Plant, Soil and Nutrition Research
Phone: 1-607-255-5434
Fax: 1-607-255-1132
Room 227

Robert W Holley Center, USDA-ARS
538 Tower Road
Ithaca, NY 14853-2901

• Projects

  Micronutrient Bioavailability of Foods Cooperative Agreement (A)   Accession Number:430750

  Micronutrient Bioavailability of Foods Cooperative Agreement (A)   Accession Number:431224

  Bioavailability of Iron, Zinc and Select Phytochemicals for Improved Health (Bridging Project) In-House Appropriated (D)   Accession Number:433201

  Optimizing the Convenience, Nutrition, and Taste of Yellow Dry Beans (Phaseolus vulgaris L.) to Promote Pulse Consumption in the U.S. Interagency Reimbursable Agreement (I)   Accession Number:432743

  Engineering a Small Intestinal Microbiome to Evaluate Food Additive Exposure Reimbursable Cooperative Agreement (R)   Accession Number:435922

• Publications

  • (Clicking on the reprint icon will take you to the publication reprint.)
  • Iron biofortified carioca bean (phaseolus vulgaris l.) —based Brazilian diet delivers more absorbable iron and affects the gut microbiota in vivo (gallus gallus)-(Peer Reviewed Journal)
    Morais Dias, D., Kolba, N.J., Binyamin, D., Ziv, O., Regini Nutti, M., Stampini Duarte, M., Glahn, R.P., Koren, O., Tako, E.N. 2018. Iron biofortified carioca bean (phaseolus vulgaris l.) —based Brazilian diet delivers more absorbable iron and affects the gut microbiota in vivo (gallus gallus). Nutrients. 10(12):1970. https://doi.org/10.3390/nu10121970.
    
  • ZnO nanoparticles affect nutrient transport in an in vitro model of the small intestine-(Peer Reviewed Journal)
    Tako, E.N., Mahler, G., Olivas, F.M. 2018. ZnO nanoparticles affect nutrient transport in an in vitro model of the small intestine. Food and Chemical Toxicology. https://doi.org/10.1016/j.fct.2018.11.048.
    
  • Alterations in the gut (Gallus gallus) microbiota following the consumption of zinc biofortified wheat (Triticum aestivum) -based diet-(Peer Reviewed Journal)
    Reed, S., Knez, M., Uzan, A., Stangoulis, J., Glahn, R.P., Koren, O., Tako, E.N. 2018. Alterations in the gut (Gallus gallus) microbiota following the consumption of zinc biofortified wheat (Triticum aestivum) -based diet. Journal of Agricultural and Food Chemistry. 66(25):6291-6299. https://doi.org/10.1021/acs.jafc.8b01481.
    
  • Silicon dioxide nanoparticle exposure affects small intestine function in an in vitro model-(Peer Reviewed Journal)
    Guo, Z., Martucci, N., Liu, Y., Mahler, G., Yoo, E., Tako, E.N. 2018. Silicon dioxide nanoparticle exposure affects small intestine function in an in vitro model. Nanotoxicology. 12(5):485-508. 10.1080/17435390.2018.1463407
    
  • The in ovo feeding administration (gallus gallus)-an emerging in vivo approach to assess bioactive compounds with potential nutritional benefits-(Peer Reviewed Journal)
    Hou, T., Tako, E.N. 2018. The in ovo feeding administration (gallus gallus)-an emerging in vivo approach to assess bioactive compounds with potential nutritional benefits. Nutrients. 10(4):418. https://doi.org/10.3390/nu10040418.
    
  • The linoleic acid: dihomo-y-linolenic acid ratio (LA:DGLA)—an emerging biomarker of Zn status-()
    Knez, M., Stangoulis, J., Glibetic, M., Tako, E. 2018. The linoleic acid: dihomo-y-linolenic acid ratio (LA:DGLA)—an emerging biomarker of Zn status. In: Tako, E. Dietary Zn and Human Health. Basel, Switzerland: MDPI Books. p. 1-12.
    
