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ARS Home » Pacific West Area » Albany, California » Western Regional Research Center » Foodborne Toxin Detection and Prevention Research » People & Locations » Luisa Wai Wai Cheng

Luisa Wai Wai Cheng
Foodborne Toxin Detection and Prevention Research
Research Leader

Phone: (510) 559-6337
Fax: (510) 559-6429

USDA, ARS, PWA, WRRC-FTDP
800 BUCHANAN ST
ALBANY, CA 94710
Projects
Advance the Development of Technologies for Detecting and Determining the Stability and Bioavailability of Toxins that Impact Food Safety and Food Defense
In-House Appropriated (D)
  Accession Number: 430056
Biocontrol Interventions for High-Value Agricultural Commodities
In-House Appropriated (D)
  Accession Number: 430817
A Survey of Azole-resistant Aspergillus Fumigatus in California Farms at the Animal-Human-Environmental Interface
Interagency Reimbursable Agreement (I)
  Accession Number: 434892
Development of Detection Technologies for Botulinum Neurotoxins and Their Validation in Food Matrices
Non-Assistance Cooperative Agreement (S)
  Accession Number: 433368
Development of Detection Technologies and Therapeutics for Botulinum Neurotoxins
Non-Assistance Cooperative Agreement (S)
  Accession Number: 438895
Development of Bithional Against Botulinum Neurotoxins
Trust Fund Cooperative Agreement (T)
  Accession Number: 436609
Identification of Pistachio Associated Volatiles for the Control of Navel Orangeworm
Trust Fund Cooperative Agreement (T)
  Accession Number: 436707
Use of Pistachio Mummy Volatiles as Lures for Navel Orangeworm
Trust Fund Cooperative Agreement (T)
  Accession Number: 438083

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Crosstalk between the antioxidant and cell wall integrity systems in fungi by 2-hydroxy-4-methoxybenzaldehyde Reprint Icon - (Peer Reviewed Journal)
Kim, J., Chan, K.L., Tam, C.C., Cheng, L.W., Land, K.M. 2020. Crosstalk between the antioxidant and cell wall integrity systems in fungi by 2-hydroxy-4-methoxybenzaldehyde. Cogent Food & Agriculture. 6:1823593. https://doi.org/10.1080/23311932.2020.1823593.
Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review Reprint Icon - (Peer Reviewed Journal)
Friedman, M., Tam, C.C., Cheng, L.W., Land, K.M. 2020. Anti-trichomonad activities of different compounds from foods, marine products, and medicinal plants: a review. BMC Complementary Medicine and Therapies. 20:271. https://doi.org/10.1186/s12906-020-03061-9.
The inhibitory activity of anthraquinones against pathogenic protozoa, bacteria, and fungi and the relationship to structure Reprint Icon - (Peer Reviewed Journal)
Friedman, M., Xu, A., Lee, R., Nguyen, D.N., Phan, T.A., Hamada, S.M., Panchel, R., Tam, C.C., Kim, J., Cheng, L.W., Land, K.M. 2020. The inhibitory activity of anthraquinones against pathogenic protozoa, bacteria, and fungi and the relationship to structure. Molecules. 25(13):3101. https://dx.doi.org/10.3390/molecules25133101.
Lateral flow immunoassay (LFIA) for the detection of lethal amatoxins from mushrooms Reprint Icon - (Peer Reviewed Journal)
Bever, C.R., Adams, C.A., Hnasko, R.M., Cheng, L.W., Stanker, L.H. 2020. Lateral flow immunoassay (LFIA) for the detection of lethal amatoxins from mushrooms. PLoS One. 15(4). https://doi.org/10.1371/journal.pone.0231781.
Investigation of the immunogenicity of Zika glycan loop Reprint Icon - (Peer Reviewed Journal)
Henderson, E., Tam, C.C., Cheng, L.W., Ngono, A.E., Nguyen, A., Shresta, S., McGee, M., Padgett, H., Gill, L., Martchenko, M. 2020. Investigation of the immunogenicity of Zika glycan loop. Virology Journal. 17:43. https://doi.org/10.1186/s12985-020-01313-1.
Rapid, sensitive, and accurate point-of-care detection of lethal amatoxins in urine Reprint Icon - (Peer Reviewed Journal)
Bever, C.R., Swanson, K.D., Hamelin, E.I., Filigenzi, M., Poppenga, R., Kaae, J., Cheng, L.W., Stanker, L.H. 2020. Rapid, sensitive, and accurate point-of-care detection of lethal amatoxins in urine. Toxins. 12(2):123. https://doi.org/10.3390/toxins12020123.
