Page Banner

United States Department of Agriculture

Agricultural Research Service

Panickar's Publications
headline bar

Kiran Panickar, PhD

Research Biologist, Diet Genomics and Immunology Lab

Beltsville Human Nutrition Research Center

USDA, Agriculture Research Service



Journal articles and book chapters:




Panickar, K.S & Anderson R.A. (2010) Dietary polyphenols exert neuroprotective effects by attenuating neuronal and astrocytic damage in cerebral ischemia. In, Phytochemicals and Human Heath: Pharmacological and Molecular Aspects (Ed) Farooqui, A.A. Springer, NY. (in press).


Panickar, K.S (2010) Corticorelin acetate, a synthetic human corticotropin-releasing factor analog for the treatment of peritumoral brain edema. Thomson Reuters' Thomson Pharma ( (submitted).


Qin, B; Panickar, K.S & Anderson, R.A (2010) Cinnamon: The potential role in the prevention of insulin resistance, metabolic syndrome and type 2 diabetes. Journal of Diabetes Science and Technology.4(3):685-693.


Panickar, K.S & Anderson R.A. (2010) Role of dietary polyphenols in attenuating brain edema and cell swelling in cerebral ischemic injury. Recent Patents on CNS Drug Discovery. 5(2): 99-108.


Jayakumar, A.R; Panickar, KS; Curtis, K.M; Tong, X.Y; Moriyama, M & Norenberg, M.D. (2010)  Na-K-Cl Cotransporter-1 in the Mechanism of Cell Swelling in Cultured Astrocytes after trauma. (submitted). 


Panickar, K.S & Anderson R.A. (2010) Mechanisms underlying the protective effects of myricetin and quercetin following oxygen-glucose deprivation-induced cell swelling and the reduction in glutamate uptakein glial cells.Experimental Neurology (Submitted).





Krishnamurthy, R; Senut, M-C; Zemke, D; Min, J; Frenkel, M.B; Greenberg, E.J; Yu, S-W; Ahn, N; , Goudreau, J;Panickar, K.S; Majid, A (2009) Asiatic acid, a pentacyclic triterpene from Centella asiatica is neuroprotective in a mouse model of focal cerebral ischemia. Journal of Neuroscience Research. 87(11):2541-50.


Panickar, K.S; Polansky, M.M & Anderson R.A. (2009) Cinnamon polyphenolsattenuate cell swelling and mitochondrial dysfunction followingoxygen-glucose deprivation in glial cells. Experimental Neurology 216: 420-427.


Panickar, K.S; Polansky, M.M & Anderson R.A. (2009) Green tea polyphenolsattenuate cell swelling and mitochondrial dysfunction followingoxygen-glucose deprivation in glial cells. Nutritional Neuroscience 12(3):105-113.



Panickar,K.S;Jayakumar, A.R; Rama Rao, K.V & Norenberg, M.D (2009)Ammonia-induced activation of p53 in cultured astrocytes: Role in cell swelling and glutamate uptake. Neurochemistry International. 55(1-3):98-105.


Panickar, K.S; Cao, H.C; Qin, B & Anderson R.A. (2009) Molecular targets and therapeutic uses of cinnamon. In, Molecular targets and therapeutic uses of spices: Modern uses for ancient medicine. Monograph of Spices. Aggarwal, B.B; Kunnumakkara, A.B. (Eds), World Scientific Publishing Co., Inc. pp. 87-115.


Panickar, K.S & Bhathena, S.J (2009) Control of fatty acid intake and the role of essential fatty acids in cognitive function and neurological disorders. In Fat detection: Taste, texture and post-ingestive effects. Montmayeur, J-P, Coutre, J (Eds). CRC Press, Boca Raton, FL. pp. 463-484.






Panickar, K.S; Nonner, D; White, M.G & Barrett, J.N (2008) Overexpression of Cdk5 or non-phosphorylatable retinoblastoma protein protects septal neurons from oxygen-glucose deprivation. Neurochemical Research33(9):1852-1858.


