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United States Department of Agriculture

Agricultural Research Service

Related Topics

Steven M Colegate
Poisonous Plant Research
Research Chemist

Phone: (435) 752-2941
Fax: (435) 753-5681

1150 EAST 1400 NORTH
POISONOUS PLANT RESEARCH LAB
LOGAN , UT 84341


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey-derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus) Reprint Icon -
Brown, A.W., Stegelmeier, B.L., Colegate, S.M., Gardner, D.R., Panter, K.E., Knoppel, E.L., Hall, J.O. 2016. The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey-derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus). Journal of Applied Toxicology. 36:716-725.
New dehydropyrrolizidine alkaloids isolated from a Crotalaria and two Cryptantha species -
Colegate, S.M., Gardner, D.R., Davis, T.Z., Joy, R.J., Betz, J.M., Panter, K.E. 2015. New dehydropyrrolizidine alkaloids isolated from a Crotalaria and two Cryptantha species. International Symposium on Poisonous Plants. 9:212-218.
Wild parsnip (Pastinaca sativa)-induced photosensitization in goats and horses -
Stegelmeier, B.L., Colegate, S.M., Knoppel, E.L., Lemos, D., Rood, K.A., Collett, M.G. 2015. Wild parsnip (Pastinaca sativa)-induced photosensitization in goats and horses. International Symposium on Poisonous Plants. 9:48-53.
Carcinogenic effects of riddelliine on P53 knockout mice -
Brown, A.W., Stegelmeier, B.L., Colegate, S.M., Panter, K.E., Knoppel, E.L., Field, R.A., Hall, J.O. 2015. Carcinogenic effects of riddelliine on P53 knockout mice. International Symposium on Poisonous Plants. 9:276-280.
In vitro cytotoxicity of various dehydropyrrolizidine ester alkaloids -
Field, R.A., Stegelmeier, B.L., Colegate, S.M., Brown, A., Mccollum, I.J., Knoppel, E.L. 2015. In vitro cytotoxicity of various dehydropyrrolizidine ester alkaloids. International Symposium on Poisonous Plants. 9:281-286.
The role of chemistry in poisonous plant research: Current status and future prospects -
Molyneux, R.J., Panter, K.E., Gardner, D.R., Lee, S.T., Colegate, S.M. 2015. The role of chemistry in poisonous plant research: Current status and future prospects. International Symposium on Poisonous Plants. 9:152-157.
A rapid HPLC-APCI-MS method to detect fluoroacetate in plants -
Lee, S.T., Cook, D., Riet-Correa, F., Pfister, J.A., Allen, J.G., Colegate, S.M., Lima, F.G., Gardner, D.R. 2015. A rapid HPLC-APCI-MS method to detect fluoroacetate in plants. International Symposium on Poisonous Plants. 9:158-163.
An in vitro comparison of the cytotoxic potential of selected dehydropyrrolizidine alkaloids and some N-oxides Reprint Icon -
Field, R.A., Stegelmeier, B.L., Colegate, S.M., Brown, A.W., Green, B.T. 2015. An in vitro comparison of the cytotoxic potential of selected dehydropyrrolizidine alkaloids and some N-oxides. Toxicon. 97:36-45.
Hydroxylic solvent-induced ring opening of the dehydropyrrolizidine alkaloids riddelliine and seneciphylline: implications for toxicity and analytical studies -
Heterozygous P53 knockout mouse model for dehydropyrrolizidine alkaloid-induced carcinogenesis Reprint Icon -
Brown, A.W., Stegelmeier, B.L., Colegate, S.M., Panter, K.E., Knoppel, E.L., Hall, J.O. 2015. Heterozygous P53 knockout mouse model for dehydropyrrolizidine alkaloid-induced carcinogenesis. Journal of Applied Toxicology. 35(12):1557-1563.
