PhD 2003 Molecular Veterinary Biosciences; University of Minnesota
MS 1997 Biology; Minnesota State University
BA 1995 Chemistry; Minnesota State University
BS 1995 Ecology; Minnesota State University
The objective of Dr. Green's research is to understand the mechanisms of plant toxin action in livestock, and develop evidence-based therapeutic approaches to mitigate livestock losses caused by poisonous plants. The specific objectives are to:
- Develop physiological measurements to quantify the effects of Delphinium spp., Lupinus spp., and related toxic plants in livestock.
- Determine biological effects in livestock of alkaloids from Delphinium spp., Lupinus spp., and related toxic plants.
- Identify drugs for treatment of plant poisonings in livestock.
- Identify candidate genes of interest through use of molecular techniques, inbred mouse lines, and knockout rodent models for future genetic marker studies in livestock.
- Test evidence-based therapeutic approaches, and genetic markers in field situations to ensure relevance to the producer.
- Improved drug therapy for larkspur intoxicated cattle. Research by Dr. Green on drug therapies for larkspur intoxicated cattle has shown that 0.04 mg/kg body weight intramuscular neostigmine is effective at reversing the toxic effects of larkspur on heart rate and muscle tone in cattle. Neostigmine is an improvement over the cholinesterase inhibitor physostigmine which has been used in the past.
- Development of high throughput cell culture-based assays for toxin evaluation and pharmacology.