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United States Department of Agriculture

Agricultural Research Service

Related Topics

Teresa De Los Santos
Foreign Animal Disease Research
Microbiology

Phone: (631) 323-3020
Fax: (631) 323-3006

40550 ROUTE 25
ORIENT POINT , NY 11957

Projects
Intervention Strategies to Support the Global Control and Eradication of Foot-and-Mouth Disease Virus(FMDV)
Appropriated (D)
  Accession Number: 422203
Development of New Generation Adenovirus Type 5 Foot-and-Mouth Disease Vaccines with Improved Performance
Specific Cooperative Agreement (S)
  Accession Number: 425674
Development of Improved Foot-and-Mouth Disease Vaccines and Biotherapeutics
Specific Cooperative Agreement (S)
  Accession Number: 426221
Use of IFN-Expressing Vectors in Control of Nipah and Ebola Virus Diseases in Swine
Specific Cooperative Agreement (S)
  Accession Number: 430693
Development of Novel Foot-and-Mouth Disease Virus with Multiple Mutations for Evaluation as Live Attenuated Diva Vaccine Candidate
Trust (T)
  Accession Number: 424159

Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Constitutively active IRF7/IRF3 fusion protein completely protects swine against Foot-and-Mouth Disease -
Ramirez-Carvajal, L., Diaz-San Segundo, F., Ramirez-Medina, E., Rodriguez, L.L., De Los Santos, T.B. 2016. Constitutively active IRF7/IRF3 fusion protein completely protects swine against Foot-and-Mouth Disease. Journal of Virology. de los Santos, T. 2016. Journal of Virology. doi: 10.1128/JVI.00800-16.
Control of foot-and-mouth disease by using replication-defective human adenoviruses to deliver vaccines and biotherapeutics -
The pathogenesis of Foot-and-Mouth Disease in pigs -
Stenfeldt, C., Diaz-San Segundo, F., De Los Santos, T.B., Rodriguez, L.L., Arzt, J. 2016. The pathogenesis of Foot-and-Mouth Disease in pigs. Frontiers in Veterinary Science. 3:41. doi: 10.3389/fvets.2016.00041.
Novel 6xHis tagged foot-and-mouth disease virus vaccine bound to nanolipoprotein adjuvant via metal ions provides antigenic distinction and effective protective immunity -
Rai, D., Daiz-San Segundo, F., Schafer, E.A., Burrage, T., Rodriguez, L.L., De Los Santos, T.B., Hoeprich, P.D., Rieder, A.E. 2016. Novel 6xHis tagged Foot-and-Mouth Disease Virus vaccine bound to nanolipoprotein adjuvant via metal ions provides antigenic distinction and effective protective immunity. Virology. 495:136-147. doi: 10.1016/j.virol.2016.04.027.
Depletion of elongation initiation factor 4E binding proteins by CRISPR/Cas9 genome editing enhances antiviral response in porcine cells -
Ramirez-Carvajal, L., Singh, N., De Los Santos, T.B., Rodriguez, L.L., Zhu, J.J., Long, C.R. 2015. Depletion of elongation initiation factor 4E binding proteins by CRISPR/Cas9 genome editing enhances antiviral response in porcine cells. Antiviral Research. 125:8-13. doi: 10.1016/j.antiviral.2015.11.002.
Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle -
Montiel, N., Medina, G.N., Sturza, D., Diaz-San Segundo, F., Ramirez-Medina, E., Grubman, M.J., De Los Santos, T.B. 2016. Evaluation of fiber-modified adenovirus vector-vaccine against foot-and-mouth diseaes in cattle. Clinical and Vaccine Immunology. 23:125-136. doi: 10.1128/CVI.00426-15.
Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response -
Diaz-San Segundo, F., Koster, M.J., Ramirez-Medina, E., Medina, G.N., Velazquez-Salinas, L., Grubman, M.J., De Los Santos, T.B. 2015. Synonymous deoptimization of the foot-and-mouth disease virus P1 coding region causes attenuation in vivo while inducing a strong neutralizing antibody response. Journal of Virology. 90:1298-1310. doi:10.1128/JVI.02167-15.
Inhibition of EHMT2 induces a robust antiviral response against Foot-and-Mouth Disease and Vesicular Stomatitis Virus infections in bovine cells -
Singh, N., Ramirez-Carvajal, L., De Los Santos, T.B., Golding, M.C., Long, C.R. 2015. Inhibition of EHMT2 induces a robust antiviral response against Foot-and-Mouth Disease and Vesicular Stomatitis Virus infections in bovine cells. Journal of Interferon and Cytokine Research. doi:10.1089/jir.2015.0006.
Treatment with interferon-alpha delays disease in swine infected with a highly virulent CSFV strain Reprint Icon -