Recognition of pyrrolizidine alkaloid esters in the invasive aquatic plant Gymnocoronis spilanthoides (Asteraceae) Reprint Icon -
Boppre, M., Colegate, S.M. 2015. Recognition of pyrrolizidine alkaloid esters in the invasive aquatic plant Gymnocoronis spilanthoides (Asteraceae). Phytochemical Analysis. 26(3):215-225.
Pyrrolizidine alkaloids: Potential role in the etiology of cancers, pulmonary hypertension, congenital anomalies, and liver disease -
Edgar, J.A., Molyneux, R.J., Colegate, S.M. 2014. Pyrrolizidine alkaloids: Potential role in the etiology of cancers, pulmonary hypertension, congenital anomalies, and liver disease. Chemical Research in Toxicology. 28(1):4-20.
Monofluoroacetate-containing plants that are potentially toxic to livestock Reprint Icon -
Lee, S.T., Cook, D., Pfister, J.A., Allen, J.G., Colegate, S.M., Riet-Correa, F., Taylor, C.M. 2014. Monofluoroacetate-containing plants that are potentially toxic to livestock. Journal of Agricultural and Food Chemistry. 62(30):7345-7354.
Profiling of dehydropyrrolizidine alkaloids and their N-oxides in herbarium-preserved specimens of Amsinckia species using HPLC-esi(+)MS Reprint Icon -
Colegate, S.M., Welsh, S.L., Gardner, D.R., Betz, J.M., Panter, K.E. 2014. Profiling of dehydropyrrolizidine alkaloids and their N-oxides in herbarium-preserved specimens of Amsinckia species using HPLC-esi(+)MS. Journal of Agricultural and Food Chemistry. 62(30):7382-7392.
Semi-automated separation of the epimeric dehydropyrrolizidine alkaloids lycopsamine and intermedine: Preparation of their N-oxides and NMR comparison with diastereoisomeric rinderine and echinatine Reprint Icon -
Colegate, S.M., Gardner, D.R., Betz, J.M., Panter, K.E. 2014. Semi-automated separation of the epimeric dehydropyrrolizidine alkaloids lycopsamine and intermedine: Preparation of their N-oxides and NMR comparison with diastereoisomeric rinderine and echinatine. Phytochemical Analysis. 25(5):429-38.
Duration of an induced resistance of sheep to acute poisoning by Crotalaria retusa seeds -
Maia, L.A., Macedo Pessoa, C.R., Rodrigues, A.F., Colegate, S.M., Dantas, A.M., Medeiros, R.T., Riet-Correa, F. 2014. Duration of an induced resistance of sheep to acute poisoning by Crotalaria retusa seeds. Ciência Rural. 44(6):1054-1059.
Natural and experimental poisoning of goats with the pyrrolizidine alkaloid-producing plant Crotalaria retusa L -
Maia, L.A., De Lucena, R.B., Da T Nobre, V.M., Dantas, A.F., Colegate, S.M., Riet-Correa, F. 2013. Natural and experimental poisoning of goats with the pyrrolizidine alkaloid-producing plant Crotalaria retusa L. Journal of Veterinary Diagnostic Investigation. 25(5):592-595.
Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys -
Pessoa, C.R., Pessoa, A.F., Maia, L.A., Medeiros, R.M., Colegate, S.M., Barros, S.S., Soares, M.P., Borges, A.S., Riet-Correa, F. 2013. Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys. Toxicon. 71:113-120.
Persistence of echimidine, a hepatotoxic pyrrolizidine alkaloid, from honey into mead Reprint Icon -
Cao, Y., Colegate, S.M., Edgar, J.A. 2013. Persistence of echimidine, a hepatotoxic pyrrolizidine alkaloid, from honey into mead. Journal of Food Composition and Analysis. 29(2): 106-9.
Identification of a lycopsamine-N-oxide chemotype of Amsinckia intermedia -
Colegate, S.M., Gardner, D.R., Davis, T.Z., Welsh, S.L., Betz, J.M., Panter, K.E. 2013. Identification of a lycopsamine-N-oxide chemotype of Amsinckia intermedia. Biochemical Systematics and Ecology. 48: 132-5.
