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United States Department of Agriculture

Agricultural Research Service

Sunghyen Lee
Animal Biosciences and Biotechnology Laboratory
Molecular Biologist

Phone: (301) 504-8771
Fax: (301) 504-5103
Room 107

BLDG 1043 BARC-EAST
BELTSVILLE, MD, 20705-2350


Publications (Clicking on the reprint icon Reprint Icon will take you to the publication reprint.)
Evaluation of Montanide ISA 71 VG adjuvant during profilin vaccination against experimental coccidiosis - (Peer Reviewed Journal)
Jang, S.I., Kim, D., Lillehoj, H.S., Lee, S.H., Lee, K.W., Bertrand, F., Dupuis, L., Deville, S., Arous, J.B., Lillehoj, E.P. 2013. Evaluation of Montanide ISA 71 VG adjuvant during profilin vaccination against experimental coccidiosis. PLoS One. 8(4):e59786.
Montanide ISA 71 VG adjuvant enhances antibody and cell-ediated immune responses to profilin subunit antigen vaccination and promotes protection against Eimeria acervulina and Eimeria tenella - (Peer Reviewed Journal)
Jang, S.I., Lillehoj, H.S., Lee, S.H., Lee, K.W., Lillehoj, E.P., Bertrand, F., Dupuis, L., Deville, S. 2013. Montanide ISA 71 VG adjuvant enhances antibody and cell-mediated immune responses to profilin subunit antigen vaccination and promotes protection against Eimeria acervulina and Eimeria tenella. Experimental Parasitology. 127:178-183.
Effects of anticoccidial and antibiotic growth promoter programs on broiler performance and immune status - (Peer Reviewed Journal)
Lee, K.W., Hong, Y.H., Lee, S.H., Jang, S.I., Park, M.S., Bautista, D.A., Ritter, D.G., Jeong, W., Jeoung, H.Y., An, D.J., Lillehoj, E.P., Lillehoj, H.S. 2013. Effects of anticoccidial and antibiotic growth promoter programs on broiler performance and immune status. Research in Veterinary Science. 93:721-728.
Parasiticidal activity of a novel synthetic peptide from the core a-helical region of NK-lysin - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Jang, S.I., Jeong, M., Tuo, W., Murphy, C.A., Hong, Y.H., Lillehoj, E.P. 2013. Parasiticidal activity of a novel synthetic peptide from the core a-helical region of NK-lysin. Veterinary Parasitology. 197:113-121.
Evaluation of novel adjuvant Eimeria profilin complex on intestinal host immune responses against live E. acervulina challenge infection - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Jang, S., Lee, K., Lillehoj, E., Yancy, R.J., Dominowski, P., Kim, D. 2010. Evaluation of novel adjuvant Eimeria profilin complex on intestinal host immune responses against live E. acervulina challenge infection. Avian Diseases. 28(39):6498-6504.
Differential gene expression profiles of ß-defensins in the crop, intestine, and spleen using a necrotic enteritis model in two commercial broiler chicken lines - (Peer Reviewed Journal)
Hong, Y., Lillehoj, H.S., Song, W., Lee, S.H. 2012. Differential gene expression profiles of ß-defensins in the crop, intestine, and spleen using a necrotic enteritis model in two commercial broiler chicken lines. Poultry Science. 91(5):1081-1088.
Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites - (Peer Reviewed Journal)
Kim, D., Lillehoj, H.S., Lee, S.H., Lillehoj, E., Bravo, D. 2012. Improved resistance to Eimeria acervulina infection in chickens due to dietary supplementation with garlic metabolites. British Journal of Nutrition. p. 1-13.
Induction of protective immunity against Eimeria tenella, Eimeria maxima, and Eimeria acervulina infections using DC-derived exosomes - (Peer Reviewed Journal)
Del Cacho, E., Gallego, M., Lee, S.H., Lillehoj, H.S., Quilez, J., Lillehoj, E., Sanchez-Acedo, C. 2012. Induction of protective immunity against Eimeria tenella, Eimeria maxima, and Eimeria acervulina infections using DC-derived exosomes. Infection and Immunity. 80:1909-1916.
Enhanced egress of intracellular Eimeria tenella sporozoites by splenic lymphocytes from coccidia-infected chickens Reprint Icon - (Peer Reviewed Journal)
Dong, X., Abdelnabi, G.H., Lee, S.H., Li, G., Jin, H., Lillehoj, H.S., Suo, X. 2012. Enhanced egress of intracellular Eimeria tenella sporozoites by splenic lymphocytes from coccidia-infected chickens. Infection and Immunity. 79:3465-3470.
