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United States Department of Agriculture

Agricultural Research Service

Related Topics

David Schneider
Animal Disease Research
Veterinary Medical Science

Phone: (509) 335-6312
Fax: (509) 335-8328

3029 ADBF, WASHINGTON STATE UNIV
PULLMAN , WA 991646630

Projects
Genetic Impact and Improved Diagnostics for Sheep and Goat Transmissible Spongiform Encephalopathies
Appropriated (D)
  Accession Number: 431730

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine and cervid prion protein -
Madsen-Bouterse, S.A., Schneider, D.A., Zhuang, D., Dassanayake, R.P., Balachandran, A., Mitchell, G.B., O'Rourke, K.I. 2016. Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine and cervid prion protein. Journal of General Virology. doi:1099/jgv.0.000539.
Anti-prion activity of DB772 and related monothiophene/furan-based analogs in a persistently infected ovine microglia culture system -
Dinkel, K.D., Stanton, J.B., Boykin, D.W., Stephens, C.E., Madsen-Bouterse, S.A., Schneider, D.A. 2016. Anti-prion activity of DB772 and related monothiophene/furan-based analogs in a persistently infected ovine microglia culture system. Antimicrobial Agents and Chemotherapy. doi: 10.1128/AAC.00811-16.
Anaplasma marginale actively modulates vacuolar maturation during intracellular infection of its tick vector dermacentor andersoni -
Magunda, F., Thompson Wright, C., Schneider, D.A., Noh, S.M. 2016. Anaplasma marginale actively modulates vacuolar maturation during intracellular infection of its tick vector dermacentor andersoni. Applied and Environmental Microbiology. doi: 10.1128/AEM.01030-16.
East coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure -
Fry, L.M., Schneider, D.A., Frevert, C.W., Nelson, D.D., Morrison, I., Knowles Jr, D.P. 2016. East coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure. PLoS One. 11(5):e0156004.
Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry -
Highland, M.A., Schneider, D.A., White, S.N., Madsen-Bouterse, S.A., Knowles Jr, D.P., Davis, W.C. 2016. Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry . Comparative Immunology Microbiology and Infectious Diseases. doi: 10.1016/j.cimid.2016.04.006.
Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry -
Highland, M.A., Schneider, D.A., White, S.N., Madsen-Bouterse, S.A., Knowles Jr, D.P., Davis, W.C. 2016. Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry . Comparative Immunology Microbiology and Infectious Diseases. DOI: 10.1016/j.cimid.2016.04.006.
A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation -
Dassanayake, R.P., Zhuang, D., Truscott, T.C., Madsen-Bouterse, S.A., O'Rourke, K.I., Schneider, D.A. 2016. A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation. Prion. 10(2):153-64.
Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep -
Dassanayke, R.P., Madsen-Bouterse, S.A., Truscott, T.C., Zhuang, D., Mousel, M.R., Davis, W.C., Schneider, D.A. 2016. Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep. BioMed Central (BMC) Veterinary Research. doi: 10.1186/s12917-016-0651-6.
Transcriptomic determinants of scrapie prion propagation in cultured ovine microglia -
Muñoz-Gutiérrez, J.F., Pierlé, S.A., Schneider, D.A., Baszler, T.V., Stanton, J.B. 2016. Transcriptomic determinants of scrapie prion propagation in cultured ovine microglia. PLoS One. 11(1):e0147727.
Sensitive and specific detection of classical scrapie prions in the brain of goats by real-time quaking-induced conversion -
Dassanayake, R.P., Orru, C.D., Hughson, A.G., Caughey, B., Graça, T., Zhuang, D., Madsen-Bouterse, S.A., Knowles Jr, D.P., Schneider, D.A. 2016. Sensitive and specific detection of classical scrapie prions in the brain of goats by real-time quaking-induced conversion. Journal of General Virology. (97):803-812.
The placenta shed from goats with classical scrapie is infectious to goat kids and lambs -
