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Sean H Adams (PhD)
Arkansas Children's Nutrition Center
Center Director

Phone: (501) 364-2785
Fax:

USDA, ARS, ARKANSAS CHILDREN`S NUTRITION CENTER
15 CHILDREN`S WAY
LITTLE ROCK, AR 72202

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Neonatal diet impacts the large intestine luminal metabolome at weaning and post-weaning in piglets fed formula or human milk - (Peer Reviewed Journal)
Human milk and dairy-based formula impact large intestine metabolome profile in a neonatal porcine model - (Abstract Only)
Fibroblast growth factor-21 to adiponectin ratio: A potential biomarker to monitor liver fat in children with obesity Reprint Icon - (Peer Reviewed Journal)
Tas, E., Bai, S., Ou, X., Mercer, K., Lin, H., Mansfield, K., Buchmann, R., Diaz, E.C., Oden, J., Borsheim, E., Adams, S.H., Dranoff, J. 2020. Fibroblast growth factor-21 to adiponectin ratio: A potential biomarker to monitor liver fat in children with obesity. Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2020.00654.
Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women Reprint Icon - (Peer Reviewed Journal)
Grapov, D., Fiehn, O., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Keim, N.L., Hunter, G.R., Fernandez, J.R., Garvey, T., Hoppel, C.L., Harper, M., Newman, J.W., Adams, S.H. 2020. Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women. Physiological Reports. 8(17):e14547. https://doi.org/10.14814/phy2.14547.
Coupling of energy intake and energy expenditure across a temperature spectrum is disrupted at thermoneutrality: Impact of diet-induced obesity in mice - (Peer Reviewed Journal)
Net release and uptake of xenometabolites across intestinal, hepatic, muscle, and renal tissue beds in healthy conscious pigs Reprint Icon - (Peer Reviewed Journal)
Mercer, K.E., Ten Have, G., Pack, L., Lan, R., Deutz, N., Adams, S.H., Piccolo, B.D. 2020. Net release and uptake of xenometabolites across intestinal, hepatic, muscle, and renal tissue beds in healthy conscious pigs. American Journal of Physiology - Gastrointestinal and Liver Physiology. 319(2):G133-G141. https://doi.org/10.1152/ajpgi.00153.2020.
Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites Reprint Icon - (Peer Reviewed Journal)
Mercer, K.E., Yeruva, L., Pack, L., Graham, J.L., Stanhope, K.L., Chintapalli, S.V., Wankhade, U.D., Shankar, K., Havel, P.J., Adams, S.H., Piccolo, B.D. 2020. Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites. American Journal of Physiology - Gastrointestinal and Liver Physiology. 319(2):G157-G169. https://doi.org/10.1152/ajpgi.00105.2020.
Carnitine palmitoyltransferase 2 (CPT2) knockout potentiates palmitate-induced insulin resistance in C2C12 myotubes: Role of palmitoylcarnitine - (Peer Reviewed Journal)
Changes in polyphenolics during storage of products prepared with freeze-dried wild blueberry powder Reprint Icon - (Peer Reviewed Journal)
Lavefve, L., Brownmiller, C., Howard, L., Reeves, D., Adams, S.H., Chen, J., Diaz, E., Mauromoustakos, A. 2020. Changes in polyphenolics during storage of products prepared with freeze-dried wild blueberry powder. Foods. 9(4):466. https://doi.org/10.3390/foods9040466.
Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk Reprint Icon - (Peer Reviewed Journal)
Carvalho, E., Adams, S.H., Borsheim, E., Blackburn, M.L., Ono-Moore, K.D., Cotter, M., Bowlin, A.K., Yeruva, L. 2020. Neonatal diet impacts liver mitochondrial bioenergetics in piglets fed formula or human milk. Biomed Central (BMC) Nutrition. 6:13. https://doi.org/10.1186/s40795-020-00338-7.
Identification and regulation of the xenometabolite derivatives cis- and trans-3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans Reprint Icon - (Peer Reviewed Journal)
Sobhi, H.F., Zhao, X.J., Plomgaard, P., Hoene, M., Karus, B., Niess, A.M., Haring, H.U., Lehmann, R., Adams, S.H., Xu, G., Weigert, C. 2020. Identification and regulation of the xenometabolite derivatives cis- and trans-3,4-methylene-heptanoylcarnitine in plasma and skeletal muscle of exercising humans. American Journal of Physiology - Endocrinology and Metabolism. 318(5):E701-E709. https://doi.org/10.1152/ajpendo.00510.2019.
