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Sean H Adams
Arkansas Children's Nutrition Center
Center Director

Phone: (501) 364-2785
Fax:

USDA, ARS, ARKANSAS CHILDREN`S NUTRITION CENTER
15 CHILDREN`S WAY
LITTLE ROCK , AR 72202

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long-chain fatty acid acid oxidation disorders -
McCoin, C.S., Gillingham, M.B., Knotts, T.A., Vockley, J., Ono-Moore, K.D., Blackburn, M.L., Norman, J.E., Adams, S.H. 2019. Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long-chain fatty acid acid oxidation disorders. Physiological Reports. https://doi.org/10.14814/phy2.14037.
Weight loss and fitness intervention increases markers of hepatic bile acid (BA) synthesis, while reducing serum total BA concentrations in sedentary, obese insulin resistant women -
Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats -
Zybaylov, B.L., Glazko, G.V., Rahmatallah, Y., Andreyev, D.S., Mcelroy, T., Karaduta, O., Byrum, S.D., Orr, L., Tackett, A.J., Mackintosh, S.G., Edmondson, R.D., Kieffer, D.A., Martin, R.J., Adams, S.H., Vaziri, N.D., Arthur, J.M. 2019. Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats. PLoS One. 14(1): e0199274. https://doi.org/10.1371/journal.pone.0199274.
Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: Application in rats and humans -
Zhang, J., Bhattacharyya, S., Hickner, R.C., Light, A.R., Lambert, C.J., Gale, B.K., Fiehn, O., Adams, S.H. 2018. Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: Application in rats and humans. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00156.2018.
Binding energies and the entry route of palmitic acid and palmitoylcarnitine into myoglobin -
Chintapalli, S.V., Anishkin, A., Adams, S.H. 2018. Binding energies and the entry route of palmitic acid and palmitoylcarnitine into myoglobin. Data in Brief. 21: 1106-1110. http://doi.org/10.1016/j.dib.2018.10.118.
Caesarean section delivery impacts infant brain development -
Deoni, S.C., Adams, S.H., Li, X., Badger, T.M., Pivik, T., Glasier, C.M., Ramakrishnaiah, R.H., Rowell, A.C., Ou, X. 2018. Caesarean section delivery impacts infant brain development. American Journal of Neuroradiology. https://doi.org/10.3174/ajnr.A5887.
Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin -
Chintapalli, S.V., Anishkin, A., Adams, S.H. 2018. Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin. Archives Of Biochemistry and Biophysics. https://doi.org/10.1016/j.abb.2018.07.024.
Functional differences in platelet mitochondrial respiration in children with excess weight -
Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis type 2-diabetes mellitus rat model -
Piccolo, B.D., Graham, J.L., Stanhope, K.L., Nookaew, I., Mercer, K.E., Chintapalli, S.V., Wankhade, U.D., Shankar, K., Havel, P.J., Adams, S.H. 2018. Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis type 2-diabetes mellitus rat model. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00203.2018.
Is palmitate truly pro-inflammatory? Experimental confounders and context-specificity -
Ono-Moore, K.D., Blackburn1, M.L., Adams, S.H. 2018. Is palmitate truly pro-inflammatory? Experimental confounders and context-specificity. American Journal of Physiology - Endocrinology and Metabolism. http://doi.org/10.1152/ajpendo.00187.2018.
Dehydroabietic Acid (DHAA) distinguishes early vs late stages of diabetes and is associated with bacterial species and bacterial metabolic pathways in the UC Davis-Type 2 Diabetes (UCD-T2DM) rat model -
Putative inflammatory effects of saturated fatty acids: Experimental confounders and context-specificity -
Fuel trafficking in muscle—potential role of myoglobin/lipid binding -
Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation -
Bhattacharyya, S., Ali, M., Smith, W.H., Minkler, P.E., Stoll, M.S., Hoppel, C.L., Adams, S.H. 2017. Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation. American Journal of Physiology - Endocrinology and Metabolism. doi:10.1152/ajpendo.00222.2017.
Early postnatal diets affect the bioregional small intestine microbiome and ileal metabolome in neonatal piglets -
Piccolo, B.D., Mercer, K.E., Bhattacharya, S., Bowlin, A.K., Saraf, M.K., Pack, L., Chintapalli, S.V., Shankar, K., Adams, S.H., Badger, T.M., Yeruva, L. 2017. Early postnatal diets affect the bioregional small intestine microbiome and ileal metabolome in neonatal piglets. Journal of Nutrition. doi:10.3945/jn.117.252767.
Neonatal diet composition modulates ileum mitochondrial function in a neonatal pig model Eugenia Carvalho1 -
Carvalho, E., Moreira, A.R., Bowlin, A.K., Saraf, M.K., Adams, S.H., Borsheim, E., Yeruva, L. 2017. Neonatal diet composition modulates ileum mitochondrial function in a neonatal pig model Eugenia Carvalho1. Journal of Federation of American Societies for Experimental Biology. 31:654.1.
Early diet has differential effects on the small intestine microbiome by region in neonatal piglets -
Piccolo, B., Bowlin, A., Saraf, M., Mercer, K., Bhattacharya, S., Chintapalli, S., Adams, S.H., Shankar, K., Badger, T.M., Yeruva, L. 2017. Early diet has differential effects on the small intestine microbiome by region in neonatal piglets. Journal of Federation of American Societies for Experimental Biology. 31:444.1.
Associations among the cecal microbiome and bacterially-derived cecal xeno-metabolites during diabetes progression in the UC Davis-Type 2 diabetes rat model -
