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Marcus Kehrli
National Animal Disease Center
Director

Phone: (515) 337-7201
Fax: (515) 337-7149

1920 DAYTON AVE
AMES , IA 50010

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Potential use of G-CSF for protection against Streptococcus suis infection in swine -
Brockmeier, S., Loving, C.L., Eberle, K.C., Hau, S.J., Mou, K.T., Kehrli Jr, M.E. 2019. Administration of granulocyte-colony stimulating factor (G-CSF) to pigs results in a longer mean survival time after exposure to Streptococcus suis. Veterinary Microbiology. 231:116-119. https://doi.org/10.1016/j.vetmic.2019.03.010.
Association of transfer RNA fragments in white blood cells with antibody response to bovine leukemia virus in Holstein cattle -
Taxis, T.M., Kehrli Jr, M.E., D'Orey-Branco, R., Casas, E. 2018. Association of transfer RNA fragments in white blood cells with antibody response to bovine leukemia virus in holstein cattle. Frontiers in Genetics. 9:236. https://doi.org/10.3389/fgene.2018.00236.
Comparison of the transcriptome response within the porcine tracheobronchial lymph node following viral infection -
Miller, L., Fleming, D., Harhay, G., Kehrli, M., Lager, K. 2018. Comparison of the transcriptome response within the porcine tracheobronchial lymph node following viral infection. Proceedings of the World Congress on Genetics Applied to Livestock Production, Volume Biology - Disease Resistance 2: 672.
Transcriptome responses to respiratory virus infection of pigs within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or IAV -
Miller, L.C., Fleming, D.S., Harhay, G.P., Kehrli, Jr., M.E., Lager, K.M. 2018. Transcriptome responses to respiratory virus infection of pigs within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or IAV. The Journal of Immunology. Vol. 200(1 Supplement):59.14.
Transcriptome responses to respiratory virus infection of pigs within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or IAV -
Miller, L.C., Fleming, D.S., Harhay, G.P., Kehrli, Jr., M.E., Lager, K.M. 2018. Transcriptome responses to respiratory virus infection of pigs within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or IAV. Plant & Animal Genome Conference XXVI, January 13-17, 2018, San Diego, California. Paper No. P1222.
Immune Dysfunction in Transition Dairy Cows: Pharmacologic and Dietary Immune Modulation -
Comparison of the transcriptome response within the tracheobronchial lymphnode following infection with PRRSV, PCV2 or SIV -
Miller, L.C., Fleming, D., Harhay, G., Bayles, D., Kehrli, M., Lager, K. 2017. Comparison of the transcriptome response within the tracheobronchial lymphnode following infection with PRRSV, PCV2, or SIV. 98th Conference of Research Workers in Animal Diseases. Abstract No. 190, p. 107.
Immune dysfunction in periparturient dairy cows: Insight into pharmacologic and dietary immune treatments -
Kehrli Jr, M.E. 2017. Immune dysfunction in periparturient dairy cows: Insight into pharmacologic and dietary immune treatments. Mid-South Ruminant Nutrition Conference, August 8-9, 2017, Grapevine, Texas. p. 25-36.
The Bordetella Bps polysaccharide is required for biofilm formation and persistence in the lower respiratory tract of swine -
Nicholson, T.L., Brockmeier, S.L., Sukumar, N., Paharik, A.E., Lister, J.L., Horswill, A.R., Kehrli, M.E. Jr., Loving, C.L., Shore, S.M., Deora, R. 2017. The Bordetella Bps polysaccharide is required for biofilm formation and enhances survival in the lower respiratory tract of swine. Infection and Immunity. 00261-17. doi:10.1128/IAI.00261-17.
Remember the basics when evaluating milk quality on a dairy farm -
Kehrli Jr, M.E., Timms, L. 2017. Remember the basics when evaluating milk quality on a dairy farm. In: 7th International Veterinary Conference, April 19-21, 2017, Ufa, Russia. p. 7.
A review of selected genes with known effects on performance and health of cattle Reprint Icon -
Casas, E., Kehrli Jr., M.E. 2016. A review of selected genes with known effects on performance and health of cattle. Frontiers in Veterinary Science. 3(113). doi: 10.3389/fvets.2016.00113.
Potential use of G-CSF for protection against Streptococcus suis infection in swine -
Brockmeier, S., Loving, C.L., Kehrli Jr, M.E., Eberle, K.C., Hau, S.J., Mou, K.T., Nicholson, T.L. 2016. Potential use of G-CSF for protection against Streptococcus suis infection in swine. Conference Research Workers Disease Meeting. Paper No. P65.
Enhancement of innate immunity with granulocyte colony-stimulating factor did not mitigate disease in pigs infected with a highly pathogenic Chinese PRRSV strain -
Schlink, S.N., Lager, K.M., Brockmeier, S.L., Loving, C.L., Miller, L.C., Vorwald, A.C., Yang, H., Kehrli, Jr., M.E., Faaberg, K.S. 2016. Enhancement of innate immunity with granulocyte colony-stimulating factor did not mitigate disease in pigs infected with a highly pathogenic Chinese PRRSV strain. Veterinary Immunology and Immunopathology. 179:70-76.
Prophylactic administration of vector-encoded porcine granulocyte-colony stimulating factor reduces Salmonella shedding,tonsil colonization,& microbiota alterations of the gastrointestinal tract in Salmonella-challenged swine -
Bearson, S.M., Bearson, B.L., Loving, C.L., Allen, H.K., Lee, I., Madson, D., Kehrli Jr, M.E. 2016. Prophylactic administration of vector-encoded porcine granulocyte-colony stimulating factor reduces Salmonella shedding, tonsil colonization, and microbiota alterations of the gastrointestinal tract in Salmonella-challenged swine. Frontiers in Veterinary Science. 3:66. doi: 10.3389/fvets.2016.00066.
Immunological dysfunction role in transition dairy cow health disorders: biotherapeutics for disease prevention -
Kehrli Jr, M.E. 2015. Immunological dysfunction role in transition dairy cow health disorders: biotherapeutics for disease prevention. In: International Veterinary Congress, April 22-24, 2015, Moscow, Russia. p. 22-44.
Immunological dysfunction in periparturient cows: Evidence, causes and ramifications -
Kehrli Jr, M.E. 2015. Immunological dysfunction in periparturient cows: Evidence, causes and ramifications. Florida Ruminant Nutrition Symposium, February 2-4, 2015, Gainsville, Florida. p. 14-29.
Live attenuated influenza A virus vaccine protects against heterologous challenge with A(H1N1)pdm09 without inducing vaccine associated enhanced respiratory disease -
Gauger, P.C., Loving, C.L., Khurana, S., Lorusso, A., Perez, D.R., Kehrli, Jr., M.E., Roth, J.A., Golding, H., Vincent, A.L. 2014. Live attenuated influenza A virus vaccine protects against A(H1N1)pdm09 heterologous challenge without vaccine associated enhanced respiratory disease. Virology. 471-473:93-104.
Efficacy of type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs -
Lager, K.M., Schlink, S.N., Brockmeier, S.L., Miller, L.C., Henningson, J.N., Kappes, M.A., Kehrli, M.E., Loving, C.L., Guo, B., Swenson, S.L., Yang, H., Faaberg, K.S. 2014. Efficacy of type 2 PRRSV vaccine against Chinese and Vietnamese HP-PRRSV challenge in pigs. Vaccine. 32(48):6457–6462.
Cross-fostering to prevent maternal cell transfer did not prevent vaccine-associated enhanced respiratory disease that occurred following heterologous influenza challenge of pigs vaccinated in presence of maternal immunity -
Loving, C.L., Brockmeier, S.L., Vincent, A.L., Gauger, P.C., Zanella, E.L., Lager, K.M., Kehrli, Jr., M.E. 2014. Cross-fostering to prevent maternal cell transfer did not prevent vaccine-associated enhanced respiratory disease that occurred following heterologous influenza challenge of pigs vaccinated in presence of maternal immunity. Viral Immunology. 27(7):334-342.
Bovine Spongiform Encephalopathy: Atypical Pros and Cons -
Kehrli Jr, M.E., Greenlee, J.J., Nicholson, E.M. 2014. Bovine Spongiform Encephalopathy: Atypical Pros and Cons. Proceedings of the California Animal Nutrition Conference, May 13-16, 2014, Fresno, California. p. 70-81.