Schneider, D.A., Madsen-Bouterse, S.A., Zhuang, D., Truscott, T.C., Dassanayake, R.P., O'Rourke, K.I. 2015. The placenta shed from goats with classical scrapie is infectious to goat kids and lambs. Journal of General Virology. doi: 10.1099/vir.0.000151.
PRNP variants in goats reduce sensitivity of detection of PrPSc by immunoassay -
Madsen-Bouterse, S.A., Schneider, D.A., Dassanayake, R.P., Truscott, T.C., Zhuang, D., Kumpula-Mcwhirter, N., O'Rourke, K.I. 2015. PRNP variants in goats reduce sensitivity of detection of PrPSc by immunoassay. Journal of Veterinary Diagnostic Investigation. 27(3):332-343.
Role of PRNP S127 allele in experimental goat infection with classical caprine scrapie -
Dassanayake, R.P., White, S.N., Madsen-Bouterse, S.A., Schneider, D.A., O'Rourke, K.I. 2015. Role of PRNP S127 allele in experimental goat infection with classical caprine scrapie. Animal Genetics. doi: 10.1111/age.12291.
Classical natural ovine scrapie prions are detected in practical volumes of blood by lamb and transgenic mouse bioassay -
Dassanayake, R.P., Truscott, T.C., Zhuang, D., Schneider, D.A., Madsen-Bouterse, S.A., Young, A.J., Stanton, J.B., Davis, W.C., O’Rourke, K.I. 2015. Classical natural ovine scrapie prions are detected in practical volumes of blood by lamb and transgenic mouse bioassay. Journal of Veterinary Science. 16(2):179-186.
hTERT-immortalized ovine microglia propagate natural scrapie isolates -
Munoz-Gutierrez, J.F., Schneider, D.A., Baszler, T.V., Dinkel, K.D., Greenlee, J.J., Nicholson, E.M., Stanton, J.J. 2015. hTERT-immortalized ovine microglia propagate natural scrapie isolates. Virus Research. 198:35-43.
Targeted surface expression of an exogenous antigen in stably transfected babesia bovis -
Laughery, J., Knowles Jr, D.P., Schneider, D.A., Mcelwain, T., Suarez, C.E. 2014. Targeted surface expression of an exogenous antigen in stably transfected babesia bovis. PLoS One. DOI:10.1371/journal.pone.0097890.
Fibroblasts express OvHV-2 capsid protein in vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever -
Nelson, D.D., Taus, N.S., Schneider, D.A., Cunha, C.W., Davis, W.C., Brown, W.C., Li, H., O'Toole, D., Oaks, L.J. 2013. Fibroblasts express OvHV-2 capsid protein in vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever. Veterinary Microbiology. doi: 10.1016/j.vetmic.2013.07.021.
Accumulation of PrP-Sc in hemal nodes of naturally and experimentally scrapie-infected sheep Reprint Icon -
Dassanayake, R.P., Truscott, T.C., Özyigit, Ö.M., Zhuang, D., Schneider, D.A., O'Rourke, K.I. 2013. Accumulation of PrP-Sc in hemal nodes of naturally and experimentally scrapie-infected sheep. BioMed Central (BMC) Veterinary Research. doi:10.1186/1746-6148-9-82.
Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and rov cells PLoS one -
Stanton, J.B., Schneider, D.A., Dinkel, K.D., Balmer, B.F., Baszler, T.V., Mathison, B.A., Boykin, D.W. 2012. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and rov cells PLoS one. Antimicrobial Agents and Chemotherapy. PloSone 7(11):e51173.
Ovine progressive pneumonia virus is transmitted more effectively via aerosol nebulization than oral administration Reprint Icon -
Herrmann-Hoesing, L.M., White, S.N., Neiswanger-Broughton, L.E., Johnson, W.C., Noh, S.M., Schneider, D.A., Li, H., Taus, N.S., Reynolds, J.O., Truscott, T.C., Dassanayake, R.P., Knowles Jr, D.P. 2012. Ovine progressive pneumonia virus is transmitted more effectively via aerosol nebulization than oral administration. Open Journal of Veterinary Medicine. 2(3):113-119.
Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay Reprint Icon -
Madsen-Bouterse, S.A., Zhuang, D., Orourke, K.I., Schneider, D.A. 2012. Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay. Biochemical and Biophysical Research Communications. 423(4):770-774.
Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America:Effects of age,sex,polymorphism at PRNP codon 96,and disease progression -
Thomsen, B.V., Schneider, D.A., O'Rourke, K., Gidlewski, T., Mclane, J., Allen, R.W., Mcisaac, A.A., Mitchell, G.B., Keane, D.P., Spraker, T., Balachandran, A. 2012. Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America:Effects of age,sex,polymorphism at PRNP codon 96,and disease progression. J Vet Diagn Invest. 24(5):878-87.