Rapid elimination of foodborne and environmental fungal contaminants by benzo analogs Reprint Icon - (Peer Reviewed Journal)
Kim, J., Chan, K.L., Mahoney, N.E., Cheng, L.W., Tautges, N., Scow, K. 2020. Rapid elimination of foodborne and environmental fungal contaminants by benzo analogs. Journal of the Science of Food and Agriculture. 100(6):2800–2806. https://doi.org/10.1002/jsfa.10288.
The novel Clostridial neurotoxin produced by strain IBCA10-7060 is immunologically equivalent to BoNT/HA Reprint Icon - (Peer Reviewed Journal)
Fan, Y., Barash, J.R., Conrad, F., Lou, J., Tam, C.C., Cheng, L.W., Arnon, S.S., Marks, J.D. 2019. The novel Clostridial neurotoxin produced by strain IBCA10-7060 is immunologically equivalent to BoNT/HA. Toxins. 12(1):9. https://doi.org/10.3390/toxins12010009.
A rapid extraction method combined with a monoclonal antibody-based immunoassay for the detection of amatoxins Reprint Icon - (Peer Reviewed Journal)
Bever, C.R., Hnasko, R.M., Cheng, L.W., Stanker, L.H. 2019. A rapid extraction method combined with a monoclonal antibody-based immunoassay for the detection of amatoxins. Toxins. 11(12). https://doi.org/10.3390/toxins11120724.
Prebiotics, probiotics, and bacterial infections Reprint Icon ()
Tam, C.C., Land, K.M., Cheng, L.W. 2019. Prebiotics, probiotics, and bacterial infections. In: Franco-Robles, E. and Ramírez-Emiliano, J., editors. Prebiotics and Probiotics, Potential Benefits in Nutrition and Health. IntechOpen. https://doi.org/10.5772/intechopen.89052.
Development and characterization of monoclonal antibodies to botulinum neurotoxin type E Reprint Icon - (Peer Reviewed Journal)
Bever, C.R., Scotcher, M., Cheng, L.W., Hnasko, R.M., Stanker, L. 2019. Development and characterization of monoclonal antibodies to botulinum neurotoxin type E. Toxins. 11:407. https://doi.org/10.3390/toxins11070407.
Synthesis and antiprotozoal activity of functionalized 1H-1,2,3-triazole-tethered isatin-ferrocene conjugates Reprint Icon - (Peer Reviewed Journal)
Singh, A., Zhang, D., Tam, C.C., Cheng, L.W., Land, K.M., Kumar, V. 2019. Synthesis and antiprotozoal activity of functionalized 1H-1,2,3-triazole-tethered isatin-ferrocene conjugates. Bioorganic and Medicinal Chemistry Letters. 896:1-4. https://doi.org/10.1016/j.jorganchem.2019.05.025.
High efficiency drug repurposing design for new antifungal agents Reprint Icon - (Peer Reviewed Journal)
Kim, J., Chan, K.L., Cheng, L.W., Tell, L.A., Byrne, B.A., Clothier, K., Land, K.M. 2019. High efficiency drug repurposing design for new antifungal agents. Methods and Protocols. 2(2):31. https://doi.org/10.3390/mps2020031.
Antiprotozoal activity of palladium (II) salicylaldiminato thiosemicarbazone complexes on metronidazole resistant Trichomonas vaginalis Reprint Icon - (Peer Reviewed Journal)
Chellan, P., Stringer, T., Shokar, A., Au, A., Tam, C.C., Cheng, L.W., Smith, G.S., Land, K.M. 2019. Antiprotozoal activity of palladium (II) salicylaldiminato thiosemicarbazone complexes on metronidazole resistant Trichomonas vaginalis. Inorganic Chemistry. (102):1-4. https://doi.org/10.1016/j.inoche.2019.01.033.
Influence of food matrices on the stability and bioavailability of abrin Reprint Icon - (Peer Reviewed Journal)
Tam, C.C., Henderson II, T.D., Stanker, L.H., Cheng, L.W. 2018. Influence of food matrices on the stability and bioavailability of abrin. Toxins. 10(12):52. https://doi.org/10.3390/toxins10120502.
A rapid, sensitive, and portable biosensor assay for the detection of botulinum neurotoxin serotype A in complex food matrices Reprint Icon - (Peer Reviewed Journal)
Tam, C.C., Flannery, A.R., Cheng, L.W. 2018. A rapid, sensitive, and portable biosensor assay for the detection of botulinum neurotoxin serotype A in complex food matrices. Toxins. 10(11):476. https://doi.org/doi:10.3390/toxins10110476.