  • Relative bioavailability of iron in Bangledeshi traditional meals prepared with iron-fortified lentil dal-(Peer Reviewed Journal)
    Podder, R., Dellavalle, D., Tyler, R., Glahn, R.P., Tako, E.N., Vandenberg, A. 2018. Relative bioavailability of iron in Bangledeshi traditional meals prepared with iron-fortified lentil dal. Nutrients. 10(3). https://doi.org/10.3390/nu10030354.
    
  • Iron bioavailability studies of the first generation of iron-biofortified beans released in Rwanda-()
    Glahn, R.P., Hart, J.J., Beebe, S., Tako, E.N. 2018. Iron bioavailability studies of the first generation of iron-biofortified beans released in Rwanda. In: Tako, E., editor. Fe deficiency, dietary bioavailability and absorption. Basel, Switzerland: MDPI Books. p. 16-27. https://doi.org/10.3390/books978-3-03897-231-0.
    
  • Intra amniotic administration of raffinose and stachyose affects the intestinal brush border functionality and alters gut microflora populations-()
    Tako, E. 2017. Intra amniotic administration of raffinose and stachyose affects the intestinal brush border functionality and alters gut microflora populations. In: McCrory, M., editor. Dietary Fibers and Human Health. Basel, Switzerland: MDPI. p. 48-58. https://doi.org/10.3390/books978-3-03842-582-3.
    
  • The linoleic acid: dihomo-y-linolenic acid ratio (LA:DGLA)— an emerging biomarker of Zn status-(Peer Reviewed Journal)
    Knez, M., Stangoulis, J., Tako, E. 2017. The linoleic acid: dihomo-y-linolenic acid ratio (LA:DGLA)— an emerging biomarker of Zn status. Nutrients. 9(8):825.
    
  • Intra-amniotic administration (Gallus gallus) of cicer arietinum and lens culinaris prebiotics extracts and duck egg white peptides affects calcium status and intestinal functionality-(Peer Reviewed Journal)
    Hou, T., Kolba, N.J., Glahn, R.P., Tako, E. 2017. Intra-amniotic administration (Gallus gallus) of cicer arietinum and lens culinaris prebiotics extracts and duck egg white peptides affects calcium status and intestinal functionality. Nutrients. 9(7):785. doi:10.3390/nu9070785.
    
  • Characterizing the gut (Gallus gallus) microbiota following the consumption of an iron biofortified Rwandan cream seeded carioca (Phaseolus Vulgaris L.) bean-based diet-(Peer Reviewed Journal)
    Reed, S., Neuman, H., Glahn, R.P., Omry, K., Tako, E.N. 2017. Characterizing the gut (Gallus gallus) microbiota following the consumption of an iron biofortified Rwandan cream seeded carioca (Phaseolus Vulgaris L.) bean-based diet. PLoS One. 12(8):e0182431. https://doi.org/10.1371/journal.pone.0182431.
    
  • Iron bioavailability studies of the first generation of iron-biofortified beans released in Rwanda-(Peer Reviewed Journal)
    Glahn, R.P., Tako, E., Hart, J.J., Haas, J., Lung'Aho, M., Beebe, S. 2017. Iron bioavailability studies of the first generation of iron-biofortified beans released in Rwanda. Nutrients. 9(7):787.
    
  • Characterization of polyphenol effects on inhibition and promotion or iron update by caco-2 cells -(Peer Reviewed Journal)
    Hart, J.J., Tako, E.N., Glahn, R.P. 2017. Characterization of polyphenol effects on inhibition and promotion or iron update by caco-2 cells. Journal of Agricultural and Food Chemistry. 65(16):3285-3294.
    