Immunological dysfunction in periparturient cows: Evidence, causes and ramifications -
Kehrli Jr, M.E. 2014. Immunological dysfunction in periparturient cows: Evidence, causes and ramifications. Proceedings of the California Animal Nutrition Conference, May 14-15, 2014, Fresno, California. p. 11-29.
Reduced salmonella fecal shedding in swine administered porcine granulocyte-colony stimulating factor (G-CSF) -
Bearson, S.M., Bearson, B.L., Loving, C.L., Allen, H.K., Lee, I.S., Kehrli Jr, M.E. 2014. Reduced salmonella fecal shedding in swine administered porcine granulocyte-colony stimulating factor (G-CSF) [abstract]. In: Proceedings of 114th General Meeting of the American Society for Microbiology, Boston, Massachusetts, May 17-20, 2014. p. 204.
The Bordetella bronchiseptica type III secretion system is required for persistence and disease severity but not transmission in swine Reprint Icon -
Nicholson, T.L., Brockmeier, S.L., Loving, C.L., Register, K.B., Kehrli, Jr., M.E., Shore, S.M. 2014. The Bordetella bronchiseptica type III secretion system is required for persistence and disease severity but not transmission in swine. Infection and Immunity. 82(3):1092-1103.
Status report on Porcine Epidemic Diarrhea Virus in the United States -
Kehrli, Jr., M.E., Stasko, J.A., Lager, K.M. 2014. Status report on porcine epidemic diarrhea virus in the United States. Animal Frontiers. 4(1):44-45.
Swine influenza virus vaccine research and technology: What does the future hold and what are our next steps? -
Kehrli Jr, M.E., Vincent, A.L., Loving, C.L., Lager, K.M. 2013. Swine influenza virus vaccine research and technology: What does the future hold and what are our next steps? Swine Disease Conference Proceedings, November 14-15, 2013, Ames, Iowa. p. 16-20.
Chinese and Vietnamese strains of HP-PRRSV cause different pathogenic outcomes in United States high health swine Reprint Icon -
Guo, B., Lager, K.M., Schlink, S.N., Kehrli, Jr., M.E., Brockmeier, S.L., Miller, L.C., Swensen, S.L., Faaberg, K.S. 2013. Chinese and Vietnamese strains of HP-PRRSV cause different pathogenic outcomes in United States high health swine. Virology. 446(1-2):238-250.
Virulence, transmission, and heterologous protection of four isolates of Haemophilus parasuis Reprint Icon -
Brockmeier, S.L., Loving, C.L., Mullins, M., Register, K.B., Nicholson, T.L., Wiseman, B.S., Baker, R.B., Kehrli, Jr., M.E. 2013. Virulence, transmission, and heterologous protection of four isolates of Haemophilus parasuis. Clinical and Vaccine Immunology. 20(9):1466-1472.
Porcine granulocyte-colony stimulating factor (G-CSF) delivered via replication-defective adenovirus induces a sustained increase in circulating peripheral blood neutrophils -
Loving, C.L., Kehrli, M.E., Brockmeier, S.L., Bayles, D.O., Michael, D.D., Schlink, S.N., Lager, K.M. 2013. Porcine granulocyte-colony stimulating factor (G-CSF) delivered via replication-defective adenovirus induces a sustained increase in circulating peripheral blood neutrophils. Biologicals. Available: http://dx.doi.org/10.1016/j.biologicals.2013.07.001.
Efficacy of inactivated and live-attenuated influenza virus vaccines in pigs against infection and transmission of emerging H3N2 similar to the 2011-2012 H3N2v -
Loving, C.L., Lager, K.M., Vincent, A.L., Brockmeier, S.L., Gauger, P.C., Anderson, T.K., Kitikoon, P., Perez, D.R., Kehrli, Jr., M.E. 2013. Efficacy in pigs of inactivated and live attenuated influenza virus vaccines against infection and transmission of an emerging H3N2 similar to the 2011-2012 H3N2v. Journal of Virology. 87(17):9895-903.
Vaccine-associated enhanced respiratory disease does not interfere with the adaptive immune response following challenge with pandemic A/H1N1 2009 -
Gauger, P.C., Loving, C.L., Lager, K.M., Janke, B.H., Kehrli, Jr., M.E., Roth, J.A., Vincent, A.L. 2013. Vaccine-associated enhanced respiratory disease does not interfere with the adaptive immune response following challenge with pandemic A/H1N1 2009. Viral Immunology. 26(5):314-321.
High-impact animal health research conducted at the USDA's National Animal Disease Center Reprint Icon -
Bannantine, J.P., Olsen, S.C., Kehrli Jr, M.E., Stanton, T.B., Casas, E., Whipple, D.L., Zuelke, K.A. 2013. High-impact animal health research conducted at the USDA's National Animal Disease Center. Veterinary Microbiology. 165(2013):224-233 DOI: 10.1016/j.vetmic.2013.04.010.
A divergent clade of circular single-stranded DNA viruses from pig feces -
Cheung, A.K., Ng, T.F., Lager, K.M., Bayles, D.O., Alt, D.P., Delwart, E.L., Pogranichniy, R.M., Kehrli, Jr., M.E. 2013. A divergent clade of circular single-stranded DNA viruses from pig feces. Archives of Virology. 158(10):2157-2162.
Cross-reactive, linear B cell epitopes of the influenza virus matrix protein 1 -
Lin, K., Vincent, A.L., Roth, J.A., Kehrli, Jr., M.E., Lager, K.M., Ramamoorthy, S. 2013. Cross-reactive, linear B cell epitopes of the influenza virus matrix protein 1. In: Proceedings of the 16th Annual Conference on Vaccine Research. April 22-24, Baltimore, Maryland. p. 115.
Two Asian highly pathogenic strains of Type 2 PRRSV in United States swine -
Faaberg, K., Lager, K., Brockmeier, S., Guo, B., Swenson, S., Yang, H., Kehrli, M., Nicholson, T., Miller, L., Henningson, J., Schlink, S., Kappes, M. 2013. Two Asian highly pathogenic strains of Type 2 PRRSV in United States swine. Positive Strand RNA Viruses, Keystone Symposia on Molecular and Cellular Biology. Paper No. 1063.
Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus Reprint Icon -
Jiang, Z., Zhou, X., Michal, J.J., Wu, X.-L., Zhang, L., Zhang, M., Ding, B., Liu, B., Manoranjan, V.S., Neill, J.D., Harhay, G.P., Kehrli, Jr., M.E., Miller, L.C. 2013. Reactomes of porcine alveolar macrophages infected with porcine reproductive and respiratory syndrome virus. PLoS One. 8(3):e59229.
Fluorescence spectroscopy of the retina from scrapie-infected mice -
Bose, S., Schonenbrucher, H., Richt, J.A., Casey, T., Rasmussen, M.A., Kehrli, Jr., M.E., Petrich, J.W. 2013. Fluorescence spectroscopy of the retina from scrapie-infected mice. Photochemistry and Photobiology. 89(4):864-868. Available: http://dx.doi.org/10.1111/php.12056.
Overview of swine influenza virus vaccine research and technology: What's on the horizon and what do we need to move forward? -
Kehrli, Jr., M.E., Vincent, A.L., Gauger, P.C., Kitikoon, P., Anderson, T.K., Loving, C.L., Lager, K.M. 2013. Overview of swine influenza virus vaccine research and technology: What's on the horizon and what do we need to move forward? In: Proceedings of 44th Annual Meeting of the American Association of Swine Veterinarians, San Diego, CA. p. 517-519.
Comparative transcriptome response in swine tracheobronchial lymph nodes to viral infection -
Miller, L.C., Harhay, G.P., Kehrli, Jr., M.E., Lager, K.M. 2013. Comparative transcriptome response in swine tracheobronchial lymph nodes to viral infection [abstract]. International Plant & Animal Genome XXI, January 12-16, 2013, San Diego, California. Paper No. W756.
Pathogenesis of HP-PRRSV in gnotobiotic pigs -
Lager, K.M., Faaberg, K.S., Brockmeier, S.L., Miller, L.C., Kappes, M.A., Spear, A., Kehrli, Jr., M.E. 2012. Pathogenesis of HP-PRRSV in gnotobiotic pigs. 2012 International PRRS Symposium. p. 92.