Acute and persistent infection by a transfected Mo7 strain of Babesia bovis Reprint Icon -
Suarez, C.E., Laughery, J., Schneider, D.A., Sondgeroth, K.S., Mcelwain, T.F. 2012. Acute and persistent infection by a transfected Mo7 strain of Babesia bovis. Molecular and Biochemical Parasitology. 185(1):52-7.
Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever Reprint Icon -
Cunha, C.W., Gailbreath, K.L., O'Toole, D., Knowles Jr, D.P., Schneider, D.A., White, S.N., Taus, N.S., Davis, C.J., Davis, W.C., Li, H. 2012. Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever. Veterinary Microbiology. 159:307-319.
Transmissibility of caprine scrapie in ovine transgenic mice Reprint Icon -
Orourke, K.I., Schneider, D.A., Spraker, T.R., Dassayanake, R., Highland, M., Zhuang, D., Truscott, T.C. 2012. Transmissibility of caprine scrapie in ovine transgenic mice. BioMed Central (BMC) Veterinary Research. 8:42.
Disease-associated prion protein in neural and lymphoid tissues of mink (Mustela vison) inoculated with transmissible mink encephalopathy Reprint Icon -
Schneider, D.A., Harrington, R., Zhuang, D., Yan, H., Truscott, T.C., Dassanayake, R., Orourke, K.I. 2012. Disease-associated prion protein in neural and lymphoid tissues of mink (Mustela vison) inoculated with transmissible mink encephalopathy. Journal of Comparative Pathology. 147:508-521.
Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222 Reprint Icon -
White, S.N., Reynolds, J.O., Waldron, D.F., Schneider, D.A., Orourke, K.I. 2012. Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222. Gene. 501(1):49-51.
Cell surface expression of PrP-c and the presence of scrapie prions in the blood of goats Reprint Icon -
Dassanayake, R.P., Schneider, D.A., Hoesing, L.M., Truscott, T.C., Davis, W.C., Orourke, K.I. 2012. Cell surface expression of PrP-c and the presence of scrapie prions in the blood of goats. Journal of General Virology. 1127-1131.
Classical scrapie prions in ovine blood are associated with B lymphocytes and platelets-rich plasma Reprint Icon -
Dassanayake, R.P., Schneider, D.A., Truscott, T.C., Young, A.J., Zhuang, D., Orourke, K.I. 2011. Classical scrapie prions in ovine blood are associated with B lymphocytes and platelets-rich plasma. BioMed Central (BMC) Veterinary Research. 7:75.
Cytokine antibody array analysis in brain and periphery of scrapie-infected Tg338 mice Reprint Icon -
Newsom, D.M., Liggitt, H.D., Orourke, K.I., Zhuang, D., Schneider, D.A., Harrington, R.D. 2011. Cytokine antibody array analysis in brain and periphery of scrapie-infected Tg338 mice. Comparative Immunology Microbiology and Infectious Diseases. 34(5):387-97.
Expression of Anaplasma marginale ankyrin repeat-containing proteins during infection of the mammalian host and tick vector -
Solomon, R.S., Schneider, D.A., Brayton, K.A., Ueti, M.W., Graca, T., Futse, J.E., Noh, S.M., Baszler, T.V., Palmer, G.H. 2011. Expression of Anaplasma marginale ankyrin repeat-containing proteins during infection of the mammalian host and tick vector. Infection and Immunity. 79(7):2847-2855.
Sparse PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie Reprint Icon -
O'Rourke, K., Zhuang, D., Truscott, T.C., Yan, H., Schneider, D.A. 2011. Sparse PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie. BioMed Central (BMC) Veterinary Research. 7(1):7.
Dynamics of bovine spleen cell populations during the response to acute Babesia bovis infection: an immunohistological study Reprint Icon -
Schneider, D.A., Yan, H., Bastos, R.G., Johnson, W.C., Gavin, P.R., Allen, A.J., Barrington, G.M., Hoesing, L.M., Knowles Jr, D.P., Goff, W.L. 2010. Dynamics of bovine spleen cell populations during the response to acute Babesia bovis infection: an immunohistological study. Parasite Immunology. Available: onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2010.01249.x/pdf.
