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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Infectious Bacterial Diseases Research » People & Locations » David Alt

David P Alt
Infectious Bacterial Diseases Research
Veterinary Medical Officer

Phone: (515) 337-7645
Fax: (515) 337-7149
Room 1507

1920 DAYTON AVE
AMES, IA 50010
Projects
Characterization of the Pathogenesis and Antigen Expression in Spirochete Diseases
In-House Appropriated (D)
  Accession Number: 432150

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Isolation and propagation of leptospires at 37C directly from the mammalian host Reprint Icon - (Peer Reviewed Journal)
Hornsby, R.L., Alt, D.P., Nally, J.E. 2020. Isolation and propagation of leptospires at 37 degree C directly from the mammalian host. Scientific Reports. 10(9620). https://doi.org/10.1038/s41598-020-66526-4.
Complete genome sequences of 16 Mycoplasma bovis isolates from Canadian bison and cattle Reprint Icon - (Peer Reviewed Journal)
Register, K.B., Bayles, D.O., Ma, H., Windeyer, C., Perez-Casal, J., Bras, A., Suleman, M., Woodbury, M., Jelinski, M., Alt, D.P. 2020. Complete genome sequences of 16 Mycoplasma bovis isolates from Canadian bison and cattle. Microbiology Resource Announcements. 9(23):e00325-20. https://doi.org/10.1128/MRA.00325-20.
Genome sequence of a chronic Staphylococcus aureus isolated from a dairy cow that was non-responsive to antibiotic treatment Reprint Icon - (Peer Reviewed Journal)
Lippolis, J.D., Putz, E.J., Ma, H., Alt, D.P., Casas, E., Reinhardt, T.A. 2020. Genome sequence of a chronic Staphylococcus aureus strain isolated from a dairy cow that was non-responsive to antibiotic treatment. Microbiology Resource Announcements. 9(20):e00206-20. https://doi.org/10.1128/MRA.00206-20.
Comparison of two multilocus sequence typing schemes for Mycoplasma bovis and revision of the pubMLST reference method Reprint Icon - (Peer Reviewed Journal)
Register, K.B., Lysnyansky, I., Jelinski, M., Boatwright Jr, W.D., Waldner, M., Bayles, D.O., Pilo, P., Alt, D.P. 2020. Comparison of two multilocus sequence typing schemes for Mycoplasma bovis and revision of the pubMLST reference method. Journal of Clinical Microbiology. 58(6):e00283-20. https://doi.org/10.1128/JCM.00283-20.
Super-shed Escherichia coli O157:H7 have potential for increased persistence on the recto-anal junction squamous epithelial cells and antibiotic resistance Reprint Icon - (Peer Reviewed Journal)
Mir, R.A., Brunelle, B.W., Alt, D.P., Arthur, T.M., Kudva, I.T. 2020. Super-shed Escherichia coli O157:H7 has potential for increased persistence on the recto-anal junction squamous epithelial cells and antibiotic resistance. International Journal of Microbiology. 2020(2368154):1-16. https://doi.org/10.1155/2020/2368154.
Bovine immune response to leptospiral antigen in different novel adjuvants and vaccine delivery platforms Reprint Icon - (Peer Reviewed Journal)
Wilson-Welder, J.H., Boggiatto, P.M., Nally, J.E., Wafa, E.I., Alt, D.P., Hornsby, R.L., Frank, A.T., Jones, D.E., Olsen, S.C., Bowden, N.B., Salem, A.K. 2020. Bovine immune response to leptospiral antigen in different novel adjuvants and vaccine delivery platforms. Vaccine. 38(18):3464-3473. https://doi.org/10.1016/j.vaccine.2020.02.086.
Comparison of two schemes for multilocus sequence typing (MLST) of Mycoplasma bovis and revision of the pubMLST reference method - (Abstract Only)
Characterization of the RB51 genome sequence in the context of vaccine properties Reprint Icon - (Peer Reviewed Journal)
Bricker, B.J., Goonesekere, N., Bayles, D.O., Alt, D.P., Olsen, S.C., Vrentas, C.E. 2020. Genome report-a genome sequence analysis of the RB51 strain of Brucella abortus in the context of its vaccine properties. G3, Genes/Genomes/Genetics. 10(4):1175-1181. https://doi.org/10.1534/g3.119.400964.
Shifts in the swine nasal microbiota of swine in response to different dosing regimens of oxytetracycline administration Reprint Icon - (Peer Reviewed Journal)
Mou, K.T., Allen, H.K., Alt, D.P., Trachsel, J.M., Hau, S.J., Coetzee, J.F., Holman, D.B., Kellner, S.G., Loving, C.L., Brockmeier, S. 2019. Shifts in the swine nasal microbiota of swine in response to different dosing regimens of oxytetracycline administration. Veterinary Microbiology. 237(1084020). https://doi.org/10.1016/j.vetmic.2019.108386.
Phenotypic and proteomic characterization of treponemes associated with bovine digital dermatitis Reprint Icon - (Peer Reviewed Journal)
Nally, J.E., Hornsby, R.L., Alt, D.P., Whitelegge, J.P. 2019. Phenotypic and proteomic characterization of treponemes associated with bovine digital dermatitis. Veterinary Microbiology. 235:35-42. https://doi.org/10.1016/j.vetmic.2019.05.023.
Comparative genomic and methylome analysis of non-virulent D74 and virulent Nagasaki Haemophilus parasuis isolates Reprint Icon - (Peer Reviewed Journal)
Nicholson, T.L., Brunelle, B.W., Bayles, D.O., Alt, D.P., Shore, S. 2018. Comparative genomic and methylome analysis of non-virulent D74 and virulent Nagasaki Haemophilus parasuis isolates. PLoS One. 13(11):e0205700. https://doi.org/10.1371/journal.pone.0205700.
Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene expression in brucellosis Reprint Icon - (Peer Reviewed Journal)
Boggiatto, P.M., Vrentas, C.E., Fitzsimmons, D.J., Bayles, D.O., Alt, D.P., Olsen, S.C. 2018. Coincidence cloning recovery of Brucella melitensis RNA from goat tissues: advancing the in vivo analysis of pathogen gene expression in brucellosis. BioMed Central (BMC) Molecular Biology. 19:10. https://doi.org/10.1186/s12867-018-0111-x.
