Shollie M Falkenberg
Ruminant Diseases and Immunology Research
Research Microbiologist
Phone: (515) 337-7338
Fax: (515) 337-7402
P.O. BOX 70
1920 DAYTON AVE
AMES, IA 50010
Publications
(Clicking on the reprint icon
will take you to the publication reprint.)
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Experimental innoculation of young calves with SARS-CoV-2
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(Peer Reviewed Journal)
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Bovine NK-lysin-derived peptides are bactericidal against Mycobacterium avium subspecies paratuberculosis
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(Peer Reviewed Journal)
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Dassanayake, R.P., Wherry, T.L., Falkenberg, S.M., Reinhardt, T.A., Casas, E., Stabel, J.R. 2021. Bovine NK-lysin-derived peptides are bactericidal against Mycobacterium avium subspecies paratuberculosis. Veterinary Research. 52. https://doi.org/10.1186/s13567-021-00893-2.
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Virus strain influenced the interspecies transmission of influenza D virus between calves and pigs
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(Peer Reviewed Journal)
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Experimental intravenous, intratracheal, and intranasal inoculation of swine with SARS-CoV-2
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(Abstract Only)
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Buckley, A.C., Falkenberg, S.M., Laverack, M., Martins, M., Palmer, M.V., Diel, D., Lager, K.M. 2020. Experimental intravenous, intratracheal, and intranasal inoculation of swine with SARS-CoV-2 [abstract]. American Association of Swine Veterinarians Annual Meeting. p. 35-37.
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Changes in circulating lymphocytes and lymphoid tissue associated with vaccination of colostrum deprived calves
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(Peer Reviewed Journal)
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Multivariate analysis as a method to evaluate antigenic relationships between BVDV vaccine and field strains
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(Peer Reviewed Journal)
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Mosena, A.C., Falkenberg, S.M., Ma, H., Casas, E., Dassanayake, R.P., Watz, P., Canal, C., Neill, J.D. 2020. Multivariate analysis as a method to evaluate antigenic relationships between BVDV vaccine and field strains. Vaccine. 38(36):5764-5772. https://doi.org/10.1016/j.vaccine.2020.07.010.
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Identification of a reliable fixative solution to preserve complex architecture of bacterial biofilms for scanning electron microscopy evaluation
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(Peer Reviewed Journal)
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Dassanayake, R.P., Falkenberg, S.M., Stasko, J.A., Shircliff, A.L., Lippolis, J.D., Briggs, R.E. 2020. Identification of a reliable fixative solution to preserve complex architecture of bacterial biofilms for scanning electron microscopy evaluation. PLoS One. 15(5):e0233973. https://doi.org/10.1371/journal.pone.0233973.
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Bovine viral diarrhea virus: an updated ACVIM consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination
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Walz, P.H., Chamorro, M.F., Falkenberg, S.M., Passler, T., van der Meer, F., Woolums, A. 2020. Bovine viral diarrhea virus: an updated American College of Veterinary Internal Medicine consensus statement with focus on virus biology, hosts, immunosuppression, and vaccination. Journal of Veterinary Internal Medicine. 2020;1-17. https://doi.org/10.1111/jvim.15816.
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Measuring CMI responses using the PrimeFlow RNA assay; a new method of evaluating BVDV vaccination response in cattle
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(Peer Reviewed Journal)
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Falkenberg, S.M., Dassanayake, R.P., Neill, J.D., Walz, P., Casas, E., Ridpath, J.F., Roth, J. 2020. Measuring CMI responses using the PrimeFlow RNA assay; a new method of evaluating BVDV vaccination response in cattle. Veterinary Immunology and Immunopathology. 221:110024. https://doi.org/10.1016/j.vetimm.2020.110024.
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Persistent atypical porcine pestivirus (APPV) infection in gilts
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(Abstract Only)
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Buckley, A.C., Arruda, B., Falkenberg, S.M., Miller, L.C., Lager, K.M. 2019. Persistent atypical porcine pestivirus (APPV) infection in gilts. Meeting Abstract. p. 35.
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In vitro method to evaluate virus competition between BVDV-1 and BVDV-2 strains using the PrimeFlow RNA assay
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(Peer Reviewed Journal)
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Silveria, S., Falkenberg, S.M., Dassanayake, R.P., Walz, P.H., Ridpath, J.F., Canal, C.W., Neill, J.D. 2019. In vitro method to evaluate virus competition between BVDV-1 and BVDV-2 strains using the PrimeFlow RNA assay. Virology. 536:101-109. https://doi.org/10.1016/j.virol.2019.07.029.
