David Schneider

Research Veterinary Medical Officer

• Publications

  • (Clicking on the reprint icon will take you to the publication reprint.)
  • Validation of a real-time quaking-induced conversion (RT-QuIC) assay protocol to detect chronic wasting disease using rectal mucosa of naturally infected, pre-clinical white-tailed deer (Odocoileus virginianus) -(Peer Reviewed Journal)
    Piel III, R.B., Veneziano, S.E., Nicholson, E.M., Walsh, D.P., Lomax, A.D., Nichols, T.A., Seabury, C.M., Schneider, D.A. 2024. Validation of a real-time quaking-induced conversion (RT-QuIC) assay protocol to detect chronic wasting disease using rectal mucosa of naturally infected, pre-clinical white-tailed deer (Odocoileus virginianus). PLOS ONE. 19(6). Article e0303037. https://doi.org/10.1371/journal.pone.0303037.
    
  • Sensitive detection of pathological seeds of a-synuclein, tau and prion protein on solid surfaces -(Peer Reviewed Journal)
    Orrú, C.D., Groveman, A.R., Hughson, A.G., Barrio, T., Isiofia, K., Race, B., Ferreira, N.C., Gambetti, P., Schneider, D.A., Masujin, K., Miyazawa, K., Ghetti, B., Zanusso, G., Caughey, B. 2024. Sensitive detection of pathological seeds of a-synuclein, tau and prion protein on solid surfaces. PLoS Pathogens. 20(4). Article e1012175. https://doi.org/10.1371/journal.ppat.1012175.
    
  • Expansion of proteome-wide Coxiella burnetii comparative T-cell epitope prediction to include small ruminant hosts -(Peer Reviewed Journal)
    Grossman, P.C., Schneider, D.A., Kirkpatrick, R., White, S.N., Piel, L.M. 2023. Expansion of proteome-wide Coxiella burnetii comparative T-cell epitope prediction to include small ruminant hosts. Cellular Immunology. 5(5):143-161. https://doi.org/10.33696/immunology.5.180.
    
  • Vaccination of cattle with a virus-vectored vaccine against a major membrane protein of Mycobacterium a. subsp. paratuberculosis elicits CD8 cytotoxic T cells that kill intracellular bacteria -(Pre-print Publication)
    Mahmoud, A.H., Abdellrazeq, G.S., Franceschi, V., Schneider, D.A., Bannantine, J.P., Fry, L.M., Hulubei, V., De Matteis, G., Park, ., Davis, W.C., Donofrio, G. 2023. Vaccination of cattle with a virus-vectored vaccine against a major membrane protein of Mycobacterium a. subsp. paratuberculosis elicits CD8 cytotoxic T cells that kill intracellular bacteria. bioRxiv. https://doi.org/10.1101/2023.11.20.567939.
    
  • B-cell leukemia in an adult sheep -(Peer Reviewed Journal)
    Furtado, A.P., Fry, L.M., Piel, L.M., Bastos, R.G., Schneider, D.A., Varvil, M.S. 2023. B-cell leukemia in an adult sheep. Veterinary Clinical Pathology. 52(4):716-721. https://doi.org/10.1111/vcp.13303.
    
  • Biphasic pleural mesothelioma in a goat-(Peer Reviewed Journal)
    Fry, L.M., DenHerder, J., Clyde, G.L., Williams, L.A., Schneider, D.A. 2023. Biphasic pleural mesothelioma in a goat. Canadian Veterinary Journal. 64(9):828-832.
    
  • Tonsil biopsy to detect chronic wasting disease in white-tailed deer (Odocoileus virginianus) by immunohistochemistry -(Peer Reviewed Journal)
    Schneider, D.A., Lehmkuhl, A.D., Spraker, T.R., Dittmar, R.O., Lockwood, M.A., Rollo, S., Nichols, T.A. 2023. Tonsil biopsy to detect chronic wasting disease in white-tailed deer (Odocoileus virginianus) by immunohistochemistry. PLOS ONE. 18(3). Article e0282356. https://doi.org/10.1371/journal.pone.0282356.
    
