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United States Department of Agriculture

Agricultural Research Service

Wang's Publications
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Dr. Thomas Wang

Research Chemist, Diet Genomics and Immunology Lab

Beltsville Human Nutrition Research Center,

USDA, Agriculture Research Service


Peer-reviewed journal publications.


Wang, T. T., Schoene, N. W., Kim, Y. S., Mizuno, C. S., and Rimando, A. M.  Differential effects of resveratrol and its naturally occurring methylether analogs on cell cycle and apoptosis in human androgen-responsive LNCaP cancer cells.  Mol. Nutr. Food Res. 54(3):335-344. 2010.


Trasino, S. E., Kim, Y.-S., and Wang, T. T.  Ligand, receptor, and cell type-dependent regulation of ABCA1 and ABCG1 mRNA in prostate cancer epithelial cells.  Mol. Cancer Ther.  8(7):1934-1945. 2009.


Payton-Stewart, F., Schoene, N. W., Kim, Y.-S., Burow, M. E., Cleveland, T. E., Boue, S. M., and Wang, T. T.  Molecular effects of soy phytoalexin glyceollins in human prostate cancer cells LNCaP.  Mol. Carcinog. 48(9): 862-871.  2009.


Hawkes, W. C., Wang, T. T., Alkan, Z., Richter, B. D., and Dawson, K.  Selenoprotein W modulates control of cell cycle entry. Biol. Trace Elem. Res. 131(3):229-244. 2009.


Zhang, J. J., Wu, M., Schoene, N. W., Cheng, W. H., Wang, T. T., Alshatwi, A. A., Alsaif, M., and Lei, K.Y. Effect of resveratrol and zinc on intracellular zinc status in normal human prostate cells.  Am. J. Physiol. Cell Physiol. 297(3):C632-644. 2009.


Wang, T. T. , Hudson, T. S., Wang, T. C., Remsberg, C. M., Davies, N. M., Takahashi, Y., Kim, Y.-S., Seifried, H., Vinyard, B. T., Perkins, S. N., and Hursting, S. D.  Differential effects of resveratrol on androgen-responsive LNCaP human prostate cancer cells in vitro and in vivo.  Carcinogenesis.  29(10):2001-2010. 2008.


Hudson TS, Hartle DK, Hursting SD, Nunez NP, Wang TT, Young HA, Arany P, Green JE. Inhibition Of Prostate Cancer Growth By Muscadine Grape Skin Extract And Resveratrol Through Distinct Mechanisms. Cancer Research, 2007 Sep 1;67(17):8396-405.


Lavigne JA, Takahashi Y, Chandramouli GV, Liu H, Perkins SN, Hursting SD, Wang TT. Concentration-dependent effects of genistein on global gene expression in MCF-7 breast cancer cells: an oligo microarray study. Breast Cancer Res Treat. 2007 Aug 9; [Epub ahead of print]



Trasino SE, Harrison EH, Wang TT. Androgen regulation of aldehyde dehydrogenase 1A3 (ALDH1A3) in the androgen-responsive human prostate cancer cell line LNCaP. Exp Biol Med (Maywood). 2007 Jun;232(6):762-71.


Daly KT, Tracy AC, Malik M, Wang TT, Francke-Carroll S, Magnuson BA. Enhanced estrogenic responses and sensitivity to azoxymethane following dietary soy isoflavone supplementation in older female rats. Food Chem Toxicol. 2007 Apr;45(4):628-37. Epub 2006 Nov 2.


Takahashi Y, Perkins SN, Hursting SD, Wang TT. 17beta-Estradiol differentially regulates androgen-responsive genes through estrogen receptor-beta- and extracellular-signal regulated kinase-dependent pathways in LNCaP human prostate cancer cells. Mol Carcinog. 2007 Feb;46(2):117-29.


Takahashi Y, Lavigne JA, Hursting SD, Chandramouli GV, Perkins SN, Kim YS, Wang TT. Molecular signatures of soy-derived phytochemicals in androgen-responsive prostate cancer cells: a comparison study using DNA microarray. Mol Carcinog. 2006 Dec;45(12):943-56.