Fernandez-Sainz, I., Zhu, J.J., O'Donnell, V., Diaz San Segundo, F.C., Velazquez, L., De Los Santos, T.B., Borca, M.V. 2015. Treatment with interferon-alpha delays disease in swine infected with a highly virulent CSFV strain. Virology. 483:284-290. DOI: 10.1016/j.virol.2015.04.024.
Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine -
Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Weiss, M., Perez-Martin, E., Salazar, A.M., Grubman, M.J., De Los Santos, T.B. 2014. Poly ICLC increases the potency of a replication-defective human adenovirus vectored foot-and-mouth disease vaccine. Virology. 468-470C:283-292.
Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication -
Ramirez-Carvajal, L., Long, C.R., Zhu, J.J., Diaz San Segundo, F.C., Rodriguez, L.L., De Los Santos, T.B. 2014. Expression of porcine fusion protein IRF7/3(5D) efficiently controls foot-and-mouth disease virus replication. Journal of Virology. 88(19):11140-11153.
Type III interferon protects swine against foot-and-mouth disease -
Perez-Martin, E., Diaz San Segundo, F.C., Weiss, M., Sturza, D., Dias, C.C., Ramirez, E., Grubman, M.J., De Los Santos, T.B. 2014. Type III interferon protects swine against foot-and-mouth disease. Journal of Interferon and Cytokine Research. 345(10):810-812 DOI:10.1089/jir.2013.0112.
Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection Reprint Icon -
Arzt, J., Pacheco Tobin, J., Tucker, M.T., Smoliga, G.R., Bishop, E.A., Pauszek, S.J., Hartwig, E.J., De Los Santos, T.B., Rodriguez, L.L. 2014. Foot and mouth disease virus virulence in cattle is co-determined by viral replication dynamics and route of infection. Virology. 452-453:12-22.
Animal health: foot-and-mouth disease -
Diaz San Segundo, F.C., Medina, G.N., Grubman, M.J., De Los Santos, T.B. 2014. Animal health: Foot-and-Mouth Disease. In: Van Alfen, N.K., editor. Encyclopedia of Agriculture and Food Systems. 2nd edition. United States of America: Elsevier/Academic Press. p. 327-345.
Understanding the mechanism of interferon-induced protection against foot-and-mouth disease Reprint Icon -
Diaz San Segundo, F.C., Montiel, N., De Los Santos, T.B., Grubman, M.J. 2014. Understanding the mechanism of interferon-induced protection against foot-and-mouth disease. In: IConcept Press, Ltd. Virology II Advanced Issues. 1st edition. United States of America: IConcept Press Ltd. p. 51-72.
Venezuelan Equine Encephalitis Virus replicon particles can induce rapid protection against Foot-and-Mouth Disease Virus Reprint Icon -
Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Weiss, M., Perez-Martin, E., Owens, G., Custer, M., Kamrud, K., De Los Santos, T.B., Grubman, M.J. 2013. Venezuelan Equine Encephalitis Virus replicon particles can induce rapid protection against Foot-and-Mouth Disease Virus. Journal of Virology. 87(10):5447-5460. DOI: 10.1128/JVI.03462-12.
Foot-and-mouth disease virus L peptidase -
Grubman, M.J., De Los Santos, T.B. 2013. Foot-and-mouth disease virus L peptidase. In: Neil D. Rawlings and Guy S. Salvesen, editors. Handbook of Proteolytic Enzymes. 3rd Edition. Oxford,UK:Academic Press. p.2183-2186.
Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease -
Grubman, M.J., Diaz San Segundo, F.C., Dias, C.C., Moraes, M.P., Perez-Martin, E., De Los Santos, T.B. 2012. Use of replication-defective adenoviruses to develop vaccines and biotherapeutics against foot-and-mouth disease. Future Virology. 7(8):767-778.
Novel antiviral therapeutics to control foot-and-mouth disease Reprint Icon -
Dias, C.C., Moraes, M.P., Weiss, M., Diaz San Segundo, F.C., Perez-Martin, E., Salazar, A.M., De Los Santos, T.B., Grubman, M.J. 2012. Novel antiviral therapeutics to control foot-and-mouth disease. Journal of Interferon and Cytokine Research. 32(10):462-473.
Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle Reprint Icon -
Perez-Martin, E., Weiss, M., Diaz San Segundo, F.C., Pacheco Tobin, J., Arzt, J., Grubman, M.J., De Los Santos, T.B. 2012. Bovine type III interferon significantly delays and reduces the severity of foot-and-mouth disease in cattle. Journal of Virology. 86(8):4477-4487.
Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease Reprint Icon -
Diaz San Segundo, F.C., Weiss, M., Perez-Martin, E., Dias, C.C., Grubman, M.J., De Los Santos, T.B. 2012. Inoculation of swine with foot-and-mouth disease SAP-mutant virus induces early protection against disease. Journal of Virology. 86(3):1316-1327.
