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ARS Home » Northeast Area » Beltsville, Maryland (BHNRC) » Beltsville Human Nutrition Research Center » Diet, Genomics and Immunology Laboratory » People & Locations » Allen Smith

Allen D Smith
Diet, Genomics and Immunology Laboratory
Research Virologist

Phone: (301) 504-8577 ext. 280
Fax: (301) 504-9062
Room 228

10300 BALTIMORE AVENUE
307 BARC-EAST
BLDG 307-C BARC-EAST
BELTSVILLE , MD 207052350
Projects
Effect of Resistant Starch and Cruciferous Vegetables on Mucosal Immunity and Disease Resistance
In-House Appropriated (D)
  Accession Number: 436393

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Pomegranate peel extract alters the microbiome in mice and dysbiosis caused by Citrobacter rodentium infection -
The regulatory actions of retinoic acid on M2 polarization of porcine macrophages -
Chen, C.T., Perry, T.L., Chitko-Mckown, C.G., Smith, A.D., Cheung, L., Beshah, E., Urban Jr, J.F., Dawson, H.D. 2019. The regulatory actions of retinoic acid on M2 polarization of porcine macrophages. Developmental and Comparative Immunology. 98(9):20-23. https://doi.org/10.1016/j.dci.2019.03.020.
Impact of micronutrients on the immune response of animals -
Smith, A.D., Panickar, K.S., Urban Jr, J.F., Dawson, H.D. 2018. Impact of micronutrients on the immune response of animals. Annual Review of Animal Biosciences. 6:227-254. https://doi.org/10.1146/annurev-animal-022516-022914.
ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production -
Damie, S.R., Martin, R.K., Cockburn, C.L., Lownik, J.C., Carlyon, J.A., Smith, A.D., Conrad, D.H. 2017. ADAM10 and Notch1 on murine dendritic cells control the development of type 2 immunity and IgE production. Allergy. 148(4):542-551. https://doi.org//101111/a11.13261.
Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice -
Ma, E.L., Smith, A.D., Desai, N., Cheung, L., Hanscom, M., Stoica, B.A., Loane, D.J., Shea-Donohue, T., Faden, A.I. 2017. Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice. Brain Behavior and Immunity. pii: S0889-1591(17)30207-6. doi: 10.1016/j.bbi.2017.06.018.
Transcriptomic analysis of swarm motility phenotype of Salmonella enterica serovar Typhimurium mutant defective in periplasmic glucan synthesis -
Bhagwat, A.A., Young, L., Smith, A.D., Bhagwat, M. 2017. Transcriptomic analysis of swarm motility phenotype of Salmonella enterica serovar Typhimurium mutant defective in periplasmic glucan synthesis. Current Microbiology. doi:10.1007/s00284-017-1267-1.
Parasites, nutrition, immune responses, and biology of metabolic tissues -
Shea-Donohue, T., Qin, B., Smith, A.D. 2017. Parasites, nutrition, immune responses, and biology of metabolic tissues. Parasite Immunology. 39(5). doi: 10.1111/pim.12422
An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome -
Dawson, H.D., Smith, A.D., Chen, C.T., Urban Jr, J.F. 2016. An in-depth comparison of the porcine, murine and human inflammasomes; lessons from the porcine genome and transcriptome. Veterinary Microbiology. pii:S0378-1135(16)30137-7. doi: 10.1016/j.vetmic.2016.05.013.
Acidic Chitinase Limits Allergic Inflammation and Promotes Intestinal Nematode Expulsion -
Vannella, K.M., Ramalingam, T.R., De Queiroz, P.R., Sciurba, J., Barron, L., Borthwick, L., Smith, A.D., Mentink-Kane, M., White, S., Thompson, R.W., Cheever, A.W., Bock, K., Moore, I., Fitz, L.J., Urban Jr, J.F., Wynn, T.A. 2016. Acidic Chitinase Limits Allergic Inflammation and Promotes Intestinal Nematode Expulsion. Nature Immunology. 17(5):538-44 doi: 101038/ni.3417.
Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of nippostrongylus brasiliensis through induction of Th2 cytokines -
Mclean, L.P., Smith, A.D., Cheung, L., Urban Jr, J.F., Sun, R., Grinchuk, V., Dasai, Zhao, A., Raufman, J.P., Shea-Donohue, T. 2016. Type 3 muscarinic receptors contribute to intestinal mucosal homeostasis and clearance of nippostrongylus brasiliensis through induction of Th2 cytokines. American Journal of Physiology - Gastrointestinal and Liver Physiology. 311(1):G130-141. doi: 10.1152/ajpgi.00461.2014.
Understanding the host-adapted state of Citrobacter rodentium by transcriptomic analysis -
Smith, A.D., Yan, X., Chen, C.T., Dawson, H.D., Bhagwat, A.A. 2016. Understanding the host-adapted state of Citrobacter rodentium by transcriptomic analysis. Archives Of Microbiology. 198:353-362.
IL-25 or IL-17E protects against high-fat diet-induced hepatic steatosis in mice dependent upon IL-13 activation of STAT6 -
Wang, A., Yang, Z., Grinchuk, V., Smith, A.D., Qin, B., Lu, N., Wang, D., Wang, H., Ramalingam, T.R., Wynn, T.A., Urban Jr, J.F., Shea-Donohue, T., Zhao, A. 2015. IL-25 or IL-17E protects against high-fat diet-induced hepatic steatosis in mice dependent upon IL-13 activation of STAT6. Journal of Immunology. 195(10): 4771-4780. doi:10.4049/jimmunol.1500337.
Immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis -
Fricke, F.W., Song, Y., Wang, A., Smith, A.D., Grinchuk, V., Mongodin, E., Pei, C., Ma, B., Lu, N., Urban Jr, J.F., Shea-Donohue, T. 2015. Immunity-dependent reduction of segmented filamentous bacteria in mice infected with the helminthic parasite Nippostrongylus brasiliensis. BMC Microbiome. doi: 10.1186/S40168-015-0103-8.
Swarm and swim motilities of Salmonella enterica serovar Typhimurium and role of osmoregulated periplasmic glucans -
Dharne, M., Kannan, P., Murphy, C.F., Smith, A.D., Bhagwat, A.A. 2015. Swarm and swim motilities of Salmonella enterica serovar Typhimurium and role of osmoregulated periplasmic glucans. Microbiology Discovery. 3:3.
Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium -
Mclean, L.P., Smith, A.D., Cheung, L., Sun, R., Grinchuk, V., Vanuytsel, T., Desai, N., Urban Jr, J.F., Zhao, A., Raufman, J.P., Shea-Donohue, T. 2015. Type 3 Muscarinic Receptors Contribute to Clearance of Citrobacter rodentium. Inflammatory Bowel Diseases. DOI: 10.1097/MIB.0000000000000408.
Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice -
Wang, A., Smith, A.D., Li, Y., Urban Jr, J.F., Thirumalai, R.R., Wynn, T., Lu, N., Shea-Donohue, T., Yang, Z., Zhao, A. 2014. Genetic deletion of IL-25 (IL-17E) confers resistance to dextran sulfate sodium-induced colitis in mice. Cell & Bioscience. DOI: 10.1186/2045-3701-4-72.
Evaluation of ribosomal RNA removal protocols for Salmonella RNA-Seq projects -
Bhagwat, A., Z Ying, I., Smith, A. 2013. Evaluation of ribosomal RNA removal protocols for Salmonella RNA-Seq projects. Advances in Microbiology. 4:25-32.
Determining RNA quality for NextGen sequencing: some exceptions to the gold standard rule of 23S to 16S rRNA ratio -
Bhagwat, A.A., Ying, I., Karns, J.S., Smith, A.D. 2013. Determining RNA quality for NextGen sequencing: some exceptions to the gold standard rule of 23S to 16S rRNA ratio. Advances in Microbiology. 1:10.
Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity -
Yang, Z., Grinchuk, V., Smith, A.D., Qin, B., Bohl, J.A., Sun, R., Notari, L., Zhang, Z., Sesaki, H., Urban Jr, J.F., Shea-Donahue, T., Zhao, A. 2013. Parasitic nematode-induced modulation of body weight and associated metabolic dysfunction in mouse models of obesity. Infection and Immunity. 81(6):1905-1914.