Wang TT, Milner MJ, Milner JA, Kim YS. Estrogen receptor alpha as a target for indole-3-carbinol. J Nutr Biochem. 2006 Oct;17(10):659-64. Epub 2005 Nov 28.


Takahashi Y, Hursting SD, Perkins SN, Wang TC, Wang TT. Genistein affects androgen-responsive genes through both androgen- and estrogen-induced signaling pathways.Mol Carcinog. 2006 Jan;45(1):18-25.


Takahashi Y, Lavigne JA, Hursting SD, Chandramouli GV, Perkins SN, Barrett JC, Wang TT. Using DNA microarray analyses to elucidate the effects of genistein in androgen-responsive prostate cancer cells: identification of novel targets. Mol Carcinog. 2004 Oct;41(2):108-119.


Rosenfeld S, Wang T, Kim Y, Milner J. Numerical deconvolution of cDNA microarray signal: simulation study. Ann N Y Acad Sci. 2004 May;1020:110-23.


Po LS, Wang TT, Chen ZY, Leung LK. Genistein-induced apoptosis in MCF-7 cells involves changes in Bak and Bcl-x without evidence of anti-oestrogenic effects. Br J Nutr. 2002 Nov;88(5):463-9.


Wang TT. beta-naphthoflavone, an inducer of xenobiotic metabolizing enzymes, inhibits firefly luciferase activity. Anal Biochem. 2002 May 1;304(1):122-6.


Hursting SD, Shen JC, Sun XY, Wang TT, Phang JM, Perkins SN.  Modulation of cyclophilin gene expression by N-4-(hydroxyphenyl)retinamide: association with reactive oxygen species generation and apoptosis. Mol Carcinog. 2002 Jan;33(1):16-24.


Leung LK, Wang TT. Bcl-2 is not reduced in the death of MCF-7 cells at low genistein concentration. J Nutr. 2000 Dec;130(12):2922-6.


Ciolino HP, Wang TT, Sathyamoorthy N. Inhibition of aromatase activity and expression in MCF-7 cells by the chemopreventive retinoid N-(4-hydroxy-phenyl)-retinamide.  Br J Cancer. 2000 Aug;83(3):333-7.


Wang TT, Jeng J. Coordinated regulation of two TRAIL-R2/KILLER/DR5 mRNA isoforms by DNA damaging agents, serum and 17beta-estradiol in human breast cancer cells. Breast Cancer Res Treat. 2000 May;61(1):87-96.


Poetschke HL, Klug DB, Perkins SN, Wang TT, Richie ER, Hursting SD. Effects of calorie restriction on thymocyte growth, death and maturation. Carcinogenesis. 2000 Nov;21(11):1959-64.


Shen JC, Klein RD, Wei Q, Guan Y, Contois JH, Wang TT, Chang S, Hursting SD. Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. Mol Carcinog. 2000 Oct;29(2):92-102.


Leung LK, Wang TT. Differential effects of chemotherapeutic agents on the Bcl-2/Bax apoptosis pathway in human breast cancer cell line MCF-7. Breast Cancer Res Treat. 1999 May;55(1):73-83.


Leung LK, Wang TT. Paradoxical regulation of Bcl-2 family proteins by 17beta-oestradiol in human breast cancer cells MCF-7. Br J Cancer. 1999 Oct;81(3):387-92.


Shen JC, Wang TT, Chang S, Hursting SD. Mechanistic studies of the effects of the retinoid N-(4-hydroxyphenyl)retinamide on prostate cancer cell growth and apoptosis. Mol Carcinog. 1999 Mar;24(3):160-8.


Ciolino HP, Daschner PJ, Wang TT, Yeh GC. Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem Pharmacol. 1998 Jul 15;56(2):197-206.


Sathyamoorthy N, Gilsdorf JS, Wang TT. Differential effect of genistein on transforming growth factor beta 1 expression in normal and malignant mammary epithelial cells. Anticancer Res. 1998 Jul-Aug;18(4A):2449-53.