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Genomic and antigenic characterization of a cytopathic bovine viral diarrhea virus 1i isolated in the United States
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(Peer Reviewed Journal)
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Neill, J.D., Crossley, B.M., Mosena, A.C., Ridpath, J.F., Bayles, D.O., Killian, M.L., Falkenberg, S.M. 2019. Genomic and antigenic characterization of a cytopathic bovine viral diarrhea virus 1i isolated in the United States. Virology. 535:279-282. https://doi.org/10.1016/j.virol.2019.07.020.
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Synthetic bovine NK-lysin-derived peptide (bNK2A) does not require intra-chain disulfide bonds for bactericidal activity
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(Peer Reviewed Journal)
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Dassanayake, R.P., Falkenberg, S.M., Nicholson, E.M., Briggs, R.E., Tatum, F.M., Sharma, V.K., Reinhardt, T.A. 2019. Synthetic bovine NK-lysin-derived peptide (bNK2A) does not require intra-chain disulfide bonds for bactericidal activity. PLoS One. 14(6). https://doi.org/10.1371/journal.pone.0218507.
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A serosurvey for bovine Influenza D virus exposure from cattle in the United States, 2014-2015
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(Peer Reviewed Journal)
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Silveira, S., Falkenberg, S.M., Kaplan, B.S., Crossley, B., Ridpath, J.F., Bauermann, F.B., Fossler, C.P., Dargatz, D.A., Dassanayake, R.P., Vincent, A.L., Canal, C.W., Neill, J.D. 2019. Serosurvey for influenza D virus exposure in cattle, United States, 2014-2015. Emerging Infectious Diseases. 25(11). https://doi.org/10.3201/eid2511.1902532.
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Bovine NK-lysin-derived peptide NK2A demonstrates immunomodulatory activity on cattle leukocytes
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(Abstract Only)
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Impact of CD46 knockout on bovine viral diarrhea virus (BVDV) replication in Madin-Darby bovine kidney cells
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(Abstract Only)
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MicroRNA expression in thymus from calves in a coinfection study challenged with bovine viral diarrhea virus and Mycoplasma bovis
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(Abstract Only)
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Identification of BVDV2b and 2c subgenotypes in the United States: genetic and antigenic characterization
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(Peer Reviewed Journal)
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Neill, J.D., Workman, A.M., Hesse, R., Bai, J., Poulsen-Porter, E., Meadors, B., Anderson, J., Bayles, D.O., Falkenberg, S.M. 2019. Identification of BVDV2b and 2c subgenotypes in the United States: genetic and antigenic characterization. Virology. 528:19-29. https://doi.org/10.1016/j.virol.2018.12.002.
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Frequency of bovine viral diarrhea virus detected in subpopulations of peripheral blood mononuclear cells in persistently infected animals and health outcome
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(Peer Reviewed Journal)
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Falkenberg, S.M., Dassanayake, R.P., Walz, P., Casas, E., Neill, J.D., Ridpath, J.F. 2019. Frequency of bovine viral diarrhea virus detected in subpopulations of peripheral blood mononuclear cells in persistently infected animals and health outcome. Veterinary Immunology and Immunopathology. 207:46-52. https://doi.org/10.1016/j.vetimm.2018.11.015.
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Distribution of atypical porcine pestivirus in the cerebellum of newborn piglets following in utero inoculation
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(Abstract Only)
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Experimental infection of calves with bovine gammaherpesvirus 4
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(Abstract Only)
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Relative virulence in bison and cattle of bison-associated genotypes of mycoplasma bovis
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(Peer Reviewed Journal)
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Register, K.B., Olsen, S.C., Sacco, R.E., Ridpath, J., Falkenberg, S., Briggs, R., Kanipe, C., Madison, R. 2018. Relative virulence in bison and cattle of bison-associated genotypes of Mycoplasma bovis. Veterinary Microbiology. 222:55-63. https://doi.org/10.1016/j.vetmic.2018.06.020.
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Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis
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(Peer Reviewed Journal)
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Dassanayake, R.P., Falkenberg, S.M., Register, K.B., Samorodnitsky, D., Nicholson, E.M., Reinhardt, T.A. 2018. Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis. PLoS One. 13(5):e0197677. https://doi.org/10.1371/journal.pone.0197677.