  • Iron reduction in Dermacentor andersoni tick cells inhibits Anaplasma marginale replication -(Peer Reviewed Journal)
    Solyman, M.M., Ujczo, J., Brayton, K.A., Shaw, D.K., Schneider, D.A., Noh, S.M. 2022. Iron reduction in Dermacentor andersoni tick cells inhibits Anaplasma marginale replication. International Journal of Molecular Sciences. 23(7). Article 3941. https://doi.org/10.3390/ijms23073941.
    
  • PrP-res in placental tissue following experimental transmission of atypical scrapie in ARR/ARR sheep is not infectious by Tg338 mouse bioassay -(Peer Reviewed Journal)
    Piel III, R., McElliott, V.R., Stanton, J.B., Zhuang, D., Madsen-Bouterse, S.A., Hamburg, L.K., Harrington, R.D., Schneider, D.A. 2022. PrP-res in placental tissue following experimental transmission of atypical scrapie in ARR/ARR sheep is not infectious by Tg338 mouse bioassay. PLoS ONE. 17(1). Article e0262766. https://doi.org/10.1371/journal.pone.0262766.
    
  • Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC -(Peer Reviewed Journal)
    Madsen-Bouterse, S.A., Stewart, P., Williamson, H., Schneider, D.A., Goldmann, W. 2021. Caprine PRNP polymorphisms N146S and Q222K are associated with proteolytic cleavage of PrPC. Genetics Selection Evolution. 53. Article 52. https://doi.org/10.1186/s12711-021-00646-x.
    
  • Differential pulmonary immunopathology of domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) with Mycoplasma ovipneumoniae infection: a retrospective study -(Peer Reviewed Journal)
    Grossman, P.C., Schneider, D.A., Herndon, D.R., Knowles, D.P., Highland, M.A. 2021. Differential pulmonary immunopathology of domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) with Mycoplasma ovipneumoniae infection: a retrospective study. Comparative Immunology Microbiology and Infectious Diseases. 76. Article 101641. https://doi.org/10.1016/j.cimid.2021.101641.
    
  • relA is Achilles’ heel for mycobacterial pathogens as demonstrated with deletion mutants in Mycobacterium avium subsp. paratuberculosis and mycobacterium bovis bacillus Calmette-Guérin (BCG) -(Peer Reviewed Journal)
    Abdellrazeq, G.S., Mahmoud, A.H., Kun-Taek, P., Fry, L.M., Elnaggar, M.M., Schneider, D.A., Hulubei, V., Davis, W.C. 2020. relA is Achilles’ heel for mycobacterial pathogens as demonstrated with deletion mutants in Mycobacterium avium subsp. paratuberculosis and mycobacterium bovis bacillus Calmette-Guérin (BCG). Tuberculosis. 120. https://doi.org/10.1016/j.tube.2020.101904.
    
  • Simultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium supsp. -(Peer Reviewed Journal)
    Abdellrazeq, G.S., Fry, L.M., Elnaggar, M.M., Bannantine, J.P., Schneider, D.A., Chamberlain, W.M., Mahmoud, A.H.A., Park, K.T., Hulubei, V., Davis, W.C. 2020. Simultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium supsp. paratubeculosis peptide vaccine. Vaccine. 38(8):2016-2025. https://doi.org/10.1016/j.vaccine.2019.12.052.
    
  • Comparison of three methods of enumeration for Mycoplasma ovipneumoniae -(Peer Reviewed Journal)
    Ackerman, M., Schneider, D.A., Baker, K.N., Besser, T.E. 2019. Comparison of three methods of enumeration for Mycoplasma ovipneumoniae. Journal of Microbiological Methods. 165. https://doi.org/10.1016/j.mimet.2019.105700.
    
  • A recombinant bovine herpesvirus-4 vectored vaccine delivered via intranasal nebulization elicits viral neutralizing antibody titers in cattle -(Peer Reviewed Journal)
    Williams, L.B., Fry, L.M., Herndon, D.R., Franceschi, V., Schneider, D.A., Donofrio, G., Knowles, D.P. 2019. A recombinant bovine herpesvirus-4 vectored vaccine delivered via intranasal nebulization elicits viral neutralizing antibody titers in cattle. PLoS One. 14(4):e0215605. https://doi.org/10.1371/journal.pone.0215605.
    
