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H Corby Kistler (Corby)

Research Geneticist

Fungal Pathogen Genetics

My research involves the genetics of fungal plant pathogens in the genus Fusarium. We are using genomic approaches to better understand the mechanisms by which fungal pathogens cause disease in plants. Most of our effort focuses on Fusarium graminearum (Gibberella zeae), the head blight pathogen of cereal crops, and related fungi. We are also interested in the population genetics and evolution of plant pathogenic Fusarium species such as Fusarium graminearum and Fusarium oxysporum.

Publications by CDL staff available in Pdf format

Selected Publications:

Boenisch, M.J., Broz, K.L., Purvine, S.O., Chrisler, W.B., Nicora, C.D., Connolly, L.R., Freitag, M., Baker, S.E., Kistler, H.C. 2017. Structural reorganization of the fungal endoplasmic reticulum upon induction of mycotoxin biosynthesis. Scientific Reports doi: 10.1038/srep44296

LeBlanc, N., Kistler, H.C., and Kinkel, L.L. 2017. Plant diversity and plant identity influence Fusarium communities in soil. Mycologia 109:128-139. doi: 10.1080/00275514.2017.1281697.

Essarioui, A., LeBlanc, N., Kistler, H.C., and Kinkel, L.L., 2017. Plant community richness mediates inhibitory interactions and resource competition between Streptomyces and Fusarium populations in the rhizosphere. Microbial Ecology, 1-11.

van Dam, P., Fokkens, L., Schmidt, S.M., Linmans, J.H.J., Kistler, H.C., Ma, L.-J., and Rep, M. 2016. Effector profiles distinguish formae speciales of Fusarium oxysporum. Environmental Microbiology 18, 4087-4102.

Ipcho, S., Sundelin, T., Erbs, G., Kistler, H.C., Newman, M.-A. and Olsson, S. 2016. Fungal Innate immunity induced by bacterial Microbe-Associated Molecular Patterns (MAMPs). G3: Genes|Genomes|Genetics 6: 1585-1595.

Guo, L., Zhao, G., Xu, J.-R., Kistler, H.C., Gao, L., Ma, L.-J. 2016. Compartmentalized gene regulatory networks of a pathogenic fungus Fusarium graminearum. New Phytologist 211: 527–541.

Liang, J., Lofgren, L., Ma, Z., Ward, T.J. and Kistler, H.C.  2015.  Population subdivision of Fusarium graminearum from barley and wheat in the upper Midwestern United States at the turn of the century.  Phytopathology 105:1466-1474.

Kelly, A.C., Clear, R.M., O'Donnell, K., McCormick, S., Turkington, T.K., Tekauz, A., Gilbert, J., Kistler, H.C., Busman, M. and Ward, T.J.  2015.  Diversity of Fusarium head blight populations and trichothecene toxin types reveal regional differences in pathogen composition and temporal dynamics.  Fungal Genetics and Biology 82:22-31.

Kistler, H.C. and Broz, K.  2015.  Cellular compartmentalization of secondary metabolism.  Frontiers in Microbiology 6:68 doi:10.3389/fmicb.2015.00068.

Varga, E., Wiesenberger, G., Hametner, C., Ward, T. J., Dong, Y., Sch?fbeck, D., McCormick, S., Broz, K., St?ckler, R., Schuhmacher, R., Krska, R., Kistler, H. C., Berthiller, F. and Adam, G. 2015. New tricks of an old enemy: Isolates of Fusariumgraminearum produce a novel type A trichothecene mycotoxin. Environmental Microbiology doi: 10.1111/1462-2920.12718.

LeBlanc, N., Kinkel, L.L. and Kistler, H.C. 2014. Soil fungal communities respond to grassland plant community richness and soil edaphics. Molecular Ecology doi:10.1007/s00248-014-0531-1 

Liang, J., Xayamongkhon, H., Broz, K., Dong, Y., McCormick, S.P., Abramova, S.,Ward, T.J., Ma, Z.H., Kistler, H.C. 2014. Temporal dynamics and population genetic structure of Fusariumgraminearum in the upper Midwestern United States. Fungal Genetics and Biology 73: 83-92.

Lys?e, E., Harris, L.J., Walkowiak, S., Subramaniam, R., Divon, H.H.,  Riiser,E.S., Llorens, C., Gabald?n,T., Kistler, H.C., Jonkers, W., Kolseth, A.-K., Nielsen, K.F., Thrane, U., Frandsen, R.J.N. 2014. The genome of the generalist plant pathogen Fusariumavenaceum is enriched with genes involved in redox, signaling and secondary metabolism. PLoS ONE 9(11): e112703. doi:10.1371/journal.pone.0112703.