Selenium status alters the immune response and expulsion of adult Heligmosomodies bakeri in mice -
Smith, A.D., Cheung, L., Shea-Donohue, T., Urban Jr, J.F. 2013. Selenium status alters the immune response and expulsion of adult Heligmosomodies bakeri in mice. Infection and Immunity. 81(7):2546-2553.
Hypervirulent- host-associated Citrobacter rodentium cells have poor acid tolerance -
Smith, A.D., Bhagwat, A.A. 2013. Hypervirulent- host-associated Citrobacter rodentium cells have poor acid tolerance. Current Microbiology. 66(5):522-526.
Role of anionic charges of osmoregulated periplasmic glucans of Salmonella enterica Serovar Typhimurium SL1344 in mice virulence Reprint Icon -
Bhagwat, A.A., Kannan, P., Leow, Y., Dharne, M., Smith, A.D. 2012. Role of anionic charges of osmoregulated periplasmic glucans of Salmonella enterica Serovar Typhimurium SL1344 in mice virulence. Archives Of Microbiology. 194(6):541-548.
Long-term selenium deficiency increases the pathogenicity of a Citrobacter rodentium infection in mice -
Smith, A.D., Cheung, L., Botero, S. 2011. Long-term selenium deficiency increases the pathogenicity of a Citrobacter rodentium infection in mice. Biological Trace Element Research. Available: dx.doi.org/10.1007/S12011-011-9071-4.
The pathogenicity of an enteric Citrobacter rodentium infection is enhanced by deficiencies in the antioxidants selenium and vitamin E -
Smith, A.D., Botero, S., Shea-Donohue, T., Urban Jr, J.F. 2011. The pathogenicity of an enteric Citrobacter rodentium infection is enhanced by deficiencies in the antioxidants selenium and vitamin E. Infection and Immunity. 79:1471-1478.
Enteric pathogens and gut function: role of cytokines and STATs -
Shea-Donohue, T., Fasano, A., Smith, A.D., Zhao, A. 2010. Enteric pathogens and gut function: role of cytokines and STATs. Gut Microbes. 1(5):316-324.
Osmoregulated periplasmic glucans synthesis gene family of Shigella flexneri Reprint Icon -
Liu, L., Dharne, M., Kannan, P., Smith, A.D., Meng, J., Fan, M., Boren, T., Ranallo, R., Bhagwat, A.A. 2010. Osmoregulated periplasmic glucans synthesis gene family of Shigella flexneri. Archives Of Microbiology. 192(3):167-174.
Motility revertants of opgGH mutants of Salmonella enterica serovar Typhimurium remain defective in mice virulence -
Kannan, P., Dharne, M., Smith, A.D., Karns, J.S., Bhagwat, A.A. 2009. Motility revertants of opgGH mutants of Salmonella enterica serovar Typhimurium remain defective in mice virulence. Current Microbiology. 59(6):641-645.
Osmoregulated periplasmic glucans are needed for competitive growth and biofilm formation by Salmonella enterica serovar Typhimurium in leafy-green vegetable wash-waters and colonization in mice -
Liu, L., Tan, S., Jun, W., Smith, A.D., Meng, J., Bhagwat, A.A. 2008. Osmoregulated periplasmic glucans are needed for competitive growth and biofilm formation by Salmonella enterica serovar Typhimurium in leafy-green vegetable wash-waters and colonization in mice. FEMS Microbiology Letters. 292:13-20.
Characterization of Salmonella isolates from retail foods based on serotyping, pulse field gel electrophoresis, antibiotic resistance and other phenotypic properties -
Xia, X., Zhao, S., Smith, A.D., Mcevoy, J.L., Jianghong, M., Bhagwat, A.A. 2009. Characterization of Salmonella isolates from retail foods based on serotyping, pulse field gel electrophoresis, antibiotic resistance and other phenotypic properties. International Journal of Food Microbiology. 129:93-98.