  • Low-volume goat milk transmission of classical scrapie to lambs and goat kids -(Peer Reviewed Journal)
    Madsen-Bouterse, S.A., Highland, M.A., Dassanayake, R.P., Zhuang, D., Schneider, D.A. 2018. Low-volume goat milk transmission of classical scrapie to lambs and goat kids. PLoS One. 13(9):e0204281. https://doi.org/10.1371/journal.pone.0204281.
    
  • A new tool: Genetic scrapie resistance in goats-(Trade Journal)
    White, S.N., Schneider, D.A. 2018. A new tool: Genetic scrapie resistance in goats. Scrapie: Eradicate It. June 2018:1.
    
  • A Mycobacterium avium subsp. paratuberculosis relA deletion mutant and a 35 kDa major membrane protein elicit development of cytotoxic T lymphocytes with ability to kill intracellular bacteria -(Peer Reviewed Journal)
    Abdellrazeq, G.S., Elnaggar, M.M., Bannantine, J.P., Park, K.T., Souza, C.D., Backer, B., Hulubei, V., Fry, L.M., Khaliel, S.A., Torky, H.A., Schneider, D.A., Davis, W.C. 2018. A Mycobacterium avium subsp. paratuberculosis relA deletion mutant and a 35 kDa major membrane protein elicit development of cytotoxic T lymphocytes with ability to kill intracellular bacteria. Veterinary Research. 49:53. https://doi.org/10.1186/s13567-018-0549-3.
    
  • Breeding scrapie resistant goats: A new DNA test to enhance goat health and your business-(Trade Journal)
    White, S.N., Schneider, D.A. 2018. Breeding scrapie resistant goats: A new DNA test to enhance goat health and your business. Dairy Goat Journal. 96(4):16-19.
    
  • Discovery of a novel species Theileria haneyi n. sp. infective to equids highlights exceptional genomic diversity within the genus Theileria: implications for apicomplexan parasite surveillance -(Peer Reviewed Journal)
    Knowles, D.P., Kappmeyer, L.S., Haney, D., Herndon, D.R., Fry, L.M., Munro, J.B., Sears, K., Ueti, M.W., Wise, L.N., Silva, M., Schneider, D.A., Grause, J., White, S.N., Trentina, K., Bishop, R., Odongo, D.O., Pelzel-McCluske, A.M., Scoles, G.A., Mealey, R.H., Silva, J.C. 2018. Discovery of a novel species Theileria haneyi n. sp. infective to equids highlights exceptional genomic diversity within the genus Theileria: implications for apicomplexan parasite surveillance. International Journal for Parasitology. 48(9-10):127-137. https://doi.org/10.1016/j.ijpara.2018.03.010.
    
  • Scrapie resistant goats: Keep your herd healthy and help your business with a new gene test-(Trade Journal)
    White, S.N., Schneider, D.A. 2018. Scrapie resistant goats: Keep your herd healthy and help your business with a new gene test. The Boer Goat. 6-8.
    
  • Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond six years-(Peer Reviewed Journal)
    Cinar Ulas, M., Schneider, D.A., Waldron, D.F., O'Rourke, K., White, S.N. 2018. Goats singly heterozygous for PRNP S146 or K222 orally inoculated with classical scrapie at birth show no disease at ages well beyond six years. Journal of Animal Breeding and Genetics. 233:19-24.
    
  • The babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction -(Peer Reviewed Journal)
    Hussein, H.E., Bastos, R.G., Schneider, D.A., Johnson, W.C., Adham, F.K., Davis, W.C., Laughery, J.M., Herndon, D.R., Alzan, H.F., Ueti, M.W., Suarez, C.E. 2017. The babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction. PLOS Neglected Tropical Diseases. 11(10):e0005965. https://doi.org/10.1371/journal.pntd.0005965.
    
  • Correlation of cellular factors and differential scrapie prion permissiveness in ovine microglia-(Peer Reviewed Journal)
    Dinkel, K.D., Schneider, D.A., Muñoz-Gutiérrez, J.F., Mcelliott, V.R., Stanton, J.B. 2017. Correlation of cellular factors and differential scrapie prion permissiveness in ovine microglia. Virus Research. 240:69-80.
    