Development and Characterization of Mouse Monoclonal Antibodies Reactive with Chicken CD83 - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Jang, S.I., Lee, K., Baldwin, C., Tomkpins, D., Wagener, B., Lillehoj, E., Hong, Y. 2012. Development and characterization of mouse monoclonal antibodies reactive with chicken CD83. Veterinary Immunology and Immunopathology. 145(1-2):527-533.
Distinct immunoregulatory properties of macrophage migration inhibitory factors encoded by Eimeria parasites and their chicken host - (Peer Reviewed Journal)
Jang, S.I., Lillehoj, H.S., Lee, S.H., Kim, D., Bosch, M., Hong, Y.H., Min, W., Lillehoj, E.P. 2012. Distinct immunoregulatory properties of macrophage migration inhibitory factors encoded by Eimeria parasites and their chicken host. Vaccine. 29:8998-9004.
Cinnamaldehyde enhances in vitro parameters of immunity and reduces in vivo infection against avian coccidiosis - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Jang, S.I., Lee, K.W., Park, M.S., Bravo, D., Lillehoj, E. 2012. Cinnamaldehyde enhances in vitro parameters of immunity and reduces in vivo infection against avian coccidiosis. British Journal of Nutrition. 106:862-869.
Recent progress in understanding host mucosal response to avian coccidiosis and development of alternative strategies to mitigate the use of antibiotics in animal production - (Peer Reviewed Journal)
Lillehoj, H.S., Lee, S.H., Jang, S.I., Kim, D., Lee, K.W. 2012. Recent progress in understanding host mucosal response to avian coccidiosis and development of alternative strategies to mitigate the use of antibiotics in animal production. Korean Journal of Poultry Science. 38:275-284.
Impact of fresh or used litter on the post-hatch immune system of commercial broilers - (Peer Reviewed Journal)
Lee, K., Lillehoj, H.S., Lee, S.H., Jang, S.I., Ritter, D.G., Bautista, D.A., Lillehoj, E. 2012. Impact of fresh or used litter on the post-hatch immune system of commercial broilers. Avian Diseases. 55:539-544.
Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens - (Peer Reviewed Journal)
Lillehoj, H.S., Kim, D., Bravo, D.M., Lee, S.H. 2012. Effects of dietary plant-derived phytonutrients on the genome-wide profiles and coccidiosis resistance in the broiler chickens. BioMed Central (BMC) Proceedings. 5:S34. Available: http://www.biomedcentral.com/1753-6561/5/S4/S34.
Effects of novel vaccine/adjuvant complexes on the protective immunity against Eimeria acervulina and transcriptome profiles - (Peer Reviewed Journal)
Kim, D., Lillehoj, H.S., Lee, S.H., Dominowski, P., Yancey, R., Lillehoj, E. 2012. Effects of novel vaccine/adjuvant complexes on the protective immunity against Eimeria acervulina and transcriptome profiles. Avian Diseases. 56:97-109.
Effects of dietary supplementation with phytonutrients on vaccine-stimulated immunity against infection with Eimeria tenella - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Jang, S., Lee, K., Bravo, D., Lillehoj, E.P. 2011. Effects of dietary supplementation with phytonutrients on vaccine-stimulated immunity against infection with Eimeria tenella. Veterinary Parasitology. 181:97-105.
Bacillus subtilis-based direct-fed microbials augment macrophage function in broiler chickens - (Peer Reviewed Journal)
Lee, K., Li, G., Lillehoj, H.S., Lee, S.H., Jang, S.I., Babu, U.S., Lillehoj, E.P., Newumann, A.P., Siragusa, G.R. 2011. Bacillus subtilis-based direct-fed microbials augment macrophage function in broiler chickens. Research in Veterinary Science. 91:E87-91.
Development and characterization of mouse monoclonal antibodies reactive with chicken CD80 - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Park, M., Baldwin, C., Tompkins, D., Wagner, B., Babu, U., Del Cacho, E., Min, W. 2011. Development and characterization of mouse monoclonal antibodies reactive with chicken CD80. Comparative Immunology Microbiology and Infectious Diseases. 34(3):273-279.
Development and characterization of mouse monoclonal antibodies specific for chicken interleukin 18 - (Peer Reviewed Journal)
Hong, Y., Lillehoj, H.S., Lee, S.H., Park, S., Min, W., Labresh, J., Tompkins, D., Baldwin, C. 2011. Development and characterization of mouse monoclonal antibodies specific for chicken interleukin 18. Veterinary Immunology and Immunopathology. 138(1-2):144-148.