Metabolomics profiling in response to a cold pressor test - (Abstract Only)
Tight regulation of energy intake and expenditure across a temperature spectrum is disrupted at thermoneutrality - (Abstract Only)
Cardiovascular disease risk factors and platelet mitochondrial function in school-age children - (Abstract Only)
Limited impact of myoglobin knockout on metabolic phenotype in mice fed a high fat diet - (Abstract Only)
Synthesis, spectroscopic characterization & detection of cyclopropyl heptanoylcarnitine stereoisomers in human plasma - (Abstract Only)
Carnitine palmitoyltransferase 2 (CPT2) knockout potentiates palmitate-induced insulin resistance in C2C12 myotubes: Role of palmitoylcarnitine - (Abstract Only)
Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: Impact of a fitness and weight loss intervention Reprint Icon - (Peer Reviewed Journal)
Grapov, D., Fiehn, O., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., Garvey, W., Hoppel, C.L., Harper, M., Adams, S.H. 2019. Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: Impact of a fitness and weight loss intervention. American Journal of Physiology - Endocrinology and Metabolism. 317(6):E999-E1014. https://doi.org/10.1152/ajpendo.00091.2019.
Data from: Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: Impact of a fitness and weight loss intervention Reprint Icon ()
Adams, S.H. 2019. Data from: Exercise plasma metabolomics and xenometabolomics in obese, sedentary, insulin-resistant women: Impact of a fitness and weight loss intervention. Ag Data Commons. https://doi.org/10.15482/USDA.ADC/1504422.
Oxylipin profiling of alzheimer's disease in nondiabetic and type 2 diabetic elderly Reprint Icon - (Peer Reviewed Journal)
Morris, J.K., Piccolo, B.D., John, C.S., Green, Z.D., Thyfault, J.P., Adams, S.H. 2019. Oxylipin profiling of alzheimer's disease in nondiabetic and type 2 diabetic elderly. Metabolites. 9(9): 177. https://doi.org/10.3390/metabo9090177.
Dairy foods and dairy fats: New perspectives on pathways implicated in cardiometabolic health Reprint Icon ()
Hirahatake, K.M., Bruno, R.S., Bolling, B.W., Blesso, C., Alexander, L.M., Adams, S.H. 2019. Dairy foods and dairy fats: New perspectives on pathways implicated in cardiometabolic health. Advances in Nutrition. https://doi.org/10.1093/advances/nmz105.
Perspective: Guiding principles for the implementation of personalized nutrition approaches that benefit health and function Reprint Icon ()
Adams, S.H., Anthony, J.C., Carvajal, R., Chae, L., Khoo, C., Latulippe, M.E., Matusheski, N.V., Mcclung, H.L., Rozga, M., Schmid, C.H., Wopereis, S., Yan, W. 2019. Perspective: Guiding principles for the implementation of personalized nutrition approaches that benefit health and function. Advances in Nutrition. https://doi.org/10.1093/advances/nmz086.
A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women Reprint Icon - (Peer Reviewed Journal)
Rose, S., Carvalho, E., Diaz, E.C., Cotter, M., Bennuri, S.C., Azhar, G., Frye, R.E., Adams, S.H., Borsheim, E. 2019. A comparative study of mitochondrial respiration in circulating blood cells and skeletal muscle fibers in women. American Journal of Physiology - Endocrinology and Metabolism. 317(3):E503-E512. https://doi.org/10.1152/ajpendo.00084.2019.
Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long-chain fatty acid acid oxidation disorders Reprint Icon - (Peer Reviewed Journal)
McCoin, C.S., Gillingham, M.B., Knotts, T.A., Vockley, J., Ono-Moore, K.D., Blackburn, M.L., Norman, J.E., Adams, S.H. 2019. Blood cytokine patterns suggest a modest inflammation phenotype in subjects with long-chain fatty acid acid oxidation disorders. Physiological Reports. https://doi.org/10.14814/phy2.14037.
