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United States Department of Agriculture

Agricultural Research Service

Related Topics

Luisa Wai Wai Cheng
Foodborne Toxin Detection and Prevention Research
General Biological Science

Phone: (510) 559-6337
Fax: (510) 559-6429

USDA, ARS, PWA, WRRC-FTDP
800 BUCHANAN ST
ALBANY , CA 94710

Projects
Advance the Development of Technologies for Detecting and Determining the Stability and Bioavailability of Toxins that Impact Food Safety and Food Defense
Appropriated (D)
  Accession Number: 430056
Biocontrol Interventions for High-Value Agricultural Commodities
Appropriated (D)
  Accession Number: 430817
Development of an Effective Attractant for Control of Leaffooted Plant Bug (LFPB) in Pomegranate, Pistachio and Almond
Reimbursable (R)
  Accession Number: 430043
Development of Detection Technologies for Bacterial Neurotoxins and Their Validation in Food Matrices
Specific Cooperative Agreement (S)
  Accession Number: 422443
Toxin Detection with the SpinDx Microfluidics Detection Technology
Specific Cooperative Agreement (S)
  Accession Number: 426477
Use of a Host Plant Volatile Blend to Monitor Navel Orangeworm Populations During Integrated Pest Management(IPM) Treatments in Almond Orchards
Trust (T)
  Accession Number: 429924