Swine tracheobronchial lymph node mRNA responses in swine infected with a highly pathogenic strain of porcine reproductive and respiratory syndrome virus -
Miller, L.C., Fleming, D., Arbogast, A., Bayles, D.O., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Yang, H., Faaberg, K.S., Kehrli, Jr., M.E. 2012. Swine tracheobronchial lymph node mRNA responses in swine infected with a highly pathogenic strain of porcine reproductive and respiratory syndrome virus. 2012 International PRRS Symposium. p. 96.
Infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus -
Guo, B., Lager, K.M., Henningson, J.N., Miller, L.C., Schlink, S.N., Kappes, M.A., Kehrli, Jr., M.E., Brockmeier, S.L., Nicholson, T.L., Yang, H., Faaberg, K.S. 2013. Experimental infection of United States swine with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. Virology. 435(2):372-384.
Biotherapeutics as alternatives to antibiotics: Effects of adenoviral delivered cytokines on innate and adaptive immunity -
Immunological dysfunction in periparturient cows: evidence, causes and ramifications -
Kehrli, Jr., M.E. 2012. Immunological dysfunction in periparturient cows: evidence, causes and ramifications. In: Proceedings of the 2012 Elanco Dairy Science Symposium, October 1-2, 2012, Chicago, Illinois. p. 4.1 - 4.16.
Analysis of the swine tracheobronchial lymphnode transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus -
Miller, L.C., Fleming, D., Arbogast, A., Bayles, D.O., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Yang, H.-C., Faaberg, K.S., Kehrli, Jr., M.E. 2012. Analysis of the swine tracheobronchial lymph node transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus. BioMed Central (BMC) Veterinary Research. 8(1):208. Available: http://www.biomedcentral.com/1746-6148/8/208.
Intranasal vaccination with replication defective adenovirus-5 encoding influenza hemagglutinin elicits protective immunity to homologous challenge and partial protection to heterologous challenge in pigs -
Braucher, D.R., Henningson, J.N., Loving, C.L., Vincent, A.L., Kim, E., Steitz, J., Gambotto, A.A., Kehrli, Jr., M.E. 2012. Intranasal vaccination with replication-defective adenovirus type 5 encoding influenza virus hemagglutinin elicits protective immunity to homologous challenge and partial protection to heterologous challenge in pigs. Clinical and Vaccine Immunology. 19(11):1722-1729.
Analysis of the swine tracheobronchial lymphnode transcriptomic response to infection with a Chinese highly pathogenic strain of porcine reproductive and respiratory syndrome virus -
Genomic sequence and virulence comparison of four type 2 porcine reproductive and respiratory syndrome virus strains -
Brockmeier, S.L., Loving, C.L., Vorwald, A.C., Kehrli, Jr., M.E., Baker, R.B., Nicholson, T.L., Lager, K.M., Miller, L.C., Faaberg, K.S. 2012. Genomic sequence and virulence comparison of four Type 2 porcine reproductive and respiratory syndrome virus strains. Virus Research. 169(1):212-221.
Adenovirus vectored vaccines against influenza a virus do not result in vaccine associated enhanced respiratory disease following heterologous challenge in contrast to whole inactivated virus vaccine -
Henningson, J.N., Braucher, D.R., Vincent, A.L., Loving, C.L., Kitikoon, P., Gauger, P.C., Kehrli, M.E. 2012. Adenovirus vectored vaccines against influenza A virus do not result in vaccine associated enhanced respiratory disease following heterologous challenge in contrast to whole inactivated virus vaccine. American College of Veterinary Pathologists Meeting 63rd Annual Meeting. Paper No. E-2.
Biotherapeutics as alternatives to antibiotics: effects of IFN-a and G-CSF on innate and adaptive immunity in swine -
Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 -
Cheung, A.K., Kehrli, Jr., M.E., Lager, K.M., Gauger, P.C., Rohrer, G.A., Michael, D.D., Miller, L.C., Vincent, A.L., Braucher, D.R. 2012. Development of antinuclear antibodies and a genetic linkage in pigs infected with porcine circovirus type 2 [abstract]. IXth International Congress of Veterinary Virology. p. 189-190.
Kinetics of lung lesion development and pro-inflammatory cytokine response in pigs with vaccine-associated enhanced respiratory disease induced by challenge with pandemic (2009) A/H1N1 influenza virus -
Gauger, P.C., Vincent, A.L., Loving, C.L., Henningson, J.N., Lager, K.M., Janke, B.H., Kehrli Jr, M.E., Roth, J.A. 2012. Kinetics of lung lesion development and pro-inflammatory cytokine response in pigs with vaccine-associated enhanced respiratory disease induced by challenge with pandemic (2009) A/H1N1 influenza virus. Veterinary Pathology. 49(6):900-912.
The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus -
Brockmeier, S.L., Loving, C.L., Nelson, E.A., Miller, L.C., Nicholson, T.L., Register, K.B., Grubman, M.J., Brough, D.E., Kehrli, Jr., M.E. 2012. The presence of alpha interferon at the time of infection alters the innate and adaptive immune responses to porcine reproductive and respiratory syndrome virus. Clinical and Vaccine Immunology. 19(4):508-514.
Effects of interferon-alpha on the immune response to porcine reproductive and respiratory syndrome virus -
Experimental Interspecies Transmission Studies of the Transmissible Spongiform Encephalopathies to Cattle: Comparison to Bovine Spongiform Encephalopathy in Cattle -
Hamir, A.N., Kehrli, Jr., M.E., Kunkle, R.A., Greenlee, J.J., Nicholson, E.M., Richt, J.A., Miller, J.M., Cutlip, R.C. 2011. Experimental interspecies transmission studies of the transmissible spongiform encephalopathies to cattle: comparison to bovine spongiform encephalopathy in cattle. Journal of Veterinary Diagnostic Investigation. 23(3):407-420.
Phenotypic modulation of the Bvg+ phase is not required for pathogenesis and transmission of Bordetella bronchiseptica in swine -
Nicholson, T.L., Brockmeier, S.L., Loving, C.L., Register, K.B., Kehrli, Jr., M.E., Stibitz, S.E., Shore, S.M. 2012. Phenotypic modulation of the virulent Bvg phase is not required for pathogenesis and transmission of Bordetella bronchiseptica in swine. Infection and Immunity. 80(3):1025-1036.
Vaccination with NS1-truncated H3N2 swine influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in pigs -
Kappes, M.A., Sandbulte, M.R., Platt, R., Wang, C., Lager, K.M., Henningson, J.N., Lorusso, A., Vincent, A.L., Loving, C.L., Roth, J.A., Kehrli Jr, M.E. 2012. Vaccination with NS1-truncated H3N2 swine influenza virus primes T cells and confers cross-protection against an H1N1 heterosubtypic challenge in pigs. Vaccine. 30(2):280-288.
Comparison of immune transcriptome response following infection with PRRSV, PCV2 and SIV -
Miller, L.C., Harhay, G., Kehrli, M., Lager, K. 2011. Comparison of immune transcriptome response following infection with PRRSV, PCV2 and SIV [abstract]. 2011 International PRRS Symposium. Paper No. 51. p. 68.
Enhancement of innate immunity with granulocyte colony-stimulating factor did not prevent disease in pigs infected with a highly pathogenic Chinese PRRSV strain -
Schlink, S.N., Lager, K.M., Brockmeier, S.L., Loving, C.L., Henningson, J.N., Faaberg, K.S., Guo, B., Miller, L.C., Vorwald, A.C., Kehrli, Jr., M.E. 2011. Enhancement of innate immunity with granulocyte colony-stimulating factor did not prevent disease in pigs infected with a highly pathogenic Chinese PRRSV strain. 2011 International PRRS Symposium. Paper No. 59. page 76.
Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus -
Brockmeier, S.L., Loving, C.L., Miller, L.C., Vorwald, A.C., Kehrli, Jr., M.E., Baker, R.B., Nicholson, T.L., Lager, K.M., Faaberg, K.S. 2011. Sequence and virulence comparison of four North American isolates of porcine reproductive and respiratory syndrome virus. Conference of Research Workers in Diseases. Paper No. 174. p. 171.
