Skip to main content
ARS Home » Pacific West Area » Davis, California » Western Human Nutrition Research Center » Immunity and Disease Prevention Research » Docs » Kable Lab

Kable Lab
headline bar

 /ARSUserFiles/20321510/Kable_Photos/Dana_in_lab.png

RESEARCH INTERESTS:

Dr. Kable is interested in the mechanisms governing how diet impacts the bacterial composition of the human gut and how these diet-bacterial interactions can influence human health. In particular, she is interested in how dietary fiber can affect the composition of the gut microbiota in such a way as to increase or decrease colonization resistance and susceptibility to food borne pathogens.

 

The Kable Lab’s research is currently focused on (1) characterization of the gut microbiota in a healthy human cohort and potential interactions between this composition and the long term dietary habits of healthy individuals, (2) optimization of methods for medium through-put culture of diverse gut microbiota, (3) in vitro fermentation of complete gut microbiota and individual bacteria from healthy human subjects with various food components, especially dietary fiber.

 

RESEARCH STUDIES

Assessing the Impact of Diet on Inflammation in Healthy and Obese Adults in a Cross-Sectional Phenotyping and a Longitudinal Intervention Trial (USDA Agricultural Research Service)

Charles Stephensen (PI), 10/01/13-10/01/18

Role: Co-Investigator

The goal of this study is to identify lifestyle, biological, and environmental factors associated with the variance in metabolic health and immune responses to dietary challenges in generally healthy US adults. The role of the Kable Lab in this project is to characterize the gut microbial community of each subject enrolled in this study and understand the relationships between diet and other lifestyle factors.

 

Milk, Health, and Genetics (California Dairy Research Foundation

Danielle Lemay (PI), 01/01/17-12/31/18

Role: Co-PI

The overall goal of this project is to understand how lactase persistence genotypes and dairy consumption interact to impact human health. The Kable lab is examining gut microbiota of individuals relative to their lactase persistence genotype and level of fluid milk consumption.

 

ADDITIONAL CURRENT COLLABORATIONS:

 

RESEARCH TEAM

 

/ARSUserFiles/20321510/Kable_Photos/MKable.jpg

Mary E. Kable, Ph.D.

Research Microbiologist

Visiting Assistant Professor, UC Davis Department of Nutrition

Office: WHNRC Rm 209, (530)752-1607

Lab: WHNRC Rm 235

Email address: mary.kable@ars.usda.gov

 

 /ARSUserFiles/20321510/Kable_Photos/Dana.png

Dana De Vries

Biological Science Technician

Lab: WHNRC Rm 235, (530)752-4725

Email address: ddevries@ucdavis.edu

 

 /ARSUserFiles/20321510/Kable_Photos/Riley_picture.png

Riley Hughes

Graduate Student Researcher, UC Davis Department of Nutrition

Office: WHNRC Rm 108

Email address: rlhughes@ucdavis.edu

 

 /ARSUserFiles/20321510/Kable_Photos/Ze_in_lab.png

Zeynep Alkan

Chemist (Support Scientist), point of collaboration with Lemay Lab

Lab: WHNRC Rm 235, (530)752-4725

Email address: zeynep.alkan@ars.usda.gov

 

METHODS AND TECHNIQUES

 The Kable Lab focuses on methods for the analysis of human gut microbes:

 For growth and fermentation experiments we use a:

-       2.7’ x 6.5’ Coy vinyl anaerobic chamber with space for two people to work, equipped with

Endpoints analyzed in the Kable Lab:

 

RECENT PUBLICATIONS (Selected)

Kable ME, LM Hansen, C Styer, S Deck, A Shetsova, K Eaton, M Martin, T Borén and JV Solnick, (2017) “Host Determinants of Expression of the Helicobacter pylori BabA Adhesin” Scientific Reports 7:46499. doi:10.1038/srep46499

Cooper DN, ME Kable, ML Marco, A De Leon, B Rust, JE Baker, W Horn, D Burnett and NL Keim, (2017) “The Effects of Moderate Whole Grain Consumption on Fasting Glucose and Lipids, Gastrointestinal Symptoms, and Microbiota” Nutrients 9(2):173. doi:10.3390/nu9020173

Zaragoza J, Z Bendiks, C Tyler, ME Kable, TR Williams, Y Luchkovska, E Chow, K Boundy-Mills and ML Marco, (2017) “Effects of Exogenous Yeast and Bacteria on the Microbial Population Dynamics and Outcomes of Olive Fermentations” mSphere 2(1):e00315-16. doi:10.1128/mSphere.00315-16

Kable ME, Y Srisengfa, M Laird, J Zaragoza, J McLeod, J Heidenreich and ML Marco, (2016) “The core and seasonal microbiota of raw bovine milk in tanker trucks and the impact of transfer to a milk processing facility” mBio 7(4): e00836-16. doi: 10.1128/mBio.00836-16

Hald S and AG Schioldan, ME Moore, A Dige, HN Lærke, J Agnholt, KE Bach Knudsen, K Hermansen, M Marco, S Gregersen and JF Dahlerup, (2016) “Effects of Arabinoxylan and Resistant Starch on Intestinal Microbiota and Short-Chain Fatty Acids in Subjects with Metabolic Syndrome: A Randomized Crossover Study” PLoS ONE 11(7): e0159223. doi:10.1371/journal.pone.0159223

Kieffer DA, BD Piccolo, ND Vaziri , S Liu , WL Lau, M Khazaeli, S Nazertehrani, ME Moore, ML Marco, RJ Martin and SH Adams, (2016) “Resistant Starch Alters Gut Microbiota, Uremic Retention Solutes and Xeno-Metabolite Profiles Concurrent with Amelioration of Chronic Kidney Disease in Rats” Journal of the American Society of Nephrology 310: F857-F871. doi:10.1152/ajprenal.00513.2015

Moore ME, A Lam, S Bhatnagar and J Solnick, (2013) “Environmental Determinants of Transformation Efficeincy in Helicobacter pylori.” Journal of Bacteriology 196 (2) 337-344.