Ma, L.-J., Terrance Shea, T., Young, S., Zeng, Q. and Kistler, H.C.  2014. Genome sequence of Fusariumoxysporum f. sp. melonis (26406), a fungus causing wilt disease on melon. Genome Announcements 2 (4) e00730-14. doi: 10.1128/genomeA.00730-14

Jonkers, W., Xayamongkhon, H., Haas, M., Olivain, C., van der Does, H.C., Broz, K., Rep, M., Alabouvette, C., Steinberg, C. and Kistler, H.C.  2014. EBR1 genomic expansion and its role in virulence of Fusarium species. Environmental Microbiology doi:10.1111/1462-2920.12331. 

Menke, J., Weber, J., Broz, K., Kistler, H.C.  2013.  Cellular development associated with induced mycotoxin synthesis in the filamentous fungus Fusarium graminearum.  PLoS ONE 8(5): e63077. doi:10.1371/journal.pone.0063077

Aoki, T., Ward, T.J., Kistler, H.C., O'Donnell, K.  2012.  Systematics, phylogeny and trichothecene mycotoxin potential of Fusarium head blight pathogens.  Mycotoxins 62:91-102

Menke, J., Dong, Y., Kistler, H.C.  2012.  Fusarium graminearumTri12p influences virulence to wheat and trichothecene accumulation.  Molecular Plant-Microbe Interactions 25:1408-1418.

Estrada, A.E.R., Jonkers, W., Kistler, H.C., May, G.  2012.  Interactions between Fusarium verticillioides, Ustilago maydis, and Zea mays: An endophyte, a pathogen, and their shared plant host.  Fungal Genetics and Biology 49:578-587.

Jonkers, W., Rodriguez Estrada, A.E., Lee, K., Breakspear, A., May, G., Kistler, H.C.  2012.  Metabolome and transcriptome of the interaction between Ustilago maydis and Fusarium verticillioidesin vitro.  Applied and Environmental Microbiology 78:3656-3667.

Jonkers, W., Dong, Y., Broz, K., Kistler, H.C.  2012.  The Wor1-like protein Fgp1 regulates pathogenicity, toxin synthesis and reproduction in the phytopathogenic fungus Fusarium graminearum.  PLoS Pathogens 8(5): e1002724.

Breakspear, A., Pasquali, M., Broz, K., Dong, Y., Kistler, H.C.  2011.  Npc1 is involved in sterol trafficking in the filamentous fungus Fusarium graminearum.  Fungal Genetics and Biology 48:725-730.

Lysoe, E., Seong, K-Y., Kistler, H.C.  2011.  The transcriptome of Fusarium graminearum during the infection of wheat.  Molecular Plant-Microbe Interactions 24:995-1000.

Li, Y., Wang, C., Liu, W., Wang, G., Kang, Z., Kistler, H.C., Xu, J-R.  2011.  The HDF1 histone deacetylase gene is important for conidiation, sexual reproduction, and pathogenesis in Fusarium graminearum.  Molecular Plant-Microbe Interactions 24:487-496. 

Wang, C., Zhang, S., Hou, R., Zhao, Z., Zheng, Q., Xu, Q., Zheng, D., Wang, G., Liu, H., Gao, X., Ma, J-W., Kistler, H.C., Zhang, Z., Xu, J-R.  Functional analysis of the kinome of the wheat scab fungus Fusarium graminearum.  PLoS Pathogens 7: e1002460.

Estrada, A.E.R., Hegeman, A., Kistler, H.C., May, G.  2011.  In vitro interactions between Fusarium verticillioides and Ustilago maydis through real-time PCR and metabolic profiling.  Fungal Genetics and Biology 48:874-885.

Wang, Y., Liu, W., Hou, Z., Wang, C, Zhou, X., Jonkers, W., Ding, S., Kistler, H.C., Xu, J-R.  2011.  A novel transcriptional factor important for pathogenesis and ascosporogenesis in Fusarium graminearum.  Molecular Plant-Microbe Interations 24:118-128.

Lysoe, E., Pasquali, M, Breakspear, A., Kistler, H.C.  2011.  The transcription factor FgStuAp influences spore development, pathogenicity, and secondary metabolism in Fusarium graminearum.  Molecular Plant-Microbe Interations 24:54-67.