Weight loss and fitness intervention increases markers of hepatic bile acid (BA) synthesis, while reducing serum total BA concentrations in sedentary, obese insulin resistant women - (Abstract Only)
Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats Reprint Icon - (Peer Reviewed Journal)
Zybaylov, B.L., Glazko, G.V., Rahmatallah, Y., Andreyev, D.S., McElroy, T., Karaduta, O., Byrum, S.D., Orr, L., Tackett, A.J., Mackintosh, S.G., Edmondson, R.D., Kieffer, D.A., Martin, R.J., Adams, S.H., Vaziri, N.D., Arthur, J.M. 2019. Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats. PLoS One. 14(1):e0199274. https://doi.org/10.1371/journal.pone.0199274.
Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: Application in rats and humans Reprint Icon - (Peer Reviewed Journal)
Zhang, J., Bhattacharyya, S., Hickner, R.C., Light, A.R., Lambert, C.J., Gale, B.K., Fiehn, O., Adams, S.H. 2018. Skeletal muscle interstitial fluid metabolomics at rest and associated with an exercise bout: Application in rats and humans. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00156.2018.
Binding energies and the entry route of palmitic acid and palmitoylcarnitine into myoglobin Reprint Icon ()
Chintapalli, S.V., Anishkin, A., Adams, S.H. 2018. Binding energies and the entry route of palmitic acid and palmitoylcarnitine into myoglobin. Data in Brief. 21:1106-1110. http://doi.org/10.1016/j.dib.2018.10.118.
Caesarean section delivery impacts infant brain development Reprint Icon - (Peer Reviewed Journal)
Deoni, S.C., Adams, S.H., Li, X., Badger, T.M., Pivik, T., Glasier, C.M., Ramakrishnaiah, R.H., Rowell, A.C., Ou, X. 2018. Caesarean section delivery impacts infant brain development. American Journal of Neuroradiology. https://doi.org/10.3174/ajnr.A5887.
Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin Reprint Icon - (Peer Reviewed Journal)
Chintapalli, S.V., Anishkin, A., Adams, S.H. 2018. Exploring the entry route of palmitic acid and palmitoylcarnitine into myoglobin. Archives Of Biochemistry and Biophysics. https://doi.org/10.1016/j.abb.2018.07.024.
Functional differences in platelet mitochondrial respiration in children with excess weight - (Abstract Only)
Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis type 2-diabetes mellitus rat model Reprint Icon - (Peer Reviewed Journal)
Piccolo, B.D., Graham, J.L., Stanhope, K.L., Nookaew, I., Mercer, K.E., Chintapalli, S.V., Wankhade, U.D., Shankar, K., Havel, P.J., Adams, S.H. 2018. Diabetes-associated alterations in the cecal microbiome and metabolome are independent of diet or environment in the UC Davis type 2-diabetes mellitus rat model. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00203.2018.
Is palmitate truly pro-inflammatory? Experimental confounders and context-specificity Reprint Icon - (Peer Reviewed Journal)
Ono-Moore, K.D., Blackburn, M.L., Adams, S.H. 2018. Is palmitate truly pro-inflammatory? Experimental confounders and context-specificity. American Journal of Physiology - Endocrinology and Metabolism. http://doi.org/10.1152/ajpendo.00187.2018.
Dehydroabietic Acid (DHAA) distinguishes early vs late stages of diabetes and is associated with bacterial species and bacterial metabolic pathways in the UC Davis-Type 2 Diabetes (UCD-T2DM) rat model - (Abstract Only)
Putative inflammatory effects of saturated fatty acids: Experimental confounders and context-specificity - (Abstract Only)
Fuel trafficking in muscle—potential role of myoglobin/lipid binding - (Abstract Only)
Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation - (Peer Reviewed Journal)
Bhattacharyya, S., Ali, M., Smith, W.H., Minkler, P.E., Stoll, M.S., Hoppel, C.L., Adams, S.H. 2017. Anesthesia and bariatric surgery gut preparation alter plasma acylcarnitines reflective of mitochondrial fat and branched-chain amino acid oxidation. American Journal of Physiology - Endocrinology and Metabolism. doi:10.1152/ajpendo.00222.2017.