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics -
Stringer, T., De Kock, C., Guzgay, H., Okombo, J., Liu, J., Kanetake, S., Kim, J., Tam, C.C., Cheng, L.W., Smith, P.J., Hendricks, D.T., Land, K.M., Egan, T.J., Smith, G.S. 2016. Mono- and multimeric ferrocene congeners of quinoline-based polyamines as potential antiparasitics. Dalton Transactions. 45:13415-13426 doi: 10.1039/c6dt02685k.
Technologies for detecting botulinum neurotoxins in biological and environmental matrices -
Cheng, L.W., Land, K.M., Tam, C.C., Brandon, D.L., Stanker, L.H. 2016. Technologies for detecting botulinum neurotoxins in biological and environmental matrices. Intech. doi: 10.5772/63064
Use of monoclonal antibodies in the sensitive detection and neutralization of botulinum neurotoxin serotype B -
Cheng, L.W., Henderson Ii, T.D., Lam, T., Stanker, L.H. 2015. Use of monoclonal antibodies in the sensitive detection and neutralization of botulinum neurotoxin serotype B. Toxins. 7:5068-5078. doi: 10.3390/toxins712863.
Augmenting the efficacy of antifungal intervention via chemo-biological approaches -
Kim, J.H., Chan, K.L., Cheng, L.W. 2015. Augmenting the efficacy of antifungal intervention via chemo-biological approaches. Meeting Abstract. Vol 1, A011 doi:10.3390/ecmc-1-A011.
Inhibiting oral intoxication of botulinum neurotoxin A by carbohydrate receptor mimics Reprint Icon -
Lee, K., Lam, K., Kruel, A.M., Mahrhold, S., Perry, K., Cheng, L.W., Rummel, A., Jin, R. 2015. Inhibiting oral intoxication of botulinum neurotoxin A by carbohydrate receptor mimics. Toxicon. 107:43-49. doi: org/10.1016/j.toxin2015.08.003.
Targeted antifungal intervention via chemo-biological approaches: Maintaining microbiome dynamics -
Kim, J.H., Chan, K.L., Cheng, L.W. 2015. Targeted antifungal intervention via chemo-biological approaches: Maintaining microbiome dynamics. Meeting Abstract. Poster No. 4.
Target discovery and antifungal intervention via chemical biology approaches -
Translocation of botulinum neurotoxin serotype a and associated proteins across the intestinal epithelia Reprint Icon -
Lam, T.I., Stanker, L.H., Lee, K., Jin, Rongsheng, Cheng, L.W. 2015. Translocation of botulinum neurotoxin serotype a and associated proteins across the intestinal epithelia. Cellular Microbiology. 17(8):1133-1143. doi: 10.1111/cmi.12424.
Natural food toxins of bacterial origin -
Cheng, L.W., Land, K.M., Stanker, L.H. 2015. Natural food toxins of bacterial origin. In: Cheung, P.C.K. Mehta, B.M., editors. Handbook of Food Chemistry. Berlin, Germany: Springer Berlin Heildelberg. p. 1-19.
Centrifugal microfluidic platform for ultrasensitive detection of Botulinum Toxin Reprint Icon -
Koh, C., Schaff, U.Y., Piccini, M., Stanker, L.H., Cheng, L.W., Ravichandran, E., Sing, B., Sommer, G.J., Singh, A.K. 2014. Centrifugal microfluidic platform for ultrasensitive detection of Botulinum Toxin. Analytical Chemistry. 87(2):922-928. DOI: 10.1021/ac504054u.
Controlled release of B-carotene in B-lactoglobulin-dextran conjugates nanoparticles in vitro digestion and the transport with Caco-2 monolayers -
Yi, J., Lam, T.I., Yokoyama, W.H., Cheng, L.W., Zhong, F. 2014. Controlled release of B-carotene in B-lactoglobulin-dextran conjugates nanoparticles in vitro digestion and the transport with Caco-2 monolayers. Journal of Agricultural and Food Chemistry. 62(35):8900-8907.
Beta-carotene encapsulated in food protein nanoparticles reduces peroxyl radical oxidation in Caco-2 cells -
Yi, J., Lam, T.I., Yokoyama, W.H., Cheng, L.W., Zhong, F. 2015. Beta-carotene encapsulated in food protein nanoparticles reduces peroxyl radical oxidation in Caco-2 cells. Food Hydrocolloids Journal. 43:31-40.
Cellular uptake of beta-carotene from protein stabilized solid lipid nano-particles prepared by homogenization-evaporation method -
Yi, J., Lam, T.I., Yokoyama, W.H., Cheng, L.W., Zhong, F. 2014. Cellular uptake of beta-carotene from protein stabilized solid lipid nano-particles prepared by homogenization-evaporation method. Journal of Agricultural and Food Chemistry. 62(5):1096-104.
A monoclonal antibody based capture ELISA for botulinum neurotoxin serotype B: toxin detection in food Reprint Icon -
Stanker, L.H., Scotcher, M.C., Cheng, L.W., Ching, K., Mcgarvey, J.A., Hodge, D., Hnasko, R.M. 2013. A monoclonal antibody based capture ELISA for botulinum neurotoxin serotype B: toxin detection in food. Toxins. 5(11):2212-2226.
Mouse in vivo neutralization of Escherichia coli Shiga toxin 2 with monoclonal antibodies Reprint Icon -
Cheng, L.W., Henderson II, T.D., Patfield, S.A., Stanker, L.H., He, X. 2013. Mouse in vivo neutralization of Escherichia coli Shiga toxin 2 with monoclonal antibodies. Infection and Immunity. 5:1845-1858. DOI: 10.3390/toxins5101845.
Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity -
Lee, K., Gu, S., Jin, L., Le, T., Cheng, L.W., Strotmeier, J., Krue, A.M., Perry, K., Yao, G., Rummel, A., Jin, R. 2013. Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity. PLoS Pathogens. 9(10):e1003690. DOI: 10.1371/journal.ppat.1003690.
Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples Reprint Icon -
Bagramyan, K., Kaplan, B.E., Cheng, L.W., Rummel, A., Kalkum, M. 2013. Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples. Analytical Chemistry. 85(11):5569-76. doi: 10.1021/ac4008418.
Translocation of botulinum neurotoxins and associated proteins across intestinal epithelial cells(Abstract) -
Detection of botulinum neurotoxin serotypes A and B using a chemiluminescent versus electrochemiluminescent immunoassay in food and serum -
Cheng, L.W., Stanker, L.H. 2013. Detection of botulinum neurotoxin serotypes A and B using a chemiluminescent versus electrochemiluminescent immunoassay in food and serum. Journal of Agricultural and Food Chemistry. 61(3):755-760 doi:10.1021/jf3041963.
Development and characterization of six monoclonal antibodies to hemagglutinin-70 (HA70) of Clostridium botulinum and their application in a sandwich ELISA -