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Serological survey for antibodies against pestiviruses in Wyoming domestic sheep
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(Peer Reviewed Journal)
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Silveira, S., Falkenberg, S.M., Elderbrook, M.J., Sondgeroth, K.S., Dassanayake, R.P., Neill, J.D., Ridpath, J.F., Canal, C.W. 2018. Serological survey for antibodies against pestiviruses in Wyoming domestic sheep. Veterinary Microbiology. 219:96-99. https://doi.org/10.1016/j.vetmic.2018.04.019.
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Comparison of reproductive protection against bovine viral diarrhea virus provided by multivalent viral vaccines containing inactivated fractions of bovine viral diarrhea virus 1 and 2
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(Peer Reviewed Journal)
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Walz, P.H., Riddell, K.P., Newcomer, B.W., Neill, J.D., Falkenberg, S.M., Cortese, V.S., Scruggs, D.W., Short, T.H. 2018. Comparison of reproductive protection against bovine viral diarrhea virus provided by multivalent viral vaccines containing inactivated fractions of bovine viral diarrhea virus 1 and 2. Vaccine. 36(26):3853-3860. https://doi.org/10.1016/j.vaccine.2018.04.005.
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Relationship between viral shedding in the transmission of bovine viral diarrhea virus to naïve calves by direct and indirect exposure routes
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(Peer Reviewed Journal)
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Falkenberg, S.M., Dassanayake, R.P., Neill, J.D., Ridpath, J.F. 2018. Evaluation of bovine viral diarrhea virus transmission potential to naïve calves by direct and indirect exposure routes. Veterinary Microbiology. 217:144-148. https://doi.org/10.1016/j.vetmic.2018.03.012.
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Sequential exposure to bovine viral diarrhea virus and bovine coronavirus results in increased respiratory disease lesions: clinical, immunologic, pathologic, and immunohistochemical findings
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(Peer Reviewed Journal)
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Ridpath, J., Fulton, R.W., Bauermann, F.V., Falkenberg, S.M., Welch, J., Confer, A.W. 2020. Sequential exposure to bovine viral diarrhea virus and bovine coronavirus results in increased respiratory disease lesions: clinical, immunologic, pathologic, and immunohistochemical findings. Journal of Veterinary Diagnostic Investigation. https://doi.org/10.1177/1040638720918561.
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Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis
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(Abstract Only)
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Clinical report: Detection and management of bovine viral diarrhea virus Type 1b in a large dairy herd
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(Peer Reviewed Journal)
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Cox, E.A., Ridpath, J.F., Falkenberg, S.M. 2017. Clinical report: Detection and management of bovine viral diarrhea virus Type 1b in a large dairy herd. Bovine Practitioner Journal. 51(2):153-156.
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Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni
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(Peer Reviewed Journal)
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Dassanayake, R.P., Falkenberg, S.M., Briggs, R.E., Tatum, F.M., Sacco, R.E. 2017. Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni. PLoS One. 12(8):1-14. doi. 10.1371/journal.pone.0183610.
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Characterization of thymus-associated lymphoid depletion in bovine calves acutely or persistently infected with bovine viral diarrhea virus 1, bovine viral diarrhea 2 or HoBi-like pestivirus
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(Peer Reviewed Journal)
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Falkenberg, S.M., Bauermann, F.V., Ridpath, J.F. 2017. Characterization of thymus-associated lymphoid depletion in bovine calves acutely or persistently infected with bovine viral diarrhea virus 1, bovine viral diarrhea 2 or HoBi-like pestivirus. Archives of Virology. 1-8. doi. 10.1007/s00705-017-3523-x.
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Improved detection of Bovine Viral Diarrhea Virus in Bovine lymphoid cell lines using PrimeFlow RNA assay
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(Peer Reviewed Journal)
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Falkenberg, S.M., Dassanayake, R.P., Silveira, S., Neill, J.D., Ridpath, J.F. 2017. Improved detection of Bovine Viral Diarrhea Virus in Bovine lymphoid cell lines using PrimeFlow RNA assay. American Association of Veterinary Laboratory Diagnosticians. 235:77-81. 10.1016/j.virol.2017.06.032.