  • Geno- and phenotypic characteristics of a transfected babesia bovis 6-Cys-E knockout clonal line-(Peer Reviewed Journal)
    Alzan, A., Silva, M., Davis, W., Herndon, D.R., Schneider, D.A., Suarez, C.E. 2017. Geno- and phenotypic characteristics of a transfected babesia bovis 6-Cys-E knockout clonal line. Parasites & Vectors. 10(1):214.
    
  • Scrapie-(Book / Chapter)
    Schneider, D.A. 2017. Scrapie. Book Chapter. SchneiderDA. 2017. Scrapie,In Chase CCL,Wiley & Sons, Inc. p. 738-740.
    
  • Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine and cervid prion protein-(Peer Reviewed Journal)
    Madsen-Bouterse, S.A., Schneider, D.A., Zhuang, D., Dassanayake, R.P., Balachandran, A., Mitchell, G.B., O'Rourke, K.I. 2016. Primary transmission of chronic wasting disease versus scrapie prions from small ruminants to transgenic mice expressing ovine and cervid prion protein. Journal of General Virology. 97(9):2451-2460.
    
  • Antiprion activity of DB772 and related monothiophene-and furan-based analogs in a persistently infected ovine microglia culture system-(Peer Reviewed Journal)
    Dinkel, K.D., Stanton, J.B., Boykin, D.W., Stephens, C.E., Madsen-Bouterse, S.A., Schneider, D.A. 2016. Antiprion activity of DB772 and related monothiophene-and furan-based analogs in a persistently infected ovine microglia culture system. Antimicrobial Agents and Chemotherapy. 60(9):5467-5482.
    
  • Anaplasma marginale actively modulates vacuolar maturation during intracellular infection of its tick vector dermacentor andersoni-(Peer Reviewed Journal)
    Magunda, F., Thompson Wright, C., Schneider, D.A., Noh, S.M. 2016. Anaplasma marginale actively modulates vacuolar maturation during intracellular infection of its tick vector dermacentor andersoni. Applied and Environmental Microbiology. doi: 10.1128/AEM.01030-16.
    
  • East coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure-(Peer Reviewed Journal)
    Fry, L.M., Schneider, D.A., Frevert, C.W., Nelson, D.D., Morrison, I., Knowles, D.P. 2016. East coast fever caused by Theileria parva is characterized by macrophage activation associated with vasculitis and respiratory failure. PLoS One. doi:10.1371/journal.pone.0156004.
    
  • Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry -(Peer Reviewed Journal)
    Highland, M.A., Schneider, D.A., White, S.N., Madsen-Bouterse, S.A., Knowles Jr, D.P., Davis, W.C. 2016. Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry . Comparative Immunology Microbiology and Infectious Diseases. doi: 10.1016/j.cimid.2016.04.006.
    
  • Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry -(Peer Reviewed Journal)
    Highland, M.A., Schneider, D.A., White, S.N., Madsen-Bouterse, S.A., Knowles Jr, D.P., Davis, W.C. 2016. Differences in leukocyte differentiation molecule abundances on domestic sheep (Ovis aries) and bighorn sheep (Ovis canadensis) neutrophils identified by flow cytometry . Comparative Immunology Microbiology and Infectious Diseases. DOI: 10.1016/j.cimid.2016.04.006.
    
  • A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation-(Peer Reviewed Journal)
    Dassanayake, R.P., Zhuang, D., Truscott, T.C., Madsen-Bouterse, S.A., O'Rourke, K.I., Schneider, D.A. 2016. A transfectant RK13 cell line permissive to classical caprine scrapie prion propagation. Prion. 10(2):153-64.
    
  • Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep-(Peer Reviewed Journal)
    Dassanayke, R.P., Madsen-Bouterse, S.A., Truscott, T.C., Zhuang, D., Mousel, M.R., Davis, W.C., Schneider, D.A. 2016. Classical scrapie prions are associated with peripheral blood monocytes and T-lymphocytes from naturally infected sheep. BioMed Central (BMC) Veterinary Research. doi: 10.1186/s12917-016-0651-6.
    