Antiviral activity of bovine type III interferon against foot-and-mouth disease virus -
Diaz-San Segundo, F., Weiss, M., Perez-Martin, E., Koster, M.J., Zhu, J.J., Grubman, M.J., De Los Santos, T.B. 2011. Antiviral activity of bovine type III interferon against foot-and-mouth disease virus. Virology. 413(2):283-292.
Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus -
Golde, W.T., De Los Santos, T.B., Robinson, L., Grubman, M.J., Sevilla, N., Summerfield, A. 2011. Evidence of activation and suppression during the early immune response to foot-and-mouth disease virus. Transboundary and Emerging Diseases. 58(4):283-290.
Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein -
Piccone, M.E., Diaz-San Segundo, F., Kramer, E., Rodriguez, L.L., De Los Santos, T.B. 2011. Introduction of tag epitopes in the inter-AUG region of foot and mouth disease virus: effect on the L protein. Virus Research. 155(1):91-97.
Springer index of viruses, 2nd edition chapter - Aphthovirus, Picornaviridae -
Grubman, M.J., De Los Santos, T.B. 2011. Aphthovirus. In: Tidona, Christian, Darai, Gholamreza, editors. The Springer Index of Viruses. 2nd edition. New York, NY: Springer. p. 1281-1286.
Porcine type I interferon rapidly protects swine against challenge with multiple serotypes of foot-and-mouth disease virus -
Dias, C.C., Moraes, M.P., Diaz-San Segundo, F., De Los Santos, T.B., Grubman, M.J. 2011. Porcine type I interferon rapidly protects swine against challenge with multiple serotypes of foot-and-mouth disease virus. Journal of Interferon and Cytokine Research. 31(2):227-236.
Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus -
Zhu, J.J., Weiss, M., Grubman, M.J., De Los Santos, T.B. 2010. Differential gene expression in bovine cells infected with wild type and leaderless foot-and-mouth disease virus. Virology. 404(1):32-40.
Interferon induced protection against foot-and-mouth disease virus correlates with enhanced tissue specific innate immune cell infiltration and interferon stimulated gene expression -
Diaz-San Segundo, F., Moraes, M.P., De Los Santos, T.B., Dias, C., Grubman, M.J. 2010. Interferon induced protection against foot-and-mouth disease virus correlates with enhanced tissue specific innate immune cell infiltration and interferon stimulated gene expression. Journal of Virology. 84:2063-2077.
Foot-and-mouth disease -
Grubman, M.J., Rodriguez, L.L., De Los Santos, T.B. 2010. Foot-and-mouth disease. In: Ehrenfeld, E., Domingo, E., Roos, R.P., editors. The Picornaviruses. Washington, DC: ASM Press. p. 397-410.
Functional genomics approach to understand the role of Lpro in FMDV virulence -
De Los Santos, T.B., Grubman, M.J., Zhu, J.J. 2009. Functional genomics approach to understand the role of Lpro in FMDV virulence. American Society for Virology Meeting. Paper No. 9-21: P.262.
Examing the mechanisms of interferon-induced protection against foot-and-mouth disease virus in swine -
Diaz-San Segundo, F., Moraes, M.P., De Los Santos, T.B., Koster, M.J., Dias, C., Grubman, M.J. 2009. Examing the mechanisms of interferon-induced protection against foot-and-mouth disease virus in swine. American Society for Virology Meeting. Paper No. W21-5: p. 133.
Exploring the role of the lab protein of Foot-and-Mouth Disease Virus (FMDV) during viral infection -
De Los Santos, T.B., Piccone, M.E., Diaz-San Segundo, F., Pauszek, S.J., Kramer, E.V., Rodriguez, L.L. 2009. Exploring the role of the lab protein of Foot-and-Mouth Disease Virus (FMDV) during viral Infection. American Society for Virology Meeting. Paper No. 32-7: p. 337.
A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Sub-Cellular Localization and Function -
De Los Santos, T.B., Diaz-San Segundo, F., Zhu, J.J., Koster, M.J., Dias, C., Grubman, M.J. 2008. A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Sub-Cellular Localization and Function. Journal of Virology. 83(4):1800-1810.
Role of IL-10 during Foot-and-Mouth Disease Virus (FMDV) Infection and Its Potential Use as Immunomodulator -
Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus -
Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Dawson, H., Golde, W.T., Grubman, M.J. 2008. Type I and II Interferons Activate the Innate Immune System to Promote Early Protection of Swine Against Foot-and-Mouth Disease Virus. European Study Group on the Molecular Biology of Picornaviruses. P 149