Induction of Protective Immunity against Eimeria tenella Infection using Antigen-loaded Dendritic Cells (DC) and DC-derived Exosomes - (Peer Reviewed Journal)
Del Cacho, E., Gallego, M., Lee, S.H., Lillehoj, H.S., Quilez, J., Sanchez-Acedo, C. 2011. Induction of protective immunity against Eimeria tenella infection using antigen-loaded dendritic cells (DC) and DC-derived exosomes. Vaccine. 29(21):3818-3825.
U. S. Veterinary Immune Reagents Network: Progress with Poultry Immune Reagents Development - (Abstract Only)
Lee, S.H., Lillehoj, H.S., Jang, S.I., Lee, K., Kim, K., Park, M., O Donnell, S.M., Chun, J., Baldwin, C., Wagner, B. 2011. U. S. Veterinary Immune Reagents Network: Progress with poultry immune reagents development. BARC Poster Day. P.27.
Immunoenhancing effects of MontanideTM ISA oil-based adjuvants on recombinant coccidia antigen vaccination against Eimeria acervulina infection - (Abstract Only)
Jang, S.I., Lillehoj, H.S., Lee, S.H., Lee, K., Park, M., Bauchan, G.R., Lillehoj, E., Bertrand, F., Dupuis, L., Deville, S. 2011. Immunoenhancing effects of MontanideTM ISA oil-based adjuvants on recombinant coccidia antigen vaccination against Eimeria acervulina infection. BARC Poster Day. P.20.
Effects of Bacillus subtilis-based direct-fed microbials on growth performance, immune characteristics and resistance against experimental coccidiosis in broiler chickens - (Abstract Only)
Lee, K., Lillehoj, H.S., Lee, S.H., Jang, S.I., Babu, U.S., Park, M., Kim, D., Chun, J., Song, W., Neumann, A.P., Siragusa, G.R. 2011. Effects of Bacillus subtilis-based direct-fed microbials on growth performance, immune characteristics and resistance against experimental coccidiosis in broiler chickens. BARC Poster Day. p.26.
Effects of novel adjuvant complex/Eimeria profilin vaccine on intestinal host immune responses against live E. acervulina challenge infection - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Jang, S., Lee, K., Yancy, R.J., Dominowski, P. 2011. Effects of novel adjuvant complex/Eimeria profilin vaccine on intestinal host immune responses against live E. acervulina challenge infection. Vaccine. 28(39):6498-6504.
Embryo vaccination of chickens using a novel adjuvant formulation stimulates protective immunity against Eimeria maxima infection - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Jang, S., Hong, Y., Min, W., Lillehoj, E., Yancy, R.J., Dobinowski, P. 2011. Embryo vaccination of chickens using a novel adjuvant formulation stimulates protective immunity against Eimeria maxima infection. Vaccine. 28(49):7774-7778.
Effect of montanide adjuvants on recombinant coccidia antigen vaccination against Eimeria infection in commercial meat-type chickens - (Peer Reviewed Journal)
Lillehoj, H.S., Jang, S.I., Lee, S.H., Lee, K.W., Park, M.S., Lillehoj, E.P., Betrand, F., Dupuis, L., Deville, S. 2011. Effect of montanide adjuvants on recombinant coccidia antigen vaccination against Eimeria infection in commercial meat-type chickens. Veterinary Parasitology. 172(3-4):221-228.
Induction of passive immunity in broiler chickens against Eimeria acervulina by hyperimmune egg yolk IgY - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Park, D.W., Jang, S.I., Morales, A., Garcia, D., Lucio, E., Larios, R., Victoria, G., Marrufo, D. 2010. Induction of passive immunity in broiler chickens against Eimeria acervulina by hyperimmune egg yolk IgY. Poultry Science. 88(3):562-566.
High-throughput gene expression analysis of intestinal intraepithelial lymphocytes following oral feeding of Carvacrol, cinnamaldehyde, or capsicum oleoresin - (Peer Reviewed Journal)
Lillehoj, H.S., Kim, D.K., Lee, S.H., Jang, S.I., Bravo, D. 2011. High-throughput gene expression analysis of intestinal intraepithelial lymphocytes following oral feeding of Carvacrol, cinnamaldehyde, or capsicum oleoresin. Poultry Science. 89(1):68-81.