  • Transcriptomic determinants of scrapie prion propagation in cultured ovine microglia-(Peer Reviewed Journal)
    Muñoz-Gutiérrez, J.F., Pierlé, S.A., Schneider, D.A., Baszler, T.V., Stanton, J.B. 2016. Transcriptomic determinants of scrapie prion propagation in cultured ovine microglia. PLoS One. 11(1):e0147727.
    
  • Sensitive and specific detection of classical scrapie prions in the brain of goats by real-time quaking-induced conversion-(Peer Reviewed Journal)
    Dassanayake, R.P., Orru, C.D., Hughson, A.G., Caughey, B., Graça, T., Zhuang, D., Madsen-Bouterse, S.A., Knowles Jr, D.P., Schneider, D.A. 2016. Sensitive and specific detection of classical scrapie prions in the brain of goats by real-time quaking-induced conversion. Journal of General Virology. (97):803-812.
    
  • The placenta shed from goats with classical scrapie is infectious to goat kids and lambs-(Peer Reviewed Journal)
    Schneider, D.A., Madsen-Bouterse, S.A., Zhuang, D., Truscott, T.C., Dassanayake, R.P., O'Rourke, K.I. 2015. The placenta shed from goats with classical scrapie is infectious to goat kids and lambs. Journal of General Virology. doi: 10.1099/vir.0.000151.
    
  • PRNP variants in goats reduce sensitivity of detection of PrPSc by immunoassay-(Peer Reviewed Journal)
    Madsen-Bouterse, S.A., Schneider, D.A., Dassanayake, R.P., Truscott, T.C., Zhuang, D., Kumpula-Mcwhirter, N., O'Rourke, K.I. 2015. PRNP variants in goats reduce sensitivity of detection of PrPSc by immunoassay. Journal of Veterinary Diagnostic Investigation. 27(3):332-343.
    
  • Role of PRNP S127 allele in experimental goat infection with classical caprine scrapie-(Peer Reviewed Journal)
    Dassanayake, R.P., White, S.N., Madsen-Bouterse, S.A., Schneider, D.A., O'Rourke, K.I. 2015. Role of PRNP S127 allele in experimental goat infection with classical caprine scrapie. Animal Genetics. doi: 10.1111/age.12291.
    
  • Classical natural ovine scrapie prions are detected in practical volumes of blood by lamb and transgenic mouse bioassay-(Peer Reviewed Journal)
    Dassanayake, R.P., Truscott, T.C., Zhuang, D., Schneider, D.A., Madsen-Bouterse, S.A., Young, A.J., Stanton, J.B., Davis, W.C., O’Rourke, K.I. 2015. Classical natural ovine scrapie prions are detected in practical volumes of blood by lamb and transgenic mouse bioassay. Journal of Veterinary Science. 16(2):179-186.
    
  • hTERT-immortalized ovine microglia propagate natural scrapie isolates-(Peer Reviewed Journal)
    Munoz-Gutierrez, J.F., Schneider, D.A., Baszler, T.V., Dinkel, K.D., Greenlee, J.J., Nicholson, E.M., Stanton, J.J. 2015. hTERT-immortalized ovine microglia propagate natural scrapie isolates. Virus Research. 198:35-43.
    
  • Targeted surface expression of an exogenous antigen in stably transfected babesia bovis-(Peer Reviewed Journal)
    Laughery, J., Knowles Jr, D.P., Schneider, D.A., Mcelwain, T., Suarez, C.E. 2014. Targeted surface expression of an exogenous antigen in stably transfected babesia bovis. PLoS One. DOI:10.1371/journal.pone.0097890.
    
  • Fibroblasts express OvHV-2 capsid protein in vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever-(Peer Reviewed Journal)
    Nelson, D.D., Taus, N.S., Schneider, D.A., Cunha, C.W., Davis, W.C., Brown, W.C., Li, H., O'Toole, D., Oaks, L.J. 2013. Fibroblasts express OvHV-2 capsid protein in vasculitis lesions of American bison (Bison bison) with experimental sheep-associated malignant catarrhal fever. Veterinary Microbiology. doi: 10.1016/j.vetmic.2013.07.021.
    