Intranasal vaccination with Ad5-encoding influenza HA elicits sterilizing immunity to homologous challenge and partial protection to heterologous challenge in pigs -
Braucher, D.R., Henningson, J.N., Loving, C.L., Vincent, A.L., Kim, E., Steitz, J., Gambotto, A.A., Kehrli, Jr., M.E. 2011. Intranasal vaccination with Ad5-encoding influenza HA elicits sterilizing immunity to homologous challenge and partial protection to heterologous challenge in pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 131.
Fulminant sepsis is a cardinal sign of HP-PRRSV in pigs -
Lager, K.M., Faaberg, K.S., Guo, B., Brockmeier, S.L., Henningson, J.N., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Nicholson, T.L., Yang, H.-C. 2011. Fulminant sepsis is a cardinal sign of HP-PRRSV in pigs [abstract]. 2011 International PRRS Symposium. Paper No. 60. page 77.
DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs -
Gorres, J.P., Lager, K.M., Kong, W.P., Royals, M., Todd, J.P., Vincent, A.L., Wei, C.J., Loving, C.L., Zanella, E.L., Janke, B., Kehrli, Jr., M.E., Nabel, G.J., Rao, S.S. 2011. DNA vaccination elicits protective immune responses against pandemic and classic swine influenza viruses in pigs. Clinical and Vaccine Immunology. 18(11):1987-1995.
Comparison of the pathogenicity of Chinese and low virulent US porcine reproductive and respiratory syndrome viruses -
Henningson, J.N., Faaberg, K.S., Guo, B., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Brockmeier, S.L., Nicholson, T.L., Vorwald, A.C., Lager, K.M. 2011. Comparison of the pathogenicity of Chinese and low virulent US porcine reproductive and respiratory syndrome viruses [abstract]. American College of Veterinary Pathologists. Paper No. 164. Veterinary Pathology. 48(6):E30.
Leukogram abnormalities in gnotobiotic pigs infected with porcine circovirus type 2 -
Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Cheung, A.K., Butler, J.E., Kehrli, Jr., M.E. 2011. Leukogram abnormalities in gnotobiotic pigs infected with porcine circovirus type 2. Veterinary Microbiology. 154(1-2):185-190.
Postweaning multisystemic wasting syndrome produced in gnotobiotic pigs following exposure to various amounts of porcine circovirus type 2a or type 2b -
Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E., Cheung, A.K. 2011. Postweaning multisystemic wasting syndrome produced in gnotobiotic pigs following exposure to various amounts of porcine circovirus type 2a or type 2b. Veterinary Microbiology. 153(3-4):229-239.
Immune transcriptome response to PRRSV infection -
Miller, L.C., Harhay, G.P., Lager, K.M., Kehrli, Jr., M.E. 2011. Immune transcriptome response to PRRSV infection [abstract]. XIIth International Nidovirus Symposium. p. 79.
Highly pathogenic porcine reproductive and respiratory syndrome virus JXwn06 causes high mortality in vivo -
Kappes, M.A., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Miller, L.C., Brockmeier, S., Kehrli, Jr., M.E., Yang, H., Faaberg, K.S. 2011. Highly pathogenic porcine reproductive and respiratory syndrome virus JXwn06 causes high mortality in vivo [abstract]. XIIth International Nidovirus Symposium. p. 80.
Comparison of Humoral and Cellular Immune Responses to Inactivated Swine Influenza Virus Vaccine in Weaned Pigs -
Platt, R., Vincent, A.L., Gauger, P.C., Loving, C.L., Zanella, E.L., Lager, K.M., Kehrli, Jr., M.E., Kimura, K., Roth, J.A. 2011. Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs. Veterinary Immunology and Immunopathology. 142(3-4):252-257.
Highly pathogenic Chinese porcine reproductive and respiratory syndrome virus strain JXwn06 in US swine -
Kappes, M.A., Guo, B., Lager, K.M., Henningson, J.N., Schlink, S.N., Miller, L.C., Brockmeier, S., Kehrli, Jr., M.E., Yang, H., Faaberg, K.S. 2011. Highly pathogenic Chinese porcine reproductive and respiratory syndrome virus strain JXwn06 in US swine [abstract]. 30th Annual Meeting of the American Society for Virology. p. 211.
HP-PRRSV challenge of 4 and 10-week-old pigs -
Lager, K.M., Faaberg, K.S., Guo, B., Brockmeier, S., Henningson, J.N., Schlink, S.N., Miller, L.C., Kappes, M.A., Kehrli, Jr., M.E., Loving, C.L., Nicholson, T.L., Yang, H.C. 2011. HP-PRRSV challenge of 4 and 10-week-old pigs. In: Proceedings of the 5th Asian PRRSpective Symposium, May 10, 2011, Bangkok, Thailand. 6 pages.
Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus -
Gauger, P.C., Vincent, A.L., Loving, C.L., Lager, K.M., Janke, B.H., Kehrli, Jr., M.E., Roth, J.A. 2011. Enhanced pneumonia and disease in pigs vaccinated with an inactivated human-like (delta-cluster) H1N2 vaccine and challenged with pandemic 2009 H1N1 influenza virus. Vaccine. 29(15):2712-2719.
Pathogenesis and Transmission of Feral Swine Pseudorabies Virus Isolates in Domestic Pigs -
In depth global analysis of transcript abundance levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus -
Miller, L.C., Neill, J.D., Harhay, G.P., Lager, K.M., Laegreid, W.W., Kehrli, Jr., M.E. 2010. In-depth global analysis of transcript abundance levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus. Advances in Virology. 2010:Article 864181. Available: http://downloads.hindawi.com/journals/av/2010/864181.pdf.
Pandemic H1N1 influenza: zoonoses are a two-way street -
G-CSF Analogue Treatment Increases Peripheral Neutrophil Numbers in Pigs - a Potential Alternative for In-Feed Antibiotics -
Loving, C.L., Brockmeier, S.L., Bayles, D.O., Greenlee, J.J., Lager, K.M., Kehrli, Jr., M.E. 2010. G-CSF analogue treatment increases peripheral neutrophil numbers in pigs - a potential alternative for in-feed antibiotics. Conference of Research Workers in Animal Diseases. Paper No. 140.
Comparison of Humoral and Cellular Immune Responses to Inactivated Swine Influenza Virus Vaccine in Weaned Pigs -
Platt, R., Gauger, P., Kimura, K., Roth, J., Vincent, A., Loving, C., Zanella, E., Lager, K., Kehrli, M. 2010. Comparison of humoral and cellular immune responses to inactivated swine influenza virus vaccine in weaned pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 085P/85P.
Pathogenesis Studies of the 2009 Pandemic Influenza Virus and Pseudorabies Virus From Wild Pigs In Swine -
Lager, K.M., Vincent, A.L., Ciacci-Zanella, J.R., Zanella, E.L., Miller, L.C., Kehrli, Jr., M.E. 2010. Pathogenesis studies of the 2009 pandemic influenza virus and pseudorabies virus from wild pigs in swine. In: Proceedings of the Brazilian Society for Virology XXI Meeting, October 18-20, 2010, Gramado, Rio Grande do Sul, Brazil. p. 33-34.
Influenza Vaccination in the Face of Maternal Antibody Results in Enhanced Pneumonia Following Heterologous, Homosubtypic Influenza Challenge -
Loving, C.L., Brockmeier, S.L., Vincent, A.L., Gauger, P.C., Kehrli, Jr., M.E. 2010. Influenza vaccination in the face of maternal antibody results in enhanced pneumonia following heterologous, homosubtypic influenza challenge [abstract]. Keystone Symposia, Immunological Mechanisms of Vaccination. Paper No. 243.
In Vivo Growth of Porcine Reproductive and Respiratory Syndrome Virus Engineered Nsp2 Deletion Mutants -
Faaberg, K.S., Kehrli, Jr., M.E., Lager, K.M., Guo, B., Han, J. 2010. In vivo growth of porcine reproductive and respiratory syndrome virus engineered Nsp2 deletion mutants. Virus Research. 154(1-2):77-85.
Biological Markers of Neonatal Calf Performance: The Relationship of Insulin-like Growth Factor-I, Zinc, and Copper to Poor Neonatal Growth -
Graham, T.W., Breher, J.E., Farver, T.B., Cullor, J.S., Kehrli, Jr., M.E., Oberbauer, A.M. 2010. Biological Markers of Neonatal Calf Performance: the Relationship of Insulin-like Growth Factor-I, Zinc, and Copper to Poor Neonatal Growth. Journal of Animal Science. 88(8):2585-2593.