Osmoregulated periplasmic glucans of Salmonella enterica serovar Typhimurium are required for optimal virulence in mice -
Bhagwat, A.A., Jun, W., Liu, L., Porteen, K., Dharne, M., Pheh, B., Tall, B.D., Kothary, M.H., Gross, K.C., Angle, S., Jianghong, M., Smith, A.D. 2009. Osmoregulated periplasmic glucans of Salmonella enterica serovar Typhimurium are required for optimal virulence in mice. Microbiology. 155:229-237.
Copper deficiency increases the virulence of amyocarditic and myocarditic strains of cocksackievirus B3 in Mice -
Smith, A.D., Botero, S., Levander, O. 2008. Copper deficiency increases the virulence of amyocarditic and myocarditic strains of cocksackievirus B3 in mice. Journal of Nutrition. 138(5):849-55.
Intestinal inflammation caused by magnesium deficiency alters basal and oxidative stress-induced intestinal function -
Scanlan, B.J., Tuft, B., Elfrey, J.E., Smith, A., Zhao, A., Morimoto, M., Chmielinska, J.J., Tejero-Taldo, M.I., Mak, I.T., Weglicki, W.B., and Shea-Donohue, T. 2007. Intestinal inflammation caused by magnesium deficiency alters basal and oxidative stress-induced intestinal function. Molecular and Cellular Biochemistry. Jul27;[Epub ahead of print].
Selenium (Se) deficiency alters intestinal diaphorase activity in mice infected with the intestinal parasitic worm Heligmosomoides polygyrus -
Urban Jr, J.F., Smith, A.D., Botero, S., Dawson, H.D., Anthony, R., Gause, W., Shea-Donohue, T. 2007. Selenium (Se) deficiency alters intestinal diaphorase activity in mice infected with the intestinal parasitic worm Heligmosomoides polygyrus. Experimental Biology.
COPPER DEFICIENCY INCREASES THE VIRULENCE OF COXSACKIEVIRUS B3 INFECTIONS IN MICE. -
Smith, A.D., Botero, S., Levander, O.A. 2006. Copper deficiency increases the virulence of coxsackievirus B3 infections in mice [abstract]. Federation of American Societies for Experimental Biology Conference. 20(4):A554.
GLUTATHIONE IS REQUIRED FOR EFFICIENT PRODUCTION OF INFECTIOUS PICORNAVIRUSES VIRIONS -
Smith, A.D., Dawson, H.D. 2006. Glutathione is required for efficient production of infectious picornavirus virions. Electronic Virology. Available: http://www.sciencedirect.com/
EFFECT OF PHYSICAL RESTRAINT ON OXIDATIVE STRESS IN MICE FED A SELENIUM AND VITAMIN E DEFICIENT DIET -
South, P., Smith, A.D., Guidry, C.A., Levander, O.A. 2006. Effect of physical restraint on oxidative stress in mice fed a selenium and vitamin e deficient diet[abstract]. Biological Trace Element Research. 109(3):293-300.
EFFECT OF PHYSICAL RESTRAINT ON OXIDATIVE STRESS IN MICE FED A SELENIUM AND VITAMIN E DEFICIENT DIET -
South, P.K., Smith, A.D., Guidry, C.A., Levander, O.A. 2006. Effect of physical restraint on oxidative stress in mice fed a selenium and vitamin E deficient diet. Biological Trace Element Research. 109(3):293-300.
PRETREATMENT OF HELA CELLS WITH THE GLUTATHIONE SYNTHESIS INHIBITOR, L-BUTHIONINE-SULFOXIMINE (BSO), INHIBITS REPLICATION OF PICORNAVIRUSES -
Smith, A.D. 2005. Pretreatment of hela cells with the glutathione synthesis inhibitor, l-buthionine-sulfoximine (bso), inhibits replication of picornaviruses. Federation of American Societies for Experimental Biology Conference.
EFFECT OF SELENIUM AND/OR VITAMIN E DEFICIENCIES ON HELIGMOSOMOIDES POLYGYRUS INFECTIONS IN MICE -
Smith, A.D., Madden, K. B., Au Yeung, K., Zhao, A., Elfrey, J., Finkelman, F., Levander, O.A., Shea Donohue, P.T., and Urban Jr, J.F. 2005. Effect of selenium and/or vitamin E deficiencies on Heligmosomoides polygyrus infections in mice. Journal of Nutrition. 135:830-836.