Bulk soil bacterial community structure and function respond to long-term organic and conventional agricultural management Reprint Icon - (Peer Reviewed Journal)
Bakker, M.G., Looft, T., Alt, D.P., Delate, K., Cambardella, C.A. 2018. Bulk soil bacterial community structure and function respond to long-term organic and conventional agricultural management. Canadian Journal of Microbiology. 64(12):901-914. https://doi.org/10.1139/cjm-2018-0134.
Short communication: Lymphocyte proliferative responses in cattle naturally infected with digital dermatitis consists of CD8+ and gamma delta T cells but lack CD4+ T cells Reprint Icon - (Peer Reviewed Journal)
Wilson-Welder, J.H., Nally, J.E., Alt, D.P., Humphrey, S.B., Olsen, S.C. 2018. Short communication: Lymphocyte proliferative responses in cattle naturally infected with digital dermatitis consists of CD8plus and gamma delta T cells but lack CD4plus T cells. Journal of Dairy Science. 101(9):8301-8307. https://doi.org/10.3168/jds.2017-13913.
Isolation and characterization of pathogenic leptospires associated with cattle Reprint Icon - (Peer Reviewed Journal)
Nally, J.E., Hornsby, R.L., Alt, D.P., Bayles, D.O., Wilson-Welder, J.H., Bauer, N.E. 2018. Isolation and characterization of pathogenic leptospires associated with cattle. Veterinary Microbiology. 218:25-30. https://doi.org/10.1016/j.vetmic.2018.03.023.
Inbred rats as a model to study persistent renal colonization and associated cellular immune responsiveness Reprint Icon - (Peer Reviewed Journal)
Nally, J.E., Wilson-Welder, J.H., Hornsby, R.L., Palmer, M.V., Alt, D.P. 2018. Inbred rats as a model to study persistent renal colonization and associated cellular immune responsiveness. Frontiers in Cellular and Infection Microbiology. https://doi.org/10.3389/fcimb.2018.00066.
Experimental transmission of bovine digital dermatitis to sheep: development of an infection model. Reprint Icon - (Peer Reviewed Journal)
Wilson-Welder, J.H., Nally, J.E., Alt, D.P., Palmer, M.V., Cotaney, J., Plummer, P. 2017. Experimental transmission of bovine digital dermatitis to sheep: development of an infection model. Veterinary Pathology. 55(2):245-257. https://doi.org/10.1177/0300985817736572.
Draft genome sequences of 64 swine associated LA-MRSA ST5 isolates from the USA - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Frana, T.S., Nicholson, T.L. 2017. Draft genome sequences of 63 swine-associated methicillin-resistant Staphylococcus aureus sequence type 5 isolates from the United States. Genome Announcements. 5(44):e01081-17.
Draft genome sequences of 50 MRSA ST5 isolates obtained from a U.S. hospital - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Nicholson, T.L. 2017. Draft genome sequences of 50 methicillin-resistant Staphylococcus aureus sequence type 5 isolates obtained from a U.S. hospital. Genome Announcements. 5(44):e01083-17.
Draft genome sequences of 9 LA-MRSA ST5 isolates from humans with long term swine contact - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Davies, P.R., Haan, J.S., Nicholson, T.L. 2017. Draft genome sequences of nine livestock-associated methicillin-resistant Staphylococcus aureus sequence type 5 isolates from humans with long-term swine contact. Genome Announcements. 5(41):e01079-17.
Draft genome sequences of 9 LA-MRSA ST5 isolates obtained from humans after short term swine contact - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Frana, T.S., Nicholson, T.L. 2017. Draft genome sequences of nine livestock-associated methicillin-resistant Staphylococcus aureus sequence type 5 isolates obtained from humans after short-term swine contact. Genome Announcements. 5(41):e01080-17.
Draft genome sequences of 14 swine associated LA-MRSA ST398 isolates from the U.S. - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Frana, T.S., Nicholson, T.L. 2017. Draft genome sequences of 14 livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 isolates from swine farms in the United States. Genome Announcements. 5(44):e01082-17.
Draft genome sequences of 1 MSSA and 7 MRSA ST5 isolates obtained from California - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Nicholson, T.L. 2017. Draft genome sequences of one methicillin-sensitive and seven methicillin-resistant Staphylococcus aureus sequence type 5 Isolates obtained in California. Genome Announcements. 5(42):e01084-17.
Complete genome sequence of livestock associated methicillin resistant Staphylococcus aureus ST398 isolated from swine in USA Reprint Icon - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Frana, T.S., Nicholson, T.L. 2017. Complete genome sequence of livestock-associated methicillin-resistant Staphylococcus aureus sequence type 398 isolated from swine in the United States. Genome Announcements. 5(32):pii: e00790-17. https://doi.org/10.1128/genomeA.00790-17.
Complete genome sequence of a swine associated LA-MRSA ST5 isolate from the USA Reprint Icon - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Frana, T.S., Nicholson, T.L. 2017. Complete genome sequence of a livestock-associated methicillin-resistant Staphylococcus aureus sequence type 5 isolate from the United States. Genome Announcements. 5(32):e00791-17. https://doi.org/10.1128/genomeA.00791-17.
Treponeme-associated hoof disease of wild elk (Cervus elaphus spp.) in southwestern Washington State, USA Reprint Icon - (Peer Reviewed Journal)
Han, S., Mansfield, K., Haldorson, G., Bradway, D., Besser, T., Reed, D., Alt, D.P., Wilson-Welder, J.H. 2018. Treponeme-associated hoof disease of wild elk (Cervus elaphus spp.) in southwestern Washington State, USA. Veterinary Pathology. https://doi.org/10.1177/0300985818798108.