Susceptibility of Swine to Low Pathogenic H5 and H7 Avian Influenza Viruses -
Lager, K.M., Vincent, A.L., Gauger, P.C., Senne, D.A., Swayne, D.E., Miller, L.C., Richt, J., Ma, W., Suarez, D.L., Kehrli Jr, M.E. 2010. Susceptibility of Swine to Low Pathogenic H5 and H7 Avian Influenza Viruses. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 79.
Discovery of Antinuclear Antibodies in Pigs Infected with Porcine Circovirus Type 2 -
Kehrli, Jr., M.E., Gauger, P.C., Cheung, A.K., Vincent, A.L., Lager, K.M. 2010. Discovery of Antinuclear Antibodies in Pigs Infected with Porcine Circovirus Type 2. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 332.
Efficacy of Inactivated Swine Influenza Virus Vaccines Against 2009 H1N1 Influenza Virus in Pigs -
Vincent, A.L., Ciacci-Zanella, J.R., Lorusso, A., Gauger, P.C., Zanella, E.R., Kehrli, Jr., M.E., Janke, B.H., Lager, K.M. 2010. Efficacy of Inactivated Swine Influenza Virus Vaccines Against 2009 H1N1 Influenza Virus in Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 299.
Pathogenesis and Transmission of Feral Swine Pseudorabies Virus Isolates -
Zanella, E.L., Lager, K.M., Miller, L.C., Swenson, S.L., Bigelow, T.T., Kehrli, Jr., M.E. 2010. Pathogenesis and Transmission of Feral Swine Pseudorabies Virus Isolates. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 875.
Experimental Challenge with Two Isolates of 2009 A/H1N1 in Weaned Pigs -
Vincent, A.L., Ciacci Zanella, J.R., Lorusso, A., Zanella, E.L., Lager, K.M., Gauger, P.C., Janke, B.H., Kehrli, Jr., M.E. 2010. Experimental Challenge with Two Isolates of 2009 A/H1N1 in Weaned Pigs. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 74.
In Depth Global Analysis of Transcript Abundance Levels Following Infection with Porcine Reproductive and Respiratory Syndrome Virus -
Miller, L.C., Harhay, G.P., Lager, K.M., Neill, J.D., Kehrli, Jr., M.E. 2010. In-Depth Global Analysis of Transcript Abundance Levels Following Infection with Porcine Reproductive and Respiratory Syndrome Virus [abstract]. In: Proceedings of the 9th International Positive Strand RNA Virus Symposium, May 17-21, 2010, Atlanta, Georgia. p. 54.
Efficacy of Inactivated Swine Influenza Virus Vaccines Against the 2009 A/H1N1 Influenza Virus in Pigs -
Vincent, A.L., Ciacci-Zanella, J.R., Lorusso, A., Gauger, P.C., Zanella, E.L., Kehrli Jr, M.E., Janke, B.H., Lager, K.M. 2010. Efficacy of Inactivated Swine Influenza Virus Vaccines Against the 2009 A/H1N1 Influenza Virus in Pigs. Vaccine 28(15):2782-2787.
Experimental Inoculation of Spiroplasma mirum and Transmissible Mink Encephalopathy (TME) into Raccoons (Procyon lotor) -
Hamir, A.N., Greenlee, J.J., Stanton, T.B., Smith, J.D., Doucette, S., Kunkle, R.A., Stasko, J.A., Richt, J.A., Kehrli, Jr., M.E. 2011. Experimental inoculation of raccoons (Procyon lotor) with Spiroplasma mirum and transmissible mink encephalopathy (TME). Canadian Journal of Veterinary Research. 75(1):18–24.
Research Updates: Experimental Evaluation of 2009 Pandemic A/H1N1 in Pigs -
Vincent, A.L., Lager, K.M., Harland, M.L., Lorusso, A., Ciacci-Zanella, J.R., Zanella, E.L., Kehrli, Jr., M.E., Gauger, P.C., Janke, B.H., Klimov, A. 2010. Research Updates: Experimental Evaluation of 2009 Pandemic A/H1N1 in Pigs. In: Proceedings of the 41st Annual Meeting of the American Association of Swine Veterinarians, March 6-9, 2010, Omaha, Nebraska. p. 495-497.
Experimental Inoculation of Pigs with Pandemic H1N1 2009 Virus and HI Cross-Reactivity with Contemporary Swine Influenza Virus Antisera -
Vincent, A.L., Lager, K.M., Faaberg, K.S., Harland, M., Zanella, E.L., Zanella, J.R., Kehrli, Jr., M.E., Janke, B.H., Klimov, A. 2009. Experimental Inoculation of Pigs with Pandemic H1N1 2009 Virus and HI Cross-Reactivity with Contemporary Swine Influenza Virus Antisera. Influenza and Other Respiratory Viruses. 4(2):53-60.
Absence of Pandemic H1N1 Influenza A Virus in Fresh Pork -
Vincent, A.L., Lager, K.M., Harland, M., Lorusso, A., Zanella, E., Ciacci-Zanella, J.R., Kehrli, Jr., M.E., Klimov, A. 2009. Absence of Pandemic H1N1 Influenza A Virus in Fresh Pork. PLoS ONE. 4:(12):e8367.
Large-Scale Parallel Pyrosequencing Technology Reveals PRRSV VR-2332 Nsp2 Deletion Mutants Stable in Swine -
Guo, B., Faaberg, K.S., Lager, K.M., Kehrli, Jr., M.E. 2009. Large-Scale parallel pyrosequencing technology reveals PRRSV VR-2332 Nsp2 deletion mutants stable in swine [abstract]. International PRRS Symposium, Chicago, IL. Paper No. 34.
Swine Influenza Update -
Lager, K.M., Vincent, A.L., Ciacci-Zanella, J.R., Zanella, E.L., Lorusso, A., Faaberg, K.S., Kehrli, Jr., M.E. 2009. Swine influenza update. In: Proceedings of the 17th Annual Swine Disease Conference, November 5-6, 2009, Iowa State University, Ames, Iowa. pp. 128-131.
Lack of Prion Accumulation in Lymphoid Tissues of Scrapie-affected Sheep with the AA136, QR171 Prion Protein Genotype -
Kunkle, R.A., Hamir, A.N., Richt, J., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2009. Lack of Prion Accumulation in Lymphoid Tissues of Scrapie-affected Sheep with the AA136, QR171 Prion Protein Genotype [abstract]. American Association of Veterinary Laboratory Diagnosticians. Paper No. 186.
Genetic stability of PRRSV VR-2332 nsp2 deletion mutants in swine -
Guo, B., Faaberg, K.S., Lager, K.M., Kehrli, Jr., M.E. 2009. Genetic stability of PRRSV VR-2332 nsp2 deletion mutants in swine [abstract]. 28th Annual Meeting of the American Society for Virology, Vancouver, Canada. Paper No. W33-12.
A comparison of the fluorescence spectra of murine and bovine central nervous system (CNS) and other tissues -
Adhikary, R., Schonenbrucher, H.H., Rasmussen, M.A., Casey, T., Hamir, A.N., Kehrli Jr, M.E., Richt, J., Petrich, J.W. 2009. A Comparison of the Fluorescence Spectra of Murine and Bovine Central Nervous System (CNS) and Other Tissues. Photochemistry and Photobiology. 85(6):1322-1326.
Immune suppression in cattle: contributors and consequences -
Kehrli, Jr., M.E., Ridpath, J.F., Neill, J.D. 2009. Immune Suppression in Cattle: Contributors and Consequences. In: Proceedings of the NMC 48th Annual Meeting, January 25-28, 2009, Charlotte, North Carolina. p. 103-112.
Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus -
Brockmeier, S., Lager, K.M., Grubman, M.J., Brough, D.E., Ettyreddy, D., Sacco, R.E., Gauger, P.C., Loving, C.L., Vorwald, A.C., Kehrli Jr, M.E., Lehmkuhl, H.D. 2009. Adenovirus-Mediated Expression of Interferon-Alpha Delays Viral Replication and Reduces Disease Signs in Swine Challenged with Porcine Reproductive and Respiratory Syndrome Virus. Viral Immunology. 22(3):173-180.