Dehydropyrrolizidine alkaloids in two Cryptantha species: Including two new open chain diesters one of which is amphoteric -
Colegate, S.M., Gardner, D.R., Davis, T.Z., Betz, J.M., Panter, K.E. 2013. Dehydropyrrolizidine alkaloids in two Cryptantha species: Including two new open chain diesters one of which is amphoteric. Phytochemical Analysis. 24: 201-12.
Dietary exposure of livestock and humans to hepatotoxic natural products Reprint Icon -
Colegate, S.M., Stegelmeier, B.L., Edgar, J.A. 2012. Dietary exposure of livestock and humans to hepatotoxic natural products. In: Fink-Gremmels, J., editor. Animal Feed Contamination: Effects on Livestock and Food Safety. Philadelphia, PA: Woodhead Publishing Series in Food Sciences, Technology and Nutrition. p. 352-82.
Dehydropyrrolizidine alkaloids, including monoesters with an unusual esterifying acid, from cultivated Crotalaria juncea (Sunn Hemp cv. 'Tropic Sun') -
Colegate, S.M., Gardner, D.R., Joy, R.J., Betz, J.M., Panter, K.E. 2012. Dehydropyrrolizidine alkaloids, including monoesters with an unusual esterifying acid, from cultivated Crotalaria juncea (Sunn Hemp cv. 'Tropic Sun'). Journal of Agricultural and Food Chemistry. 60: 3541-50.
Detection and measurement of carbohydrate deficient transferrin in serum using immuno-capture mass spectrometry: Diagnostic applications for annual regrass toxicity and corynetoxin exposure -
Penno, M.A., Colegate, S.M., Michalski, W.P., Hoffmann, P. 2012. Detection and measurement of carbohydrate deficient transferrin in serum using immuno-capture mass spectrometry: Diagnostic applications for annual regrass toxicity and corynetoxin exposure. Research in Veterinary Science. 93(2):611-617.
Detection of high levels of pyrrolizidine-N-oxides in the endangered plant cryptantha crassipes (Terlingua creek cat's-eye)using HPLC-ESI-MS -
Williams, M.T., Warnock, B.J., Betz, J.M., Beck, J.J., Gardner, D.R., Lee, S.T., Molyneux, R.J., Colegate, S.M. 2011. Detection of high levels of pyrrolizidine-N-oxides in the endangered plant cryptantha crassipes (Terlingua creek cat's-eye)using HPLC-ESI-MS. Phytochemical Analysis. 22(3): 532-540
Pyrrolizidine alkaloids in food: A spectrum of potential health consequences Reprint Icon -
Edgar, J.A., Colegate, S.M., Boppre, M., Molyneux, R.J. 2011. Pyrrolizidine alkaloids in food: A spectrum of potential health consequences. Journal of Food Additives & Contaminants. Part A. 28(3):308-24.
Pyrrolizidine alkaloid toxicity in livestock: A paradigm for human poisoning Reprint Icon -
Molyneux, R.J., Gardner, D.R., Colegate, S.M., Edgar, J.A. 2011. Pyrrolizidine alkaloid toxicity in livestock: A paradigm for human poisoning. Journal of Food Additives & Contaminants. Part A. 28(3): 293-307.
Tremetone and structurally related compounds in white snakeroot (Ageratina altissima): A plant associated with trembles and milk sickness -
Lee, S.T., Davis, T.Z., Gardner, D.R., Colegate, S.M., Cook, D., Green, B.T., Meyerholtz, K.A., Wilson, C.R., Stegelmeier, B.L., Evans, T.J. 2010. Tremetone and structurally related compounds in white snakeroot (Ageratina altissima): A plant associated with trembles and milk sickness. Journal of Agricultural and Food Chemistry. 58(15):8560-65. DOI: 10.1021/jf1012456.
Last Modified: 5/2/2016
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