A Conserved Domain in the Leader Proteinase of Foot-and-Mouth Disease Virus is Required for Proper Subcellular Localization and Function -
De Los Santos, T., San Segundo-Diaz, F., Zhu, J., Koster, M.J., Grubman, M.J. 2008. A conserved domain in the leader proteinase of foot-and-mouth disease virus is required for proper subcellular localization and function. European Study Group on the Molecular Biology of Picornaviruses. P 86
Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen -
Grubman, M.J., Moraes, M., Diaz-San Segundo, F., Pena, L., De Los Santos, T. 2008. Evading the Host Immune Response: How Foot-and-Mouth Disease Virus Has Become an Effective Pathogen. Federation of European Microbiological Societies Microbiology Letters. 53:8-17.
Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection -
De Los Santos, T., Diaz-San Segundo, F., Grubman, M.J. 2007. Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. Journal of Virology. 81(23):12803-12815.
Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons -
Moraes, M., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andreyev, V.G., Grubman, M.J. 2007. Enhanced Antiviral Activity against Foot-and-Mouth Disease Virus by a Combination of Type 1 and 2 Porcine Interfereons. Journal of Virology. Vol 81. No.13: P7124-7135
Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection -
De Los Santos, T., Diaz San-Segundo, F., Grubman, M.J., 2007, Degradation of Nuclear Factor Kappa B During Foot-and-Mouth Disease Virus Infection. American Society for Virology Meeting. W1-3, p.71
Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine -
Diaz-San Segundo, F., Moraes, M., De Los Santos, T., Pacheco Tobin, J., Koster, M.J., Turecek, T.E., Dawson, H., Golde, W.T., Grubman, M.J. 2007 Porcine Interferon Gamma Promotes a Protective Innate Immune Response Against Foot-and-Mouth Disease in Swine. American Society for Virology Meeting. W20-3, P. 30
THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS REDUCES THE EXPRESSION OF INTERFERON BY SUPPRESSING THE ACTIVITY OF THE NUCLEAR FACTOR KAPPA B -
De Los Santos, T., Brum, M., Grubman, M.J. 2006. The leader proteinase of foot-and-mouth disease virus reduces the expression of interferon by suppressing the activity of the nuclear factor kappa b. American Society of Virology Annual Meeting. 2006. P. 67.
ENHANCED ANTIVIRAL ACTIVITY AGAINST FOOT-AND-MOUTH DISEASE VIRUS BY A COMBINATION OF TYPE 1 AND 2 PORCINE INTERFERONS -
Grubman, M.J., De Los Santos, T., Koster, M.J., Turecek, T.E., Wang, H., Andryev, V., Moraes, M.P. 2006. Enhanced antiviral activity against foot-and-mouth disease virus by a combination of type 1 and 2 porcine interferons. American Society of Virology Annual Meeting. 2006. P. 150.
THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE -
De Los Santos, T., Botton, S.D., Weiblen, R., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. Journal of Virology.(2006) 80.4.1906-1914
THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE -
De Los Santos, T., Botton, S.D., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. American Society for Virology 24th Annual Meeting. P. W3-2.
THE LEADER PROTEINASE OF FOOT-AND-MOUTH DISEASE VIRUS INHIBITS THE INDUCTION OF INTERFERON BETA MRNA AND BLOCKS THE HOST INNATE IMMUNE RESPONSE -
De Los Santos, T., De Avila Botton, S., Grubman, M.J. 2005. The Leader Proteinase of Foot-and-Mouth Disease Virus Inhibits the Induction of Interferon Beta mRNA and Blocks the Host Innate Immune Response. European Study Grop on the Molecular Biology of Picornaviruses (ERUOPIC)2005. P. G06.
SHORT HAIRPIN RNA TARGETED TO THE HIGHLY CONSERVED 2B NONSTRUCTURAL PROTEIN CODING REGION INHIBITS REPLICATION OF MULTIPLE SEROTYPES OF FOOT-AND-MOUTH DISEASE VIRUS -
De Los Santos, T., Wu, Q., Botton, S., Grubman, M.J. 2005. Short Hairpin RNA Targeted to the Highly Conserved 2B Nonstructural Protein Coding Region Inhibits Replication of Multiple Serotypes of Foot-and-Mouth Disease Virus. Virology. 335: P222-231.
RAPID CONTROL OF FOOT-AND-MOUTH DISEASE: IS RNAI A POSSIBLE SOLUTION? -
De Los Santos, T., Grubman, M.J. 2005. Rapid Control of Foot-and-Mouth Disease: Is RNAi a Possible Solution?. Trends in Immunology 26 (2)P 65-68.
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Last Modified: 5/2/2016
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