  • Accumulation of PrP-Sc in hemal nodes of naturally and experimentally scrapie-infected sheep -(Peer Reviewed Journal)
    Dassanayake, R.P., Truscott, T.C., Özyigit, Ö.M., Zhuang, D., Schneider, D.A., O'Rourke, K.I. 2013. Accumulation of PrP-Sc in hemal nodes of naturally and experimentally scrapie-infected sheep. BioMed Central (BMC) Veterinary Research. doi:10.1186/1746-6148-9-82.
    
  • Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and rov cells PLoS one -(Peer Reviewed Journal)
    Stanton, J.B., Schneider, D.A., Dinkel, K.D., Balmer, B.F., Baszler, T.V., Mathison, B.A., Boykin, D.W. 2012. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and rov cells PLoS one. Antimicrobial Agents and Chemotherapy. PloSone 7(11):e51173.
    
  • Ovine progressive pneumonia virus is transmitted more effectively via aerosol nebulization than oral administration-(Peer Reviewed Journal)
    Herrmann-Hoesing, L.M., White, S.N., Neiswanger-Broughton, L.E., Johnson, W.C., Noh, S.M., Schneider, D.A., Li, H., Taus, N.S., Reynolds, J.O., Truscott, T.C., Dassanayake, R.P., Knowles Jr, D.P. 2012. Ovine progressive pneumonia virus is transmitted more effectively via aerosol nebulization than oral administration. Open Journal of Veterinary Medicine. 2(3):113-119.
    
  • Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay-(Peer Reviewed Journal)
    Madsen-Bouterse, S.A., Zhuang, D., Orourke, K.I., Schneider, D.A. 2012. Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay. Biochemical and Biophysical Research Communications. 423(4):770-774.
    
  • Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America:Effects of age,sex,polymorphism at PRNP codon 96,and disease progression-(Peer Reviewed Journal)
    Thomsen, B.V., Schneider, D.A., O'Rourke, K., Gidlewski, T., Mclane, J., Allen, R.W., Mcisaac, A.A., Mitchell, G.B., Keane, D.P., Spraker, T., Balachandran, A. 2012. Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America:Effects of age,sex,polymorphism at PRNP codon 96,and disease progression. J Vet Diagn Invest. 24(5):878-87.
    
  • Acute and persistent infection by a transfected Mo7 strain of Babesia bovis-(Peer Reviewed Journal)
    Suarez, C.E., Laughery, J., Schneider, D.A., Sondgeroth, K.S., Mcelwain, T.F. 2012. Acute and persistent infection by a transfected Mo7 strain of Babesia bovis. Molecular and Biochemical Parasitology. 185(1):52-7.
    
  • Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever-(Peer Reviewed Journal)
    Cunha, C.W., Gailbreath, K.L., O'Toole, D., Knowles Jr, D.P., Schneider, D.A., White, S.N., Taus, N.S., Davis, C.J., Davis, W.C., Li, H. 2012. Ovine herpesvirus 2 infection in american bison: virus and host dynamics in the development of sheep-associated malignant catarrhal fever. Veterinary Microbiology. 159:307-319.
    
  • Transmissibility of caprine scrapie in ovine transgenic mice-(Peer Reviewed Journal)
    Orourke, K.I., Schneider, D.A., Spraker, T.R., Dassayanake, R., Highland, M., Zhuang, D., Truscott, T.C. 2012. Transmissibility of caprine scrapie in ovine transgenic mice. BioMed Central (BMC) Veterinary Research. 8:42.
    
  • Disease-associated prion protein in neural and lymphoid tissues of mink (Mustela vison) inoculated with transmissible mink encephalopathy-(Peer Reviewed Journal)
    Schneider, D.A., Harrington, R., Zhuang, D., Yan, H., Truscott, T.C., Dassanayake, R., Orourke, K.I. 2012. Disease-associated prion protein in neural and lymphoid tissues of mink (Mustela vison) inoculated with transmissible mink encephalopathy. Journal of Comparative Pathology. 147:508-521.
    
  • Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222-(Peer Reviewed Journal)
    White, S.N., Reynolds, J.O., Waldron, D.F., Schneider, D.A., Orourke, K.I. 2012. Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222. Gene. 501(1):49-51.
    
  • Cell surface expression of PrP-c and the presence of scrapie prions in the blood of goats-(Peer Reviewed Journal)
    Dassanayake, R.P., Schneider, D.A., Hoesing, L.M., Truscott, T.C., Davis, W.C., Orourke, K.I. 2012. Cell surface expression of PrP-c and the presence of scrapie prions in the blood of goats. Journal of General Virology. 1127-1131.
    
  • Classical scrapie prions in ovine blood are associated with B lymphocytes and platelets-rich plasma-(Peer Reviewed Journal)
    Dassanayake, R.P., Schneider, D.A., Truscott, T.C., Young, A.J., Zhuang, D., Orourke, K.I. 2011. Classical scrapie prions in ovine blood are associated with B lymphocytes and platelets-rich plasma. BioMed Central (BMC) Veterinary Research. 7:75.
    
  • Cytokine antibody array analysis in brain and periphery of scrapie-infected Tg338 mice-(Peer Reviewed Journal)
    Newsom, D.M., Liggitt, H.D., Orourke, K.I., Zhuang, D., Schneider, D.A., Harrington, R.D. 2011. Cytokine antibody array analysis in brain and periphery of scrapie-infected Tg338 mice. Comparative Immunology Microbiology and Infectious Diseases. 34(5):387-97.
    
  • Expression of Anaplasma marginale ankyrin repeat-containing proteins during infection of the mammalian host and tick vector-(Peer Reviewed Journal)
    Solomon, R.S., Schneider, D.A., Brayton, K.A., Ueti, M.W., Graca, T., Futse, J.E., Noh, S.M., Baszler, T.V., Palmer, G.H. 2011. Expression of Anaplasma marginale ankyrin repeat-containing proteins during infection of the mammalian host and tick vector. Infection and Immunity. 79(7):2847-2855.
    
  • Sparse PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie-(Peer Reviewed Journal)
    O'Rourke, K., Zhuang, D., Truscott, T.C., Yan, H., Schneider, D.A. 2011. Sparse PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie. BioMed Central (BMC) Veterinary Research. 7(1):7.
    
  • Dynamics of bovine spleen cell populations during the response to acute Babesia bovis infection: an immunohistological study-(Peer Reviewed Journal)
    Schneider, D.A., Yan, H., Bastos, R.G., Johnson, W.C., Gavin, P.R., Allen, A.J., Barrington, G.M., Hoesing, L.M., Knowles Jr, D.P., Goff, W.L. 2010. Dynamics of bovine spleen cell populations during the response to acute Babesia bovis infection: an immunohistological study. Parasite Immunology. Available: onlinelibrary.wiley.com/doi/10.1111/j.1365-3024.2010.01249.x/pdf.
    
  • The bovine spleen: Interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections-(Review Article)
    Goff, W.L., Bastos, R.G., Brown, W.C., Johnson, W.C., Schneider, D.A. 2010. The bovine spleen: interactions among splenic cell populations in the innate immunologic control of hemoparasitic infections. Veterinary Immunology and Immunopathology. 138:1-14.
    
  • Sheep (Ovis aries) airway epithelial cells support ovine herpesvirus 2 lytic replication in vivo-(Peer Reviewed Journal)
    Taus, N.S., Schneider, D.A., Oaks, J.L., Yan, H., Gailbreath, K.L., Knowles Jr, D.P., Li, H. 2010. Sheep (Ovis aries) airway epithelial cells support ovine herpesvirus 2 lytic replication in vivo. Veterinary Microbiology. 145(1-2):47-53.
    
  • Ovine Progressive Pneumonia Virus Capsid Antigen as Found in CD163- and CD172a-Positive Alveolar Macrophages of Persistently Infected Sheep-(Peer Reviewed Journal)
    Hoesing, L.M., Noh, S.M., Snekvik, K.R., White, S.N., Schneider, D.A., Truscott, T.C., Knowles Jr, D.P. 2010. Ovine Progressive Pneumonia Virus Capsid Antigen as Found in CD163- and CD172a-Positive Alveolar Macrophages of Persistently Infected Sheep. Veterinary Pathology. 47(3):518-528.
    