The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections Reprint Icon -
Goff, W.L., Bastos, R.G., Brown, W.C., Johnson, W.C., Schneider, D.A. 2010. The bovine spleen: interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections. Veterinary Immunology and Immunopathology. 138:1-14.
Sheep (Ovis aries) airway epithelial cells support ovine herpesvirus 2 lytic replication in vivo -
Taus, N.S., Schneider, D.A., Oaks, J.L., Yan, H., Gailbreath, K.L., Knowles Jr, D.P., Li, H. 2010. Sheep (Ovis aries) airway epithelial cells support ovine herpesvirus 2 lytic replication in vivo. Veterinary Microbiology. 145(1-2):47-53.
Ovine Progressive Pneumonia Virus Capsid Antigen as Found in CD163- and CD172a-Positive Alveolar Macrophages of Persistently Infected Sheep Reprint Icon -
Hoesing, L.M., Noh, S.M., Snekvik, K.R., White, S.N., Schneider, D.A., Truscott, T.C., Knowles Jr, D.P. 2010. Ovine Progressive Pneumonia Virus Capsid Antigen as Found in CD163- and CD172a-Positive Alveolar Macrophages of Persistently Infected Sheep. Veterinary Pathology. 47(3):518-528.
Sensitive detection of PrPCWD in rectoanal mucosa-associated lymphoid tissue from preclinical white-tailed deer Reprint Icon -
Schneider, D.A., Orourke, K.I., Balachandran, A., Keane, D. 2009. Sensitive Detection of PrPCWD in Rectoanal Mucosa-Associated Lymphoid Tissue from Preclinical White-Tailed Deer. United States Animal Health Association Proceedings. pg.224-225.
Diagnosis of preclinical CWD in farmed white-tailed deer in Canada by the immunohistochemical examination of recto-anal mucosa- associated lymphoid tissue (RAMALT) Reprint Icon -
Balachandran, A., Thomsen, B.V., Gidlewski, T., Spraker, T.R., Mitchell, G., Soutyrine, A., Harrington, N.P., Munger, R., Schneider, D.A., Orourke, K.I. 2009. Diagnosis of preclinical CWD in farmed white-tailed deer in Canada by the immunohistochemical examination of recto-anal mucosa- associated lymphoid tissue (RAMALT). NeuroPrion Workshop: New developments in TSEs of domestic and wild animals. pg.9
Validation of Use of Rectoanal Mucosa-Associated Lymphoid Tissue for Immunohistochemical Diagnosis of Chronic Wasting Disease in White-Tailed Deer (Odocoileus virginianus) Reprint Icon -
Keane, D., Barr, D., Osborn, R., Langenberg, J., Orourke, K.I., Schneider, D.A., Bochsler, P. 2009. Validation of Use of Rectoanal Mucosa-Associated Lymphoid Tissue for Immunohistochemical Diagnosis of Chronic Wasting Disease in White-Tailed Deer (Odocoileus virginianus). Journal of Veterinary Diagnostic Investigation. 47(5):1412-1417.
Blood chimerism confounds genetic relative susceptibility testing for classical scrapie in sheep Reprint Icon -
Schneider, D.A., Tibary, A., Raudsepp, T., Das, P.J., Orourke, K.I. 2009. Blood chimerism confounds genetic relative susceptibility testing for classical scrapie in sheep. Journal of Veterinary Diagnostic Investigation. 21(3):295-305.
Antemortem detection of PrP-CWD in preclinical, ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) by biopsy of the rectal mucosa Reprint Icon -
Spraker, T.R., Vercauteren, K.C., Gidlewski, T., Schneider, D.A., Munger, R., Balanchandran, A., Orourke, K.I. 2009. Antemortem detection of PrP-CWD in preclinical, ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) by biopsy of the rectal mucosa. Journal of Veterinary Diagnostic Investigation. 21(1):15-24.
Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie Reprint Icon -
Schneider, D.A., Yan, H., Fry, L.M., Alverson, J., White, S.N., Orourke, K.I. 2008. Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie. Acta Neuropathologica. 115(6):651-661.
A species barrier limits transmission of chronic wasting disease to mink (Mustela vison) Reprint Icon -
Harrington, R.D., Baszler, T.V., Orourke, K.I., Schneider, D.A., Spraker, T.R., Liggitt, H.D., Knowles Jr, D.P. 2008. A species barrier limits transmission of chronic wasting disease to mink (Mustela vison). Journal of General Virology. 89(4):1086-1096.
Last Modified: 5/2/2016
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