Highly potent 1H-1,2,3-triazole-tethered isatin-metronidazole conjugates against anaerobic foodborne, waterborne, and sexually-transmitted protozoal parasites Reprint Icon - (Peer Reviewed Journal)
Kumar, S., Bains, T., Kim, A., Tam, C.C., Kim, J., Cheng, L.W., Land, K.M., Debnath, A., Kumar, V. 2018. Highly potent 1H-1,2,3-triazole-tethered isatin-metronidazole conjugates against anaerobic foodborne, waterborne, and sexually-transmitted protozoal parasites. Frontiers in Cellular and Infection Microbiology. 8:380. https://doi.org/10.3389/fcimb.2018.00380.
Cinnamoyl-oxaborole amides: Synthesis and their in Vitro biological activity Reprint Icon - (Peer Reviewed Journal)
Gumbo, M., Beteck, R.M., Mandizvo, T., Seldon, R., Warner, D.F., Hoppe, H.C., Issacs, M., Laming, D., Tam, C.C., Cheng, L.W., Liu, N., Land, K.M., Khanye, S.D. 2018. Cinnamoyl-oxaborole amides: Synthesis and their in Vitro biological activity. Molecules. 23(8):2038. https://doi.org/10.3390/molecules23082038.
Potato peels and their bioactive glycoalkaloids and phenolic compounds inhibit the growth of pathogenic trichomonads Reprint Icon - (Peer Reviewed Journal)
Friedman, M., Huang, V., Quiambao, Q., Noritake, S.S., Liu, J., Kwon, O., Chintalapati, S., Levin, C.E., Tam, C.C., Cheng, L.W., Land, K.M. 2018. Potato peels and their bioactive glycoalkaloids and phenolic compounds inhibit the growth of pathogenic trichomonads. Journal of Agricultural and Food Chemistry. 66(30):7942-7947. https://doi.org/10.1021/acs.jafc.8b01726.
A new conjugation method used for the development of an immunoassay for amanitin, a deadly mushroom toxin Reprint Icon - (Peer Reviewed Journal)
Bever, C.R., Barnych, B., Hnasko, R.M., Cheng, L.W., Stanker, L.H. 2018. A new conjugation method used for the development of an immunoassay for amanitin, a deadly mushroom toxin. Toxins. 10(7):265. https://doi.org/10.3390/toxins10070265.
Investigating host plant-based semiochemicals for attracting the leaffooted bug (Hemiptera: Coreidae), an insect pest of California agriculture Reprint Icon - (Peer Reviewed Journal)
Beck, J.J., Gee, W.S., Cheng, L.W., Higbee, B.S., Wilson, H., Daane, K.M. 2018. Investigating host plant-based semiochemicals for attracting the leaffooted bug (Hemiptera: Coreidae), an insect pest of California agriculture. ACS Symposium Series. 1294:143-165. https://doi.org/10.1021/bk-2018-1294.ch011.
Octyl gallate as an intervention catalyst to augment antifungal efficacy of caspofungin Reprint Icon - (Peer Reviewed Journal)
Kim, J.H., Chan, K.L., Cheng, L.W. 2018. Octyl gallate as an intervention catalyst to augment antifungal efficacy of caspofungin. Open Access Journal of Multidisciplinary Science. 1(1):19-28. https://doi.org/10.3390/j1010004.
Synthesis and preliminary antimicrobial analysis of Isatin-ferrocene and Isatin-ferrocenyl-chalcone conjugates Reprint Icon - (Peer Reviewed Journal)
Singh, A., Fong, G., Liu, J., Wu, Y., Chang, K., Park, W., Kim, J., Tam, C.C., Cheng, L.W., Land, K.M., Kumar, V. 2018. Synthesis and preliminary antimicrobial analysis of Isatin-ferrocene and Isatin-ferrocenyl-chalcone conjugates. ACS Omega. 3(5):5808-5813. https://doi.org/10.1021/acsomega.8b00553.
Organometallic conjugates of the drug sulfadoxine for combatting antimicrobial resistance Reprint Icon - (Peer Reviewed Journal)
Chellan, P., Avery, V., Duffy, S., Triccas, J.A., Nagalingam, G., Tam, C.C., Cheng, L.W., Liu, J., Land, K.M., Clarkson, G.J., Romero, I., Sadler, P.J. 2018. Organometallic conjugates of the drug sulfadoxine for combatting antimicrobial resistance. Chemistry - A European Journal. 24(40):10078-10090. https://doi.org/10.1002/chem.201801090.
A single tri-epitopic antibody virtually recapitulates the potency of a combination of three monoclonal antibodies in neutralization of Botulinum Neurotoxin Serotype A Reprint Icon - (Peer Reviewed Journal)
Lou, J., Wen, W., Conrad, F., Meng, Q., Dong, J., Sun, Z., Garcia-Rodriguez, C., Farr-Jones, S., Cheng, L.W., Henderson Ii, T.D., Brown, J., Smith, T.J., Smith, L.A., Cormier, A., Marks, J.D. 2018. A single tri-epitopic antibody virtually recapitulates the potency of a combination of three monoclonal antibodies in neutralization of Botulinum Neurotoxin Serotype A. Toxins. 10(2):84. doi: 10.3390/toxins10020084.