Effect of porcine reproductive and respiratory syndrome virus infection of porcine alveolar macrophages on Toll-like receptors elicitation of type I interferon responses -
Miller, L.C., Lager, K.M., Kehrli, Jr., M.E. 2009. Role of Toll-Like Receptors in Activation of Porcine Alveolar Macrophages by Porcine Reproductive and Respiratory Syndrome Virus. Clinical and Vaccine Immunology. 16(3):360-365.
Development of a replication defective adenovirus 5 vector expressing porcine interleukin-18 and a mutated analog -
Kappes, M.A., Ma, W., Richt, J.A., Lager, K.M., Vincent, A.L., Roth, J.A., Murtaugh, M.P., Kehrli, Jr., M.E. 2008. Development of a Replication Defective Adenovirus 5 Vector Expressing Porcine Interleukin-18 and a Mutated Analog [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 99P. p. 121.
Proteomics of mastitis causing Escherichia coli -
Lippolis, J.D., Reinhardt, T.A., Kehrli Jr, M.E. 2009. Proteomics of mastitis causing Escherichia coli. Proceedings of National Mastitis Council. 48:236-237.
Differential roles of Toll-like receptors in the elicitation of type I interferon responses by alveolar macrophages -
Miller, L.C., Chitko-Mckown, C.G., Lager, K.M., Kehrli, Jr., M.E. 2008. Differential Roles of Toll-Like Receptors in the Elicitation of Type I Interferon Responses by Alveolar Macrophages [abstract]. International PRRS Symposium. p. 58.
Origins of BSE: evidence of sporadic and heritable BSE -
Nicholson, E.M., Brunelle, B.W., Kehrli, Jr., M.E., Greenlee, J.J. 2008. Origins of BSE: Evidence of Sporadic and Heritable BSE [abstract]. United States-Japan Cooperative Program in Natural Resources. p. 7.
Isotype restricted exceptionally long CDR3H expression and extensive somatic mutations contribute to antibody diversification in cattle -
Kaushik, A.K., Kehrli Jr., M.E., Kurtz, A., Ng, S., Koti, M., Shojaei, F., Saini, S.S. 2009. Somatic Hypermutations and Isotype Restricted Exceptionally Long CDR3H Contribute to Antibody Diversification in Cattle. Veterinary Immunology and Immunopathology. 127(1-2):106-113.
Effects of PRRSV infection on TLR-dependent induction of NOS -
Chitko McKown, C.G., Miller, L.C., Lager, K.M., Kehrli Jr, M.E. 2008. Effects of PRRSV infection on TLR-dependent induction of NOS (abstract). Proceedings of the 89th Conference of Research Workers in Animal Health. Poster No. 104P. p. 122.
PRRSV strain VR-2332 Nsp2 deletion mutants attenuate clinical symptoms in swine -
Faaberg, K.S., Han, J., Guo, B., Lager, K.M., Kehrli, Jr., M.E. 2008. PRRSV Strain VR-2332 NSP2 Deletion Mutants Attenuate Clinical Symptoms in Swine [abstract]. International PRRS Symposium. p. 55.
Experimental transmission of transmissible spongiform encephalopathies (scrapie, chronic wasting disease, transmissible mink encephalopathy) to cattle and their differentiation from bovine spongiform encephalopathy -
Hamir, A.N., Cutlip, R.C., Miler, J.M., Kunkle, R.A., Richt, J.A., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2008. Experimental Transmission of Transmissible Spongiform Encephalopathies (Scrapie, Chronic Wasting Disease, Transmissible Mink Encephalopathy) to Cattle and Their Differentiation from Bovine Spongiform Encephalopathy [abstract]. American College of Veterinary Pathologists. Paper No. 153. p. 770.
Identification of a heritable polymorphism in bovine PRNP associated with genetic transmissible spongiform encephalopathy: evidence of heritable BSE -
Nicholson, E.M., Brunelle, B.W., Richt, J.A., Kehrli, Jr., M.E., Greenlee, J.J. 2008. Identification of a Heritable Polymorphism in Bovine PRNP Associated with Genetic Transmissible Spongiform Encephalopathy: Evidence of Heritable BSE. PloS ONE. 3(8):e2912.
Lack of prion accumulation in lymphoid tissues of scrapie-affected sheep with AA136, QR171 polymorphism type -
Kunkle, R.A., Hamir, A.N., Richt, J.A., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2008. Lack of Prion Accumulation in Lymphoid Tissues of Scrapie-Affected Sheep with AA136, QR171 Polymorphism Type [abtract]. Prion 2008. p. 75.
Identification of a heritable polymorphism in the bovine prion gene associated with genetic transmissible spongiform encephalopathy: evidence of heritable BSE -
Nicholson, E.M., Brunelle, B.W., Richt, J.A., Kehrli, Jr., M.E., Greenlee, J.J. 2008. Identification of a Heritable Polymorphism in the Bovine Prion Gene Associated with Genetic Transmissible Spongiform Encephalopathy: Evidence of Heritable BSE [abstract]. Prion 2008. p. 114.
Experimental transmission of transmissible spongiform encephalopathies (scrapie, chronic wasting disease, transmissible mink encephalopathy) to cattle and their differentiation from bovine spongiform encephalopathy -
Hamir, A.N., Kunkle, R.A., Richt, J.A., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2008. Experimental Transmission of Transmissible Spongiform Encephalopathies (Scrapie, Chronic Wasting Disease, Transmissible Mink Encephalopathy) to Cattle and their Differentiation from Bovine Spongiform Encephalopathy [abstract]. Prion 2008. p. 65.
Bovine immunophysiology and genetics: a review of the research and career of J. L. Burton -
Mallard, B.A., McBride, B.W., Kehrli, Jr., M.E., Coussens, P.M. 2009. Bovine Immunophysiology and Genetics: a Review of the Research and Career of J. L. Burton. Veterinary Immunology and Immunopathology. 128(1-3):96-103.
PRRSV strain VR-2332 Nsp2 deletion mutants attenuate clinical symptoms in swine -
Faaberg, K.S., Han, J., Lager, K.M., Kehrli, Jr., M.E., Rutherford, M.S. 2008. PRRSV Strain VR-2332 Nsp2 Deletion Mutants Attenuate Clinical Symptoms in Swine [abstract]. XIth International Symposium on Nidoviruses. Paper No. P63. p. 70.
A fluorescence based method, exploiting lipofuscin, for the real-time detection of central nervous system (CNS) tissues on bovine carcasses -
Schonenbrucher, H., Adhikary, R., Mukherjee, P., Casey, T.A., Rasmussen, M.A., Maistrovich, F.D., Hamir, A.N., Kehrli, Jr., M.E., Richt, J.A., Petrich, J.W. 2008. Fluorescence-Based Method, Exploiting Lipofuscin, for Real-Time Detection of Central Nervous System Tissues on Bovine Carcasses. Journal of Agricultural and Food Chemistry. 56(15):6220-6226.
Pathogenesis of PCV2a and PCV2b virus in germ-free pigs -
Gauger, P.C., Lager, K.M., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E., Cheung, A.K. 2008. Pathogenesis of PCV2a and PCV2b Virus in Germ-Free pigs. In: Proceedings of the International Pig Veterinary Society Congress, June 22-26, 2008, Durban, South Africa. Paper No. OR.01.28.
In depth global analysis of gene expression levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus -
Miller, L., Harhay, G., Lager, K., Kehrli Jr., M., Laegreid, W., Neill, J. 2008. In depth global analysis of gene expression levels in porcine alveolar macrophages following infection with porcine reproductive and respiratory syndrome virus [abstract]. ARK-Genomics Conference 2008: 3rd International Symposium on Animal Functional Genomics. Paper No. ISAFG-P22. p. 38.
Fluorescence of tissues fluororophores such as lipofuscin as a possible basis for the detection of CNS tissues on bovine carcasses -
Schonenbrucher, H., Adhikary, R., Maistrovich, F., Casey, T.A., Rasmussen, M.A., Mukherje, P., Kehrli, Jr., M.E., Petrich, J.W., Richt, J.A, 2007. Fluorescence of tissues fluororophores such as lipofuscin as a possible basis for the detection of CNS tissues on bovine carcasses [abstract]. Conference of Research Workers in Animal Diseases Annual Meeting. Paper No. 66P. p. 104.