  • Sensitive detection of PrPCWD in rectoanal mucosa-associated lymphoid tissue from preclinical white-tailed deer-(Abstract Only)
    Schneider, D.A., Orourke, K.I., Balachandran, A., Keane, D. 2009. Sensitive Detection of PrPCWD in Rectoanal Mucosa-Associated Lymphoid Tissue from Preclinical White-Tailed Deer. United States Animal Health Association Proceedings. pg.224-225.
    
  • Diagnosis of preclinical CWD in farmed white-tailed deer in Canada by the immunohistochemical examination of recto-anal mucosa- associated lymphoid tissue (RAMALT)-(Abstract Only)
    Balachandran, A., Thomsen, B.V., Gidlewski, T., Spraker, T.R., Mitchell, G., Soutyrine, A., Harrington, N.P., Munger, R., Schneider, D.A., Orourke, K.I. 2009. Diagnosis of preclinical CWD in farmed white-tailed deer in Canada by the immunohistochemical examination of recto-anal mucosa- associated lymphoid tissue (RAMALT). NeuroPrion Workshop: New developments in TSEs of domestic and wild animals. pg.9
    
  • Validation of Use of Rectoanal Mucosa-Associated Lymphoid Tissue for Immunohistochemical Diagnosis of Chronic Wasting Disease in White-Tailed Deer (Odocoileus virginianus)-(Peer Reviewed Journal)
    Keane, D., Barr, D., Osborn, R., Langenberg, J., Orourke, K.I., Schneider, D.A., Bochsler, P. 2009. Validation of Use of Rectoanal Mucosa-Associated Lymphoid Tissue for Immunohistochemical Diagnosis of Chronic Wasting Disease in White-Tailed Deer (Odocoileus virginianus). Journal of Veterinary Diagnostic Investigation. 47(5):1412-1417.
    
  • Blood chimerism confounds genetic relative susceptibility testing for classical scrapie in sheep-(Peer Reviewed Journal)
    Schneider, D.A., Tibary, A., Raudsepp, T., Das, P.J., Orourke, K.I. 2009. Blood chimerism confounds genetic relative susceptibility testing for classical scrapie in sheep. Journal of Veterinary Diagnostic Investigation. 21(3):295-305.
    
  • Antemortem detection of PrP-CWD in preclinical, ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) by biopsy of the rectal mucosa-(Peer Reviewed Journal)
    Spraker, T.R., Vercauteren, K.C., Gidlewski, T., Schneider, D.A., Munger, R., Balanchandran, A., Orourke, K.I. 2009. Antemortem detection of PrP-CWD in preclinical, ranch-raised Rocky Mountain elk (Cervus elaphus nelsoni) by biopsy of the rectal mucosa. Journal of Veterinary Diagnostic Investigation. 21(1):15-24.
    
  • Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie-(Peer Reviewed Journal)
    Schneider, D.A., Yan, H., Fry, L.M., Alverson, J., White, S.N., Orourke, K.I. 2008. Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie. Acta Neuropathologica. 115(6):651-661.
    
  • A species barrier limits transmission of chronic wasting disease to mink (Mustela vison)-(Peer Reviewed Journal)
    Harrington, R.D., Baszler, T.V., Orourke, K.I., Schneider, D.A., Spraker, T.R., Liggitt, H.D., Knowles Jr, D.P. 2008. A species barrier limits transmission of chronic wasting disease to mink (Mustela vison). Journal of General Virology. 89(4):1086-1096.
    

• Projects

  Genetic Approaches and Tools to Prevent, Control, and Eradicate Transmissible Spongiform Encephalopathies In-House Appropriated (D)   Accession Number:441236

  Understanding Host-Bacterial Interactions to Mitigate Disease in Small Ruminants In-House Appropriated (D)   Accession Number:443841

  Enhancing Detection of CWD in Tissue Samples from Cervids Non-Assistance Cooperative Agreement (S)   Accession Number:444897