An improved method for the sensitive detection of Shiga toxin 2 in human serum Reprint Icon - (Peer Reviewed Journal)
He, X., Ardissino, G., Patfield, S.A., Cheng, L.W., Silva, C.J., Brigotti, M. 2018. An improved method for the sensitive detection of Shiga toxin 2 in human serum. Toxins. 10(2):59. https://doi.org/10.3390/toxins10020059.
Detection of abrin holotoxin using novel monoclonal antibodies Reprint Icon - (Peer Reviewed Journal)
He, X., Patfield, S.A., Cheng, L.W., Stanker, L.H., Rasooly, R., McKeon, T.A., Zhang, Y., Brandon, D.L. 2017. Detection of abrin holotoxin using novel monoclonal antibodies. Toxins. 9(12):386. https://doi.org/10.3390/toxins9120386.
Cinnamic acid analogs as intervention catalysts for overcoming antifungal tolerance Reprint Icon - (Peer Reviewed Journal)
Kim, J., Chan, K.L., Cheng, L.W. 2017. Cinnamic acid analogs as intervention catalysts for overcoming antifungal tolerance. Molecules. 22(10):1783. https://doi.org/10.3390/molecules22101783.
A monoclonal-monoclonal antibody based capture elisa for abrin Reprint Icon - (Peer Reviewed Journal)
Tam, C.C., Cheng, L.W., He, X., Merrill, P.A., Hodge, D., Stanker, L.H. 2017. A monoclonal-monoclonal antibody based capture elisa for abrin. Toxins. 9(10):328. https://doi.org/10.3390/toxins9100328.
Abrin toxicity and bioavailability after temperature and pH treatment Reprint Icon - (Peer Reviewed Journal)
Tam, C.C., Henderson, T.D., Stanker, L.H., He, X., Cheng, L.W. 2017. Abrin toxicity and bioavailability after temperature and pH treatment. Toxins. 9(10):320. https://doi.org/10.3390/toxins9100320.
Design, synthesis and preliminary antimicrobial evaluation of n-alkyl chain tethered c-5 functionalized bis-isatins Reprint Icon - (Peer Reviewed Journal)
Singh, A., Nisha, Bains, T., Hahn, H.J., Liu, N., Tam, C.C., Cheng, L.W., Kim, J.H., Debnath, A., Land, K.M., Kumar, V. 2017. Design, synthesis and preliminary antimicrobial evaluation of n-alkyl chain tethered c-5 functionalized bis-isatins. MedChemComm. 8(10):1982-1992. https://doi.org/10.1039/C7MD00434F.
Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes Reprint Icon - (Peer Reviewed Journal)
Stringer, T., Seldon, R., Liu, N., Warner, D.F., Tam, C.C., Cheng, L.W., Land, K.M., Smith, P.J., Chibale, K., Smith, G.S. 2017. Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes. Dalton Transactions. 46:9875-9885. https://doi.org/10.1039/c7dt01952a.
Phytochemical-rich foods inhibit the growth of pathogenic trichomonads Reprint Icon - (Peer Reviewed Journal)
Noritake, S.M., Liu, J., Kanetake, S., Levin, C.E., Tam, C.C., Cheng, L.W., Land, K.M., Friedman, M. 2017. Phytochemical-rich foods inhibit the growth of pathogenic trichomonads. BMC Complementary and Alternative Medicine. 17(1):461. https://doi.org/10.1186/s12906-017-1967-x.
Design and testing of safer more effective preservatives for consumer products Reprint Icon - (Peer Reviewed Journal)
Buckley, H.L., Hart-Cooper, W.M., Kim, J.H., Faulkner, D.N., Cheng, L.W., Chan, K.L., Vulpe, C.D., Orts, W.J., Amrose, S.E., Mulvihill, M.J. 2017. Design and testing of safer, more effective preservatives for consumer products. ACS Sustainable Chemistry & Engineering. 5(5):4320-4331. doi: 10.1021/acssuschemeng.7b00374.
Historical perspectives and guidelines for botulinum neurotoxin subtype nomenclature ()
Peck, M.W., Smith, T.J., Anniballi, F., Arnon, S.S., Austin, J.W., Bano, L., Bradshaw, M., Cuervo, M.P., Cheng, L.W., Derman, Y., Dorner, B., Dover, N., Fischer, A., Hill, K.K., Kalb, S., Korkeala, H., Lindstrom, M., Lista, F., Luquez, C., Mazuet, C., Pellett, S., Pirazzini, M., Popoff, M.R., Rasetti-Escargueil, C., Rossetto, O., Rummel, A., Sesardic, T., Singh, B., Stringer, S.C. 2017. Historical perspectives and guidelines for botulinum neurotoxin subtype nomenclature. Toxins. 9(1):38. doi: 10.3390/toxins9010038.