Leung LK, Do L, Wang TT. Regulation of death promoter Bak expression by cell density and 17 beta-estradiol in MCF-7 cells. Cancer Lett. 1998 Feb 13;124(1):47-52.


Sun XY, Plouzek CA, Henry JP, Wang TT, Phang JM. Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells. Cancer Res. 1998 Jun 1;58(11):2379-84.


Ciolino HP, Wang TT, Yeh GC. Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity. Cancer Res. 1998 Jul 1;58(13):2754-60.


Sathyamoorthy N, Wang TT. Differential effects of dietary phyto-oestrogens daidzein and equol on human breast cancer MCF-7 cells. Eur J Cancer. 1997 Dec;33(14):2384-9.


Wang TT, Hursting SD, Perkins SN, Phang JM. Effects of dehydroepiandrosterone and calorie restriction on the Bcl-2/Bax-mediated apoptotic pathway in p53-deficient mice. Cancer Lett. 1997 Jun 3;116(1):61-9.


Wang TT, Sathyamoorthy N, Phang JM. Molecular effects of genistein on estrogen receptor mediated pathways. Carcinogenesis. 1996 Feb;17(2):271-5.


Farres J, Wang TT, Cunningham SJ, Weiner H. Investigation of the active site cysteine residue of rat liver mitochondrial aldehyde dehydrogenase by site-directed mutagenesis. Biochemistry. 1995 Feb 28;34(8):2592-8.


Wang TT, Phang JM. Effects of estrogen on apoptotic pathways in human breast cancer cell line MCF-7. Cancer Res. 1995 Jun 15;55(12):2487-9.


Sathyamoorthy N, Wang TT, Phang JM. Stimulation of pS2 expression by diet-derived compounds. Cancer Res. 1994 Feb 15;54(4):957-61.


Farres J, Wang X, Takahashi K, Cunningham SJ, Wang TT, Weiner H. Effects of changing glutamate 487 to lysine in rat and human liver mitochondrial aldehyde dehydrogenase. A model to study human (Oriental type) class 2 aldehyde dehydrogenase. J Biol Chem. 1994 May 13;269(19):13854-60.


Zheng CF, Wang TT, Weiner H. Cloning and expression of the full-length cDNAS encoding human liver class 1 and class 2 aldehyde dehydrogenase. Alcohol Clin Exp Res. 1993 Aug;17(4):828-31.


Wang TT, Lewis KC, Phang JM. Production of human plasma retinol-binding protein in Escherichia coli. Gene. 1993 Nov 15;133(2):291-4.


Wang TT, Wang Y, Weiner H. Effects of protein size on the rate of import of the precursors of aldehyde dehydrogenase and ornithine transcarbamylase into rat liver mitochondria. Alcohol Clin Exp Res. 1991 Mar;15(2):286-90.


Weiner H, Wang TT, Farres J. Molecular biological studies on liver mitochondrial aldehyde dehydrogenase. Alcohol Alcohol Suppl. 1991;1:91-5.


Weiner H, Farres J, Wang TT, Cunningham SJ, Zheng CF, Ghenbot G. Probing the active site of aldehyde dehydrogenase by site directed mutagenesis. Adv Exp Med Biol. 1991;284:13-7.


Wang TT, Pak YK, Weiner H. Effects of alcohol on the import of aldehyde dehydrogenase precursor into rat liver mitochondria. Alcohol Clin Exp Res. 1990 Aug;14(4):600-4.


Wang TT, Farres J, Weiner H. Liver mitochondrial aldehyde dehydrogenase: in vitro expression, in vitro import, and effect of alcohols on import. Arch Biochem Biophys. 1989 Aug 1;272(2):440-9.


Weiner H, Wang TT, Farres J, Jeng JJ. Precursors and post translational modification of mitochondrial aldehyde dehydrogenase. Prog Clin Biol Res. 1989;290:81-92.


Chandler CJ, Wang TT, Halsted CH. Pteroylpolyglutamate hydrolase from human jejunal brush borders. Purification and characterization. J Biol Chem. 1986 Jan 15;261(2):928-33.