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Serological survey for antibodies against pestiviruses in sheep in Wyoming
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(Abstract Only)
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Demonstration of systemic infection of BVDV Vaccine virus after vaccination in presence of PI calves
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Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni
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(Abstract Only)
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Improved detection of bovine viral diarrhea virus in bovine lymphoid cell lines using PrimeFlow RNA assay
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(Peer Reviewed Journal)
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Falkenberg, S.M., Dassanayake, R.P., Neill, J.D., Ridpath, J.F. 2017. Improved detection of bovine viral diarrhea virus in bovine lymphoid cell lines using PrimeFlow RNA assay. Virology. 509(2017):260-265. doi. 10.1016/j.virol.2017.06.032.
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Isolation and characterization of a novel cervid adenovirus from white-tailed deer (Odocoileus virginianus) fawns in a captive herd
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(Peer Reviewed Journal)
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Ridpath, J.F., Neill, J.D., Palmer, M.V., Bauermann, F.V., Falkenberg, S.M., Wolff, P.L. 2017. Isolation and characterization of a novel cervid adenovirus from white-tailed deer (Odocoileus virginianus) fawns in a captive herd. Virus Research. 238:198-203. doi: 10.1016/j.virusres.2017.06.020.
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An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge
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(Peer Reviewed Journal)
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Hause, B.M., Huntimer, L., Falkenberg, S.M., Henningson, J., Lechtenberg, K., Halbur, T. 2016. An inactivated influenza D virus vaccine partially protects cattle from respiratory disease caused by homologous challenge. Veterinary Microbiology. 199(2017):47-53.
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Morphological changes in cultured bovine lymphoid cell lines associated with bovine viral diarrhea virus (BVDV) single and dual infections with bovine leukemia virus (BLV)
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(Abstract Only)
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HoBi-like virus challenge of pregnant cows that had previously given birth to calves persistently infected with bovine viral diarrhea virus
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(Peer Reviewed Journal)
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Evaluation of the innate immune response of Angus heifers with genetic marker variation for intramuscular fat deposition following a lipopolysaccharide challenge
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(Peer Reviewed Journal)
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Buntyn, J.O., Carroll, J.A., Smith, T., Rivera, J.D., Sanchez, N.C., Broadway, P.R., Falkenberg, S.M., Schmidt, T.B. 2016. Evaluation of the innate immune response of Angus heifers with genetic marker variation for intramuscular fat deposition following a lipopolysaccharide challenge. Livestock Science. 188:103-110.
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Comparison of the breadth and complexity of bovine viral diarrhea (BVDV) populations circulating in 34 persistently infected cattle generated in one outbreak
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(Peer Reviewed Journal)
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Ridpath, J.F., Bayles, D.O., Neill, J.D., Falkenberg, S.M., Bauermann, F.F., Holler, L., Braun, L.J., Young, D.B., Kane, S.E., Chase, C.C. 2015. Comparison of the breadth and complexity of bovine viral diarrhea (BVDV) populations circulating in 34 persistently infected cattle generated in one outbreak. Virology. 485:297-304. doi. 10.1016/j.virol.2015.07.022.
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Relative virulence in bison and cattle of bison-associated genotypes of Mycoplasma bovis
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(Abstract Only)
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Association of serum antibody levels following vaccination with a modified live BVDV vaccine and protection from clinical disease upon challenge
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(Peer Reviewed Journal)
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Falkenberg, S.M., Ridpath, J.F., Tait Jr, R.G., Vander Ley, B., Bauermann, F.V., Reecy, J.M. 2015. Association of serum antibody levels following vaccination with a modified live BVDV vaccine and protection from clinical disease upon challenge. Jacobs Journal of Vaccines and Vaccination. 1(1):002.
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Changes observed in the thymus and lymph nodes 14 days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves
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(Peer Reviewed Journal)
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Falkenberg, S.M., Johnson, C., Bauermann, F.V., McGill, J.L., Palmer, M.V., Sacco, R.E., Ridpath, J.F. 2014. Changes observed in the thymus and lymph nodes 14 days after exposure to BVDV field strains of enhanced or typical virulence in neonatal calves. Veterinary Immunology and Immunopathology. 160(1-2):70-80. DOI: 10.1016/j.vetimm.2014.03.018.
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Comparison of temperature fluctuations at multiple anatomical locations in cattle during exposure to bovine viral diarrhea virus
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(Peer Reviewed Journal)
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Falkenberg, S.M., Ridpath, J.F., Vander Ley, B., Bauermann, F.V., Carroll, J.A. 2014. Comparison of temperature fluctuations at multiple anatomical locations in cattle during exposure to bovine viral diarrhea virus. Livestock Science. 164(2014):159-167. DOI:10.1016/j.livsci.2014.03.018.