Application of an in vivo hepatic triacylglycerol production method in the setting of a high fat diet in mice -
Ono-Moore, K.D., Ferguson, M., Blackburn, M.L., Issafras, H., Adams, S.H. 2016. Application of an in vivo hepatic triacylglycerol production method in the setting of a high fat diet in mice. Nutrients. 9(1):16. doi:10.3390/nu9010016.
A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3 -
Aguer, C., Piccolo, B., Fiehn, O., Adams, S.H., Harper, M. 2016. A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3. Journal of Federation of American Societies for Experimental Biology. doi:10.1096/fj.201600914R.
Novel molecular interactions of acylcarnitines and fatty acids with myoglobin -
Chintapalli, S.V., Jayanthi, S., Mallipeddi, P.L., Gundampati, R.K., Suresh Kumar, T.K., Van Rossum, D.B., Anishkin, A., Adams, S.H. 2016. Novel molecular interactions of acylcarnitines and fatty acids with myoglobin. Journal of Biological Chemistry. 291(48):25133-25143. doi:10.1074/jbc.M116.754978.
Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons -
Zhang, J., Light, A.R., Hoppel, C.L., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Hughen, R.W., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., Garvey, W.T., Harper, M., Fiehn, O., Adams, S.H. 2017. Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Experimental Physiology. 102(1):48-69. doi:10.1113/EP086019.
Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria -
Kieffer, D.A., Piccolo, B.D., Marco, M.L., Kim, E., Goodson, M.L., Keenan, M.J., Dunn, T.N., Knudsen, K., Martin, R.J., Adams, S.H. 2016. Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria. Journal of Nutrition. doi:10.3945/jn.116.238931.
Obese mice fed a diet supplemented with enzyme-treated wheat bran display marked shifts in the liver metabolome concurrent with altered gut bacteria -
Kieffer, D.A., Piccolo, B.D., Marco, M.L., Kim, E., Goodson, M.L., Keenan, M.J., Dunn, T.N., Knudsen, K.E., Adams, S.H., Martin, R.J. 2016. Obese mice fed a diet supplemented with enzyme-treated wheat bran display marked shifts in the liver metabolome concurrent with altered gut bacteria. Journal of Nutrition. doi:10.3945/jn.116.238923.
Profiling of urinary bile acids in piglets by a combination of enzymatic deconjugation and targeted LC-MRM-MS -
Fang, N., Yu, S., Adams, S.H., Ronis, M.J., Badger, T.M. 2016. Profiling of urinary bile acids in piglets by a combination of enzymatic deconjugation and targeted LC-MRM-MS. Journal of Lipid Research. doi:10.1194/jlr.D069831.
Impact of dietary fibers on nutrient management and detoxification organs: Gut, liver, and kidneys -
Kieffer, D., Martin, R.J., Adams, S.H. 2016. Impact of dietary fibers on nutrient management and detoxification organs: Gut, liver, and kidneys. Advances in Nutrition. 7(6):1111-1121. doi:10.3945/an.116.013219.
Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model -
Piccolo, B., Graham, J., Stanhope, K., Fiehn, O., Havel, P., Adams, S.H. 2016. Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model. American Journal of Physiology - Endocrinology and Metabolism. 310(11):958-969. doi: 10.1152/ajpendo.00052.2016.
Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators -
Bedinger, D.H., Adams, S.H. 2015. Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators. Molecular and Cellular Endocrinology. 415:143-156. doi: 10.1016/j.mce.2015.08.013.
Acylcarnitines: old actors auditioning for new roles in metabolic physiology -
Mccoin, C.S., Knotts, T.A., Adams, S.H. 2015. Acylcarnitines: Old actors auditioning for new roles in metabolic physiology. Nature Reviews Endocrinology. doi:10.1038/2015.129.
Enzyme-treated wheat bran alters gut microbiota and liver metabolome in mice fed a high fat diet -
Kieffer, D.A., Martin, R.J., Piccolo, B.D., Marco, M.L., Kim, E.B., Keenan, K.E., Knudsten, T.N., Dunn, T.N., Adams, S.H. 2015. Enzyme-treated wheat bran alters gut microbiota and liver metabolome in mice fed a high fat diet. Federation of American Societies for Experimental Biology Conference. 29(1):258.6.
Differential pathway coupling efficiency of the activated insulin receptor drives signaling selectivity by xmeta, an allosteric partial agonist antibody -
Bedinger, D.H., Goldfine, I.D., Corbin, J.A., Roell, M.K., Adams, S.H. 2015. Differential pathway coupling efficiency of the activated insulin receptor drives signaling selectivity by xmeta, an allosteric partial agonist antibody. Journal of Pharmacology and Experimental Therapeutics. 353(1):35-43.
Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial -
Piccolo, B.D., Comerford, K.B., Karakas, S.E., Knotts, T.A., Fiehn, O., Adams, S.H. 2015. Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial. Journal of Nutrition. 145(4):691-700, R1-R134.
High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease -
Vaziri, N.D., Oiu, S., Lau, W., Nazertehrani, S., Farzaneh, S.H., Kieffer, D.A., Adams, S.H., Martin, R.J. 2014. High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease. PLoS One. 9(12) doi:http://dx.doi.org/10.1371/journal.pone.0114881.
Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures -
Meissen, J.K., Hirahatake, K.M., Adams, S.H., Fiehn, O. 2015. Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures. Metabolomics. 11(3):707-721.
Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction -
Piccolo, B.D., Keim, N.L., Fiehn, O., Adams, S.H., Van Loan, M.D., Newman, J.W. 2014. Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction. Journal of Nutrition. 145(4):681-690.