.M. 2002. Prospects for using genetic transformation for improved SIT and new biocontrol methods. Genetica. 116:137-149.
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Isolation and analysis of a new hopper hAT transposon from the Bactrocera dorsalis white eye strain
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(Peer Reviewed Journal)
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Handler, A.M. 2003. Isolation and analysis of a new hopper hAT transposon from the Bactrocera dorsalis white eye strain. Genetica. 118:18-24.
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TRANSPOSABLE ELEMENT-MEDIATED TRANSGENIC INSECTS IN THE SCREWWORM PROGRAM
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()
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Use of the piggyBac transposon for germ-line transformation of insects
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(Peer Reviewed Journal)
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Handler, A.M. 2002. Use of the piggyBac transposon for germ-line transformation of insects. Journal of Insect Biochemistry and Molecular Biology. 32:1211-1220.
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Germ-line transformation of the South American malaria vector, Anopheles albimanus, with a piggyBac/EGFP transposon vector is routine and highly efficient
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(Peer Reviewed Journal)
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Perera, O.P., Harrell Ii, R.A., Handler, A.M. 2002. Germ-line transformation of the South American malaria vector, Anopheles albimanus, with a piggyBac/EGFP transposon vector is routine and highly efficient. Insect Molecular Biology. 11:291-297.
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CRYOPRESERVATION OF FRUIT FLY (TEPHRITIDAE) EMBRYOS
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(Abstract Only)
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A Polyubiquitin-regulated DsRed marker for transgenic insects
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(Peer Reviewed Journal)
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Handler, A.M., Harrell Ii, R.A. 2001. A Polyubiquitin-regulated DsRed marker for transgenic insects. Biotechniques. 31:820-828.
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CRYOPRESERVATION OF CARIBBEAN FRUIT FLY (ANASTREPHA SUSPENSA) EMBRYOS
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(Abstract Only)
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A current perspective on insect gene transfer
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(Peer Reviewed Journal)
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Handler, A.M. 2001. A current perspective on insect gene transfer. Journal of Insect Biochemistry and Molecular Biology. 31:111-128.
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The piggyBac transposon mediates germ-line transformation in the oriental fruit fly and closely related elements exist in its genome
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(Peer Reviewed Journal)
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Handler, A.M., Mccombs, S.D. 2000. The piggyBac transposon mediates germ-line transformation in the oriental fruit fly and closely related elements exist in its genome. Insect Molecular Biology. 9:605-612.
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Transformation of the Caribbean fruit fly with a piggyBac transposon vector marked with polyubiquitin-regulated GFP
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(Peer Reviewed Journal)
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Handler, A.M., Harrell, R.A. 2001. Transformation of the Caribbean fruit fly with a piggyBac transposon vector marked with polyubiquitin-regulated GFP. Journal of Insect Biochemistry and Molecular Biology. 31:199-205.
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An introduction to the history and methodology if insect gene transfer
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()
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Handler, A.M. 2000. An introduction to the history and methodology if insect gene transfer. Book Chapter. pps. 3-26.
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Germline transformation of Drosophila melanogaster with piggyBac transposon vector
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(Peer Reviewed Journal)
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Handler, A.M., Harrell, R.A. 1999. Germline transformation of Drosophila melanogaster with piggyBac transposon vector. Insect Molecular Biology. 8:449-458.
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The lepidopteran transposon vector, piggyBac, mediates germline transformation in the Mediterranean fruitfly
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(Peer Reviewed Journal)
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Handler, A.M., Mccombs, S.D., Fraser, M.J., Saul, S.H. 1998. The lepidopteran transposon vector, piggyBac, mediates germline transformation in the Mediterranean fruitfly. Proceedings of the National Academy of Sciences. 95:7520-7525.
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Developmental regulation of yolk protein gene expression in Anastrepha suspensa
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(Peer Reviewed Journal)
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Handler, A.M. 1997. Developmental regulation of yolk protein gene expression in Anastrepha suspensa. Archives of Insect Biochemistry and Physiology. 6:25-35.