Comparative genomic and transcriptional analysis of virulent and non-virulent Haemophilus parasuis isolates - (Abstract Only)
Disruption of rcsB by a duplicated sequence in a curli-producing Escherichia coli O157:H7 results in differential gene expression in relation to biofilm formation, stress responses, and metabolism - (Peer Reviewed Journal)
Sharma, V.K., Bayles, D.O., Alt, D.P., Looft, T.P., Brunelle, B.W., Stasko, J.A. 2017. Disruption of rcsB by a duplicated sequence in a curli-producing Escherichia coli O157:H7 results in differential gene expression in relation to biofilm formation, stress responses, and metabolism. BMC Microbiology. 17(1):56. doi: 10.1186/s12866-017-0966-x.
Effect of in-feed versus injected oxytetracycline on piglet nasal and tonsil microbiota - (Abstract Only)
Complete genome sequences of two Staphylococcus aureus ST5 isolates from California, USA - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Nicholson, T.L. 2017. Complete genome sequences of two Staphylococcus aureus sequence type 5 isolates from California, USA. Genome Announcements. 5:e00099-17. doi.org/10.1128/genomeA.00099-17.
Draft genome sequences of 14 Staphylococcus aureus ST5 isolates from California, USA - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Nicholson, T.L. 2017. Draft genome sequences of 14 Staphylococcus aureus sequence type 5 isolates from California, USA. Genome Announcements. 5(13):e00098-17. doi.org/10.1128/genomeA.00098-17.
Complete genome sequences of curli-negative and curli-positive isolates of foodborne Escherichia coli O157:H7 strain 86-24 - (Peer Reviewed Journal)
Sharma, V.K., Bayles, D.O., Alt, D.P., Looft, T.P. 2016. Complete genome sequences of curli-negative and curli-positive isolates of foodborne Escherichia coli O157:H7 strain 86-24. Genome Announcements. 4(6):e01323-16. doi: 10.1128/genomeA.01323-16.
Interaction of bovine peripheral blood polymorphonuclear cells and Leptospira species; innate responses in the natural bovine reservoir host. - (Peer Reviewed Journal)
Wilson-Welder, J.H., Frank, A.T., Hornsby, R.L., Olsen, S.C., Alt, D.P. 2016. Interaction of bovine peripheral blood polymorphonuclear cells and Leptospira species; innate responses in the natural bovine reservoir host. Frontiers in Microbiology. 7:1110.
Digital dermatitis in cattle: current bacterial and immunological findings - (Peer Reviewed Journal)
Wilson-Welder, J.H., Alt, D.P., Nally, J.E. 2015. Digital dermatitis in cattle: current bacterial and immunological findings. Animals. 5:114-1135. doi: 10.3390/ani5040400.
Draft genome sequences of nine Streptococcus suis strains isolated in the United States - (Peer Reviewed Journal)
Hau, S.J., Bayles, D.O., Alt, D.P., Brockmeier, S.L., Frana, T.S., Nicholson, T.L. 2015. Draft genome sequences of nine Streptococcus suis strains isolated in the United States. Genome Announcements. 3(6):e01301-15.
Complete genome sequence of Coriobacteriaceae Strain 68-1-3, a novel mucus- degrading isolate from the swine intestinal tract - (Peer Reviewed Journal)
Comparative transcriptional profiling reveals differential expression of pathways directly and indirectly influencing biofilm formation in Escherichia coli O157:H7 - (Abstract Only)
Sharma, V.K., Alt, D.P., Bayles, D.O., Looft, T.P., Brunelle, B.W. 2015. Comparative transcriptional profiling reveals differential expression of pathways directly and indirectly influencing biofilm formation in Escherichia coli O157:H7 [abstract]. Verocytotoxin Producing Escherichia Coli. p. 119.
Complete genome sequence of Leptospira interrogans serovar Bratislava, strain PigK151 - (Peer Reviewed Journal)
Alt, D.P., Wilson-Welder, J.H., Bayles, D.O., Cameron, C., Adler, B., Bulach, D.M., Seemann, T., Lehane, M.J., Haines, L.R., Darby, A.C., Hall, N., Radford, A.D., Zuerner, R.L. 2015. Complete genome sequence of Leptospira interrogans serovar Bratislava, strain PigK151. Genome Announcements. 3(3):e00678-15. DOI: 10.1128/genomeA.00678-15.
The etiology of digital dermatitis in ruminants: recent perspectives Reprint Icon - (Peer Reviewed Journal)
Wilson-Welder, J.H., Alt, D.P., Nally, J.E. 2015. The etiology of digital dermatitis in ruminants: recent perspectives. Veterinary Medicine: Research and Reports. 2015(6):155-164.
Antibiotic efficacy in eliminating leptospiruria in California sea lions (Zalophus californianus) stranding with leptospirosis - (Peer Reviewed Journal)
Prager, K.C., Alt, D.P., Buhnerkempe, M.G., Greig, D.J., Galloway, R.L., Wu, Q., Gulland, F.M., Lloyd-Smith, J.O. 2015. Antibiotic efficacy in eliminating leptospiruria in California sea lions (Zalophus californianus) stranding with leptospirosis. Aquatic Mammals. 41(2):203-212.
Role of intraocular Leptospira infections in the pathogenesis of Equine Recurrent Uveitis in the Southern United States - (Peer Reviewed Journal)
Polle, F., Storey, E., Eades, S., Alt, D.P., Hornsby, R.L., Zuerner, R., Carter, R. 2014. Role of intraocular Leptospira infections in the pathogenesis of equine recurrent uveitis in the Southern United States. Journal of Equine Veterinary Science. 34(11-12):1300-1306.
Identification of several clades of novel single-stranded circular DNA viruses with conserved stem-loop structures in pig feces - (Peer Reviewed Journal)
Cheung, A.K., Ng, TF., Lager, K.M., Alt, D.P., Delwart, E., Pogranichniy, R.M. 2015. Identification of several clades of novel single-stranded circular DNA viruses with conserved stem-loop structures in pig feces. Archives of Virology. 160(1):353-358.
Identification of eight clades of novel single-stranded circular DNA viruses in pig feces - (Abstract Only)
Carbadox has both temporary and lasting effects on the swine gut microbiota - (Peer Reviewed Journal)
Looft, T.P., Allen, H.K., Casey, T., Alt, D.P., Stanton, T.B. 2014. Carbadox has both temporary and lasting effects on the swine gut microbiota. Frontiers in Microbiology. DOI: 10.3389/fmicb.2014.00276.