Sinke, A; Jayakumar, A.R; Panickar, K.S; Moriyama, M; Reddy, P.V.B & Norenberg, M.D. (2008) NF?B in the mechanism of ammonia-induced astrocyte swelling in culture. Journal of Neurochemistry. 106(6):2302-2311.


Jayakumar, A.R; Rama Rao, K.V; Panickar,K.S; Moriyama, M; Reddy, P.V.B & Norenberg, M.D (2008) Trauma-induced cell swelling in cultured astrocytes. Journal of Neuropathology and Experimental Neurology. 67(5):417-427.


Cao, H.C; Qin, B; Panickar, K.S & Anderson, R.A. (2008) Tea and cinnamon polyphenols improve the metabolic syndrome. Agro Food Industry High Tech. 19(6): 16-19.






Panickar, K.S; Jayakumar, A.R; Rama Rao K.V & Norenberg, M.D (2007) Downregulation of the 18 kDA translocator protein (TSPO): Effects on the ammonia-induced mitochondrial permeability transition and cell swelling in cultured astrocytes. Glia. 55(16):1720-1727.


Norenberg, M.D; Jayakumar, A.R; Rama Rao, K.V & Panickar, K.S. (2007) New concepts in the mechanism of ammonia-induced astrocyte swelling. Metabolic Brain Disease. 22(3-4):219-234.






Jayakumar, A.R; Panickar, K.S. Murthy, C.R & Norenberg, M.D (2006) Oxidative stress and MAPK phosphorylation mediate ammonia-induced cell swelling and glutamate uptake inhibition in cultured astrocytes. Journal of Neuroscience. 26(18):4774-4784.



Norenberg, M.D; Jayakumar, A.R; Rama Rao, K.V & Panickar, K.S (2006) The peripheral benzodiazepine receptor and neurosteroids in the pathogenesis of Hepatic Encephalopathy and ammonia neurotoxicity. In, Hepatic Encephalopathy and nitrogen metabolism. Haussinger D, Kircheis G, Schliess F (Eds). Springer Dordrecht, The Netherlands. pp143-159.





Panickar, K.S; Nonner, D & Barrett, J.N (2005) Overexpression of Bcl-xl protects septal neurons from prolonged hypoglycemia and from acute ischemia-like stress. Neuroscience. 135(1):73-80.


Panickar, K.S & Norenberg, M.D (2005) Astrocytes in cerebral ischemic injury: General & morphological considerations. Glia. 50(4):287-98.


Rama Rao, K.V; Panickar, K.S; Jayakumar, A.R & Norenberg, M.D (2005)  Astrocytes protect neurons from ammonia toxicity. Neurochemical Research. 30(10):1311-1318.






Nonner, D; Panickar, K.S; Barrett, E.F & Barrett, J.N (2004) Bone morphogenetic proteins (BMPs) and neurotrophins provide complementary protection of septal cholinergic function during phosphatase inhibitior-induced stress. Journal of Neurochemistry. 91:77-87.


Fass, U; Panickar, K.S.; Williams, K; Nevels, K; Personett, D & McKinney, M (2004) The role of glutathione in nitric oxide donor toxicity to SN56 cholinergic neuron-like cells. Brain Research. 1005: 90-100.







Panickar, K.S; Jayakumar, A.R & Norenberg, M.D. (2002) Differential response of neural cells to trauma-induced free radical production in vitro. Neurochemical Research. 27(1-2):161-166.


Jayakumar, A.R; Panickar, K.S & Norenberg, M.D. (2002) Effects on free radical generation by ligands of the peripheral benzodiazepine receptor in cultured neural cells. Journal of Neurochemistry. 83:1226-1234.