Probiotic microorganisms inhibit epithelial cell internalization of botulinum neurotoxin serotype A Reprint Icon - (Peer Reviewed Journal)
Lam, T.L., Tam, C.C., Stanker, L.H., Cheng, L.W. 2016. Probiotic microorganisms inhibit epithelial cell internalization of botulinum neurotoxin serotype A. Toxins. 8(12):377. doi: 10.3390/toxins8120377.
Antifungal efficacy of octylgallate and 4-isopropyl-3-methylphenol for control of Aspergillus Reprint Icon - (Peer Reviewed Journal)
Kim, J.H., Hart-Cooper, W.M., Chan, K.L., Cheng, L.W., Orts, W.J., Johnson, K. 2016. Antifungal efficacy of octylgallate and 4-isopropyl-3-methylphenol for control of Aspergillus. Microbiology Discovery. 4:2.
Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties Reprint Icon - (Peer Reviewed Journal)
Adams, M., Stringer, T., De Kock, C., Smith, P.J., Land, K.M., Liu, N., Tam, C.C., Cheng, L.W., Njoroge, M., Chibale, K., Smith, G.S. 2016. Bioisosteric ferrocenyl-containing quinolines with antiplasmodial and antitrichomonal properties. Dalton Transactions. 45(47):19086-19095.
Anti-protozoal effects of the tomato tetrasaccharide glycoalkaloid tomatine and the aglycone tomatidine on mucosal trichomonads - (Peer Reviewed Journal)
Liu, J., Kanetake, S., Wu, Y., Tam, C.C., Cheng, L.W., Land, K.M., Friedman, M. 2016. Anti-protozoal effects of the tomato tetrasaccharide glycoalkaloid tomatine and the aglycone tomatidine on mucosal trichomonads. Journal of Agricultural and Food Chemistry. 64:8806-8810. doi: 10.1021/acs.jafc.6b04030.
Identification of botulinum neurotoxin serotype a inhibitors using in vitro cell and oral models of intoxication - (Proceedings)
Cheng, L.W., Tam, C.C., Lam, T.A., Stanker, L.H., Martchenko, M. 2016. Identification of botulinum neurotoxin serotype a inhibitors using in vitro cell and oral models of intoxication. TOXINS 2017 Basic Science and Clinical Aspects of Botulinum and Other Neurotoxins. Meeting Proceedings. Toxicon. Rose Puleo ed. 123 supplement:S16-S17 (25 December 2016).
Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus Reprint Icon - (Peer Reviewed Journal)
Leonardi, W., Zilbermintz, L., Cheng, L.W., Zozaya, J., Tran, S.H., Elliott, J.H., Polukhina, K., Manasherob, R., Li, A., Chi, X., Gharaibeh, D., Kenny, T., Zamani, R., Soloveva, V., Haddow, A., Nasar, F., Bavari, S., Bassik, M., Cohen, S.N., Levitin, A., Martchenko, M. 2016. Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus. Scientific Reports. 6:34475. doi: 10.1038/srep34475.
Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics Reprint Icon - (Peer Reviewed Journal)
Stringer, T., De Kock, C., Guzgay, H., Okombo, J., Liu, J., Kanetake, S., Kim, J., Tam, C.C., Cheng, L.W., Smith, P.J., Hendricks, D.T., Land, K.M., Egan, T.J., Smith, G.S. 2016. Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics. Dalton Transactions. 45:13415-13426 doi: 10.1039/c6dt02685k.
Technologies for detecting botulinum neurotoxins in biological and environmental matrices ()
Cheng, L.W., Land, K.M., Tam, C.C., Brandon, D.L., Stanker, L.H. 2016. Technologies for detecting botulinum neurotoxins in biological and environmental matrices. Intech. doi: 10.5772/63064
Methyl-esterified 3-hydroxybutyrate oligomers protect bacteria from hydroxyl radicals - (Peer Reviewed Journal)
Koskimaki, J.J., Kajula, M., Hokkanen, J., Ihantola, E., Kim, J.H., Hautajarvi, H., Hankala, E., Suokas, M., Pohjanen, J., Podolich, O., Kozyrovska, N., Turpeinen, A., Paakkonen, M., Mattila, S., Campbell, B.C., Pirttila, A., Cheng, L.W. 2016. Methyl-esterified 3-hydroxybutyrate oligomers protect bacteria from hydroxyl radicals. Nature Chemical Biology. 2016 12:332-338. doi: 10.1038/nchembio.2043.