Early postnatal diets affect the bioregional small intestine microbiome and ileal metabolome in neonatal piglets - (Peer Reviewed Journal)
Piccolo, B.D., Mercer, K.E., Bhattacharya, S., Bowlin, A.K., Saraf, M.K., Pack, L., Chintapalli, S.V., Shankar, K., Adams, S.H., Badger, T.M., Yeruva, L. 2017. Early postnatal diets affect the bioregional small intestine microbiome and ileal metabolome in neonatal piglets. Journal of Nutrition. doi:10.3945/jn.117.252767.
Neonatal diet composition modulates ileum mitochondrial function in a neonatal pig model Eugenia Carvalho1 - (Abstract Only)
Carvalho, E., Moreira, A.R., Bowlin, A.K., Saraf, M.K., Adams, S.H., Borsheim, E., Yeruva, L. 2017. Neonatal diet composition modulates ileum mitochondrial function in a neonatal pig model Eugenia Carvalho1. Journal of Federation of American Societies for Experimental Biology. 31:654.1.
Early diet has differential effects on the small intestine microbiome by region in neonatal piglets - (Abstract Only)
Piccolo, B., Bowlin, A., Saraf, M., Mercer, K., Bhattacharya, S., Chintapalli, S., Adams, S.H., Shankar, K., Badger, T.M., Yeruva, L. 2017. Early diet has differential effects on the small intestine microbiome by region in neonatal piglets. Journal of Federation of American Societies for Experimental Biology. 31:444.1.
Associations among the cecal microbiome and bacterially-derived cecal xeno-metabolites during diabetes progression in the UC Davis-Type 2 diabetes rat model - (Abstract Only)
Application of an in vivo hepatic triacylglycerol production method in the setting of a high fat diet in mice - (Peer Reviewed Journal)
Ono-Moore, K.D., Ferguson, M., Blackburn, M.L., Issafras, H., Adams, S.H. 2016. Application of an in vivo hepatic triacylglycerol production method in the setting of a high fat diet in mice. Nutrients. 9(1):16. doi:10.3390/nu9010016.
A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3 - (Peer Reviewed Journal)
Aguer, C., Piccolo, B., Fiehn, O., Adams, S.H., Harper, M. 2016. A novel amino acid and metabolomics signature in mice overexpressing muscle uncoupling protein 3. Journal of Federation of American Societies for Experimental Biology. doi:10.1096/fj.201600914R.
Novel molecular interactions of acylcarnitines and fatty acids with myoglobin - (Peer Reviewed Journal)
Chintapalli, S.V., Jayanthi, S., Mallipeddi, P.L., Gundampati, R.K., Suresh Kumar, T.K., Van Rossum, D.B., Anishkin, A., Adams, S.H. 2016. Novel molecular interactions of acylcarnitines and fatty acids with myoglobin. Journal of Biological Chemistry. 291(48):25133-25143. doi:10.1074/jbc.M116.754978.
Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons - (Peer Reviewed Journal)
Zhang, J., Light, A.R., Hoppel, C.L., Campbell, C., Chandler, C.J., Burnett, D.J., Souza, E.C., Casazza, G.A., Hughen, R.W., Keim, N.L., Newman, J.W., Hunter, G.R., Fernandez, J.R., Garvey, W.T., Harper, M., Fiehn, O., Adams, S.H. 2017. Acylcarnitines as markers of exercise-associated fuel partitioning, xenometabolism, and potential signals to muscle afferent neurons. Experimental Physiology. 102(1):48-69. doi:10.1113/EP086019.
Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria - (Peer Reviewed Journal)
Kieffer, D.A., Piccolo, B.D., Marco, M.L., Kim, E., Goodson, M.L., Keenan, M.J., Dunn, T.N., Knudsen, K., Martin, R.J., Adams, S.H. 2016. Mice fed a high-fat diet supplemented with resistant starch display marked shifts in the liver metabolome concurrent with altered gut bacteria. Journal of Nutrition. doi:10.3945/jn.116.238931.
Obese mice fed a diet supplemented with enzyme-treated wheat bran display marked shifts in the liver metabolome concurrent with altered gut bacteria - (Peer Reviewed Journal)
Kieffer, D.A., Piccolo, B.D., Marco, M.L., Kim, E., Goodson, M.L., Keenan, M.J., Dunn, T.N., Knudsen, K.E., Adams, S.H., Martin, R.J. 2016. Obese mice fed a diet supplemented with enzyme-treated wheat bran display marked shifts in the liver metabolome concurrent with altered gut bacteria. Journal of Nutrition. doi:10.3945/jn.116.238923.