Gale, L.R., Harrison, S.A., Ward, T.J., O'Donnell, K., Milus, E.A., Gale, S.W., Kistler, H.C.  2011.  Nivalenol-type populations of Fusarium graminearum and F. asiaticum are prevelant on wheat in southern Louisiana.  Phytopathology 101:124-134.

Rep, M., Kistler, H.C.  2010.  The genomic organization of plant pathogenicity in Fusarium species.  Current Opinion in Plant Biology 13:420-426.

Kumar, L., Breakspear, A., Kistler, C., Ma, L-J, Xie, X.  2010. Systematic discovery of regulatory motifs in Fusarium graminearum by comparing four Fusarium genomes.  BMC Genomics 11:208.

Ma, L-J, et. al.  2010. Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium.  Nature 464:367-373.

Ding, S., Mehrabi, R., Koten, C., Kang, Z., Wei, Y., Seong, K., Kistler, H.C. and JR. Xu.  2009.  Transducin beta-like gene FTL1 is essential for pathogenesis in Fusarium graminearum.  Eukaryotic Cell 8:867-878.

Seong,KY., Pasquali, M., Zhou, X., Song, J., Hilburn, K., McCormick, S., Dong, Y., Xu, JR. and H.C. Kistler.  2009.  Global gene regulation by Fusarium transcription factors Tri6 and Tri10 reveals adaptations for toxin biosynthesis.  Molecular Microbiology 72:354-367.

O'Donnell, K., Ward, T.J., Aberra, D., Kistler, H.C., Aoki, T., Orwig, N., Kimura, M., Bj?rnstad, ? and S.S. Klemsdal.  2008.  Multilocus genotyping and molecular phylogenetics resolve a novel head blight pathogen within the Fusarium graminearum species complex from Ethiopia.  Fungal Genetics and Biology 45:1514-1522.

Seong, K., Zhao, X., Xu, J.-R., G?ldener, U., and Kistler, H.C. 2008. Conidial germination in the filamentous fungus Fusarium graminearum.  Fungal Genetics and Biology 45:389-399.

Cuomo, C.A.,  G?ldener, U., Xu, J.-R.,  Trail, F., Turgeon, B.G., Di Pietro, A., Walton, J.D., Ma, L.-J., Baker, S.E., Rep, M., Adam, G., Antoniw, J., Baldwin, T., Calvo, S.,  Chang, Y.-L., DeCaprio, D., Gale, L.R., Gnerre, S., Goswami, R.S., Hammond-Kosack, K.,  Harris, L.J., Hilburn, K., Kennell, J.C., Kroken, S., Magnuson, J.K., Mannhaupt, G.,  Mauceli, E., Mewes, H.-W., Mitterbauer, R., Muehlbauer, G., M?nsterk?tter, M., Nelson, D., O'Donnell, K., Ouellet, T.,  Qi, W., Quesneville, H., Roncero, M.I.G., Seong, K.-Y., Tetko, I.V., Urban, M.,  Waalwijk, C., Ward, T.J.,  Yao, J.,  Birren, B.W., Kistler, H.C.  2007. The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. Science 317:1400-1402.

G?ldener, U., Seong, K.-Y., Boddu, J., Cho, S., Trail, F., Xu, J.-R., Adam, G., Mewes, H.-W., Muehlbauer, G.J., and Kistler, H.C. 2006. Development of a Fusarium graminearum Affymetrix GeneChip for profiling fungal gene expression in vitro and in planta. Fungal Genet. Biol. 43:316-325.

Gale, L.R., Bryant, J.D., Calvo, S., Giese, H., Katan, T., O'Donnell, K., Suga, H., Taga, M.,  Usgaard, T.R., Ward, T.J. and Kistler, H.C. 2005. Chromosome complement of the fungal plant pathogen Fusarium graminearum based on genetic and physical mapping and cytological observations. Genetics 171:985-1001.
Seong, K., Hou, Z., Tracy, M., Kistler, H.C. and Xu, J.-R. 2005. Random insertional mutagenesis identifies genes associated with virulence in the wheat scab fungus Fusarium graminearum. Phytopathology 95:744-750.
O'Donnell, K., Ward, T.J., Geiser, D.M., Kistler, H.C. and Aoki, T. 2004. Genealogical concordance between the mating type locus and seven other nuclear genes supports formal recognition of nine phylogenetically distinct species within the Fusarium graminearum clade. Fungal Genetics and Biology 41:600-623.