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P-element excision in Drosophila is stimulated by gamma-irradiation in transient embryonic assays
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(Peer Reviewed Journal)
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Handler, A.M., Gomez, S.P. 1997. P-element excision in Drosophila is stimulated by gamma-irradiation in transient embryonic assays. Genetical Research. 70:75-78.
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A Drosophila melanogaster hobo-white + vector mediates low frequency gene transfer in D. vlrllls with full Interspecific white + complementation
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(Peer Reviewed Journal)
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Gomea, S.P., Handler, A.M. 1997. A Drosophila melanogaster hobo-white + vector mediates low frequency gene transfer in D. vlrllls with full Interspecific white + complementation. Insect Molecular Biology. 6:165-171.
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A NEW HAT TRANSPOSABLE ELEMENT FROM BACTROCERA DORSALIS, HOPPER, IS DISTANTLY RELATED TO HOBO AND AC
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(Peer Reviewed Journal)
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A new hobo, Ac, Tam3 transposable element, hopper, from Bactrocera
dorsalis is distantly related to hobo and Ac
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(Peer Reviewed Journal)
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Handler, A.M., Gomez, S.P. 1977. A new hobo, Ac, Tam3 transposable element, hopper, from Bactrocera dorsalis is distantly related to hobo and Ac. GENE-Elsevier. 185:133-135.
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THE HOBO TRANSPOSABLE ELEMENT EXCISES AND HAS RELATED ELEMENTED IN TEPHRITID SPECIES
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(Peer Reviewed Journal)
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The hobo transposable element excises and has related elements in tephritid species
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(Peer Reviewed Journal)
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Handler, A.M., Gomez, S.P. 1966. The hobo transposable element excises and has related elements in tephritid species. Genetics. 143:1339-1347.
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The hobo transposable element has transposase-dependent and
-independent excision activity in drosophilid species
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(Peer Reviewed Journal)
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Handler, A.M., Gomez, S.P. 1995. The hobo transposable element has transposase-dependent and -independent excision activity in drosophilid species. Molecular and General Genetics. 247:399-408.
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Negative regulation of P element excision by the somatic product and terminal sequences of P in drosophila melanogaster
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(Peer Reviewed Journal)
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Handler, A.M., Gomez, S.P., O'Brochta, D.A. 1993. Negative regulation of P element excision by the somatic product and terminal sequences of P in drosophila melanogaster. Molecular and General Genetics. 237:145-151.
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A functional analysis of the P-element gene-transfer vector in insects
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(Peer Reviewed Journal)
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Handler, A.M., Gomez, S.P., O'Brochta, D.A. 1991. A functional analysis of the P-element gene-transfer vector in insects. Archives of Insect Biochemistry and Physiology. 22:373-384.
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P element excision in drosophila melanogaster and related drosophilids
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(Peer Reviewed Journal)
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O'Brochta, D.A., Gomez, S.P., Handler, A.M. 1991. P element excision in drosophila melanogaster and related drosophilids. Molecular and General Genetics. 225:387-394.
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Prospects for gene transmformation in insects
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(Peer Reviewed Journal)
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Handler, A.M., O'Brochta, D.A. 1991. Prospects for gene transmformation in insects. Annual Review Of Entomology. 36:159-183.
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Ecdysteroid receptors in Drosophila melanogaster adult females
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(Peer Reviewed Journal)
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Handler, A.M., Maroy, P. 1989. Ecdysteroid receptors in Drosophila melanogaster adult females. Molecular and Cellular Endocrinology. 63:103-109.
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Identification and analysis of the major yolk polypeptide from the caribbean fruit fly, Anastrepha suspensa (Loew)
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(Peer Reviewed Journal)
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Handler, A.M., Galette, A.S. 1988. Identification and analysis of the major yolk polypeptide from the caribbean fruit fly, Anastrepha suspensa (Loew). Archives of Insect Biochemistry and Physiology. 9:91-106.
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Mobility of P elements in drosophilids and nondrosophilids
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(Peer Reviewed Journal)
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Handler, A.M., O'Brochta, D. . 1988. Mobility of P elements in drosophilids and nondrosophilids. Proceedings of the National Academy of Sciences. 85:6052-6056.
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