Use of monoclonal antibodies in the sensitive detection and neutralization of botulinum neurotoxin serotype B Reprint Icon - (Peer Reviewed Journal)
Cheng, L.W., Henderson Ii, T.D., Lam, T., Stanker, L.H. 2015. Use of monoclonal antibodies in the sensitive detection and neutralization of botulinum neurotoxin serotype B. Toxins. 7:5068-5078. doi: 10.3390/toxins712863.
Augmenting the efficacy of antifungal intervention via chemo-biological approaches - (Proceedings)
Kim, J.H., Chan, K.L., Cheng, L.W. 2015. Augmenting the efficacy of antifungal intervention via chemo-biological approaches. Meeting Abstract. Vol 1, A011 doi:10.3390/ecmc-1-A011.
Inhibiting oral intoxication of botulinum neurotoxin A by carbohydrate receptor mimics Reprint Icon - (Peer Reviewed Journal)
Lee, K., Lam, K., Kruel, A.M., Mahrhold, S., Perry, K., Cheng, L.W., Rummel, A., Jin, R. 2015. Inhibiting oral intoxication of botulinum neurotoxin A by carbohydrate receptor mimics. Toxicon. 107:43-49. doi: org/10.1016/j.toxin2015.08.003.
Targeted antifungal intervention via chemo-biological approaches: Maintaining microbiome dynamics - (Abstract Only)
Kim, J.H., Chan, K.L., Cheng, L.W. 2015. Targeted antifungal intervention via chemo-biological approaches: Maintaining microbiome dynamics. Meeting Abstract. Poster No. 4.
Target discovery and antifungal intervention via chemical biology approaches - (Abstract Only)
Translocation of botulinum neurotoxin serotype a and associated proteins across the intestinal epithelia Reprint Icon - (Peer Reviewed Journal)
Lam, T.I., Stanker, L.H., Lee, K., Jin, R., Cheng, L.W. 2015. Translocation of botulinum neurotoxin serotype a and associated proteins across the intestinal epithelia. Cellular Microbiology. 17(8):1133-1143. doi:10.1111/cmi.12424.
Natural food toxins of bacterial origin ()
Cheng, L.W., Land, K.M., Stanker, L.H. 2015. Natural food toxins of bacterial origin. In: Cheung, P.C.K. Mehta, B.M., editors. Handbook of Food Chemistry. Berlin, Germany: Springer Berlin Heildelberg. p. 1-19.
Centrifugal microfluidic platform for ultrasensitive detection of Botulinum Toxin Reprint Icon - (Peer Reviewed Journal)
Koh, C., Schaff, U.Y., Piccini, M., Stanker, L.H., Cheng, L.W., Ravichandran, E., Sing, B., Sommer, G.J., Singh, A.K. 2014. Centrifugal microfluidic platform for ultrasensitive detection of Botulinum Toxin. Analytical Chemistry. 87(2):922-928. DOI: 10.1021/ac504054u.
Controlled release of B-carotene in B-lactoglobulin-dextran conjugates nanoparticles in vitro digestion and the transport with Caco-2 monolayers - (Peer Reviewed Journal)
Yi, J., Lam, T.I., Yokoyama, W.H., Cheng, L.W., Zhong, F. 2014. Controlled release of B-carotene in B-lactoglobulin-dextran conjugates nanoparticles in vitro digestion and the transport with Caco-2 monolayers. Journal of Agricultural and Food Chemistry. 62(35):8900-8907.
Beta-carotene encapsulated in food protein nanoparticles reduces peroxyl radical oxidation in Caco-2 cells - (Peer Reviewed Journal)
Yi, J., Lam, T.I., Yokoyama, W.H., Cheng, L.W., Zhong, F. 2015. Beta-carotene encapsulated in food protein nanoparticles reduces peroxyl radical oxidation in Caco-2 cells. Food Hydrocolloids Journal. 43:31-40.
Cellular uptake of beta-carotene from protein stabilized solid lipid nano-particles prepared by homogenization-evaporation method - (Peer Reviewed Journal)
Yi, J., Lam, T.I., Yokoyama, W.H., Cheng, L.W., Zhong, F. 2014. Cellular uptake of beta-carotene from protein stabilized solid lipid nano-particles prepared by homogenization-evaporation method. Journal of Agricultural and Food Chemistry. 62(5):1096-104.
A monoclonal antibody based capture ELISA for botulinum neurotoxin serotype B: toxin detection in food Reprint Icon - (Peer Reviewed Journal)
Stanker, L.H., Scotcher, M.C., Cheng, L.W., Ching, K., Mcgarvey, J.A., Hodge, D., Hnasko, R.M. 2013. A monoclonal antibody based capture ELISA for botulinum neurotoxin serotype B: toxin detection in food. Toxins. 5(11):2212-2226.