Wang TT, Chandler CJ, Halsted CH. Intracellular pteroylpolyglutamate hydrolase from human jejunal mucosa. Isolation and characterization. J Biol Chem. 1986 Oct 15;261(29):13551-5.


Wang TT, Reisenauer AM, Halsted CH. Comparison of folate conjugase activities in human, pig, rat and monkey intestine. J Nutr. 1985 Jun;115(6):814-9.


Proceedings and book chapters.



Wang, T. T., Kim, Y.- S., Hursting, S. D., Takahashi, Y., Schoene, N. W., Mizuno, C. S., and Rimando, A. M., Cleveland, T. E., and Boue, S. M. Continuing saga of understanding the relationship between phytochemicals and cancer prevention. Proc. 38th Meeting of UJNR Food and Agriculture Panel members, Tsukuba, Japan. pp. 30-32. 2009. (Proceedings)


Wang, T. T.  DNA microarray in nutrigenomics and cancer prevention research: elucidating molecular signatures of cancer preventive hytochemicals.  JAACT.  2008. (Proceedings)


Wang, T. T., Kim, Y.-S., Hursting, S. D., Perkins, S. N., Chandramouli, G. V. R., Lavigne, J. A., and Takahashi, Y.  Regulation of hormone-dependent pathways by cancer preventive phytochemicals.  Proc. 35th Meeting of UJNR Food and Agriculture Panel members, Sonoma, CA. pp. FF39-FF42. 2006. (Proceedings)

Jeng J, Goldman D, Eriksson CJP, Kallarakal AT, Wang T, Weiner H, Song BJ. Accumulation of Hepatic Acetaldehyde and Reduced Alcohol Drinking in Transgenic Mice Carrying the Oriental Variant of the Human Aldehyde Dehydrogenase 2 Gene. Enzymology and Molecular Biology of Carbonyl Metabolism 12 (In press, Book chapter)


Wang T, Kim YS, Hursting SD, Perkins SN, Chandramouli GVR, Lavigne JA, Takahashi Y. Deciphering Molecular Signatures of Phytochemicals in Cells Proceedings, 34th Meeting of UJNR Food and Agriculture Panel members, Susono, Japan. pp. 267-271, 2005. (Proceeding)


Takahashi Y, Hursting SD, Perkins SN, Wang, T. Genistein is a Modulator of Both Androgen and Estrogen Receptor-Mediated Pathways in Androgen-Dependent Prostate Cancer Cell LNCaP. Proceedings, 33nd Meeting of UJNR Food and Agriculture Panel members, Hawaii. pp. 153-157, 2004. (Proceeding)


Wang T, Wang T-C, Kim YS, Hursting SD, Perkins SN, Lavigne JA, Loh Y, Takahashi Y. Phytochemicals as Modulator of Apoptosis Pathways. Proceedings, 33nd Meeting of UJNR Food and Agriculture Panel members, Hawaii. pp. 148-152, 2004. (Proceeding)


Takahashi Y, Hursting SD, Wang T. Soy Isoflavone Genistein Modulates Expression of An Androgen-Responsive Gene SPAK in Human Prostate Caner Cells. Proceedings, 32nd Meeting of UJNR Food and Agriculture Panel members, Tsukuba, Japan. pp. 313-316. 2003 (Proceeding)


Wang T, Lavigne JA, Hursting SD, Chandramouli GVR, Takahashi Y. Utility of Microarray Technology in Studies of Cancer Preventive Phytochemicals. Proceedings, 32nd Meeting of UJNR Food and Agriculture Panel members, Tsukuba, Japan. pp. 304-307. 2003 (Proceeding)


Weiner H, Wang T, Guan K-L, Farres J, Pak YK, Saigal D, Cunningham S, Jeng JJ. Application of molecular biological techniques in alcohol research: study of aldehyde dehydrogenase. Biomedical and Social Aspects of Alcohol and Alcoholism, 377-380. 1988. (Book chapter)


Chandler CJ, Wang T, Halsted CH. Brush border pteroylpolyglutamate hydrolase in pig jejunum. Chemistry and Biology of Pteridines, 539-542. 1986. (Book chapter)


Last Modified: 8/13/2016
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