  • Intra amniotic administration of raffinose and stachyose affects the intestinal brush border functionality and alters gut microflora populations-(Peer Reviewed Journal)
    Pacifici, S., Song, J., Zhang, C., Wang, Q., Glahn, R.P., Kolba, N.J., Tako, E.N. 2017. Intra amniotic administration of raffinose and stachyose affects the intestinal brush border functionality and alters gut microflora populations. Nutrients. 9(3):304. doi:10.3390/nu9030304.
    
  • Advantages and limitations of in vitro and in vivo methods of iron and zinc bioavailability evaluation in the assessment of biofortification program effectiveness-(Peer Reviewed Journal)
    Dias, D., Costa, N., Nutti, M., Tako, E.N., Martino, H. 2017. Advantages and limitations of in vitro and in vivo methods of iron and zinc bioavailability evaluation in the assessment of biofortification program effectiveness. Critical Reviews in Food Science and Nutrition. http://doi.org/10.1080/10408398.2017.1306484.
    
  • Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine -(Peer Reviewed Journal)
    Guo, Z., Martucci, N., Moreno-Olivas, F., Mahler, G., Tako, E.N. 2017. Titanium dioxide nanoparticle ingestion alters nutrient absorption in an in vitro model of the small intestine. NanoImpact. 5:70-82.
    
  • The combined application of the Caco-2 cell bioassay coupled with in vivo (Gallus gallus) feeding trial represents an effective approach to predicting Fe bioavailability in humans-(Peer Reviewed Journal)
    Tako, E.N., Bar, H., Glahn, R.P. 2016. The combined application of the Caco-2 cell bioassay coupled with in vivo (Gallus gallus) feeding trial represents an effective approach to predicting Fe bioavailability in humans. Nutrients. 8(11):732.
    
  • Demonstrating a nutritional advantage to the fast cooking dry bean (Phaseolus vulgaris L.)-(Peer Reviewed Journal)
    Wiesinger, J.A., Cichy, K.A., Glahn, R.P., Grusak, M.A., Brick, M., Thompson, H., Tako, E.N. 2016. Demonstrating a nutritional advantage to the fast cooking dry bean (Phaseolus vulgaris L.). Journal of Agricultural and Food Chemistry. 64(45):8592-8603.
    
  • A novel in vivo model for assessing the impact of geophagic earth on iron status-(Peer Reviewed Journal)
    Siem, G., Tako, E.N., Ahn, C., Bodis, M., Glahn, R.P., Young, S. 2016. A novel in vivo model for assessing the impact of geophagic earth on iron status. Nutrients. 8(6):E362. doi:10.3390/nu8060362.
    
  • The cotyledon cell wall of the common bean (phaseolus vulgaris) resists digestion in the upper intestine and thus may limit iron bioavailability -(Peer Reviewed Journal)
    Glahn, R.P., Tako, E.N., Cichy, K.A., Wiesinger, J.A. 2016. The cotyledon cell wall of the common bean (phaseolus vulgaris) resists digestion in the upper intestine and thus may limit iron bioavailability. Food & Function. 7(7):3193-3200.
    
  • Biofortified indica rice attains iron and zinc nutrition dietary targets in the field -(Peer Reviewed Journal)
    Trijatmiko, K.R., Duenas, C., Torrizo, L., Oliva, N., Francisco, P., Mae Arines, F., Adeva, C., Balindong, J., Sapasap, V., Barry, G., Slamet-Loedin, I.H., Lombi, E., Stangoulis, J., Johnson, A., Tako, E.N., Glahn, R.P. 2016. Biofortified indica rice attains iron and zinc nutrition dietary targets in the field. Scientific Reports. 6:19792.
    
  • Chronic zinc deficiency alters chick gut microbiota composition and function -(Peer Reviewed Journal)
    Reed, S.M., Neuman, H., Moskovitch, S., Glahn, R.P., Koren, O., Tako, E.N. 2015. Chronic zinc deficiency alters chick gut microbiota composition and function. Nutrients. 7:1-17.
    