Mouse in vivo neutralization of Escherichia coli Shiga toxin 2 with monoclonal antibodies Reprint Icon - (Peer Reviewed Journal)
Cheng, L.W., Henderson II, T.D., Patfield, S.A., Stanker, L.H., He, X. 2013. Mouse in vivo neutralization of Escherichia coli Shiga toxin 2 with monoclonal antibodies. Infection and Immunity. 5:1845-1858. DOI: 10.3390/toxins5101845.
Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity - (Peer Reviewed Journal)
Lee, K., Gu, S., Jin, L., Le, T., Cheng, L.W., Strotmeier, J., Krue, A.M., Perry, K., Yao, G., Rummel, A., Jin, R. 2013. Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity. PLoS Pathogens. 9(10):e1003690. DOI: 10.1371/journal.ppat.1003690.
Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples Reprint Icon - (Peer Reviewed Journal)
Bagramyan, K., Kaplan, B.E., Cheng, L.W., Rummel, A., Kalkum, M. 2013. Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples. Analytical Chemistry. 85(11):5569-76. doi: 10.1021/ac4008418.
Translocation of botulinum neurotoxins and associated proteins across intestinal epithelial cells(Abstract) - (Abstract Only)
Detection of botulinum neurotoxin serotypes A and B using a chemiluminescent versus electrochemiluminescent immunoassay in food and serum - (Peer Reviewed Journal)
Cheng, L.W., Stanker, L.H. 2013. Detection of botulinum neurotoxin serotypes A and B using a chemiluminescent versus electrochemiluminescent immunoassay in food and serum. Journal of Agricultural and Food Chemistry. 61(3):755-760 doi:10.1021/jf3041963.
Development and characterization of six monoclonal antibodies to hemagglutinin-70 (HA70) of Clostridium botulinum and their application in a sandwich ELISA - (Peer Reviewed Journal)
Scotcher, M.C., Cheng, L.W., Ching, K.H., Mcgarvey, J.A., Hnasko, R.M., Stanker, L.H. 2013. Development and characterization of six monoclonal antibodies to hemagglutinin-70 (HA70) of Clostridium botulinum and their application in a sandwich ELISA. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 32(1):6-15. doi: 10.1089/mab.2012.0071.
Monoclonal antibodies and reagents for botulinum research - (Proceedings)
Stanker, L.H., Cheng, L.W. 2012. Monoclonal antibodies and reagents for botulinum research. The Botulinum Journal. 2(2):150-155 doi: 10.1504/tbj2012.050197.
Replacement of animals in assays for detection of toxins in food(Abstract) - (Abstract Only)
Detection of botulinum neurotoxin serotypes A and B using chemiluminescence and electrochemiluninescene immunoassays in food and serum matrices - (Abstract Only)
Current methods for detecting the presence of botulinum neurotoxins in food and other biological samples ()
Cheng, L.W., Land, K.M., Stanker, L.H. 2012. Current methods for detecting the presence of botulinum neurotoxins in food and other biological samples. Morse, S., editor. Bioterrorism. Rijeka, Croatia: Intech. p. 1-16.
Comparison of oral toxicological properties of botulinum neurotoxin - (Peer Reviewed Journal)
Cheng, L.W., Henderson II, T.D. 2011. Comparison of oral toxicological properties of botulinum neurotoxin. Toxicon. 58:62-67.
Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR - (Peer Reviewed Journal)
He, X., Mcmahon, S.A., Henderson II, T.D., Griffey, S.M., Cheng, L.W. 2010. Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR. PLoS One. 5(9):e12858. doi:10.1371/journal.pone.0012858.
Botulinum neurotoxin: a deadly protease with applications to human medicine ()
Land, K.M., Cheng, L.W. 2010. Botulinum neurotoxin: a deadly protease with applications to human medicine. Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology. Spain. Formatex Research Center. 965-971.
Detection of Botulinum Neurotoxin Serotype B at Sub Mouse LD50 Levels by a Sandwich Immunoassay and its Application to Toxin Detection in Milk - (Peer Reviewed Journal)
Scotcher, M.C., Cheng, L.W., Stanker, L.H. 2010. Detection of Botulinum Neurotoxin Serotype B at Sub Mouse LD50 Levels by a Sandwich Immunoassay and its Application to Toxin Detection in Milk. PLos One. 5(6):e11047.doi:10.1371/journal.pone.0011047.
Comparison of Toxicological Properties of Botulinum Neurotoxin Serotypes A and B in Mice - (Abstract Only)
Cheng, L.W., Henderson Ii, T.D., Scotcher, M.C., Stanker, L.H. 2009. Comparison of Toxicological Properties of Botulinum Neurotoxin Serotypes A and B in Mice. American Chemical Society [Abstract]. Paper No. 26541
Antibody Protection Against Botulinum Neurotoxin Intoxication In Mice - (Peer Reviewed Journal)
Cheng, L.W., Stanker, L.H., Henderson Ii, T.D., Lou, J., Marks, J.D. 2009. Antibody Protection Against Botulinum Neurotoxin Intoxication In Mice. Infection and Immunity. 77(10):4305-4313.