Induction of Passive Immunity in Broiler Chickens Against Eimeria acervulina by Hyperimmune Egg Yolk IgY - (Peer Reviewed Journal)
Lillehoj, H.S., Lee, S.H., Park, D., Jang, S., Lillehoj, E., Morales, A., Garcia, D., Lucio, E., Larios, R., Victoria, G., Marrufo, D. 2010. Induction of Passive Immunity in Broiler Chickens Against Eimeria acervulina by Hyperimmune Egg Yolk IgY. Poultry Science. 88(3):562-566.
Eimeria maxima recombinant Gam82 gametocyte antigen vaccine protects against coccidiosis and augments humoral and cell-mediated immunity - (Peer Reviewed Journal)
Jang, S.I., Lillehoj, H.S., Lee, S.H., Lee, K.W., Park, M.S., Cha, S.R., Lillehoj, E.P., Subramanian, B.M., Sriraman, R., Srinivasan, V.A. 2010. Eimeria maxima recombinant Gam82 gametocyte antigen vaccine protects against coccidiosis and augments humoral and cell-mediated immunity. Vaccine. 28(17):2980-2985.
In vitro effects of plant and mushroom extracts on immunological function of chicken lymphocytes and macrophages - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Hong, Y.H., Jang, S.I., Lillehoj, E.P., Ionescu, C., Mazuranok, L., Bravo, D. 2010. In vitro effects of plant and mushroom extracts on immunological function of chicken lymphocytes and macrophages. British Poultry Science. 51(2):213-221.
Effects of Direct-Fed Microbials on Growth Performance, Gut Morphometry, and Immune Characteristics in Broiler Chickens - (Peer Reviewed Journal)
Lee, K.W., Lee, S.H., Lillehoj, H.S., Li, G.X., Jang, S.I., Park, M.S., Kim, D.K., Lillehoj, E.P., Neumann, A.P., Rehberger, T.G., Siragusa, G.R., Babu, U.S. 2010. Effects of Direct-Fed Microbials on Growth Performance, Gut Morphometry, and Immune Characteristics in Broiler Chickens. Poultry Science. 89:203-216.
Effects of direct-fed microbials on growth performance, gut morphometry, and immune characteristics in broiler chickens - (Peer Reviewed Journal)
Lillehoj, H.S., Lee, S.H., Siragusa, G.R., Neumann, M.A., Rehberger, T.G., Lee, K.W., Li, G.X., Jang, S.I., Park, S., Kim, D.K., Babu, U.S. 2010. Effects of direct-fed microbials on growth performance, gut morphometry, and immune characteristics in broiler chickens. International Poultry Scientific Forum, Atlanta, GA, January 25-26, 2010. P. 19.
In vitro Treatment Effect of the Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages and Tumor Cells - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Lillehoj, E.P., Chun, H., Park, H., Cho, S. 2009. In vitro Treatment Effect of the Methanol Extracts of Korean Medicinal Fruits (Persimmon, Raspberry, Tomato) on Chicken Lymphocytes, Macrophages and Tumor Cells. Poultry Science 46:149-154.
Protective effects of dietary Safflower (Carthamus tinctorius) on experimental coccidiosis - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Hong, Y., Cho, S., Park, D., Park, H., Chun, H. 2009. Protective effects of dietary Safflower (Carthamus tinctorius) on experimental coccidiosis. Journal of Poultry Science. 46:155-162.
Protective effect of hyperimmune egg yolk Ig Y antibodies against Eimeria tenella and Eimeria maxima infections - (Peer Reviewed Journal)
Lee, S.H., Lillehoj, H.S., Park, J.W., Jang, S.I., Morales, A., Garcia, D., Lucio, E., Larios, R., Victoria, G., Marrufo, D. 2009. Protective effect of hyperimmune egg yolk Ig Y antibodies against Eimeria tenella and Eimeria maxima infections. Veterinary Parasitology. 163:123-126.
Protection against Coccidiosis: Role of Passive Immunity (Immediate Immunity) Mediated by Hyperimmune IgY Antibodies - (Proceedings)
Lillehoj, H.S., Lee, S.H., Morales, A., Garcia, D., Larios, R., Victoria, G., Marrufo, D., Decannini, E., Lucio, E. 2009. Protection against Coccidiosis: Role of Passive Immunity (Immediate Immunity) Mediated by Hyperimmune IgY Antibodies. Asociacion National de Especialistas en Ciencias Avicolas de Mexico (ANECA), Acapulco, Mexico, p. 13-20.
Last Modified: 4/17/2014
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