Development of a real-time PCR for the detection of pathogenic Leptospira spp. in California sea lions Reprint Icon - (Peer Reviewed Journal)
Wu, Q., Prager, K.C., Goldstein, T., Alt, D.P., Galloway, R.L., Zuerner, R.L., Lloyd-Smith, J.O., Schwacke, L. 2014. Development of a real-time PCR for the detection of pathogenic Leptospira spp. in California sea lions. Diseases of Aquatic Organisms. 110(3):165-172.
Identification of a novel circular DNA virus in pig feces - (Peer Reviewed Journal)
Cheung, A.K., Ng, T.F., Lager, K.M., Alt, D.P., Delwart, E.L., Pogranichniy, R.M. 2014. Identification of a novel single-stranded circular DNA virus in pig feces. Genome Announcements. 2(2):e00347-14.
A unique circovirus-like genome detected in pig feces - (Peer Reviewed Journal)
Cheung, A.K., Ng, T.F., Lager, K.M., Alt, D.P., Delwart, E.L., Pogranichniy, R.M. 2014. Unique circovirus-like genome detected in pig feces. Genome Announcements. 2(2):e00251-14.
Bacteria, phages, and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations Reprint Icon - (Peer Reviewed Journal)
Looft, T.P., Allen, H.K., Cantarel, B., Levine, U.Y., Bayles, D.O., Alt, D.P., Henrissat, B., Stanton, T.B. 2014. Bacteria, phages, and pigs: the effects of in-feed antibiotics on the microbiome at different gut locations. Journal of the International Society for Microbial Ecology. 8(8):1566-1576. DOI: 10.1038/ismej.2014.12.
Biochemical and molecular characterization of Treponema phagedenis-like spirochetes isolated from a bovine digital dermatitis lesion Reprint Icon - (Peer Reviewed Journal)
Wilson-Welder, J.H., Elliott, M.K., Zuerner, R.L., Bayles, D.O., Alt, D.P., Stanton, T.B. 2013. Biochemical and molecular characterization of Treponema phagedenis-like spirochetes isolated from a bovine digital dermatitis lesion. BMC Microbiology. 13:280. Available: http://www.biomedcentral.com/content/pdf/1471-2180-13-280.pdf.
Dynamic phages in the swine gut ecosystem - (Abstract Only)
Allen, H.K., Looft, T.P., Bayles, D.O., Alt, D.P., Stanton, T.B. 2013. Dynamic phages in the swine gut ecosystem [abstract]. Molecular Genetics of Bacteria and Phage Meeting. p. 94.
Expansion of the in vitro assay for Leptospira potency testing to other Serovars: Case study with Leptospira hardjo Reprint Icon ()
Alt, D.P., Wilson-Welder, J.H. 2013. Expansion of the in vitro assay for Leptospira potency testing to other serovars: Case study with Leptospira hardjo. Biologicals. 41(5):323-324.
Gene expression changes in the swine microbiota with the in-feed antibiotic carbadox - (Abstract Only)
Looft, T.P., Allen, H.K., Severin, A., Levine, U.Y., Bayles, D.O., Alt, D.P., Stanton, T.B. 2013. Gene expression changes in the swine microbiota with the in-feed antibiotic carbadox. [abstract]. 113th General Meeting, American Society for Microbiology. p. 200.
A divergent clade of circular single-stranded DNA viruses from pig feces - (Peer Reviewed Journal)
Cheung, A.K., Ng, T.F., Lager, K.M., Bayles, D.O., Alt, D.P., Delwart, E.L., Pogranichniy, R.M., Kehrli, Jr., M.E. 2013. A divergent clade of circular single-stranded DNA viruses from pig feces. Archives of Virology. 158(10):2157-2162.
Profiling the gastrointestinal microbiota in response to Salmonella: low versus high Salmonella shedding in the natural porcine host Reprint Icon - (Peer Reviewed Journal)
Bearson, S.M., Allen, H.K., Bearson, B.L., Looft, T.P., Brunelle, B.W., Kich, J.D., Tuggle, C.K., Bayles, D.O., Alt, D.P., Levine, U.Y., Stanton, T.B. 2013. Profiling the gastrointestinal microbiota in response to Salmonella: low versus high Salmonella shedding in the natural porcine host. Infection, Genetics and Evolution. 16:330-340.
Asymptomatic and chronic carriage of Leptospira interrogans serovar Pomona in California sea lions (Zalophus californianus) Reprint Icon - (Peer Reviewed Journal)
Prager, K.C., Greig, D.J., Alt, D.P., Galloway, R.L., Hornsby, R.L., Palmer, L.J., Soper, J., Wu, Q., Zuerner, R.L., Gulland, F.M., Lloyd-Smith, J.O. 2013. Asymptomatic and chronic carriage of Leptospira interrogans serovar Pomona in California sea lions (Zalophus californianus). Veterinary Microbiology. 164(1-2):177-183.
Diversity of viruses detected by deep sequencing in pigs from a common background - (Peer Reviewed Journal)
Lager, K.M., Ng, T.F., Bayles, D.O., Alt, D.P., Delwart, E.L., Cheung, A.K. 2012. Diversity of viruses detected by deep sequencing in pigs from a common background. Journal of Veterinary Diagnostic Investigation. 24(6):1177-1179.
Letter to the Editor ()
Alt, D.P., Olsen, S.C., Bolin, C. 2012. Letters to the Editor. American Journal of Veterinary Research. 73(7):928-929.
Profiling the gastrointestinal microbiota in response to Salmonella: low versus high Salmonella shedding in the porcine host - (Abstract Only)
Bearson, S.M., Allen, H.K., Bearson, B.L., Looft, T.P., Brunelle, B.W., Kich, J.D., Bayles, D.O., Alt, D.P., Levine, U.Y., Stanton, T.B. 2012. Profiling the gastrointestinal microbiota in response to Salmonella: low versus high Salmonella shedding in the porcine host [abstract]. American Society for Microbiology General Meeting, June 16-19, 2012, San Francisco, California. p. 3150.