Detection of Protein Toxins - (Abstract Only)
Brandon, D.L., Cheng, L.W., He, X., Rasooly, R., Scotcher, M.C., Stanker, L.H., Carter, J.M. 2009. Detection of Protein Toxins. Meeting Abstract. Poster No. 8.
Botulinum Neurotoxin Research at the Western Regional Research Center - (Abstract Only)
Influence of Gene Expression on Variable Aflatoxin Production by Different Strains of Aspergillus flavus - (Abstract Only)
Detection and bioavailability of two biothreat toxins - (Abstract Only)
Brandon, D.L., Cheng, L.W., He, X., Rasooly, R., Scotcher, M.C., Stanker, L.H., Carter, J.M. 2008. Detection and bioavailability of two biothreat toxins. Meeting Abstract. Poster No. 2.
BOTOX and our tax dollars at work ()
Immunochemical technologies for replacement of rodent bioassays in sensitive detection of toxins in foods - (Proceedings)
Carter, J.M., Cheng, L.W., He, X., Rasooly, R., Brandon, D.L., Stanker, L.H. 2010. Immunochemical technologies for replacement of rodent bioassays in sensitive detection of toxins in foods. Proceedings from Biodetection Technologies 6th Edition. 5:75-95.
Effect of food matrices on the biological activity of ricin - (Peer Reviewed Journal)
He, X., Lu, S.S., Cheng, L.W., Rasooly, R., Carter, J.M. 2008. Effect of food matrices on the biological activity of ricin. Journal of Food Protection 71(10):2053-2058.
Detection of botulinum neurotoxin-A activity in food by peptide cleavage assay - (Peer Reviewed Journal)
Rasooly, R., Stanker, L.H., Carter, J.M., Do, P.M., Cheng, L.W., He, X., Brandon, D.L. 2008. In vitro peptide cleavage assay for detection of Botulinum Neurotoxin-A activity in food. International Journal of Food Microbiiology. 126 (2008):135-139
Effects of purification on the bioavailability of botulinum neurotoxin type A - (Peer Reviewed Journal)
Cheng, L.W., Onisko, B.C., Johnson, E.A., Reader, J.R., Griffey, S.M., Larson, A.E., Tepp, W.H., Stanker, L.H., Brandon, D.L., Carter, J.M. 2008. Effects of purification on the bioavailability of botulinum neurotoxin type A. Toxicology. 249(2008):123-129.
Development and Partial Characterization of High-affinity Monoclonal Antibodies for Botulinum Toxin Type A and their use in Analysis of Milk by Sandwich ELISA - (Peer Reviewed Journal)
Stanker, L.H., Merrill, P.A., Scotcher, M.C., Cheng, L.W. 2008. Development and Partial Characterization of High-affinity Monoclonal Antibodies for Botulinum Toxin Type A and their use in Analysis of Milk by Sandwich ELISA. Journal of Immunological Methods, 336:1-8.
Application of a real time PCR method to detect castor toxin contamination in fluid milk and eggs - (Peer Reviewed Journal)
He, X., Carter, J.M., Brandon, D.L., Cheng, L.W., Mckeon, T.A. 2007. Application of a real time PCR method to detect castor toxin contamination in fluid milk and eggs. Journal of Agricultural and Food Chemistry. 55:6897-6902
Molecular Approaches for the Identification of Toxin in Foods - (Abstract Only)
BIOAVAILABILITY OF CRUDE RICIN IN FOOD MATRICES - (Abstract Only)
Cheng, L.W., Brandon, D.L., He, X., Chen, G.Q., Carter, J.M. 2006. Bioavailability of crude ricin in food matrices. [Abstract]. ACS National Meeting and Exposition. Poster AGFD 64
DEVELOPMENT OF NEW MONOCLONAL ANTIBODIES SPECIFIC FOR BOTULINUM NEUROTOXIN TYPE A - (Abstract Only)
Stanker, L.H., Merrill, P.A., Cheng, L.W., Carter, J.M., Brandon, D.L. 2006. Development of new monoclonal antibodies specific for botulinum neurotoxin type a. [Abstract]. ACS National Meeting. Oral Presentation AGRO 235.
DEVELOPMENT OF MONOCLONAL ANTIBODIES SPECIFIC FOR RICIN - (Abstract Only)
Brandon, D.L., Cheng, L.W., He, X., Carter, J.M. 2006. Development of monoclonal antibodies specific for ricin. [Abstract]. ACS National Meeting and Exposition. Oral Presentation AGRO 234
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