Scotcher, M.C., Cheng, L.W., Ching, K.H., Mcgarvey, J.A., Hnasko, R.M., Stanker, L.H. 2013. Development and characterization of six monoclonal antibodies to hemagglutinin-70 (HA70) of Clostridium botulinum and their application in a sandwich ELISA. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 32(1):6-15. doi: 10.1089/mab.2012.0071.
Monoclonal antibodies and reagents for botulinum research -
Stanker, L.H., Cheng, L.W. 2012. Monoclonal antibodies and reagents for botulinum research. The Botulinum Journal. 2(2):150-155 doi: 10.1504/tbj2012.050197.
Replacement of animals in assays for detection of toxins in food(Abstract) -
Detection of botulinum neurotoxin serotypes A and B using chemiluminescence and electrochemiluninescene immunoassays in food and serum matrices -
Current methods for detecting the presence of botulinum neurotoxins in food and other biological samples -
Cheng, L.W., Land, K.M., Stanker, L.H. 2012. Current methods for detecting the presence of botulinum neurotoxins in food and other biological samples. Morse, S., editor. Bioterrorism. Rijeka, Croatia: Intech. p. 1-16.
Comparison of oral toxicological properties of botulinum neurotoxin -
Cheng, L.W., Henderson II, T.D. 2011. Comparison of oral toxicological properties of botulinum neurotoxin. Toxicon. 58:62-67.
Botulinum neurotoxin: a deadly protease with applications to human medicine -
Land, K.M., Cheng, L.W. 2010. Botulinum neurotoxin: a deadly protease with applications to human medicine. Current Research, Technology and Education Topics in Applied Microbiology and Microbial Biotechnology. Spain. Formatex Research Center. 965-971.
Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR -
He, X., Mcmahon, S.A., Henderson II, T.D., Griffey, S.M., Cheng, L.W. 2010. Ricin toxicokinetics and its sensitive detection in mouse sera or feces using immuno-PCR. PLoS One. 5(9):e12858. doi:10.1371/journal.pone.0012858.
Detection of Botulinum Neurotoxin Serotype B at Sub Mouse LD50 Levels by a Sandwich Immunoassay and its Application to Toxin Detection in Milk -
Scotcher, M.C., Cheng, L.W., Stanker, L.H. 2010. Detection of Botulinum Neurotoxin Serotype B at Sub Mouse LD50 Levels by a Sandwich Immunoassay and its Application to Toxin Detection in Milk. PLos One. 5(6):e11047.doi:10.1371/journal.pone.0011047.
Comparison of Toxicological Properties of Botulinum Neurotoxin Serotypes A and B in Mice -
Cheng, L.W., Henderson Ii, T.D., Scotcher, M.C., Stanker, L.H. 2009. Comparison of Toxicological Properties of Botulinum Neurotoxin Serotypes A and B in Mice. American Chemical Society [Abstract]. Paper No. 26541
Antibody Protection Against Botulinum Neurotoxin Intoxication In Mice -
Cheng, L.W., Stanker, L.H., Henderson Ii, T.D., Lou, J., Marks, J.D. 2009. Antibody Protection Against Botulinum Neurotoxin Intoxication In Mice. Infection and Immunity. 77(10):4305-4313.
Detection of Protein Toxins -
Brandon, D.L., Cheng, L.W., He, X., Rasooly, R., Scotcher, M.C., Stanker, L.H., Carter, J.M. 2009. Detection of Protein Toxins. Meeting Abstract. Poster No. 8.
Botulinum Neurotoxin Research at the Western Regional Research Center -
Influence of Gene Expression on Variable Aflatoxin Production by Different Strains of Aspergillus flavus -
BOTOX and our tax dollars at work -
Immunochemical technologies for replacement of rodent bioassays in sensitive detection of toxins in foods -
Carter, J.M., Cheng, L.W., He, X., Rasooly, R., Brandon, D.L., Stanker, L.H. 2010. Immunochemical technologies for replacement of rodent bioassays in sensitive detection of toxins in foods. Proceedings from Biodetection Technologies 6th Edition. 5:75-95.
Effect of food matrices on the biological activity of ricin -
He, X., Lu, S.S., Cheng, L.W., Rasooly, R., Carter, J.M. 2008. Effect of food matrices on the biological activity of ricin. Journal of Food Protection 71(10):2053-2058.
Detection of botulinum neurotoxin-A activity in food by peptide cleavage assay -
Rasooly, R., Stanker, L.H., Carter, J.M., Do, P.M., Cheng, L.W., He, X., Brandon, D.L. 2008. In vitro peptide cleavage assay for detection of Botulinum Neurotoxin-A activity in food. International Journal of Food Microbiiology. 126 (2008):135-139
Effects of purification on the bioavailability of botulinum neurotoxin type A -
Cheng, L.W., Onisko, B.C., Johnson, E.A., Reader, J.R., Griffey, S.M., Larson, A.E., Tepp, W.H., Stanker, L.H., Brandon, D.L., Carter, J.M. 2008. Effects of purification on the bioavailability of botulinum neurotoxin type A. Toxicology. 249(2008):123-129.
Development and Partial Characterization of High-affinity Monoclonal Antibodies for Botulinum Toxin Type A and their use in Analysis of Milk by Sandwich ELISA -
Stanker, L.H., Merrill, P.A., Scotcher, M.C., Cheng, L.W. 2008. Development and Partial Characterization of High-affinity Monoclonal Antibodies for Botulinum Toxin Type A and their use in Analysis of Milk by Sandwich ELISA. Journal of Immunological Methods, 336:1-8.
Application of a real time PCR method to detect castor toxin contamination in fluid milk and eggs -
He, X., Carter, J.M., Brandon, D.L., Cheng, L.W., Mckeon, T.A. 2007. Application of a real time PCR method to detect castor toxin contamination in fluid milk and eggs. Journal of Agricultural and Food Chemistry. 55:6897-6902
Molecular Approaches for the Identification of Toxin in Foods -
BIOAVAILABILITY OF CRUDE RICIN IN FOOD MATRICES -
Cheng, L.W., Brandon, D.L., He, X., Chen, G.Q., Carter, J.M. 2006. Bioavailability of crude ricin in food matrices. [Abstract]. ACS National Meeting and Exposition. Poster AGFD 64
DEVELOPMENT OF NEW MONOCLONAL ANTIBODIES SPECIFIC FOR BOTULINUM NEUROTOXIN TYPE A -
Stanker, L.H., Merrill, P.A., Cheng, L.W., Carter, J.M., Brandon, D.L. 2006. Development of new monoclonal antibodies specific for botulinum neurotoxin type a. [Abstract]. ACS National Meeting. Oral Presentation AGRO 235.
DEVELOPMENT OF MONOCLONAL ANTIBODIES SPECIFIC FOR RICIN -
Brandon, D.L., Cheng, L.W., He, X., Carter, J.M. 2006. Development of monoclonal antibodies specific for ricin. [Abstract]. ACS National Meeting and Exposition. Oral Presentation AGRO 234
ARS News Articles
Last Modified: 5/2/2016
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