Genome sequencing of ovine isolates of Mycobacterium avium subspecies paratuberculosis offer insights into host association - (Peer Reviewed Journal)
Bannantine, J.P., Wu, C., Hsu, C., Zhou, S., Schwartz, D.C., Bayles, D.O., Paustian, M.L., Alt, D.P., Sreevatsan, S., Kapur, V., Talaat, A.M. 2012. Genome sequencing of ovine isolates of Mycobacterium avium subspecies paratuberculosis offers insights into host association. Biomed Central (BMC) Genomics. 13:89. Available: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3337245/pdf/1471-2164-13-89.pdf.
In-feed antibiotic effects on the swine intestinal microbiome - (Peer Reviewed Journal)
Looft, T.P., Johnson, T., Allen, H.K., Bayles, D.O., Alt, D.P., Cole, J., Hashsham, S., Stedtfeld, R., Stedtfeld, T., Chai, B., Tiedje, J., Stanton, T.B. 2012. In-feed antibiotic effects on the swine intestinal microbiome. Proceedings of the National Academy of Sciences. 109(5):1691-1696.
Antibiotics in feed induce prophages in swine fecal microbiomes - (Peer Reviewed Journal)
Allen, H.K., Looft, T.P., Bayles, D.O., Humphrey, S.B., Levine, U.Y., Alt, D.P., Stanton, T.B. 2011. Antibiotics in feed induce prophages in swine fecal microbiomes. mBio [serial online]. 2(6). Available: http://mbio.asm.org/content/2/6/e00260-11.
Large scale parallel pyrosequencing technology: PRRSV strain VR-2332 nsp2 deletion mutant stability in swine - (Peer Reviewed Journal)
Guo, B., Vorwald, A.C., Alt, D.P., Lager, K.M., Bayles, D.O., Faaberg, K.S. 2011. Large scale parallel pyrosequencing technology: PRRSV strain VR-2332 nsp2 deletion mutant stability in swine. Virus Research. 161(2):162-169.
Development of Chronic and Acute Golden Syrian Hamster Infection Models with Leptospira borgpetersenii serovar Hardjo - (Peer Reviewed Journal)
Zuerner, R.L., Alt, D.P., Palmer, M.V. 2011. Development of chronic and acute Golden Syrian Hamster infection models with Leptospira borgpetersenii serovar Hardjo. Veterinary Pathology. 49(2):403-411.
A Leptospira borgpetersenii Serovar Hardjo vaccine induces a Th1 response, activates NK cells, and reduces renal colonization - (Peer Reviewed Journal)
Zuerner, R.L., Alt, D.P., Palmer, M.V., Thacker, T.C., Olsen, S.C. 2011. A Leptospira borgpetersenii Serovar Hardjo vaccine induces a Th1 response, activates NK cells, and reduces renal colonization. Clinical and Vaccine Immunology. 18(4):684-691.
Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008 - (Peer Reviewed Journal)
Lorusso, A., Vincent, A.L., Harland, M.L., Alt, D., Bayles, D.O., Swenson, S.L., Gramer, M.R., Russel, C.A., Smith, D.J., Lager, K.M., Lewis, N.S. 2011. Genetic and antigenic characterization of H1 influenza viruses from United States swine from 2008. Journal of General Virology. 92(Pt 4):919-930.
Genetic and Antigenic Characterization of H1 Influenza Viruses from United States Swine Prior to the Emergence of the 2009 Pandemic H1N1 - (Abstract Only)
Lorusso, A., Vincent, A., Harland, M., Alt, D., Bayles, D., Swenson, S., Gramer, M., Russell, C., Smith, D., Lager, K., Lewis, N. 2010. Genetic and antigenic characterization of H1 Influenza Viruses from United States swine prior to the emergence of the 2009 pandemic H1N1 [abstract]. Conference of Research Workers in Animal Diseases. Paper No. 194.
Genome Sequence of Mycobacterium avium subspecies paratuberculosis Sheep Isolate 397 Reveals Striking Differences Among a Genetically Homogeneous Subspecies - (Abstract Only)
Metagenomic and 16S rRNA Analyses of Fecal Bacteria of Swine Given Diets Containing Antibiotics - (Abstract Only)
Genetic and Antigenic Characterization of 2008 Swine Influenza Viruses from the United States - (Proceedings)
Vincent, A.L., Harland, M.L., Lorusso, A., Alt, D.P., Bayles, D.O., Swenson, S.L., Gramer, M.R., Lager, K.M., Lewis, N. 2010. Genetic and Antigenic Characterization of 2008 Swine Influenza Viruses from the United States. In: Proceedings of the International Pig Veterinary Society Congress, July 18-21, 2010, Vancouver, Canada. p. 259.
Development of Hamster Models for Acute and Chronic Infections with Leptospira borgpetersenii serovar Hardjo - (Abstract Only)
Zuerner, R.L., Alt, D.P., Palmer, M.V. 2009. Development of Hamster Models for Acute and Chronic Infections with Leptospira borgpetersenii serovar Hardjo. Meeting Abstract.
Bovine Immune Response to Papillomatous Digital Dermatitis (PDD)-associated Spirochetes is Skewed in Isolate Reactivity and Subclass Elicitation - (Peer Reviewed Journal)
Elliott, M.K., Alt, D.P. 2009. Bovine Immune Response to Papillomatous Digital Dermatitis (PDD)-associated Spirochetes is Skewed in Isolate Reactivity and Subclass Elicitation. Veterinary Immunology and Immunopathology. 130(3-4):256-261.
Variable Nucleotide Tandem-Repeat Analysis Revealing a Unique Group of Leptospira interrogans Serovar Pomona Isolates Associated with California Sea Lions - (Peer Reviewed Journal)
Zuerner, R.L., Alt, D.P. 2009. Variable Nucleotide Tandem-Repeat Analysis Revealing a Unique Group of Leptospira interrogans Serovar Pomona Isolates Associated with California Sea Lions. Journal of Clinical Microbiology. 47(4):1202-1205.