Allele, genotype, and haplotype data for BSE-resistance polymorphisms from healthy U.S. holstein cattle -
Brunelle, B.W., Kehrli, Jr., M.E., Stabel, J.R., Moody Spurlock, D., Hansen, L.B., Nicholson, E.M. 2007. Allele, genotype, and haplotype data for bovine spongiform encephalopathy-resistance polymorphisms from healthy US holstein cattle. Journal of Dairy Science. 91:338–342.
VIRUS VACCINE RESEARCH AT THE NATIONAL ANIMAL DISEASE CENTER: LESSONS FROM SWINE INFLUENZA VIRUS AND BOVINE VIRAL DIARRHEA VIRUS -
Kehrli, Jr., M.E., Vincent, A.L., Richt, J.A., Wesley, R.D., Lager, K.M., Ridpath, J.F., Kimura, K., Roth, J.A. 2007. Virus vaccine research at the National Animal Disease Center: lessons from swine influenza virus and bovine viral diarrhea virus [abstract]. The Changing Landscape of Vaccine Development: Vaccines for Global Health. The University of Texas Medical Branch, Sealy Center for Vaccine Development. p. 14
Experimental transmission of transmissible spongiform encephalopathies (scrapie, chronic wasting disease, transmissible mink encephalopathy) to cattle and their differentiation from bovine spongiform encephalopathy -
Hamir, A.N., Cutlip, R.C., Miller, J.M., Kunkle, R.A., Richt, J.A., Greenlee, J.J., Nicholson, E.M., Kehrli, Jr., M.E. 2007. Experimental transmission of transmissible spongiform encephalopathies (scrapie, chronic wasting disease, transmissible mink encephalopathy) to cattle and their differentiation from bovine spongiform encephalopathy. In: Proceedings of the World Association of Veterinary Laboratory Diagnosticians 13th International Symposium, November 11-14, 2007, Melbourne, Australia. p. 29.
Reproduction of PMWS of high mortality with a porcine circovirus type 2-group 1 isolate -
Cheung, A.K., Lager, K.M., Gauger, P.C., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E. 2007. Reproduction of PMWS of high mortality with a porcine circovirus type 2-group 1 isolate. In: Proceedings of the 13th International World Association of Veterinary Laboratory Diagnosticians Symposium, November 11-14, 2007, Melbourne, Australia. p. 213.
Age-related lesions in laboratory-confined raccoons (Procyon lotor) inoculated with the agent of chronic wasting disease of mule deer -
Hamir, A.N., Kunkle, R.A., Miller, J.M., Cutlip, R.C., Richt, J.A., Kehrli, Jr., M.E., Williams, E.S. 2007. Age-related lesions in laboratory-confined raccoons (Procyon lotor) inoculated with the agent of chronic wasting disease of mule deer. Journal of Veterinary Diagnostic Investigation. 19(6):680-686.
Cumulative physiological events modulate the inflammatory response of the bovine udder to Escherichia coli infections around parturition -
Burvenich, C., Bannerman, D.D., Lippolis, J.D., Peelman, L., Nonnecke, B.J., Kehrli Jr, M.E., Paape, M.J. 2007. Cumulative physiological events modulate the inflammatory response of the bovine udder to Escherichia coli infections around parturition. Proceedings of the Heifer Mastitis Conference. pp. 75-76. June 24-26, 2007. Ghent, Belgium. . Meeting Abstract.
Mortality in pigs given PCV2 virus derived from DNA clones -
Lager, K.M., Gauger, P.C., Vincent, A.L., Opriessnig, T., Kehrli, Jr., M.E., Cheung, A.K. 2007. Mortality in pigs given porcine circovirus type 2 subgroup 1 and 2 viruses derived from DNA clones. Veterinary Record. 161(12):428-429.
Pathobiology and diagnosis of animal transmissible spongiform encephalopathies: current knowledge, research gaps, and opportunities -
Kehrli, Jr., M.E., O'Rourke, K.I., Hamir, A.N., Richt, J.A., Nicholson, E.M., Silva, C.J., Edelman, D., Gay, C.G. 2007. Pathobiology and diagnosis of animal transmissible spongiform encephalopathies: current knowledge, research gaps, and opportunities [government white paper]. Beltsville, MD: Interagency Working Group on Prion Science, Subcommittee on Pathobiology and Diagnostics. USDA, Agriculture Research Service. 33 p.
Age-related lesions in laboratory-confined raccoons (Procyon lotor) inoculated with the agent of chronic wasting disease -
Hamir, A.N., Kunkle, R.A., Miller, J.M., Cutlip, R.C., Richt, J.A., Kehrli, Jr., M.E., Williams, Jr., E.S. 2007. Age-related lesions in laboratory-confined raccoons (Procyon lotor) inoculated with the agent of chronic wasting disease. Journal of Veterinary Diagnostic Investigation. 19(6):680-686.
Cumulative physiological events influence the inflammatory response of the bovine udder to Escherichia coli infections during the transition period -
Burvenich, C., Bannerman, D.D., Lippolis, J.D., Peelman, L., Nonnecke, B.J., Kehrli, Jr., M.E., Paape, M.J. 2007. Cumulative physiological events influence the inflammatory response of the bovine udder to Escherichia coli infections during the transition period. Journal of Dairy Science. 90(E.Suppl.):E39-E54.
Analysis of activated immune cell populations in the bronchoalveolar lavage fluid of pigs immunized and/or infected with SIV -
Kimura, K., Vincent, A.L., Richt, J.A., Lager, K.M., Roth, J.A., Kehrli, Jr., M.E. 2006. Effect of vaccination and/or challenge of swine influenza virus on the proportion of activated cells in bronchoalveolar lavage fluid [abstract]. Great Lakes International Imaging and Flow Cytometry Association. Paper No. 7.
INTERLEUKIN-8 EXPRESSION BY MAMMARY GLAND ENDOTHELIAL AND EPITHELIAL CELLS FOLLOWING EXPERIMENTAL MASTITIS INFECTION WITH E COLI -
Mcclenahan, D., Krueger, R., Lee, H.Y., Thomas, C., Kehrli, Jr., M.E., Czuprynski, C. 2006. Interleukin-8 expression by mammary gland endothelial and epithelial cells following experimental mastitis infection with E coli. Comparative Immunology Microbiology and Infectious Diseases. 29:127-137.
ASSAY FOR PROLIFERATION OF PORCINE PBMC WITH OREGON GREEN 488 AND ITS APPLICATION FOR EVALUATION OF T CELL RESPONSIVENESS TO SWINE INFLUENZA VIRUS -
Kimura, K., Vincent, A.L., Lager, K.M., Roth, J.A., Kehrli, Jr., M.E. 2006. Assay for proliferation of porcine PBMC with Oregon Green 488 and its application for evaluation of T cell responsiveness to swine influenza virus [astract]. Journal of Immunology Supplement. 176:S118. Paper No. 59.12.
CUMULATIVE PHYSIOLOGICAL EVENTS INFLUENCE THE INFLAMMATORY RESPONSE OF THE BOVINE UDDER TO E-COLI INFECTIONS DURING THE TRANSITION PERIOD -
Burvenich, C., Kehrli Jr, M.E., Paape, M.J., Bannerman, D.D., Lippolis, J.D. 2006. Cumulative physiological events influence the inflammatory response of the bovine udder to e-coli infections during the transition period. Journal of Dairy Science. 84(Suppl. 1):273.
INDIVIDUAL COW RESPONSES TO ESCHERICHIA COLI MASTITIS -
Burvenich, C., Kehrli, Jr., M.E., Paape, M.J. 2006. Individual cow responses to Escherichia coli mastitis. In: Proceedings of the 45th National Mastitis Council, January 22-25, 2006, Tampa, Florida. 45:61-87.
ROLE OF NEUTROPHILS IN THE PATHOGENESIS OF BOVINE COLIFORM MASTITIS -
Burvenich, C., Kehrli, Jr., M.E., Paape, M.J., Bannerman, D.D. 2005. Role of neutrophils in the pathogenesis of bovine coliform mastitis. In: Proceedings of the 29th National Buiatrics Congress, August 11-13, 2005, Puebla, Pue, Mexico. p. S1.