IMPACT OF VITAMIN E OR SELENIUM DEFICIENCY ON NEMATODE-INDUCED ALERATIONS IN MURINE INTESTINAL FUNCTION -
Auyeung, K., Smith, A.D., Zhao, A., Madden, K., Elfrey, J., Sullivan, C., Levander, O.A., Urban Jr, J.F., Shea Donohue, P.T. 2005. Impact of vitamin E or selenium deficiency on nematode-induced alerations in murine intestinal function. Experimental Parasitology. 109:201-208.
MEMBRANE-DERIVED OLIGOSACCHARIDES OF SALMONELLA ENTERICA SEROVAR TYPHIMURIUM -
Jun, W., Bhagwat, A.A., Gross, K.C., Smith, A.D., Angle, S.J. 2004. Membrane-derived oligosaccharides of Salmonella enterica serovar Typhimurium. American Society for Microbiology Annual Meeting. p. 107.
SELENIUM (SE) AND VITAMIN E (VE) DEFICIENCIES IMPAIR INTESTINAL FUNCTION AND RESULT IN PERSISTENT INFECTION WITH HELIGMOSOMOIDES POLYGYRUS -
Smith, A.D., Madden, K., Zhao, A., Auyeung, K., Levander, O.A., Finkelman, F., Urban Jr, J.F., Shea Donohue, P.T. 2004. Selenium (se) and vitamin E (ve) deficiencies impair intestinal function and result in persistent infection with heligmosomoides polygyrus [abstract]. Federation of American Society of Experimental Biology Journal. 18(4):A9.
STUDY OF THE EFFECT OF COPPER DEFICIENCY ON CVB3/0 AND CVB3/20 INFECTIONS: THE LIGHT MICROSCOPIC EVALUATION OF THE PANCREATA AND HEARTS OF C3H/HEJ MICE -
Nelva, B., Levander, O.A., Hines, F., Smith, A.D. 2004. Study of the effect of copper deficiency on cvb3/0 and cvb3/20 infections: The light microscopic evaluation of the pancreata and hearts of c3h/hej mice [abstract]. Toxicologic Pathology. 32(1):146.
CRYSTAL STRUCTURE OF A HUMAN RHINOVIRUS TYPE 14 (HRV14): HUMAN IMMUNO- DEFICIENCY VIRUS TYPE 1 (HIV-1) V3 LOOP CHIMERIC VIRUS THAT INDUCES NEUTRALIZING ANTIBODIES AGAINST HIV-1. -
Ding, J., Smith, A.D., Geisler, S., Arnold, G., Arnold, E. 2002. Crystal structure of a human rhinovirus type 14 (hrv14): human immuno- deficiency virus type 1 (hiv-1) v3 loop chimeric virus that induces neutralizing antibodies against hiv-1.. Structure.
EFFECTS OF DIETARY IRON OVERLOAD ON GLUTATHIONE PEROXIDASE KNOCK-OUT MICE -
South, P., Levander, O.A., Smith, A.D. 2002. Effects of dietary iron overload on glutathione peroxidase knock-out mice. Biological Trace Element Research.
EFFECT OF GOLD (I) COMPOUNDS ON THE VIRULENCE OF AN AMYOCORDITIC STRAIN OF COXSACKIEVIRUS -
Smith, A.D., South, P.K., Levander, O.A. 2001. Effect of gold (i) compounds on the virulence of an amyocorditic strain of coxsackievirus. Biological Trace Element Research.
HIGH THROUGHPUT 96-WELL MICROPLATE ASSAY FOR DETERMINING THE SPECIFIC ACTIVITIES OF GLUTATHIONE PEROXIDASE AND THIOREDOXIN REDUCTASE -
Smith, A.D., Levander, O.A. 2002. High throughput 96-well microplate assay for determining the specific activities of glutathione peroxidase and thioredoxin reductase. Methods in Enzymology.