Geographical Dissemination of Leptospira interrogans serovar Pomona During Seasonal Migration of California Sea Lions - (Peer Reviewed Journal)
Zuerner, R.L., Cameron, C.E., Raverty, S., Robinson, J., Colegrove, K., Norman, S.A., Lambourn, D., Jeffries, S., Alt, D.P., Gulland, F. 2009. Geographical Dissemination of Leptospira interrogans serovar Pomona During Seasonal Migration of California Sea Lions. Veterinary Microbiology. 137(1-2):105-110.
Western-blot detection of PrP**sc in archived paraffin-embedded brainstem from scrapie-affected sheep - (Peer Reviewed Journal)
Kunkle, R.A., Nicholson, E.M., Lebepe-Mazur, S., Orcutt, D.L., Srinivas, M.L., Greenlee, J.J., Alt, D.P., Hamir, A.N. 2008. Western blot detection of PrP**sc in archived paraffin-embedded brainstem from scrapie-affected sheep. Journal of Veterinary Diagnostic Investigation. 20(4):522-526.
Antigenic Targets of the Bovine Humoral Response to PDD-associated Spirochetes Change with Subsequent Exposure - (Abstract Only)
Lesion Formation and Antibody Response Induced by Papillomatous Digital Dermatitis-Associated Spirochetes in a Murine Abscess Model - (Peer Reviewed Journal)
Elliott, M.K., Alt, D.P., Zuerner, R.L. 2007. Lesion Formation and Antibody Response Induced by Papillomatous Digital Dermatitis (PDD)-associated spirochetes in a Murine Abscess Model. Infection and Immunity. 75(9):4400-4408.
Papillomatous Digital Dermatitis Spirochetes Suppress the Bovine Macrophage Innate Immune Response - (Peer Reviewed Journal)
Zuerner, R.L., Heidari, M., Elliott, M.K., Alt, D.P., Neill, J.D. 2007. Papillomatous Digital Dermatitis Spirochetes Suppress the Bovine Macrophage Innate Immune Response. Veterinary Microbiology. 125(2007):256-264.
Diagnostic Characterization of a Feral Swine Herd Enzootically Infected with Brucella - (Peer Reviewed Journal)
Stoffregen, W.C., Olsen, S.C., Wheeler, C.J., Bricker, B.J., Palmer, M.V., Jensen, A.E., Halling, S.M., Alt, D.P. 2007. Diagnostic Characterization of a Feral Swine Herd Enzootically Infected with Brucella. Journal of Veterinary Diagnostic Investigation. 19(3):227-237.
Identification and characterization of two bovine spongiform encephalopathy cases diagnosed in the United States - (Peer Reviewed Journal)
Richt, J.A., Kunkle, R.A., Alt, D., Nicholson, E.M., Hamir, A.N., Czub, S., Kluge, J., Davis, A.J., Hall, S.M. 2007. Identification and characterization of two bovine spongiform encephalopathy cases diagnosed in the United States. Journal of Veterinary Diagnostic Investigation. 19(2):142-154.
Genome reduction in Leptospira borgpetersenii reflects limited transmission potential - (Peer Reviewed Journal)
Bulach, D., Zuerner, R.L., Wilson, P., Seemann, T., Mcgrath, A., Cullen, P., Davies, J., Kuczek, E., Alt, D.P., Peterson-Burch, B. 2006. Genome reduction in Leptospira borgpetersenii reflects limited transmission potential. Proceedings of the National Academy of Sciences. 103(39):14560-14565.
DETERMINATION OF SHEEP PRION GENE POLYMORPHISMS FROM PARAFFIN-EMBEDDED TISSUE - (Peer Reviewed Journal)
Kunkle, R.A., Miller, J.M., Alt, D.P., Cutlip, R.C., Cockett, N.E., Wang, S., Richt, J.A., Thomsen, B.V., Hall, S.M. 2006. Determination of sheep prion gene polymorphisms from paraffin-embedded tissue. Journal of Veterinary Diagnostic Investigation. 18(5):443-447.
IDENTIFICATION OF A HAEMOMYCOPLASMA SPECIES IN ANEMIC REINDEER (RANGIFER TARANDUS) - (Peer Reviewed Journal)
Stoffregen, W.C., Alt, D.P., Palmer, M.V., Olsen, S.C., Waters, W.R., Stasko, J.A., Peterson Burch, B.D. 2006. Identification of a Haemomycoplasma Species in Anemic Reindeer (Rangifer Tarandus). Journal of Wildlife Diseases. 42(2):249-258.
STATUS OF THE RB51 GENOME SEQUENCING PROJECT - (Abstract Only)
Bricker, B.J., Peterson Burch, B.D., Alt, D.P., Halling, S.M., Stoffregen, W.C., Olsen, S.C. 2005. Status of the RB51 Genome Sequencing Project [abstract]. 58th Brucellosis Research Conference. p. 92.
THE COMPLETE GENOME SEQUENCE OF MYCOBACTERIUM AVIUM SUBSP. PARATUBERCULOSIS - (Peer Reviewed Journal)
Li, L., Bannantine, J.P., Zhang, Q., Amonsin, A., May, B.J., Alt, D.P., Banerji, N., Kanjilal, S., Kapur, V. 2005. The Complete Genome Sequence of Mycobacterium avium subsp. paratuberculosis. Proceedings of the National Academy of Sciences. 102:12344-12349.
THE GENOME OF LEPTOSPIRA BIFLEXA - (Abstract Only)
Bulach, D.M., Seemann, T., Mcgrath, A., Kuczek, E., Coppel, R.L., Davies, J.K., Rood, J.I., Alt, D.P., Zuerner, R.L., Adler, B. 2005. The genome of Leptospira biflexa [abstract]. International Leptospirosis Society Meeting Abstracts and Proceedings. p. 136.