INFECTION WITH PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS STIMULATES AN EARLY GAMMA INTERFERON RESPONSE IN THE SERUM OF PIGS -
Wesley, R.D., Lager, K.M., Kehrli, Jr., M.E. 2006. Infection with porcine reproductive and respiratory syndrome virus stimulates an early gamma interferon response in the serum of pigs. Canadian Journal of Veterinary Research. 70(3):176-182.
ASSAY FOR PROLIFERATION OF PORCINE PBMC WITH OREGON GREEN 488 AND ITS APPLICATION FOR EVALUATION OF T CELL RESPONSIVENESS TO SWINE INFLUENZA VIRUS -
Kimura, K., Lager, K.M., Kehrli, Jr., M.E., Roth, J.A., Richt, J.A. 2005. Assay for proliferation of porcine PBMC with Oregon Green 488 and its application for evaluation of T cell responsiveness to swine influenza virus [abstract]. Great Lakes International Imaging and Flow Cytometry Association. Paper No. 10. p. 22.
VARIATION IN MAMMARY DEFENSE DURING BOVINE LACTATION AND SUSCEPTIBILITY TO TOXIC MASTITIS: PATHOGENESIS, PROPHYLAXIS AND TREATMENT -
Burvenich, C., Kehrli, Jr., M.E., Paape, M.J. 2005. Variation in mammary defense during bovine lactation and susceptibility to toxic mastitis: pathogenesis, prophylaxis and treatment. In: Malinowski, E., Bednarek, D., editors. Proceedings of the 6th Middle European Buiatrics Congress, June 1-4, 2005, Krakow, Poland. p. S1.
BIOCHEMISTRY OF PRION DISEASES -
Nicholson, E.M., Greenlee, J.J., Richt, J., Hamir, A.N., Kunkle, R.A., Kehrli, Jr., M.E. 2005. Biochemistry of prion diseases. Association of Analytical Communities International, Midwest Section [abstract]. Abstract No. 601. p. 38.
LOSS OF PRION PROTEIN IMMUNOREACTIVITY AFTER BOILING IN SATURATED CALCIUM HYDROXIDE SOLUTION -
Greenlee, J.J., Nicholson, E.M., Hamir, A.N., Richt, J.A., Kunkle, R.A., Noyes, G., Hotzapple, M.T., Kehrli Jr., M.E. 2005. Loss of prion protein immunoreactivity after boiling in saturated calcium hydroxide solution [abstract]. Keystone Symposia: Molecular Mechanisms of Transmissible Spongiform Encephalopathies. Poster No. 125.
GENETIC BASIS AND RISK FACTORS OF INFECTIOUS AND NONINFECTIOUS DISEASES IN US HOLSTEINS. I. ESTIMATION OF GENETIC PARAMETERS FOR SINGLE DISEASES AND GENERAL HEALTH -
Abdel-Azim, G.A., Freeman, A.E., Kehrli, Jr., M.E., Klem, S.C., Burton, J.L., Kuck, A.L., Schnell, S. 2005. Genetic basis and risk factors of infectious and noninfectious diseases in US holsteins. I. Estimation of genetic parameters for single diseases and general health. Journal of Dairy Science. 88(3):1199-1207.
INTERLEUKIN-8 EXPRESSION IN MAMMARY GLAND TISSUE INFECTED WITH ESCHERICHIA COLI -
Krueger, R., McClenahan, D., Kehrli Jr., M.E., Czuprynski, C. 2004. Interleukin-8 expression in mammary gland tissue infected with Escherichia coli [abstract]. Conference of Research Workers in Animal Diseases. Paper No. P45. p. 94.
PRRSV INFECTION STIMULATES AN EARLY SERUM IFN-GAMMA RESPONSE IN PIGS -
Wesley, R.D., Lager, K.M., Kehrli Jr., M.E. 2004. PRRSV infection stimulates an early serum IFN-gamma response in pigs [abstract]. Conference of Research Workers in Animal Diseases. Paper No. P89. p. 103.
ENERGY AND PROTEIN EFFECTS ON THE IMMUNE SYSTEM -
Kehrli, Jr., M.E., Neill, J.D., Burvenich, C., Goff, J.P., Lippolis, J.D., Reinhardt, T.A., Nonnecke, B.J. 2006. Energy and protein effects on the immune system. In: Sejrsen, K., Hvelplund, T., Nielsen, M.O., editors. Ruminant Physiology. Wageningen, The Netherlands: Wageningen Academic Publishers. p. 455-471.
ENERGY AND PROTEIN EFFECTS ON THE IMMUNE SYSTEM -
GENETIC VARIATION IN BOVINE MONONUCLEAR LEUKOCYTE RESPONSES TO DEXAMETHASONE -
Saama, P.M., Jacob, J.B., Kehrli Jr, M.E., Freeman, A.E., Kelm, S.C., Kuck, A.L., Tempelman, R.J., Burton, J.L. 2004. Genetic variation in bovine mononuclear leukocyte responses to dexamethasone. Journal of Dairy Science. 11:3928-37.
IMMUNOGLOBULINS AND IMMUNOCYTES IN THE MAMMARY GLAND AND ITS SECRETIONS -
Butler, J.E., Kehrli, Jr., M.E. 2004. Immunoglobulins and immunocytes in the mammary gland and its secretions. In: Mestecky, J.F., Beinenstock, J., Lamm, M., Mayer, L, McGhee, J.R., Strover, W., editors. Mucosal Immunology. 3rd edition. San Diego: Acadamic Press. p. - .
THE GENETIC IMMUNODEFICIENCY DISEASE LEUKOCYTE ADHESION DEFICIENCY IN HUMANS, DOGS, CATTLE, AND MICE -
Gu, Y., Bauer Jr, T.R., Ackermann, M.R., Smith, C.W., Kehrli Jr, M.E., Starost, M.F., Hickstein, D.D. 2004. The genetic immunodeficiency disease leukocyte adhesion deficiency in humans, dogs, cattle, and mice. Comparative Medicine. 54(4):363-72.
THE GENETIC IMMUNODEFICIENCY DISEASE LEUKOCYTE ADHESION DEFICIENCY IN MAN, DOG, CATTLE, AND MOUSE -
Gu, Y., Bauer, T.R., Ackermann, M.R., Smith, W.C., Kehrli Jr, M.E., Starost, M.F., Hickstein, D.D. 2004. The genetic immunodeficiency disease leukocyte adhesion deficiency in man, dog, cattle, and mouse. Comparative Medicine. 54:363-372.
PRRSV INFECTION STIMULATES AN IMMEDIATE SERUM INTERFERON-GAMMA RESPONSE -
Wesley, R.D., Lager, K.M., Kehrli, Jr., M.E. 2004. PRRSV infection stimulates an immediate serum interferon-gamma response. In: Proceedings of the 18th Congress of the International Pig Veterinary Society (IPVS) Congress, June 27-July 2, 2004, Hamburg, Germany. p. 90.
DECREASED NEUTROPHIL FUNCTION AS A CAUSE OF RETAINED PLACENTA IN DAIRY CATTLE -
Kimura, K., Goff, J.P., Kehrli Jr., M.E., Reinhardt, T.A. 2003. Decreased neutrophil function as a cause of retained placenta in dairy cattle [abstract]. ARS Immunology Research Workshop. p. 58.
RELATIONSHIP OF THE PROBABILITY OF DISEASE INCIDENCE WITH IMMUNITY -
Abdel-Azin, G.A., Freeman, A.E., Kehrli, Jr., M.E., Kelm, S.C., Burton, J.L., Kuck, A.L., Schnell, S. 2003. Relationship of the probability of disease incidence with immunity. ARS Immunology Research Workshop. p. 75.
BOVINE TUMOR NECROSIS FACTOR RECEPTOR-1 AND METHODS OF USE -
Taylor, M.J., Kehrli, Jr., M.E., Lee, E. 2002. Bovine tumor necrosis factor receptor-1 and methods of use. U.S. Patent 6,406,907 B1.
BOVINE TUMOR NECROSIS FACTOR RECEPTOR-1 AND METHODS OF USE -
Taylor, M.J., Kehrli, Jr., M.E., Lee, E., Mwangi, S. 2005. Bovine tumor necrosis factor receptor-1 and methods of use. U.S. Patent 6,939,950 B2.
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