Profiling of urinary bile acids in piglets by a combination of enzymatic deconjugation and targeted LC-MRM-MS - (Peer Reviewed Journal)
Fang, N., Yu, S., Adams, S.H., Ronis, M.J., Badger, T.M. 2016. Profiling of urinary bile acids in piglets by a combination of enzymatic deconjugation and targeted LC-MRM-MS. Journal of Lipid Research. doi:10.1194/jlr.D069831.
Impact of dietary fibers on nutrient management and detoxification organs: Gut, liver, and kidneys ()
Kieffer, D., Martin, R.J., Adams, S.H. 2016. Impact of dietary fibers on nutrient management and detoxification organs: Gut, liver, and kidneys. Advances in Nutrition. 7(6):1111-1121. doi:10.3945/an.116.013219.
Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model - (Peer Reviewed Journal)
Piccolo, B., Graham, J., Stanhope, K., Fiehn, O., Havel, P., Adams, S.H. 2016. Plasma amino acid and metabolite signatures tracking diabetes progression in the UCD-T2DM rat model. American Journal of Physiology - Endocrinology and Metabolism. 310(11):958-969. doi: 10.1152/ajpendo.00052.2016.
Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators ()
Bedinger, D.H., Adams, S.H. 2015. Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators. Molecular and Cellular Endocrinology. 415:143-156. doi: 10.1016/j.mce.2015.08.013.
Acylcarnitines: old actors auditioning for new roles in metabolic physiology ()
Mccoin, C.S., Knotts, T.A., Adams, S.H. 2015. Acylcarnitines: Old actors auditioning for new roles in metabolic physiology. Nature Reviews Endocrinology. doi:10.1038/2015.129.
Enzyme-treated wheat bran alters gut microbiota and liver metabolome in mice fed a high fat diet - (Abstract Only)
Kieffer, D.A., Martin, R.J., Piccolo, B.D., Marco, M.L., Kim, E.B., Keenan, K.E., Knudsten, T.N., Dunn, T.N., Adams, S.H. 2015. Enzyme-treated wheat bran alters gut microbiota and liver metabolome in mice fed a high fat diet. Federation of American Societies for Experimental Biology Conference. 29(1):258.6.
Differential pathway coupling efficiency of the activated insulin receptor drives signaling selectivity by xmeta, an allosteric partial agonist antibody - (Peer Reviewed Journal)
Bedinger, D.H., Goldfine, I.D., Corbin, J.A., Roell, M.K., Adams, S.H. 2015. Differential pathway coupling efficiency of the activated insulin receptor drives signaling selectivity by xmeta, an allosteric partial agonist antibody. Journal of Pharmacology and Experimental Therapeutics. 353(1):35-43.
Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial - (Peer Reviewed Journal)
Piccolo, B.D., Comerford, K.B., Karakas, S.E., Knotts, T.A., Fiehn, O., Adams, S.H. 2015. Whey protein supplementation does not alter plasma branched-chained amino acid profiles but results in unique metabolomics patterns in obese women enrolled in an 8-week weight loss trial. Journal of Nutrition. 145(4):691-700, R1-R134.
High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease - (Peer Reviewed Journal)
Vaziri, N.D., Oiu, S., Lau, W., Nazertehrani, S., Farzaneh, S.H., Kieffer, D.A., Adams, S.H., Martin, R.J. 2014. High amylose resistant starch diet ameliorates oxidative stress, inflammation, and progression of chronic kidney disease. PLoS One. 9(12) doi:http://dx.doi.org/10.1371/journal.pone.0114881.
Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures - (Peer Reviewed Journal)
Meissen, J.K., Hirahatake, K.M., Adams, S.H., Fiehn, O. 2015. Temporal metabolomic responses of cultured HepG2 liver cells to high fructose and high glucose exposures. Metabolomics. 11(3):707-721.
Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction - (Peer Reviewed Journal)
Piccolo, B.D., Keim, N.L., Fiehn, O., Adams, S.H., Van Loan, M.D., Newman, J.W. 2014. Habitual physical activity and plasma metabolomic patterns distinguish individuals with low vs. high weight loss during controlled energy restriction. Journal of Nutrition. 145(4):681-690.