COMPLETION OF THE GENOME SEQUENCE OF BRUCELLA ABORTUS AND COMPARISON TO THE HIGHLY SIMILAR GENOMES OF B. MELITENSIS AND B. SUIS - (Peer Reviewed Journal)
Halling, S.M., Peterson Burch, B.D., Bricker, B.J., Zuerner, R.L., Qing, Z., Li, L., Kapur, V., Alt, D.P., Olsen, S.C. 2005. Completion of the genome sequence of brucella abortus and comparison to the highly similar genomes of b. melitensis and b. suis. Journal of Bacteriology. 187(8):2715-26.
EXPERIMENTAL CANINE LEPTOSPIROSIS CAUSED BY LEPTOSPIRA INTERROGANS SEROVARS POMONA AND BRATISLAVA - (Peer Reviewed Journal)
Greenlee, J.J., Alt, D.P., Bolin, C.A., Zuerner, R.L., Andreasen, C.B. 2005. Experimental canine Leptospirosis caused by Leptospira interrogans serovars Pomona and Bratislava. American Journal of Veterinary Research. 66(10):1816-1822.
CHARACTERIZATION OF THE RECENT U.S. BSE CASE AND METHODS FOR SURVEILLANCE - (Proceedings)
Richt, J.A., Kluge, J.P., Alt, D.P., Kunkle, R.A., Hamir, A.N., Czub, S., Davis, A.J., Hall, S.M. 2004. Characterization of the recent U.S. BSE case and methods for surveillance. In: Proceedings of the 108th Annual Meeting of the United States Animal Health Association, October 22-27, 2004, Greensboro, North Carolina. p. 91-92.
INFLUENCE OF THE SPIROVAC(R) LEPTOSPIROSIS VACCINE ON IMMUNOLOGIC RESPONSES OF BISON TO BRUCELLA ABORTUS STRAIN RB51 VACCINE - (Abstract Only)
Olsen, S.C., Stoffregen, W.C., Zuerner, R.L., Alt, D.P. 2004. Influence of the spirovac(r) leptospirosis vaccine on immunologic responses of bison to brucella abortus strain rb51 vaccine [abstract]. Research Workers in Animal Diseases Conference Proceedings. p.98.
IDENTIFICATION AND CHARACTERIZATION OF THE U.S. BOVINE SPONGIFORM ENCEPHALOPATHY CASE - (Abstract Only)
Richt, J.A., Kluge, J.P., Alt, D.P., Kunkle, R.A., Hamir, A.N., Czub, S., Davis, A.J., Hall, S.M. 2004. Identification and characterization of the U.S. bovine spongiform encephalopathy case [abstract]. Animal Prion Diseases and the Americas. p. 38.
CLINICAL AND PATHOLOGIC COMPARISON OF ACUTE CANANE LEPTOSPIROSIS CAUSED BY TWO STRAINS OF LEPTOSPIRA KIRSCHNER SERVAL GRIPPOTYPHOSA - (Peer Reviewed Journal)
Greenlee, J., Bolin, C., Alt, D.P., Cheville, N., Andreasen, C. 2004. Clinical and pathologic comparison of acute canane leptospirosis caused by two strains of leptospira kirschner serval grippotyphosa. American Journal of Veterinary Research. 65(8):1100-7.
IDENTIFICATION OF HAEMOMYCOPLASMA SPECIES IN ANEMIC REINDEER (RANGIFER TARANDUS) - (Abstract Only)
Stoffregen, W.C., Alt, D.P., Palmer, M.V., Olsen, S.C., Waters, W.R. 2004. Identification of haemomycoplasma species in anemic reindeer (rangifer tarandus) [abstract]. American College of Veterinary Pathologists Meeting. 41:550.
MOLECULAR EVOLUTION AND MOSAICISM OF LEPTOSPIRA OUTER MEMBRANE PROTEINS INVOLVES HORIZONTAL DNA TRANSFER - (Peer Reviewed Journal)
Haake, D.A., Suchard, M.A., Kelley, M.M., Dundoo, M., Alt, D.P., Zuerner, R.L. 2004. Molecular evolution and mosaicism of leptospira outer membrane proteins involves horizontal dna transfer. Journal of Bacteriology. 186(9):2818-2828.
SAGE ANALYSIS OF BOVINE MACROPHAGES: IDENTIFICATION OF GENES TARGETED FOR IMMUNE SUPPRESSION BY DIGITAL DERMATITIS SPIROCHETES - (Proceedings)
Heidari, M., Zuerner, R.L., Alt, D.P., Neill, J.D. 2004. Sage analysis of bovine macrophages: identification of genes targeted for immune suppression by digital dermatitis spirochetes. Gordon Research Conference Proceedings. p. 20.
IDENTIFICATION AND CHARACTERIZATION OF THE FIRST U.S. BOVINE SPONGIFORM ENCEPHALOPATHY CASE - (Abstract Only)
Richt, J.A., Kluge, J.P., Alt, D.P., Kunkle, R.A., Hamir, A.N., Czub, S., Davis, A.J., Hall, S. 2004. Identification and characterization of the first U.S. bovine spongiform encephalopathy case. Poster created for use by the USDA at a meeting with the Office of International Epizootics.
IDENTIFICATION AND CLONING OF THE GENE ENCODING BMPC: AN OUTER MEMBRANE LIPOPROTEIN ASSOCIATED WITH BRACHYSPIRA PILOSICOLI MEMBRANE VESICLES - (Peer Reviewed Journal)
Trott, D.J., Alt, D.P., Zuerner, R.L., Bulach, D.M., Wannemuehler, M.J., Stasko, J.A., Townsend, K.M., Stanton, T.B. 2004. Identification and cloning of the gene encoding BmpC: an outer membrane lipoprotein associated with Brachyspira pilosicoli membrane vesicles. Microbiology. 150 (Pt 4):1041-1053.
THE GENOME SEQUENCE OF MYCOBACTERIUM AVIUM SUBSP PARATUBERCULOSIS - (Abstract Only)
CHARACTERIZATION OF SPHINGOMYELINASE-LIKE GENES IN LEPTOSPIRA BORGPETERSENII SEROVAR HARDJO - (Abstract Only)
BRUCELLA 'HOOF-PRINTS': STRAIN TYPING BY MULTI-LOCUS ANALYSIS OF VARIABLE NUMBER TANDEM REPEATS (VNTRS) - (Peer Reviewed Journal)
Bricker, B.J., Alt, D.P., Ewalt, D.R., Halling, S.M. 2003. Brucella 'hoof-prints': strain typing by multi-locus analysis of variable number tandem repeats (vntrs). Journal of Clinical Microbiology.