  • Studies of cream seeded carioca beans (phaseolus vulgaris L.) from a Rwandan efficacy trial: in vitro and in vivo screening tools reflect human studies and predict beneficial results from iron biofortified beans-(Peer Reviewed Journal)
    Tako, E.N., Reed, S.M., Anandaraman, A., Hart, J.J., Beebe, S.E., Glahn, R.P. 2015. Studies of cream seeded carioca beans (phaseolus vulgaris L.) from a Rwandan efficacy trial: in vitro and in vivo screening tools reflect human studies and predict beneficial results from iron biofortified beans. PLoS One. DOI: 10.1371/journal.pone.0138479.
    
  • Identification of black bean (Phaseolus vulgaris L.) polyphenols that inhibit and promote iron uptake by caco-2 cells-(Peer Reviewed Journal)
    Hart, J.J., Tako, E.N., Kochian, L.V., Glahn, R.P. 2015. Identification of black bean (Phaseolus vulgaris L.) polyphenols that inhibit and promote iron uptake by caco-2 cells. Journal of Agricultural and Food Chemistry. DOI: 10.1021/acs.jafc.5b00531.
    
  • Higher iron pearl millet (Pennisetum glaucum L.) provides more absorbable iron that is limited by increased polyphenolic content-(Peer Reviewed Journal)
    Tako, E.N., Reed, S.M., Budiman, J., Hart, J.J., Glahn, R.P. 2015. Higher iron pearl millet (Pennisetum glaucum L.) provides more absorbable iron that is limited by increased polyphenolic content. Nutrition Journal. 14:11.
    
  • Alterations in gut microflora populations and brush border functionality following intra-amniotic daidzein administration-(Peer Reviewed Journal)
    Hortono, K., Reed, S.M., Ankrah, A., Glahn, R.P., Tako, E.N. 2014. Alterations in gut microflora populations and brush border functionality following intra-amniotic daidzein administration. RSC Advances. 5:6407-6412.
    
  • The effect of wheat prebiotics on the gut bacterial population and iron status of iron deficient broiler chickens-(Peer Reviewed Journal)
    Tako, E.N., Marija, K., Glahn, R.P., Stangoulis, J. 2014. The effect of wheat prebiotics on the gut bacterial population and iron status of iron deficient broiler chickens. Nutrition Journal. 13:58.
    
  • Hydrolysis of soybean protein improves iron bioavailability-(Peer Reviewed Journal)
    Lv, Y., Shuntang, G., Zhiqiang, C., Glahn, R.P., Tako, E.N. 2014. Hydrolysis of soybean protein improves iron bioavailability. Food and Nutrition Research. 2(4):162-166. DOI: 10.12691/jfnr-2-4-5.
    
  • Polyphenolic compounds appear to limit the nutritional benefit of biofortified higher iron black bean (phaseolus vulgaris L.) -(Peer Reviewed Journal)
    Tako, E.N., Beebe, S.E., Hart, J.J., Reed, S.M., Glahn, R.P. 2014. Polyphenolic compounds appear to limit the nutritional benefit of biofortified higher iron black bean (phaseolus vulgaris L.). Nutrition Journal. 13:28.
    
  • Dietary zinc deficiency affects blood linoleic acid: dihomo-gamma-linolenic acid (LA:DGLA) ratio; a reactive physiological marker of zinc status in vivo (Gallus gallus)-(Peer Reviewed Journal)
    Reed, S., Xia, Q., Rinat, R., Thomas, B., Glahn, R.P., Tako, E. 2014. Dietary zinc deficiency affects blood linoleic acid: dihomo-gamma-linolenic acid (LA:DGLA) ratio; a reactive physiological marker of zinc status in vivo (Gallus gallus). Nutrients. 6:1164-1180. DOI: 10.3390/nu6031164.
    