Bai, G; Rama Rao, K.V; Murthy, Ch. R.K ; Panickar, K.S; Jayakumar, A.R. & Norenberg, M.D (2001) Ammonia induces the mitochondrial permeability transition in primary cultures of rat astrocytes. Journal of Neuroscience Research. 66:981-991



Personett, D; Fass, U; Panickar, K & McKinney, M. (2000) Retinoic acid enhancement of the cholinergic phenotype of SN56 neuroblastoma cells: differentiation establishes a nitric oxide-sensitive proapoptotic state. Journal of Neurochemistry. 74(6):2412- 2424.


Fass, U; Panickar, K; Personett, D; Bryan, D; Williams, K; Gonzalez, J & McKinney, M (2000) Differential vulnerability of cholinergic neurons in primary cultures to nitric oxide excess. Neuroreport. 11(57):931-936







Panickar, K.S; Purushotham, K.R; King, M.A; Rajakumar, G & Simpkins, J.W. (1998) Hypoglycemia-induced seizures reduce CREB levels in the rat hippocampus. Neuroscience. 83(4):1155-1160.


Shi, J; Panickar, K.S; Yang, S.H; Rabbani, O; Day, A.L & Simpkins, J.W. (1998) Estrogen attenuates overexpression of ?-amyloid precursor protein mRNA in an animal model of focal ischemia. Brain Research. 810:87-92.


Simpkins, J.W; Rabbani, O; Shi, J; Panickar, K.S; Green, P.S and Day, A.L. (1998) A system for the brain-enhanced delivery of estradiol: As assessment of its potential for the treatment of Alzheimer's disease and stroke. Die Pharmazie. 53(8) 505-511.


Rabbani, O; Panickar, K.S; Rajakumar, G; King, M.A; Meyer, E.M., and Simpkins, J.W. (1997) 17 ?-estradiol attenuates fimbrial lesion-induced decline of ChAT-immunoreactive neurons in the rat medial septum. Experimental Neurology.146:179 186.


Panickar, K.S; Guan, G; King, M.A; Rajakumar, G, & Simpkins, J.W. (1997) 17 ?- estradiol attenuates CREB decline in the rat hippocampus following seizure. Journal of Neurobiology. 33:961-967.


McNaughton, N; Panickar, K.S & Logan, B. (1996) The pituitary-adrenal axis and the different behavioral effects of buspirone and chlordiazepoxide. Pharmacology Biochemistry & Behavior. 54(1): 51-56.


McNaughton, N; Logan, B; Panickar, K. S; Kirk, I; Pan, W-X; Brown, N & Heenan, A (1995) The contribution of synapses in the medial supramammillary nucleus to the frequency of hippocampal theta rhythm in freely-moving rats. Hippocampus. 5(6): 534-545.







Eileen J. Martin; Kiran S. Panickar; Michael A. King; Malgorzata Deyrup; Bruce E. Hunter & Edwin M. Meyer (1994) Cytoprotective actions of 2,4- dimethoxybenzylidene anabeseine in differentiated PC 12 cells and septal cholinergic neurons. Drug Development Research. 31(2): 135-141.


Panickar, Kiran S. (1994) Role of nicotine and nicotinic compounds in the treatment of neurodegenerative diseases and neuropsychiatric disorders. Italian Journal of Addictions. 82-83.


Panickar, Kiran S & McNaughton, N (1992) Comparison of the effects of chlordiazepoxide and buspirone on differential reinforcement of low rates of response. European Journal of Pharmacology. 210, 307-313.


Panickar, Kiran S & McNaughton, N (1991) Dose-response analysis of the effects of buspirone on rearing in rats. Journal of Psychopharmacology. 5(1), 72-76.


Panickar, Kiran S & McNaughton, N (1991) Comparison of the effects of chlordiazepoxide and buspirone on successive discrimination. Pharmacology Biochemistry & Behavior. 39(2), 275-278.


Panickar, Kiran S & McNaughton, N (1991) Effects of buspirone on fixed interval responding in rats. Journal of Psychopharmacology. 5(4), 408-415



Last Modified: 8/13/2016
Footer Content Back to Top of Page