CHARACTERIZATION OF TREPONEMA-PHAGEDENIS-LIKE SPIROCHETES ISOLATED FROM PAPILLOMATOUS DIGITAL DERMATITIS LESIONS IN DAIRY CATTLE - (Peer Reviewed Journal)
Trott, D.J., Moeller, M.R., Zuerner, R.L., Goff, J.P., Waters, W.R., Alt, D.P., Walker, R.L., Wannemuehler, M.J. 2003. Characterization of treponema-phagedenis-like spirochetes isolated from papillomatous digital dermatitis lesions in dairy cattle. Infection and Immunity.
GENOMIC SEQUENCE ANALYSIS OF LEPTOSPIRA BORGPETERSENII SEROVAR HARDJO - (Abstract Only)
Zuerner, R.L., Alt, D.P., Bulach, D., Adler, B., Cullen, P., Haake, D. 2002. Genomic sequence analysis of leptospira borgpetersenii serovar hardjo [abstract]. International Leptospirosis Society Meeting Abstracts and Proceedings. pg. 32.
EVALUATION OF TYPE 1 IMMUNE RESPONSE IN NAIVE AND VACCINATED ANIMALS FOLLOWING CHALLENGE WITH LEPTOSPIRA BORGPETERSENII SEROVAR HARDJO: INVOLVEMENT OF WC1**+ GAMMA DELTA AND CD4 T CELLS - (Peer Reviewed Journal)
Naiman, B., Blumerman, S., Alt, D.P., Bolin, C., Brown, R., Zuerner, R.L., Baldwin, C. 2002. Evaluation of type 1 immune response in naive and vaccinated animals following challenge with leptospira borgpetersenii serovar hardjo: involvement of wc1**+ gamma delta and cd4 t cells. Infection and Immunity. 70(11)6147-57.
NATURALLY OCCURRING TUBERCULOSIS IN WHITE-TAILED DEER - (Abstract Only)
THE SEARCH FOR BRACHYSPIRA OUTER MEMBRANE PROTEINS THAT INTERACT WITH THE HOST - (Peer Reviewed Journal)
PHYSICAL MAPPING OF THE BRACHYSPIRA PILOSICOLI GENOME (35TH MEETING U.S.-JAPAN COOPERATIVE PROGRAM IN NATURAL RESOURCES) - (Abstract Only)
MOLECULAR CLONING, EXPRESSION, AND DNA SEQUENCE ANALYSIS OF A GENE ENCODINGAN OUTER MEMBRANE PROTEIN OF BRACHYSPIRA (SERPULINA) PILOSICOLI - (Abstract Only)
MOLECULAR CLONING, EXPRESSION AND DNA SEQUENCE ANALYSIS OF A GENE ENCODING AN OUTER MEMBRANE PROTEIN OF BRACHYSPRIA (SERPULINA) PILOSICOLI - (Proceedings)
MOLECULAR CLONING, EXPRESSION AND DNA SEQUENCE ANALYSIS OF A GENE ENCODING AN OUTER MEMBRANE PROTEIN OF BRACHYSPIRA (SERPULINA) PILOSICOLI (FOR INT. PIG VET. CONGR., MELBOURNE, AUSTRALIA, SEPT. 17-21, 2000) - (Proceedings)
NATURALLY OCCURRING TUBERCULOSIS IN WHITE-TAILED DEER - (Peer Reviewed Journal)
NATURALLY OCCURRING TUBERCULOSIS IN WHITE-TAILED DEER - (Abstract Only)
NATURALLY OCCURRING TUBERCULOSIS IN WHITE-TAILED DEER - (Abstract Only)
NATURALLY OCCURRING TUBERCULOSIS IN WHITE-TAILED DEER CONF. ON EMERGING DISEASES: VET MED, AGRICULTURE, AND HUMAN HEALTH - (Abstract Only)
NATURALLY OCCURRING TUBERCULOSIS IN WHITE-TAILED DEER THE INFECTIOUS DISEASE REVIEW: PROC. OF CONF. ON EMERGING DISEASES: VET. MED., AGRICULTURE, AND HUMAN HEALTH; SEE ABSTRACT 102635 - (Proceedings)
NATURALLY OCCURRING TUBERCULOSIS IN WHITE-TAILED DEER. ANNU MEET WILDLIFE DIS ASSOC, AUG 8-13, 1999, ATHENS, GA - (Abstract Only)
CLINICAL SIGNS, DIAGNOSIS, AND PREVENTION OF BOVINE LEPTOSPIROSIS ()
POLYMERASE CHAIN REACTION ASSAY FOR THE DETECTION OF LEPTOSPIRA INTERROGANSIN BOVINE URINE - (Abstract Only)
CHARACTERIZATION OF LEPTOSPIRA ISOLATED FROM HUMANS AND ANIMALS DURING A LEPTOSPIROSIS EPIDEMIC IN NICARAGUA - (Abstract Only)
DEMONSTRATION AND CHARACTERIZATION OF RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN SPHB OF LEPTOSPIRA BORGPETERSENII SEROVAR HARDJO TYPE HARDJOBOVIS ISOLATES USING DNA HYBRIDIZATION ANALYSIS AND PCR - (Abstract Only)
PREVIOUS INFECTION PREVENTS REINFECTION WITH HOMOLOGOUS AND HETEROLOGOUS STRAINS OF LEPTOSPIRA BORGPETERSENII SEROVAR HARDJO TYPE HARDJOBOVIS IN CATTLE - (Abstract Only)
DEMONSTRATION AND CHARACTERIZATION OF RESTRICTION FRAGMENT LENGTH POLYMORPHISMS IN SPHB OF LEPTOSPIRA BORGPETERSENII SEROVAR HARDJO TYPE HARDJOBOVIS ISOLATES USING SOUTHERN BLOTTING AND PCR - (Abstract Only)
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