  • Bioavailability of iron in geophagic earths and clay minerals, and their effect on dietary iron absorption using an in vitro digestion/Caco-2 cell model -(Peer Reviewed Journal)
    Seim, G., Ahn, C.I., Bodis, M., Luwedde, F., Miller, D., Hillier, S., Tako, E.N., Glahn, R.P., Young, S.L. 2013. Bioavailability of iron in geophagic earths and clay minerals, and their effect on dietary iron absorption using an in vitro digestion/Caco-2 cell model. Food and Function. 4(8):1263-1270.
    
  • Soil consumed by chacma baboons is low in bioavailable iron and high in clay-(Peer Reviewed Journal)
    Pebsworth, P.A., Seim, G., Huffman, M.A., Glahn, R.P., Tako, E.N., Young, S.L. 2013. Soil consumed by chacma baboons is low in bioavailable iron and high in clay. Journal of Chemical Ecology. http://www.springerlink.com/openurl.asp?genre=article&id=DOI: 10.1007/s10886-013-0258-3.
    
  • High bioavailable iron maize (Zea mays L.) developed through molecular breeding provides more absorbable iron in vitro and in vivo -(Peer Reviewed Journal)
    Tako, E.N., Hoekenga, O., Kochian, L.V., Glahn, R.P. 2013. High bioavailable iron maize (Zea mays L.) developed through molecular breeding provides more absorbable iron in vitro and in vivo. Nutrition Journal. 12:3.
    
  • Oral exposure to polystyrene nanoparticles effects iron absorption -(Peer Reviewed Journal)
    Mahler, G., Esch, M., Tako, E.N., Southard, T., Glahn, R.P., Shuler, M. 2012. Oral exposure to polystyrene nanoparticles effects iron absorption. Nature Nanotechnology. DOI: 10.1038/nnano.2012.3.
    
  • Evaluation of metallothionein formation as a proxy for zinc absorption in an in vitro digestion/caco-2 cell culture model-(Peer Reviewed Journal)
    Zhiqiang, C., Tako, E.N., Yeung, A., Welch, R., Glahn, R.P. 2012. Evaluation of metallothionein formation as a proxy for zinc absorption in an in vitro digestion/caco-2 cell culture model. Food and Function. 3(7):732-736.
    
  • Intra amniotic administration and dietary inulin affect the iron status and intestinal functionality of iron deficient broiler chickens-(Peer Reviewed Journal)
    Tako, E.N., Glahn, R.P. 2012. Intra amniotic administration and dietary inulin affect the iron status and intestinal functionality of iron deficient broiler chickens. Poultry Science. 91(6):1361-1370.
    
  • Biofortified red mottled beans (phaseolus vulgaris L.) in a maize and bean diet provide more bioavailable iron than standard red mottled beans: studies in poultry (Gallus gallus) and an in vitro digestion/Caco-2 model-(Peer Reviewed Journal)
    Tako, E.N., Blair, M., Glahn, R.P. 2011. Biofortified red mottled beans (phaseolus vulgaris L.) in a maize and bean diet provide more bioavailable iron than standard red mottled beans: studies in poultry (Gallus gallus) and an in vitro digestion/Caco-2 model. Nutrition Journal. 10:113.
    
  • Iron status of the late term broiler (Gallus gallus) embryo and hatchling-(Peer Reviewed Journal)
    Tako, E.N., Glahn, R.P. 2011. Iron status of the late term broiler (Gallus gallus) embryo and hatchling. International Journal of Poultry Science. 10(1):42-48.
    
  • White beans provide more bioavailable iron than red beans: studies in poultry (Gallus gallus) and an in vitro digestion/Caco-2 model-(Peer Reviewed Journal)
    Tako, E.N., Glahn, R.P. 2010. White beans provide more bioavailable iron than red beans: studies in poultry (Gallus gallus) and an in vitro digestion/Caco-2 model. International Journal for Vitamin and Nutrition Research. 80(6)416:429.
    

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