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Lack of evidence for the presence of emerging HoBi-like viruses in North American fetal bovine serum lots.
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(Peer Reviewed Journal)
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Bauermann, F.V., Flores, E.F., Falkenberg, S.M., Ridpath, J.F. 2014. Lack of evidence for the presence of emerging HoBi-like viruses in North American fetal bovine serum lots.. Journal of Veterinary Diagnostic Investigation. 26(1):10-17. DOI: 10.1177/1040638713518208.
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Evaluation of endocrine and immune disruption of infectious bovine rhinotracheitis virus vaccinated steers challenged with infectious bovine rhinotracheitis virus
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(Peer Reviewed Journal)
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Falkenberg, S.M., Carroll, J.A., Elsasser, T.H., Best, T., Sartin, J.L., Buntyn, J.O., Schmidt, T.B. 2013. Evaluation of endocrine and immune disruption of infectious bovine rhinotracheitis virus vaccinated steers challenged with infectious bovine rhinotracheitis virus. American Journal of Veterinary Research. 74(12):1552-1529.
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In vitro neutralization against HoBi-like viruses by antiobodies in serum of cattle immunized with inactivated or modified live vaccines of bovine viral diarrhea virus 1 and 2
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(Peer Reviewed Journal)
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Bauermann, F.V., Harmon, A., Flores, E.F., Falkenberg, S.M., Reecy, J.M., Ridpath, J.F. 2013. In vitro neutralization against HoBi-like viruses by antiobodies in serum of cattle immunized with inactivated or modified live vaccines of bovine viral diarrhea virus 1 and 2. Veterinary Microbiology. 166(1-2):242-245 DOI: 10.1016/j.vetmic.2013.04.032.
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Circulating immune cell subpopulations in pestivirus persistently infected calves and non-infected calves varying in immune status.
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Circulating immune cell subpopulations in pestivirus persistently infected calves and non-infected calves varying in immune status [Abstract]
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(Proceedings)
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Falkenberg, S.M., Ridpath, J.F., Bauermann, F.V. 2013. Circulating immune cell subpopulations in pestivirus persistently infected calves and non-infected calves varying in immune status [Abstract]. Journal of Animal Science Supplement. American Society of Animal Science Meeting, July 8-12, 2013,Indianapolis, Indiana. 91:649.
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Association of hematological variables and castration status at the time of arrival at a research facility with the risk of bovine respiratory disease in beef calves
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(Peer Reviewed Journal)
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Richeson, J.T., Pinedo, P.J., Kegley, E.B., Powell, J.G., Gadberry, M.S., Beck, P.A., Falkenberg, S.M. 2013. Association of hematological variables and castration status at the time of arrival at a research facility with the risk of bovine respiratory disease in beef calves. Journal of the American Veterinary Medical Association. 243(7):1035-1041. DOI: 10.2460/javma.243.7.1035.
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Use of bioluminescent Escherichia coli to determine retention during the life cycle of the housefly, Musca domestica (Diptera: Muscidae, L)
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(Peer Reviewed Journal)
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Schuster, G.L., Donaldson, J.R., Buntyn, J.O., Duoss, H.A., Callaway, T.R., Carroll, J.A., Falkenberg, S.M., Schmidt, T.B. 2013. Use of bioluminescent Escherichia coli to determine retention during the life cycle of the housefly, Musca domestica (Diptera: Muscidae, L). Foodborne Pathogens and Disease. 10:442-447.
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Comparison of acute infection of calves exposed to a high-virulence or low-virulence bovine viral diarrhea virus or a HoBi-like virus
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(Peer Reviewed Journal)
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Ridpath, J.F., Falkenberg, S.M., Bauermann, F.V., VanderLey, B.L., Do, Y., Flores, E.F., Rodman, D.M., Neill, J.D. 2013. Comparison of acute infection of calves exposed to a high-virulence or low-virulence bovine viral diarrhea virus or a HoBi-like virus. American Journal of Veterinary Research. 74(3):438-442. DOI: 10.2460/ajvr.74.3.438.
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Correlation between circulating white blood cell counts and level of protective immune response against bovine viral diarrhea virus elicited by a modified live vaccine
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(Abstract Only)
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